ライフサイエンスコーパス: amide group

1 everal common donors (Arg, Lys, and backbone amide groups).

2 iride containing a dodecyl (12 carbon units) amide group.

3 icity linked to the aromatic ring through an amide group.

4 ssociated with introducing the P2'-P3' retro amide group.

5 nding capability associated with the P1'-P2' amide group.

6 f the amino group, and installation of the N-amide group.

7 r molecule in a hydrogen bond with the sugar amide group.

8 posttranslationally converted to a terminal amide group.

9 l changes in this general orientation of the amide group.

10 minium ion on the same face as the l-proline amide group.

11 pyrazole NH, as well as the free amino or N-amide group.

12 as achieved by N-methylation of the C2-ethyl amide group.

13 wherein the alkyne bond was replaced with an amide group.

14 the CRF C terminus, including the C-terminal amide group.

15 ment are much broader than those of backbone amide groups.

16 es in peak intensity for individual backbone amide groups.

17 hs (14.4 and 18.8 T) for 135 of 162 backbone amide groups.

18 the gel matrix by interaction with the amino/amide groups.

19 ns directed by weakly coordinating directing amide groups.

20 couplings between (15)N and (1)H in backbone amide groups.

21 interactions with several adjacent backbone amide groups.

22 er rim of the cavity, hydrogen-bonded to the amide groups.

23 by two intramolecular hydrogen bonds between amide groups.

24 are weakened and lead to the rehydration of amide groups.

25 1)H] NOE were measured for 80 of 91 backbone amide groups.

26 nd (1)H-(15)N NOE) measured for 153 backbone amide groups.

27 pai* states with excitation localized on the amide groups.

28 of the carboxylate and N-propyl-substituted amide groups.

29 e difference in hydration of carboxylate and amide groups.

30 ium exchange rates of nearly all the peptide amide groups.

31 arise from their opposite interactions with amide groups.

32 ed to four trivalent aromatic amines through amide groups.

33 ring C=O-H-N hydrogen bond between backbone amide groups.

34 m channels that are decorated with cyano and amide groups.

35 rboxylate of 4-ACPCA (2) with hydroxamate or amide groups.

36 ar pi-pi stacking and hydrogen bonding among amide groups.

37 less than one per year are observed for some amide groups.

38 cepting and donating a H-bond to neighboring amide groups.

39 be a valuable aid in protein NMR, leading to amide group (1)H polarizations that are orders of magnit

40 helical elements and the pattern of backbone amide group 15N nuclear relaxation rates within the cont

41 e its carboxyl group interacts with backbone amide groups 299 to 303 and the side-chain of Arg303.

42 llowed by BMS-mediated reduction of tertiary amide groups (53-93%).

43 Due to the underlying redox mechanism, a new amide group accompanies the formation of the nitroso gro

44 Catalysts bearing tertiary benzylic amide groups afforded highest enantioselectivities, with

45 Unique in this approach is that the amide group also enables a novel safeguarding mechanism

46 Backbone amide groups, among the most stable of biological moieti

47 Analogues containing a diethanolamine amide group and an aryl di(methylphosphonate) were both

48 a specific interaction between its terminal amide group and an mRNA residue 3'-adjacent to the AUA c

49 n-dipole interactions between the catalyst's amide group and potassium cation aid in the preorganizat

50 ferred secondary carbon radical alpha to the amide group and subsequent steric hindrance associated w

51 gen-bonding interactions with both the Asn68 amide group and the imidazole side chain of His64.

52 olumns of four to six ceramides H-bonded via amide groups and arranged as staves in either a parallel

53 entary structural information to that of the amide groups and hence promises to provide a greatly enh

54 centres and responds to that of neighbouring amide groups and in turn influences stereoselective reac

55 larity by replacing the sulfonamide first by amide groups and subsequently by isosteric oxazoles.

56 ions: one from pi-polarization of beta-sheet amide groups and the other from rotation of an isoleucin

57 the intermolecular hydrogen bonding between amide groups and the pai-stacking of the aromatic cores.

58 contrast, KCl interacts favorably with these amide groups and therefore inhibits LLPS and NNN-coopera

59 ular hydrogen bonds among the terminal amine/amide groups and urea moieties resulted in the formation

60 , bearing a terminal rotationally restricted amide group, and 30 bearing a terminal achiral bromophen

61 pH jump leads to deprotonation of the Ser-20 amide group, and a subsequent rapid O to N acyl shift re

62 tion bands for the sugar moiety, the protein amide group, and water.

63 nar imidazole rings, an anti relationship of amide groups, and intramolecular (NH(amide).N(imid)) and

64 raction followed by hydrogen-bonding between amide groups, and then van der Waals interactions-paves

65 uring two positive charges, four nonpeptidic amide groups, and variable hydrophobic/hydrophilic (amph

66 ng interactions are induced as the substrate amide group approaches the nucleophile, moving more than

67 tions and solvent exposure of the beta-sheet amide groups are also characterized by increases in homo

68 ucturally unique in the sense that their two amide groups are connected via a N-N single bond, and as

69 Furthermore, because these amide groups are important in the assembly process for t

70 nates along the backbone because neighboring amide groups are oriented in opposite directions.

71 tes that a number of side chain and backbone amide groups are perturbed upon Ala substitution at cons

72 When all four beta-sheet amide groups are polarized, the ab initio calculations i

73 persion, and a large portion of the backbone amide groups are solvent-exposed leading to fast hydroge

74 xyl, acetal, heteroaryl, nitrile, nitro, and amide groups are tolerated, which is an unexpected rever

75 ing two pivotal hydrogen bonds and a central amide group as a mediator.

76 he enthalpy of interaction with water of the amide group as approximately -11.5 kcal/mol.

77 ring, a short ethylene oxide segment, and an amide group as well as a short alkyl chain (propyl or is

78 the selenium atom may serve as acceptor and amide groups as donors.

79 esidues (Met(38) and Ile(41)) as well as two amide groups (Asn(34) and the C-terminal amide) on one f

80 with participation of the oxygen of ester or amide group at C(1) of corresponding 2-azabuta-1,3-diene

81 In this design, an amide group at the 3'-position of the ligand framework d

82 adical stabilizing group such as an alkyl or amide group at the C3-position of indole furnishes the 3

83 teady-state {(1)H}-(15)N NOE of the backbone amide group at three different magnetic field strengths

84 es were determined for 52 of the 65 backbone amide groups at 10 degrees C and ph 6.5 at 11.74 T.

85 nding interactions with neighboring backbone amide groups at positions i + 2/3/4 from Cys-384 and wit

86 R1 but has a clear preference for bulky aryl amide groups at R2, while methylation at R3 increased in

87 Six 2,2'-biimidazoles with various amide groups at the 4- and 4'-positions were prepared fr

88 py has higher sensitivity than does backbone amide group-based NMR spectroscopy.

89 strates where the aromatic ring trans to the amide group bears o-methyl, -chloro, or -bromo substitue

90 spatiotemporal concepts where embedding the amide group between two carboxylic moieties in proper ge

91 ted by a reciprocal exchange of aromatic and amide groups between positions 4 and 111 of Ang II and t

92 minal heterocycles of the dimer stack on the amide groups between the two heterocycles at the C-termi

93 e-reduced arginine onto sterically proximate amide group blocks one of the current mechanisms for ele

94 l histidine 95 and the adjacent glutamine 91 amide group but is not coordinated to the heme iron.

95 rates of more than one third of all backbone amide groups, but had little effect on the longitudinal

96 ently, a one pot reduction of both nitro and amide groups by BH(3)-tetrahydrofuran yielded the nonrad

97 rucial internal hydrogen bonding between the amide group (C=O...H-O) and the ethylene hydroxyl of the

98 te with H-bonding in circumstances where the amide groups can be brought into a stacking configuratio

99 The motion of water molecules close to amide groups causes their vibrational frequencies to var

100 used three complementary NMR methods, namely amide group chemical shift titrations, NOE and cross-sat

101 e of hydrogen/deuterium exchange of backbone amide groups combined with NMR.

102 The N-butyl amide group, CONHBu, has been found to be an effective p

103 A beta-alanine-derived embedded urea and amide group-containing C18 phase (Sil-Ala-C18) was prepa

104 Thus, the burial of an amide group contributes more to protein stability than t

105 is extra information, 86 % of all side-chain amide groups could be oriented quite unambiguously.

106 tion of the npai* states with respect to the amide group deplanarization and the concomitant increase

107 Remarkably, amide groups derived from protein compounds can still be

108 With isolated protein, tertiary amide groups dictate high affinity and high stimulation

109 is stabilized by interaction with a backbone amide group dictates the R stereochemistry of the tetrah

110 The amide group directed ortho-metalation in the julolidine

111 t parallel to the plane of the heme with its amide group directed toward the back of the distal heme

112 Ka of the hydroxyl group indicating that the amide group does not strongly transmit the electronic in

113 Incorporation of the amide group does, however, increase the yields of workin

114 is an n-alkyl fragment (-CH(2)-)(2 or 3), an amide group (either -CONH- or -NHCO-), a urea group (-NH

115 Removing the ligands' derivatized amide group eliminated the effect of the mutations.

116 Upon gold-catalyzed activation, the amide group enables the S(N)2 process by directing the a

117 IAM features both carbonyl and amide groups, enabling it to act as a dual-site hydrogen

118 kinetic transitions to be observed for many amide groups; especially important are short time points

119 with three carbons in the side chain and one amide group exhibited a selectivity index of 35 (Ki/IC50

120 H instability, rather it is a consequence of amide groups experiencing two processes; rapid fluctuati

121 of pentaglycine results from its hydrophilic amide groups, facilitating partitioning into water.

122 tions: (1) identification of the pyrrolidine amide group for a significant LipE improvement, and (2)

123 ire the presence of a carboxy-terminal alpha-amide group for biological activity.

124 f a 1,2,4-triazole group to substitute a key amide group for CSNK2 binding present in many potent pyr

125 e incorporated into the products by means of amide-group formation.

126 ond network that connects, via the inhibitor amide group fragment, two remote functionally essential

127 ding to the selective formation of a primary amide group from a chemically inert alkyl group.

128 In addition, the faster exchange of amide groups from residues at the subunit interfaces sug

129 is coordinated by three Cys residues, two N-amide groups from the protein backbone, and one OH(-).

130 tial imidization between carboxylic acid and amide groups, gave the multilayer good stability at high

131 acement of the carboxyl group of Glu46 by an amide group (Glu46Gln) has shown that changing the natur

132 en-bonding interactions between two backbone amide groups (Gly 721 and Gly 722) and the beta- and gam

133 The readily cleavable amide group has been utilized as a directing group for t

134 ergies of unfolding of some highly protected amide groups have been determined.

135 and 1540 cm(-1) corresponding to presence of amide group; however, such band was absent in control.

136 ontaining residues (N/Q), and the C-terminal amide group in a peptide.

137 one with respect to hydration changes in the amide group in combination with cooperative interactions

138 The amide group in compound 1 acts as an acid component as w

139 rder to study base pairing properties of the amide group in DNA duplexes, a nucleoside analog, 1-(2'-

140 The stabilization of the amide group in its high energy, perpendicular conformati

141 C[bond]N vibrational stretching modes of the amide group in the alpha-helix and the parallel and anti

142 hape in the 13-membered chelate in which one amide group in the chiral scaffold projects its NH unit

143 An asymmetrically positioned remote amide group in the designed chiral binaphthyl-based liga

144 electron transfer (ET) quenching by a nearby amide group in the peptide bond.

145 e adsorbed CO2/CH4 molecules and the pendant amide group in the pore.

146 ing a simple and weakly coordinating primary amide group in the presence of an inexpensive Ru(II) sal

147 N-Heterocyclic carbenes (NHCs) containing an amide group in the ring are a rare class of cyclic carbe

148 Undesired solvolysis of the amide group in the side chain of Asn or Gln leads to une

149 Replacement of an amide group in this class of compounds with an acetyl gr

150 amine functionality, a weakly BrOnsted-basic amide group in WangPhos is surprisingly effective in dep

151 aragine (Asn) and glutamine (Gln) side-chain amide groups in a dataset of 100 unrelated, high-quality

152 The N-OTases catalyze the glycan transfer to amide groups in asparagines in a reaction named N-linked

153 The amide groups in both the minimized antitau and syntau co

154 ation of the ways side-chain carboxylate and amide groups in high-resolution protein crystal structur

155 n exposure to 2H2O (D2O), 30% of the peptide amide groups in hPLB undergo a slow deuterium/hydrogen e

156 ement of the peptide backbone's carbonyl and amide groups in hydrogen-bond stabilization of helical s

157 ctural and functional importance of backbone amide groups in ion channels for subunit folding, hydrog

158 enable the direct observation of the role of amide groups in substrate binding, representing an examp

159 The protection factors for many of backbone amide groups in the beta-domain of the T70N variant are

160 endence of the number and position of chiral amide groups in the formation of a fibrillar nanomateria

161 Conversion of the carboxylate anions into amide groups in the lower acidic cluster (residues 42 an

162 on at the phenyl, oxime, and right-hand side amide groups in the oximino-piperidino-piperidine series

163 w that two hydrogen bonds formed between the amide groups in the peptide backbone are important in ma

164 urea preferentially interacts with not only amide groups in the peptide backbone but also aliphatic

165 oward CO2 due to higher density of selective amide groups in the polymer network.

166 The hydrogen bonding with the amide groups in the side chains has to be contrasted wit

167 s measure the coupling between the different amide groups in the structure.

168 These hydroxide ions can hydrolyze the amide groups in the substrates, resulting in tetrazolate

169 lymers with both charged amine and uncharged amide groups in their backbones exhibit superior inhibit

170 Ndelta1 atom of the His and the peptide Gln amide group indicates the His of the bound peptide in th

171 IN1 extends further into the enzyme, with an amide group interacting with more deeply buried catalyti

172 avourable conformational switch of the trans-amide group into the cis-form required for protein bindi

173 ucture was observed via the disappearance of amide group IR frequencies, indicating chain scission of

174 2-carboxyphthalanilic acid (2CPA), where the amide group is flanked by two catalytic carboxyls, revea

175 Once an ester or amide group is introduced into the system (derivatives o

176 These values indicate that the carbon of the amide group is more stiffly bonded in DHO while the slig

177 transfer from the guanidinium group onto the amide group is not observed.

178 ay be one source of destabilization when the amide group is placed in the helix.

179 es have shown that the N-formylamino-salicyl-amide group is responsible for most of the binding speci

180 rsors to monofluoroalkenes that are valuable amide group isosteres.

181 orter was the 15N-H 2D spectrum of aspartate amide groups labeled with 15N.

182 ation reaction directed by a pyrazole and an amide group leads to the well-controlled construction of

183 The incorporation of the amide group led to an unexpected reversal in selectivity

184 d with N-alkyl substituents or replaced with amide groups led to a significant loss of activity.

185 lytic activity have shown that the glutamine amide group makes only ambiguous hydrogen-bonding intera

186 urvey of DGAT1 inhibitors revealed that this amide group may serve as a common pharmacophore for inhi

187 an N-heterocyclic carbene that features two amide groups N-bound to the carbene nucleus with various

188 chemoselective hydrosilane reduction of the amide group occurred while other reducible groups remain

189 acement of the metabolically labile N-methyl amide group of a series of benzoxazinones with small het

190 no group and the second between the backbone amide group of Arg 94 and the sugar C-5' carboxylate.

191 ctrostatically with Arg 242 and the backbone amide group of Asn 245, components of the J loop of the

192 The amide group of Asn(95), the first Asn of the NXN motif,

193 , this residue makes hydrogen bonds with the amide group of Asn-160, and thus, the usual metal-bindin

194 The hydrogen bond between the amide group of Asn-204 and O(4) of uracil is disrupted b

195 te was unoccupied, apparently blocked by the amide group of Asn51.

196 We postulate that the dipole formed by the amide group of asparagine 614 of the epsilon 1 subunit c

197 localized negative charges on carboxylate or amide group of deprotonated quinolone or sulfonamide, re

198 In the wild-type protein, the side-chain amide group of Gln 143 is about 5 A from the metal and i

199 Unexpectedly, the main-chain amide group of Gln 230 in the universally conserved GGQ

200 [5-(15)N]-glutamine and use the (15)N of the amide group of glutamine to produce labeled uric acid.

201 In addition, the backbone amide group of Gly 159 provides an oxyanion hole for sta

202 the iridal forming a hydrogen bond with the amide group of Gly23.

203 catalysed by a hydrogen bond to the backbone amide group of leucine 126 and the side-chain carboxyl g

204 group of the pT residue with the side-chain amide group of N86 and the guanidino group of R70, and t

205 rk between Asp338, the 2'-OH of IMP, and the amide group of NAD(+).

206 change in the protein structure, moving the amide group of residue 114 out of H-bonding distance, al

207 ol, formed a hydrogen bond with the backbone amide group of Ser(212), which is the key interaction fo

208 for specific H-bonding between Chol and the amide group of SM.

209 The formation of several acyl groups and an amide group of Taxol is catalyzed by regioselective CoA

210 ad relying on chelation through the internal amide group of the allenamide sulfonyl.

211 vate beta-lactams by rapidly hydrolyzing the amide group of the beta-lactam ring.

212 We found that the amide group of the glutamine side chain could provide tw

213 toms of Thr-80 and Phe-79 and the side chain amide group of the invariant Gln-78.

214 The side-chain amide group of the rare d-Hyn(5) residue is not essentia

215 H ... O==C interchain hydrogen bonds for the amide group of the residue following Gly.

216 We speculate that the tertiary amide group of the substrate engages in hydrogen bonding

217 The amide group of this asparagine is buried and forms two s

218 position forming two hydrogen bonds with the amide group of Thr12 and with the carbonyl group of Leu

219 But the amide groups of bicyclic bridgehead lactams are highly t

220 uces relatively minor dehydration around the amide groups of dihydrosphingomyelin and a slight enhanc

221 the oxyanion hole, provided by the backbone amide groups of G141 and A98, are important for the form

222 stent with hydrogen bonds between side chain amide groups of Gln18 residues.

223 The backbone amide groups of Gly-165 and Gly-166 participate in hydro

224 Both the backbone amide groups of Gly241 and Leu270, and O(gamma) of Ser47

225 ate group of GAA interacts with the backbone amide groups of L170 and T171.

226 emical reaction between amine and hydrolyzed amide groups of nylon and MAH groups on the MAHgEO at th

227 re prepared by deprotection of the ester and amide groups of ortho-benzoxylated cyclic benzamides.

228 urface area of the Phe side chain and of the amide groups of Phe1, Gly2, and Gly3 involved in Ar-HN i

229 ium tetra(tert-butoxide) reacts with surface amide groups of polyamide nylon 6/6 to give (eta(2)-amid

230 The amide groups of residues in helices and sheets are those

231 The results indicate motion in the backbone amide groups of rhodopsin at time scales depending on th

232 The amide groups of the compound likely adsorb onto the pola

233 the backbone (especially Gly) and side chain amide groups of the IDL, promoting amide-amide interacti

234 ricyclic structure of the parent ligand; the amide groups of the methyl-protected cage compound gener

235 cated hydrogen-bonding interactions from the amide groups of the netropsin to the A x T base pairs of

236 GGGL(172)) and forms hydrogen bonds with the amide groups of those amino acid residues, suggesting th

237 ma) of Ser 346 and the backbone carbonyl and amide groups of Val 272, Leu 232, and Gly 347.

238 237 and also hydrogen bonded to the backbone amide groups of Val-201 and Leu-202.

239 3-(2,4-dinitrophenyl)-L-2,3-diaminopropionic amide group on the C-terminal end.

240 Phenol solvates the amide groups on the ligands strongly, increasing the ste

241 oluril dimers (1-8) bearing hydrogen-bonding amide groups on their aromatic rings.

242 ss formation temperature for surface Trp and amide groups over a wide temperature excursion.

243 interaction between Tyr-73 of mCD1d and the amide group oxygen of alphaGSAs.

244 ridinyl group pointing toward Tyr155 and the amide group placed near a hydrophobic pocket next to Tyr

245 an amine group (K side chain) with a primary amide group (Q side chain) weakens the hydrophobic inter

246 Although hydrogen bonding involving the amide group raises the energies associated with some ele

247 O of the amide linkage, with rotation of the amide group relative to the aromatic ring.

248 he similarity between the orientation of the amide group relative to the bilayer interface in melted

249 to yield a new Blatter-type radical with an amide group replacing a phenyl at the C(3)-position.

250 s and the nitrogens of deprotonated backbone amide groups, resulting in either distorted T-shaped or

251 One family, Series-A, is nonionic and has amide groups separating the long chains from the trehalo

252 Changes in generalized-order parameters of amide groups show a distinct trend towards increased str

253 xation to determine the dynamics of backbone amide groups, side chain methyl groups, and tryptophan s

254 This network formed by amide groups significantly contributes to constructing t

255 broadly similar fashion, but with the larger amide group substituent able to reach and contact the si

256 The dramatic effect of the amide group substitution pattern on the binding affinity

257 he synthesized product contains an important amide group that can be further functionalized to afford

258 mutants, the gain in stability from burying amide groups that are hydrogen bonded to peptide groups

259 e concerted exchange behaviour of subsets of amide groups that become accessible at a given free ener

260 forced by the intermolecular H bonding among amide groups that is evidenced by IR spectroscopy.

261 onds and on the other hand, three peripheral amide groups that promote self-assembly due to their sta

262 as a consequence of the additional covalent amide groups that provide a new hydrogen bonding molecul

263 be achieved with rigid compounds containing amide groups: the conformation of the amides can be cont

264 i+3 CO...H-N hydrogen bonds between backbone amide groups; these hydrogen bonds occur in 11-atom ring

265 CsA has partially N-methylated amide groups, this unique molecular structure, not prese

266 lite precursor, and (2) modifications of the amide group to a 3-THF group, guided by metabolite ident

267 -energy fluctuation that does not expose its amide group to exchange.

268 Its catalytic site does not utilize backbone amide groups to bind phosphate, as in the common P-loop,

269 obal transition that exposes these protected amide groups to solvent.

270 This method involves the deprotonation of amide groups under phase-transfer conditions and subsequ

271 l element in peptides is the locally achiral amide group, VCD senses the polymeric structure through

272 h contains a benzoxazole ring instead of the amide group was found to be a good alternative, with goo

273 The nicotinamide amide group was found to be in a cis conformation.

274 between the solvent and Phe1, Gly2, and Gly3 amide groups was also lower in conformations with Ar-HN

275 Using this technique, several ester and amide groups were efficiently introduced on the dyes.

276 ene carbon present between the adamantyl and amide groups were essential to produce potent inhibition

277 erent polarization states for the beta-sheet amide groups were identified and linked to the overall c

278 Protection factors for 58 amide groups were measured across the pH range and the h

279 pendent changes in the chemical shifts of 22 amide groups were observed in (1)H-(15)N HSQC NMR spectr

280 Macrocycles containing amide groups were self-assembled in a columnar fashion t

281 nds 10 and 11, which contain a P2'-P3' retro amide group, were modest competitive inhibitors of a ser

282 A significant part (23%) of the amide groups which are buried in pG become exposed to th

283 ode of internal deprotonation enacted by the amide group, which is a crucial structural feature of th

284 portant catalytic role for a P-loop backbone amide group, which is eliminated in the A30P mutant, and

285 ned to explore the importance of the P1'-P2' amide group, which is known to form highly conserved hyd

286 tic experiments reveal the importance of the amide group, which presumably enables initial bidentate

287 Our approach employs a simple N-methoxy amide group, which serves as both a directing group and

288 Replacement of the amide group with a carbamate one led to different stereo

289 ation is the irreversible substitution of an amide group with a carboxylate group.

290 Replacement of the amide group with a methylene-oxime moiety produced compo

291 e acyl chain controls the positioning of the amide group with respect to the molecular switch and wor

292 Due to conjugation of the amide group with the terpyridine pai system in the excit

293 This approach, replacing backbone amide groups with thioamides, was evaluated in two well-

294 Previous studies have shown that backbone amide groups within the trypsin-binding region of the wi