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2 )((aq)), NTO was quantitatively reduced to 3-amino-1,2,4-triazol-5-one following first-order kinetics
3 ic testing of 90 in rats revealed that the 5-amino-1,3,4-oxadiazole analogues may have limited brain
4 gent reverses the regioselectivity to give 5-amino-1,3-oxazoles, in comparison with the previously re
6 reported a series of novel substituted N-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide analog
8 iscovery of TNO155, (3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2
10 activity of oligodendrocyte NMDARs and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA
11 ve aminotransferase inactivator (1R,3S,4S)-3-amino-4-fluoro cyclopentane-1-carboxylic acid (1), in th
13 isage that our reported protocol to access 7-amino-4-methylcoumarin derivatives will find use toward
14 ted in the discovery of TNO155, (3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl
15 The composition of beer wort in terms of amino acid (AA) content affects the final product qualit
20 port the first application of the system for amino acid analysis coupled to an extraction unit in ord
24 in of type P(N) SadP adhesin showed that the amino acid asparagine 285, which is replaced by an aspar
25 le fermentation product (isocaproate) and an amino acid associated with tissue damage (taurine), whic
27 n developed to identify regions with LCRs or amino acid bias, but most of them as stand-alone applica
28 s essential for biological processes such as amino acid biogenesis, iron-sulfur cluster formation, an
29 ynthase (DAH7PS), at the gateway to aromatic amino acid biosynthesis in Mycobacterium tuberculosis, w
33 The highest-affinity variant contained seven amino acid changes and bound to the RBD 170-fold more ti
35 he domain provides a binding platform for 21 amino acid CIF peptide ligands, which are tyrosine sulfa
37 equences are characterized by a less diverse amino acid composition compared to typically observed se
38 ictions to gain insights on the interplay of amino acid composition, structure, self-association, and
42 C have impaired growth in the absence of the amino acid cysteine and that gigC regulates the expressi
43 is interaction is promoted during oxygen and amino acid depletion and protects LRS from degradation.
44 ar to non-polar molecule, while for the VP4, amino acid differences at position D195G was radical in
45 ng penicillin G (pcbAB, pcbC and penDE) show amino acid divergence between the Fleming strain and bot
48 between structural water and strain-specific amino acid groups is fundamental to the stabilisation of
50 hr518Met mutation altered a highly conserved amino acid in the MYRF protein and three of four algorit
51 to predicted self-regulatory intramolecular amino acid interactions between the SnoaL_2 domain and t
52 ketoimine rather than an alpha,beta-dehydro-amino acid intermediate during C(alpha)-thioether bridge
53 led by demonstrating that for ABCG2 a single amino acid is essential for engaging and initiating tran
54 , we demonstrate that the mammalian Expi293F amino acid labelling kit is suitable for preparation of
56 ary administration of high protein increases amino acid levels in the gut and promotes pathogen colon
58 in skeletal muscle may contribute to reduced amino acid metabolism and insulin resistance in MHD pati
59 is might impair glucagon's action on hepatic amino acid metabolism and lead to hyperaminoacidemia and
62 oid and phytol metabolism, a limited role in amino acid metabolism, and dual sets of the SUF pathway
63 uding AOX, TCA cycle, fatty acid metabolism, amino acid metabolism, organic acid metabolism, and ethy
65 transcriptional activation and that this 90-amino acid mini-protein is cell permeable and can inhibi
66 has recently emerged as a mild approach for amino acid modification, generating a sizable toolbox of
70 pth structural analyses to identify key ACE2 amino acid positions including 30, 83, 90, 322, and 354
73 rial encapsulation affected the volatile and amino acid profile of the wines, while the biogenic amin
77 Virtually all analyzed strains had single amino acid replacements in penicillin-binding protein 2X
79 inase K (PK), an N-terminal truncation up to amino acid residue 209 altered the conformation of the S
82 sequences annotated to indicate whether the amino acid residue is located within a hinge-bending reg
83 eolytic cleavage site of MuV F, because this amino acid residue shows a striking variability dependin
84 ighly reactive and footprint broadly several amino acid residue side chains on the time scale of subm
86 y activity, we propose that those C-terminal amino acid residues are a potentially targetable motif o
89 e designed a systematic approach to identify amino acid residues crucial for the expression and stabi
90 d light on this issue, we exchanged selected amino acid residues in a highly conserved stretch within
91 enthalpy of unfolding provides the number of amino acid residues nu participating in the unfolding re
92 the structure of apo-hGGT reveal movement of amino acid residues within the active site as the substr
94 (TFs) regulated by the Ssy1-Ptr3-Ssy5 (SPS) amino acid sensing system and have been proposed to have
95 tated peptide peaks with their corresponding amino acid sequence by database search and subsequent MA
96 11 teleost Sws2 photopigments for which both amino acid sequence information and experimentally measu
97 ted how natural interstrain variation in the amino acid sequence of gO influences the biology of HCMV
99 3a, respectively, and translated these into amino acid sequences and used for genotype variation ana
101 existing tools can not perform alignment of amino acid sequences, which could prove useful in variou
102 gions (IDRs), are modulated by the nature of amino acid side chains as well as by local solvent expos
103 vestigated the stability of the conventional amino acid side-chain-protecting groups, t-Bu, Boc, Trt,
104 ain a conserved helicase core domain and key amino acid sites affecting helicase function, which shar
105 pended on extracellular macromolecules as an amino acid source by activating endocytosis to sustain c
106 HPF1, an accessory factor that switches the amino acid specificity of PARP1 and PARP2 from aspartate
107 This structural feature means that each amino acid spends sufficient time in the pore for sensit
108 Th17 cells that led to the induction of the amino acid starvation response and altered cellular fatt
109 f Gln4p inhibited growth, and induced a GCN4 amino acid starvation response, indicative of uncharged
112 e, virtually all emm12 isolates had a single amino acid substitution in penicillin-binding protein PB
113 escribe a new mouse model featuring a single amino acid substitution in the coiled-coil motif of BRCA
114 her SSB folds and creation of truncation and amino acid substitution mutants, we provide the first ev
116 plasticity in PR with resistance-associated amino acid substitutions by formation of optimal sulfur
117 e methods provides insight into how specific amino acid substitutions distant from the active site in
119 g and requires a particular investigation of amino acid substitutions in the context of protein struc
120 cell viability assays, we report that point amino acid substitutions in the trigger loop, a flexible
122 able increase in stability with as few as 18 amino acid substitutions suggests that this bovinization
124 ng with interspecies chimeras and individual amino acid substitutions, to identify regions required f
125 be associated with oil synthesis (27 genes), amino acid synthesis (four genes) and the tricarboxylic
127 Here, we apply bioorthogonal non-canonical amino acid tagging (BONCAT) to visualize and quantify ba
128 tidine produces a vibrational-probe-equipped amino acid that can readily be incorporated into any pep
129 der Mer (vdM)-that maps the backbone of each amino acid to statistically preferred positions of inter
130 nsporter-mediated histidine uptake, system L amino acid transporter activity and Na(+) K(+) -ATPase a
131 orter-mediated histidine uptake and system L amino acid transporter activity were similar in sarcolem
133 clude a glycine-proline-hydroxyproline (GPO) amino acid triad are biomimetic analogs of the collagen
134 86%), and liver (47%) is predominantly a 129-amino acid truncated mature frataxin (79-207) in which t
135 om gut bacterial metabolism of the essential amino acid tryptophan, in regulating intestinal barrier
136 oadly considering LCRs as regions with fewer amino acid types compared to an average composition.
139 44,604 single codon changes encoding 14,160 amino acid variants in Hsp90 and quantified growth effec
140 (DMS) datasets probing the effects of single amino acid variation on enzyme activity and steady-state
141 rch over a template database of fixed-length amino acid words to determine estimated class-membership
145 ant heme proteins that degrade the essential amino acid, l-tryptophan (Trp), along the kynurenine pat
146 erated by the brain, D-serine, an endogenous amino acid, offers new hope as a therapeutic agent for r
147 to confirm the central role of GLR3.3 in the amino acid-elicited cytosolic Ca(2+) increase in Arabido
152 /MLL4 human sequences, we mapped a short ~80-amino-acid UTX stabilization domain (USD) that promotes
153 Neuregulin protein 1 (NRG1) is a large (> 60-amino-acid) natural peptide ligand for the ErbB protein
156 lation, the reduced charging of tRNA(Gln) in amino-acid-deprived cells also leads to specific depleti
157 We found that the cleavage site in this 1192-amino-acid-long fragment is located between amino acids
158 ribes the use of amino acid quantitation and amino-acid-specific isotope ratio analysis of scalp hair
159 ; P = 0.04; eta2p = 0.31] and branched-chain amino acids (BCAAs) [between-group difference (95% CI):
161 an open reading frame (ORF) that encodes 539 amino acids (molecular mass of 62.7 kDa); dsRNA2 dsRNA i
165 t is, the predominance of "left-handed" or l-amino acids and "right-handed" or d-sugars, is a unique
166 nt in metabolic pathways (eg, branched chain amino acids and arginine biosynthesis) and virulence gen
167 orphology of the subpopulations, and 20 free amino acids and glucose in EV subpopulations were identi
168 indings indicate that sequential inputs from amino acids and growth factors trigger PA production req
170 -to-tail cyclized, composed of proteinogenic amino acids and lack disulfide bonds; they are also know
171 sent entities of the protein-ligand complex (amino acids and ligands) and the edges represent structu
174 ameters and fluorescence spectra of aromatic amino acids and nucleic acids (AAA + NA), tryptophan res
177 ation, which results in the truncation of 45 amino acids and shifts the localization of ClVST1(97) to
179 olines, phosphatidylcholines, acylcarnitine, amino acids and sphingomyelins; Lyso.PC.a.C18.0, PC.ae.C
180 he diastereoselective synthesis of unnatural amino acids and the late-stage derivatization of a tripe
181 res seemed dependent on both their number of amino acids and their proximity with the supported lipid
183 s gateways, seven different diol-convertible amino acids are converted to diols including 1,3-propane
189 study focused on understanding the specific amino acids around the receptor binding site (RBS) that
190 lved in the biosynthesis of nonproteinogenic amino acids as building blocks of natural products and a
192 Two splice variants of MPST, differing by 20 amino acids at the N terminus, give rise to the cytosoli
193 mydial response mechanisms acting when other amino acids become limiting, we tested the efficacy of p
194 we demonstrate that increasing extracellular amino acids beyond the nutritional need of HLCs and HepG
196 and avian H3N2 influenza viruses encoded 61 amino acids but were truncated after introduction into d
197 ein-deprived diet enriched in free essential amino acids can 1) promote the brown fat thermogenic pro
198 vian ANP32A proteins harbor an additional 33 amino acids compared to human ANP32A proteins, which are
199 gSPY-MYC(3), 2) its functional dependence on amino acids critical for OGT activity, and 3) its abilit
200 omatis, has a limited capacity to synthesize amino acids de novo and therefore must obtain oligopepti
201 lite 3-MOB along with related branched-chain amino acids demonstrated strong predictability for famil
202 sequence enables the formation of sulfonated amino acids during embryo development in the egg at no c
203 talytically active hexamers to generate free amino acids from human hemoglobin and are drug targets f
205 other tRNAs retain charging of their cognate amino acids in a manner that is dependent upon intact ly
206 stry with pulsed stable isotope labelling of amino acids in cell culture to quantify the host proteom
207 beling approach using stable isotope-labeled amino acids in cells (pSILAC), phosphoproteomics, and a
209 probes that can discriminate enantiomers of amino acids in organic media or aqueous solution are dis
211 years, suggesting that the low abundances of amino acids in Tagish Lake cannot be ascribed to fluid c
213 nds, organic acids, water soluble sugars and amino acids in three onion varieties ('Shallot', 'Chata'
214 theless, the lower TID of sulphur-containing amino acids in tofu than in soya milk induced a signific
215 to enable incorporation of the rare cognate amino acids into the growing peptide chain at a rate of
216 x dynamic allostery: three distinct aromatic amino acids jointly communicate occupancy to the active
220 r becomes unstable when fused to the last 10 amino acids of SpxA2 but remained stable when fused to t
222 ite (imidazolide) and can covalently bind to amino acids other than cysteine on target proteins such
223 genotypes, most likely because of chelating amino acids present in the murine nutrient solution.
224 Site-specific replacement of active-site amino acids revealed the presence of a water-coordinatin
225 is associated with reorganization of further amino acids structurally transforming a loop adjacent to
226 orrelation is at play between a small number amino acids that either favour or disfavour hinge-bendin
228 In this study, we used a set of unnatural amino acids to fully map the substrate preferences of Gr
230 omic distances, and positioning of catalytic amino acids to rationalize the underlying electronic rea
231 The true ileal digestibility (TID) of their amino acids was determined in minipigs, to calculate the
232 ing intermediates separated by as few as two amino acids were detected using focused-ion-beam-modifie
233 uctures of inactive MCR lacking the modified amino acids were indistinguishable from the fully modifi
234 m combines the natural catabolism of charged amino acids with a catalytically efficient and thermodyn
235 ship for binding using a series of unnatural amino acids with different lengths of hydrophobic side c
237 y of ZikV-NS5 appears to be dispensable, the amino acids Y25, K28, and K29 that are involved in NS5 o
238 s, which are tags of minimal size (ca. 15-20 amino acids) affording high-affinity lanthanide ion bind
239 les (e.g. proteins, dyes, drugs, biomarkers, amino acids) based on application of the alternating ele
242 ridoxine/vitamin B6, taurine, some essential amino acids, and a conditionally essential amino acid an
244 linking studies with site-specific unnatural amino acids, and species-specific activity of AimB.
245 potential of end-to-end learning for single amino acids, as compared to more classical manually-cura
246 0.046-0.002), including five gamma-glutamyl amino acids, beta-citryl-glutamate, N-acetyl-aspartyl-gl
247 reveals that necrocytosis provides not only amino acids, but sugars, fatty acids and nucleotides for
248 this method, including enantiomerically pure amino acids, enabling us to explore structural diversity
249 ; secreted glutamine and other nitrogen-rich amino acids, indicating active protein breakdown, at a r
250 s the decoding of some triplets of these two amino acids, leading to reduced translation efficiency.
253 signal intensity for polar molecules such as amino acids, which has important implications for SIMS i
270 gin of life there were only seven primordial amino acids: Valine (coded by GUX [X = U, C, A or G]), a
271 ectars contain nitrogenous compounds such as amino acids; however, little is known about the role(s)
275 g product, dibenzosuberenone, bearing a beta-amino-alpha-ketone group was secured by X-ray crystallog
276 n, an unstable metabolic intermediate, alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS),
277 that both arylation and alkylation of alpha-amino C(sp3)-H bonds occurs via the sequence of nickel o
278 [(CAAC)(2)Be](+*) (2) [CAAC = cyclic (alkyl)(amino)carbene], prepared by oxidation of a zero-valent b
283 induction for the most efficient diether and amino ether ligands prove to be foreseeable by modeling
285 on can be greatly enhanced by employing a 3'-amino group at the 3'-end of each oligonucleotide, in co
286 t nucleophilic attack by the substrate alpha-amino group on the sn-2 ester to form a cyclic tetrahedr
288 crosslinking with glutaraldehyde (GA) on the amino groups of the 3D-Au-PAMAM-p-ABA-SPCE, where tau pr
290 ethod is based on the electrosynthesis of an amino moiety-bearing polymer layer on the graphene chann
291 odeposition using an equivalent mixture of 4-amino-N,N,N-trimethylanilinium and 4-aminobenzenesulfona
292 oxy-5-[(6-[(18)F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid), or (18)F-JK-P
293 -2-[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]propanoic acid) is a naturally occurring caffeoyl
294 oenergetics in the colonic epithelium with 5-amino salicylic acid, a PPAR-gamma (peroxisome prolifera
295 hylamino) -2- ((3,4,5 trimethyl benzylidene) amino)spiro [isoindoline-1,9'-xanthen] -3-one (BTSIXO) c
297 ets, including microbial necromass biomarker amino sugars and SOC, from two long-term agricultural fi
298 l-regulated kinase 1/2 (ERK1/2), p38 and Jun amino-terminal kinase (JNK), which consequently potentia
299 ructural probing revealed that the RNA binds amino-tSS about 100-times stronger than the cis photoiso
300 binds the trans isoform of a stiff-stilbene (amino-tSS)-a rapidly and reversibly photoisomerizing sma