ライフサイエンスコーパス: amide

1 rN 1, PNP = bis[2-diisopropylphosphino)ethyl]amide).

2 ion, to yield the benzoxazole and avoids the amide.

3 action of 2-aminobenzyl alcohol with primary amides.

4 compounds, for example ketones, esters, and amides.

5 nthesis of enantioenriched gamma-stereogenic amides.

6 ty of fully perpendicular N-acyl-glutarimide amides.

7 affeoylquinic acids and hydroxycinnamic acid-amides.

8 It was demonstrated that glutamine amide 1 could select an optimal aldehyde component and p

9 es water exchange, which disfavors classical amide (1)H-detection, while (13)C-detection suffers from

10 Amide (15)N relaxation measurements of the Cre(Cat) doma

11 iently leads to the formation of hydroperoxy amides, a new type of atmospheric nitrogen-containing co

12 e C4-quaternary 3,4-dihydroquinazolines from amides, amines, and ketones has been developed.

13 quantified interactions of alkyl ureas with amide and aromatic compounds, relative to interactions w

14 ation states of unified O, N, and C atoms of amide and aromatic compounds.

15 represents the first example of an apparent amide and carbamate directing effect in metal-mediated r

16 The method is applicable for backbone amide and side chain methyl groups and represents a time

17 eferentially interact with both the backbone amide and the side-chain hydroxyl (bidentate interaction

18 Diverse amides and 4-pyridylglyoxamides are simultaneously synth

19 be telescoped into the one-pot synthesis of amides and alpha-aminotrifluoroborates by exploiting the

20 arboxylic acids, as well as minor amounts of amides and aromatic compounds.

21 unsigned chemical shift changes for backbone amides and carbonyls ((1)H, (15)N, and (13)C').

22 ropionamides, including hydroxycinnamic acid amides and lignanamides, were identified by HPLC-ESI-QTO

23 introduced into the amino group of Weinreb's amides and methyl esters of amino acids, as well as into

24 nditions, the decaging of pentynoyl tertiary amides and N-propargyls occurs rapidly in aqueous system

25 core structures from non-conjugated alkenyl amides and ortho-iodoanilines/phenols.

26 f four zwitterionic/cationic polyfluoroalkyl amides and sulfonamides.

27 nts depend on the exchange rates between the amides and the water, thereby yielding diagnostic inform

28 e as a catalyst, a wide range of unsaturated amides and thioamides underwent thiocyanation to furnish

29 -H with an aldehyde, ketone, activated ester/amide, and unactivated amide consist of two different ra

30 c protons alpha to carbonyl groups, tertiary amides, and aryl rings having common organic functional

31 oducts including aldehydes, ketones, esters, amides, and carboxylic acids.

32 cium diazeniumdiolates from benzylic amines, amides, and sterically bulky amines hitherto inaccessibl

33 rbon resin), including alkanes, fatty acids, amides, and tackifying terpenoids embedded in a fluid ma

34 of zwitterionic organocatalysts based on an amide anion/iminium cation charge pair were found to be

35 uch cases two electrons from the coordinated amide are required to occupy a 3c-4e sigma* orbital whic

36 When amides are employed as unstabilized C(sp(3)) nucleophile

37 mational perturbations induced by N-(hydroxy)amides are outweighed by a network of strong interstrand

38 Carbene-metal-amides are soluble and thermally stable materials which

39 to membrane protein structures and that many amides are unaffected by dehydration within the bilayer.

40 ducible functional groups such as esters and amides are well tolerated, contributing to the overall w

41 ile sp(2)N interactions with sp(2)N and with amide/aromatic sp(2)C are modestly unfavorable.

42 o success was the use of weakly coordinating amide as the directing group, as previous studies have s

43 Here, we report an amide-assisted Fe(2)GeS(4) NP synthesis that directly fo

44 ed out the roles that Bronsted bases play in amide-assisted NP syntheses and were necessary for Ge in

45 biochemical assays, we demonstrate that the amide backbone of CTA is assembled in an unusual thiotem

46 sponsive metal-organic framework by using an amide-based [2]rotaxane as linker and copper(II) ions as

47 tion of beta-keto esters catalyzed by hybrid amide-based Cinchona derivatives.

48 Herein, we report a rationally designed amide-based electrolyte based on the desired interface p

49 his work, we studied a series of carfentanyl amide-based opioid derivatives targeting the mu opioid r

50 view the strategic decisions in selecting an amide bioisostere (the why), synthetic routes to each (t

51 that deprotonation and polarization of this amide bond by TbtD removes this barrier and provides a s

52 in the propargylation site resulted in rapid amide bond cleavage, which extends the applicability of

53 s and amines that strategically deviate from amide bond formation remains both a challenge and an opp

54 kinetic and thermodynamic driving force for amide bond formation.

55 mide isomerization kinetics and isoenergetic amide bond geometries influenced by torsional strain and

56 ite catalyzes the hydrolytic cleavage of the amide bond in DMF.

57 f an amine with a carboxylic acid to form an amide bond is the most popular chemical reaction used fo

58 he ability to achieve full distortion of the amide bond significantly expands the range of reagents a

59 ous report, replacing the ester bond with an amide bond significantly reduces biological activity, an

60 that draws from the same substrates used for amide bond synthesis: amines and carboxylic acids.

61 e of their cylindrical shape and established amide bond vibrations.

62 rimides to achieve full twist of the acyclic amide bond, and results in the discovery of N-acyl-gluta

63 modification alters the conformation of the amide bond, interferes with hydrogen bond formation, and

64 opargylation and full recovery of the native amide bond.

65 riven by ground-state destabilization of the amide bond.

66 s metabolically stable bioisosteres of trans-amide bonds (triazole scan) was recently applied to the

67 Trans amide bonds and fast cis- trans isomerization of Xaa-Pro

68 Most importantly, some amide bonds and their similar groups and even benzene ri

69 boxylic acid derivatives with amines to form amide bonds has been the most widely used transformation

70 Moreover, we found that the X-Pro amide bonds in the inter-cysteine loop are rigidly const

71 tionalized graphene (graphene acid = GA) via amide bonds is reported.

72 ically stable bioisosteres to replace labile amide bonds of the peptide.

73 e identified by modification of two or three amide bonds, which yielded both improved stability and i

74 synthetic chemistry for general formation of amide bonds.

75 h paratopes containing potential cis proline amide bonds.

76 ficient and controlled reduction of tertiary amides by a sodium hydride/sodium iodide composite, in s

77 site selectivity in iodination of chrysenyl amides by directed ortho metalation (DoM) was influenced

78 ude conventional reactivity that forms inert amide byproducts.

79 Primary sulfonamides and amides can be protected in moderate to good yields using

80 and Weinreb amides (vs primary or secondary amides) can be synthesized efficiently and with high ste

81 ives by regioselective metalation of ester-, amide-, carbamate-, and carbonate-substituted 2-phenyl-2

82 -methylumbelliferone-derived nonaflates with amides, carbamates, and sulfonamides is described.

83 taining different labile bonds (i.e., ester, amide, carbonate, or carbamate) that served as labile cr

84 ddition of two disparate nucleophiles to the amide carbonyl carbon in a single operational step.

85 Nucleophilic attack by a carboxylate on the amide carbonyl coupled to general acid catalysis at the

86 he amide carbonyl; a substantially unchanged amide carbonyl in the transition state; two concurrent b

87 onds between the chloroform C-H group and an amide carbonyl oxygen atom in solution at room temperatu

88 late engages in nucleophilic attack upon the amide carbonyl; a substantially unchanged amide carbonyl

89 using the omegaB97X-D functional, of a rapid amide cleavage in 2-carboxyphthalanilic acid (2CPA), whe

90 ved in the structure of the bimetallic penta-amide complex, [K(THF)(6)]{[(THF)(R(2)N)(2)Gd][mu-eta(2)

91 The isolated Ln(II) tris(amide) complex [K(crypt)][Tb(NR(2))(3)] (crypt = 2.2.2-c

92 that isostructural series of divalent metal amide complexes featuring extended hydrogen bond network

93 ctional groups of nitrosamine, nitriles, and amide compounds.

94 tone, activated ester/amide, and unactivated amide consist of two different rate limiting steps: the

95 ently introduced zwitterionic styrene-maleic amide copolymers (zSMAs) to overcome this limitation.

96 ality as a nucleophile, directing group, and amide coupling partner.

97 terminated surface, which further undergoes amide coupling with carboxylic acids.

98 , VCD senses the polymeric structure through amide coupling, which is directly dependent on secondary

99 such as olefins possessing esters, sulfone, amide, cyanide, and ketones, aromatic residues containin

100 n the first dimension ((1)D), and five (C18, amide, cyano, phenyl and PFP) in the second dimension ((

101 volves successive triflic anhydride mediated amide dehydration, ketimine addition, and Pictet-Spengle

102 A simple self-assembling glutamine amide derivative 1 was initially found to catalyze a mod

103 hieved in two steps from a known bis-Weinreb amide derived from l-tartaric acid.

104 to [2.2]paracyclophane resulting from larger amide dihedral angles accompanying transannular hydrogen

105 rther FLP reactivity between the uranium(IV)-amide, dihydrogen, and triphenylborane is suggested by t

106 e array of functional groups (ketone, ester, amide, diketones, ketoester, and malonate).

107 To promote the amide-directed C(sp(3))-H activation step, the use of py

108 hydroarylation of allyl aryl ethers using an amide directing group for the preparation of 3,3-disubst

109 This amide electrolyte achieves a high average Coulombic effi

110 The interface reactions with the amide electrolyte lead to the predicted solid electrolyt

111 next generation of stable blue carbene-metal-amide emitters.

112 hols and thiols with excellent tolerance for amide, ester, and carboxylic acid groups.

113 dehydes and other carbonyl derivatives, such amides, ester and carboxylic acids, are presented in a s

114 A variety of amides, esters, (hetero)aromatic ynones, and bis(hetero)

115 nctions, including hydrolase activity toward amides, esters, and thioesters.

116 as high functional group tolerance (phenols, amides, ethers, carboxylic acids, ketones, and acrylic e

117 esponsible for the degradation of fatty acid amides (FAA) including anandamide (AEA), palmitoylethano

118 -Calpha-PNA with homothymine (T(7)) on the t-amide face and homocytosine (C(5)) on the Calpha side ch

119 yl-2-oxazolines with mixed lithium-magnesium amides followed by reaction with different electrophiles

120 tial beta-C(sp(3))-H activation of aliphatic amide, followed by maleimide insertion, triggers a relay

121 l molecule cyanylating reagent at its N-side amide for undergoing nucleophilic acyl substitution with

122 as stable alpha,beta-diEWG cyclic vinylogous amides for the efficient synthesis of bicyclic N-unprote

123 In contrast, amide formation is the most-used bond-construction metho

124 merization during the alpha,beta-unsaturated amide formation.

125 A new photocatalyzed route to amides from alcohols and amines mediated by visible ligh

126 protocol enabling the formation of secondary amides from electron-poor organic bromides and isocyanid

127 These values were obtained at 33 backbone amides from hydrogen/deuterium fractionation factors by

128 The amide functional group plays a key role in the compositi

129 generated dichloromethyllithium to Weinreb's amide functional group.

130 was demonstrated by taking advantage of the amide functionality as a nucleophile, directing group, a

131 be a valuable aid in protein NMR, leading to amide group (1)H polarizations that are orders of magnit

132 tion of the npai* states with respect to the amide group deplanarization and the concomitant increase

133 2-carboxyphthalanilic acid (2CPA), where the amide group is flanked by two catalytic carboxyls, revea

134 l element in peptides is the locally achiral amide group, VCD senses the polymeric structure through

135 ode of internal deprotonation enacted by the amide group, which is a crucial structural feature of th

136 emical reaction between amine and hydrolyzed amide groups of nylon and MAH groups on the MAHgEO at th

137 pai* states with excitation localized on the amide groups.

138 cluding pollen-specific hydroxycinnamic acid amides (HCAAs) and flavonoid glycosides.

139 This differs from trends in amide-heteroarene interactions and provides insightful i

140 in range of bonding interaction, by the hexa-amide, hexaphenolate macrocyclic ligand tris-cyclo-salop

141 The optimization of a 2-formylquinoline amide hit series is described in which the aldehyde make

142 COFamides, whose layers are held together by amide hydrogen bonds.

143 te of mutation but with noticeable impact on amide hydrogen exchange rates extending as far as +/-2 h

144 Amide hydrogen-deuterium exchange mass spectrometry is p

145 Here, amide hydrogen-deuterium exchange with mass spectrometri

146 t the molecular identification of fatty acid amide hydrolase (FAAH) as a second intracellular N-acyl

147 Fatty acid amide hydrolase (FAAH) controls brain anandamide levels;

148 d anandamide due to inhibition of fatty acid amide hydrolase (FAAH) facilitates fear extinction and p

149 nhibition of its catabolic enzyme fatty acid amide hydrolase (FAAH) in the basolateral complex of amy

150 ce, pharmacological inhibition of fatty acid amide hydrolase (FAAH) produces elevated levels of anand

151 ince stress-induced activation of fatty acid amide hydrolase (FAAH) reduces AEA, we confirmed that or

152 ategy targets a specific amidase, fatty acid amide hydrolase (FAAH), an enzyme with enriched expressi

153 the anandamide-degrading enzyme, fatty acid amide hydrolase (FAAH), prolongs the regulatory effects

154 bition of its degradative enzyme, fatty acid amide hydrolase (FAAH), restored both synaptic and behav

155 65279 is a selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for the d

156 rocesses, which are terminated by fatty acid amide hydrolase (FAAH).

157 enetically inherited variation in fatty acid amide hydrolase (FAAH, C385A), which metabolizes the can

158 h higher MAGL expression (but not fatty-acid amide hydrolase or FAAH) were more vulnerable to cortica

159 on pharmacological inhibition of fatty acid amide hydrolase to elevate levels of the endocannabinoid

160 glycerol lipase (MAGL) but not by fatty acid amide hydrolase.

161 methylation, oxidative decarboxylation, and amide hydrolysis reactions.

162 ission setup for the analysis of the protein amide I and amide II band in aqueous solutions that achi

163 investigated using Raman spectroscopy in the amide I and III regions.

164 rated that 2D-IR spectroscopy of the protein amide I band can be performed in aqueous (H(2)O) rather

165 bands of H(2)O that overlap with the protein amide I band with analysis of peak patterns appearing in

166 eraged, extracted, and preprocessed, and the Amide I bands of the protein samples were compared and f

167 Raman spectral signatures in the amide I region revealed that there is no significant cha

168 sions was determined via FTIR, analyzing the Amide I/Amide II peak intensity ratio.

169 ng, baseline correction and normalization to Amide-I band (~ 1650 cm(-1)).

170 mation, as manifested by the recovery of the amide-I band of monomeric Abeta, which is red-shifted by

171 ed-shifted by 26 cm(-1) when compared to the amide-I band of the fibrillar form.

172 ble for class separation; amongst these, the Amide II (1,545 cm(-1)) and proteins (1,425 cm(-1)) were

173 for the analysis of the protein amide I and amide II band in aqueous solutions that achieves a limit

174 s determined via FTIR, analyzing the Amide I/Amide II peak intensity ratio.

175 sition state modeling indicates that the key amide-iminol tautomerization is the major hurdle in an o

176 amides with proteins and chemical effects of amides (including urea, N-ethylpyrrolidone [NEP], and po

177 Modification of their backbone with N-methyl amides inhibits folding, which directly correlates to a

178 tuted cyclopentanone, a mild reduction of an amide intermediate without N-O bond cleavage, and the ra

179 port low-coordinate and highly reducing iron amide intermediates, which are very efficient for effect

180 S precursors, and we discuss possible metal-amide intermediates.

181 e moieties from the insertion of an ester or amide into the Cu-H bond.

182 Finally, we ascertained that five coordinate amide iodine(V) complexes are unreactive toward redox re

183 Pyridinyl amide ion pairs carrying various electron-withdrawing su

184 )diborane (B(2)neop(2)) mediated by iron-bis amide is described.

185 al-free synthesis of a variety of amines and amides is reported via amination of C(sp(3))-H and C(sp(

186 Pd-catalyzed intramolecular C-H arylation of amides is reported.

187 m in D(2)O replaces hydrogen of the backbone amides, is the most common example of footprinting.

188 tives thus represent useful probes of prolyl amide isomerism with potential applications in peptidomi

189 ring pucker, cis/trans amide propensity, and amide isomerization barriers within a series of oxidatio

190 , gamma-oxo-delta-azaproline, features rapid amide isomerization kinetics and isoenergetic amide bond

191 n also be applied to the analogous potassium amide K{N(SiMe(3) )(2) }, leading to the formation of th

192 achieved using the combination of lanthanium amides La[N(SiMe(3))(2)](3) with Trost proligand H(3)L(1

193 Tris[N,N-bis(trimethylsilyl)amide]lanthanum (La(NTMS)) is an efficient and selective

194 ered Ln(II) complexes ligated by three NR(2) amide ligands (R = SiMe(3)).

195 ride complexes of U(III) are accessible with amide ligands and show the high reactivity of molecular

196 , 4-Tb, 5-Gd, and 6-Gd, have three ancillary amide ligands per metal.

197 e conjugate base, lithium bis(trimethylsilyl)amide (LiN(SiMe(3))(2)), and elemental S, respectively.

198 kbone that has nucleobases attached via tert-amide link on repeating units of aminoethylglycine.

199 HD conjugate was synthesized via an amide linkage between carboxylic acid group of HA and am

200 of the benzazole auxiliary, and tolerance of amide linkage forming conditions constitute the potentia

201 eplacing the ring-closing ester bond with an amide linkage or with a primary ester.

202 The results suggest that the amide linkage plays a key role in the formation of a pai

203 lar ascarosides and glucosides via ester and amide linkages.

204 bohydrate-binding module (CBM) identified an amide-linked 1,3-di-O-hexadecyl-glycerol moiety as the o

205 The evidence of the plasma stability of the amide-linked hybrids previously reported prompted us to

206 rough the reactions of the corresponding bis(amides), M{N(SiMe(3) )(2) }(2) (thf)(2) , with (thf)(2)

207 The conversion of amines to hydroperoxy amides may have important implications for nucleation an

208 trans isomerization of the backbone tertiary amides may impair the peptoid's adoption of stable secon

209 method relied on lithium bis(trimethylsilyl)amide-mediated intramolecular cyclization of trisubstitu

210 Amide metathesis has been used to generate the first str

211 ylamide), a thermoresponsive polymer with an amide moiety on its side chain, was studied in aqueous s

212 a dipeptide mimic, by replacing its central amide moiety with an (E) C(beta)=C(gamma) alkene unit.

213 9 in the pocket was achieved with a tertiary amide moiety, confirmed by the X-ray co-crystal structur

214 eries of zSMAs with different styrene:maleic amide molar ratios, chain sizes, and molecular weight di

215 The potent antioxidant, N-acetylcysteine amide (NACA), reduces the severity of a number of the im

216 residues 8, 10, and 11, as well as the extra amide NH group of the lactam ring, hydrogen bond to the

217 In the binding site, the macrolactam amide NH groups of residues 8, 10, and 11, as well as th

218 Amide NH...O=C hydrogen bonding and various pai-system i

219 l)benzamide derivatives designed to maximize amide-NH...F hydrogen bond interactions therein.

220 is series are among the largest measured for amide-NH...F interactions.

221 involves general acid proton delivery to the amide nitrogen by a carboxyl, while the other carboxylat

222 ther, multiple transformations of the chiral amides obtained in this process showcase the potential o

223 unsaturated amides or the dehydrogenation of amides, occurs by means of a triple C-H functionalizatio

224 s can be dehydrogenated back to a poly(oligo)amide of approximately similar molecular weight, thus co

225 ation is currently accomplished with (sulfon)amides or carbamates.

226 losing metathesis of N-homoallyl-unsaturated amides or the dehydrogenation of amides, occurs by means

227 tuted with a halide, trifluoromethyl, ester, amide, or ether group, a heterocycle, or an unprotected

228 1-migratory insertion to give a uranium(III)-amide, or with trimesitylborane a Frustrated Lewis Pair

229 p can be readily converted to amines, acids, amides, or other heterocycles.

230 nyl coupled to general acid catalysis at the amide oxygen can also be ruled out.

231 s were able to locally accumulate around the amide oxygen.

232 for ion pairing and weaker affinity for the amide oxygen.

233 een proposed to occur through intermolecular amide-pai and alkene-pai interactions, but little is kno

234 We found that amide-pai interactions between AF9 and acyllysines are e

235 eir respective polyesters (PE) or poly(ester amides) (PEA).

236 Ln(NR(2))(3)/K/N(2) reactions, have only two amides per metal.

237 isoquinoline alkaloids, hydroxycinnamic acid amides, phenylacetaldehyde-derived floral volatiles, and

238 Here we synthesise carbene-metal-amide photoemitters with CF(3)-substituted ligands to sh

239 to pipecolic acid, which exhibits a high cis amide population, the epsilon heteroatom in oxapipecolic

240 Protonation of the parent bridging amide produced ammonia in high yield, and treatment of t

241 n-coupled electron transfer to generate a mu-amide product.

242 can be diverted to exclusively yield the ene-amide products by virtue of changing the nature of the a

243 uning of heterocyclic ring pucker, cis/trans amide propensity, and amide isomerization barriers withi

244 yl traceless linker that features a tertiary amide protected MMAE was also decaged in the presence of

245 nges to both the free and bound states using amide proton temperature coefficients.

246 demonstrated by gram scale synthesis of C-8 amide quinoline N-oxide and by converting this amidated

247 , and amino functional groups well, and this amide reduction is completely selective, with the exclus

248 Kinetic studies indicate that amide reduction obeys an unusual mixed-order rate law wh

249 reased tumor uptake in comparison to the all-amide reference compound [Nle(15)]MG11.

250 Here spectral changes in the amide region were found to be important for the two cali

251 RF-amide related peptide 3 (RFRP-3) is a neuropeptide thoug

252 speptin (Kp) and arginine-phenylalanine (RF)-amide related peptide-3 (RFRP-3), two hypothalamic pepti

253 is of a short model peptide to determine the amide rotamer preference N-terminal to the cyclic residu

254 ehydro-delta-azaproline exhibit strong trans amide rotamer propensities irrespective of ring conforma

255 amolecular polymers of (S)-triarylamine tris-amides ((S)-TATA) in which both techniques are applied i

256 Redesign of an initial benzofuran-amide scaffold yielded a simplified ether series of inhi

257 try, we quantify interactions of 10 pairs of amides selected to complete this dataset.

258 entary DNAs, to form duplexes from both tert-amide side and Cgamma side.

259 ementary DNAs, one to the base sequence on t-amide side and the other to the bases on the Calpha side

260 hat arises from steric crowding, forcing the amide side groups out of plane with the COF sheets orien

261 Evidence is provided for an amide solvation shell featuring two clearly distinguisha

262 re unfavorable, indicating the preference of amide sp(2)O to interact with water.

263 Amide sp(2)O-sp(2)O interactions and sp(2)O-sp(3)C inter

264 ned to have a second nucleobase attached via amide spacer to a side chain at Cgamma on the repeating

265 While homocoupling of a terminal amide species (M-NH(2) ) to form hydrazine (N(2) H(4) )

266 yield a cyclobutane by the planarity of the amide substituent.

267 en-bond donors and thus forces the secondary amide substituents to turn around.

268 and 14, have been determined for a series of amide substituted N-(hydroxybenzyl)benzamide derivatives

269 is method is compatible with a wide range of amide substrates, including lactams, which lead to spiro

270 The synthesis of alpha-carbonyl-alpha'-amide sulfoxonium ylides by Pd/C-catalyzed carbonylative

271 e synthetically useful alpha-carbonyl-alpha'-amide sulfoxonium ylides in high efficiency.

272 Squaramides represent a class of vinylogous amides that are derived from the squarate oxocarbon dian

273 A bioisosteric amide to ester substitution yielded a series of derivati

274 Addition of acetyl-SVAFS-amide to hemolymph led to unregulated proPO activation.

275 ysis and allows for the facile conversion of amides to chiral alcohols via a one-pot Suzuki-Miyaura c

276 ompound 8i was modified to incorporate amino-amides to increase solubility and stability while retain

277 es) with racemic nucleophiles (beta-zincated amides) to form carbon-carbon bonds in doubly stereoconv

278 We show for the first time that the amide-to-triazole substitution strategy offers new oppor

279 analogs, we studied conjugates with multiple amide-to-triazole substitutions for additive or synergis

280 rimentally confirmed to produce the detected amide transformation products.

281 nes, primary anilines, secondary amines, and amide type nucleophiles together with tolerance for a ra

282 eta-unsaturated enals with cyclic vinylogous amides under oxidative conditions generating potentially

283 A methodology is reported for preparing amides using amines as an acyl source.

284 shed the metal-free catalytic formylation of amides using CO(2) and the catalytic reduction of carbon

285 taneously across a variety of olefins (vinyl amides, vinyl boranes, vinyl phosphonates) at room tempe

286 lectron-deficient esters, acids, and Weinreb amides (vs primary or secondary amides) can be synthesiz

287 N-acyl pyrazole intermediate, and a range of amides were generated in good to excellent yields.

288 via a tetrahedral hemiorthoamide to yield an amide, which is a shunt product and not, as previously t

289 sults in the discovery of N-acyl-glutarimide amide with an almost perfect twist value, tau = 89.1 deg

290 tiomer of nabscessin A (1), an aminocyclitol amide with antimicrobial activity, was synthesized from

291 Pair (FLP) route that produces a uranium(IV)-amide with sacrificial trimesitylborane radical anion.

292 ring of pharmacologically prevalent picolyl amides with an allenyl sulfone, 1-methyl-4-(propa-1,2-di

293 thetic aminopyrazole-substituted resorcylate amides with broad, potent, and fungal-selective Hsp90 in

294 elected: (1) the Stec reaction of phosphorus amides with carbon disulfide; and (2) the one-pot synthe

295 ted oxidative C-H/N-H annulation of aromatic amides with dialkyl malonates has been presented to affo

296 genative reduction of tertiary and secondary amides with pinacolborane (HBpin) at mild temperatures (

297 of primary and secondary aromatic amines and amides with primary, secondary, and tertiary benzylic al

298 trengths are used to predict interactions of amides with proteins and chemical effects of amides (inc

299 s developed, affording a set of alpha-chiral amides with unprecedented levels of enantioselectivity.

300 The method is also compatible with sodium amides, with the latter showing excellent promise as hig