ライフサイエンスコーパス: amphipathic

1 e of peptide discs made by phospholipids and amphipathic 18A peptides to mediate the formation of sup

2 rio cholerae cytolysin/hemolysin (VCC) is an amphipathic 65-kDa beta-pore-forming toxin with a C-term

3 The association of amphipathic alpha helices in water leads to alpha-helica

4 The domains form two amphipathic alpha helices separated by a rigid kink, whi

5 s-alpha" amyloid-like architecture, in which amphipathic alpha helices stacked perpendicular to the f

6 adecapeptide), which is predicted to form an amphipathic alpha helix.

7 nd synthesized ten 26-residue D-conformation amphipathic alpha-helical cationic antimicrobial peptide

8 The naturally occurring linear amphipathic alpha-helical HDP dermaseptin B1, which has

9 ponent of dry bee venom, was used as a model amphipathic alpha-helical peptide.

10 Certain amphipathic alpha-helical peptides can functionally mimi

11 -forming cytolysin alpha-toxin (Hla) and the amphipathic alpha-helical phenol-soluble modulin (PSM) p

12 talloproteinase activity, generates cationic amphipathic alpha-helical proteoforms.

13 Despite its amphipathic alpha-helical structure, Ctn[1-14] was total

14 cally to the LD surface, contains a discrete amphipathic alpha-helical targeting sequence, and partic

15 teins are disordered in water, but fold into amphipathic alpha-helices at high osmolyte concentration

16 Structural analysis of SERPINA1 identified 3 amphipathic alpha-helices clustered in the N-terminal do

17 Bla g 1 forms a novel fold consisting of 12 amphipathic alpha-helices enclosing an exceptionally lar

18 The results revealed that amphipathic alpha-helices h1 and h3 comprise a lipid-bin

19 re fibrils nor bind lipid surfaces via their amphipathic alpha-helices in a manner typical of apolipo

20 The isolated protein folds into amphipathic alpha-helices in response to increased crowd

21 TAM comprises amphipathic alpha-helices predicted to form a protein-bi

22 SERPINA1 contains a cluster of amphipathic alpha-helices that enable apolipoproteins to

23 al and cell-penetrating peptides (CPPs) form amphipathic alpha-helices when bound to lipid membranes.

24 ved positively charged residues on predicted amphipathic alpha-helices, as shown for murine gasdermin

25 eptides that interact with lipid bilayers as amphipathic alpha-helices.

26 e viral M2 protein bind membrane and form an amphipathic alpha-helix (AH).

27 at this interaction is mainly mediated by an amphipathic alpha-helix (alpha2), which undergoes a subs

28 nding EF-hands, a linker loop domain with an amphipathic alpha-helix and a C-terminal mitochondrial c

29 at this sequence (named PMasseq) contains an amphipathic alpha-helix and the FWC signature, which is

30 isordered C-terminal domain and an incipient amphipathic alpha-helix contained within it.

31 ned at the endoplasmic reticulum via its N17 amphipathic alpha-helix domain but is released by oxidat

32 d in solution, with the exception of a small amphipathic alpha-helix in residues M10-I17, which is in

33 In conclusion, we have identified an amphipathic alpha-helix in the NCX1 large intracellular

34 t that peptides corresponding to a predicted amphipathic alpha-helix in the prodomain N terminus adop

35 (SpoVM(P9A)) to reveal that SpoVM's atypical amphipathic alpha-helix inserts deeply into the membrane

36 mbrane space are high, the N-terminus of the amphipathic alpha-helix is bound to a cleft in the regul

37 endent appearance of the C-terminal cationic amphipathic alpha-helix is inducible within hours by Sta

38 lcium levels drop, the cleft closes, and the amphipathic alpha-helix is released to bind to the carri

39 We hypothesized that this segment forms an amphipathic alpha-helix whose properties facilitate Cys-

40 residue at position 175, which is part of an amphipathic alpha-helix within the C-terminal region of

41 The availability of apoAI or other amphipathic alpha-helix-rich apoproteins relieves the bu

42 um via a locking pin mechanism involving the amphipathic alpha-helix.

43 dimerization domain of the protein forms an amphipathic alpha-helix.

44 passing the Leu/Ile/Phe-rich domain forms an amphipathic alpha-helix.

45 xide-coated sensing substrate along with the amphipathic, alpha-helical (AH) peptide-induced structur

46 Phenol-soluble modulins (PSMs) are amphipathic, alpha-helical peptides that are secreted by

47 Consequently, while the secondary amphipathic, alpha-helix conformation is a key determina

48 ascribed to their ability to form secondary amphipathic, alpha-helix conformations in membrane mimic

49 dly less pronounced to that observed for the amphipathic alpha2, likely reflecting structural plastic

50 strongly activates GRK5 via ordering of the amphipathic alphaN-helix of GRK5 and allosteric disrupti

51 enetrating into the lipid droplet matrix and amphipathic amino- and carboxyl (C)-terminal peptides ly

52 s the toxic antimicrobial activities of many amphipathic AMPs and protects them from degradation duri

53 is a key mechanism of killing for cationic, amphipathic AMPs, which may explain why most AMPs requir

54 gy consisting of priming/coating dentin with amphipathic and antimicrobial peptides (AAMPs) to obtain

55 e-containing ABC transporters (PCATs) export amphipathic and hydrophilic bacteriocin and quorum-sensi

56 Further, the two partner helices, both amphipathic and located at the polar-nonpolar interface

57 ed the series of experiments confirming that amphipathic and membrane-permeabilizing properties of CS

58 rotein Ire1, located at the interface of the amphipathic and transmembrane helices.

59 tgun") or targeted profiling of hydrophilic, amphipathic, and hydrophobic constituents of plasma meta

60 We analyze three amphipathic antimicrobial peptides, a class of membrane-

61 ce, which is consistent with the behavior of amphipathic beta-strands.

62 urface (especially helix 4) are cationic and amphipathic, both classic characteristics of antimicrobi

63 The amphipathic C-helix was sufficient for this localization

64 In particular, the role of the amphipathic C-terminal tail of Atlastin is still unknown

65 The hydrogel was made of amphipathic carboxymethyl-hexanoyl chitosan (CHC), beta-

66 6, which are structural features of cationic amphipathic cell-penetrating peptides.

67 ues were still partly retained, imparting an amphipathic character and explaining its residual antimi

68 This study investigates how variations in amphipathic character associated with histidines affect

69 varying in charge patterning, increasing the amphipathic character of 6K-F17 to mimic the design of n

70 Bile acids (BAs) comprise heterogenous amphipathic cholesterol-derived molecules that carry out

71 l polar groups positioned to accommodate the amphipathic cholic core of bile acids, a fingerprint of

72 and of LF and EF unfold and dock into a deep amphipathic cleft, called the alpha clamp, which resides

73 ay be greatly potentiated by the presence of amphipathic components of plasma membrane because they m

74 many structurally dissimilar hydrophobic and amphipathic compounds, including anticancer drugs from c

75 y of structurally dissimilar hydrophobic and amphipathic compounds, including anticancer drugs.

76 The amphipathic conformation typical of PMAP-36 was not requ

77 Cationic AMPs typically exhibit an amphipathic conformation, which allows increased interac

78 t bactericidal activity was the cationic and amphipathic COOH-terminus.

79 s based on TP10W, a peptide derived from the amphipathic CPP transportan 10; the second was based on

80 The data suggest that cell uptake of amphipathic CPPs correlates with their adopted alpha-hel

81 a hydrophobic loop located at the tip of two amphipathic dimerization helices.

82 nker region facilitates client binding to an amphipathic docking surface on Hsp33.

83 odulation of gating by lipids, alcohols, and amphipathic drug molecules.

84 mediates the efflux of chemically dissimilar amphipathic drugs and confers resistance to chemotherapy

85 e to study the dye's interaction with PSMA's amphipathic entrance funnel.

86 ment for membrane proteins to be embedded in amphipathic environments such as membranes, lipid vesicl

87 A leading hypothesis proposes that a small amphipathic fragment of APP, the amyloid beta-protein (A

88 tail 'triplex' strand arrangement creates an amphipathic functional topology akin to that of the acti

89 Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inv

90 of the parasite plasma membrane (PPM) to the amphipathic glycoside saponin and engenders digestive va

91 nd via insertion of a phosphopeptide into an amphipathic groove of 14-3-3.

92 co-expression and subsequent binding at the amphipathic groove.

93 14-3-3 protein forms a dimer containing two amphipathic grooves that can potentially bind these phos

94 ides by altering the charged residues of the amphipathic helical address were unsuccessful.

95 , we focus on how alpha-helical proteins use amphipathic helical layering and bundling to form modula

96 Synthetic amphipathic helical peptides (SAHPs) designed as apolipo

97 bilizing motifs, which increase retention of amphipathic helical peptides in RP, reduce peptide reten

98 We found that interactions of amphipathic helical peptides with a hydrophobic C18 phas

99 These findings suggest that dual amphipathic helical regions mediate LD targeting and und

100 y stabilized by the shallow insertion of the amphipathic helical wedges with the BAR domain removed f

101 SDS micelles confirmed the importance of the amphipathic helices (11s --> 11sG --> 11) for antinocice

102 ical functions of LDs, and most of them bear amphipathic helices (AH), which can selectively target t

103 conformational dynamics, and the role of the amphipathic helices (AHs) on proton conductance remain e

104 igned to disrupt folding of this region into amphipathic helices (AHs) significantly decreased lipid

105 n AI-alphaE interaction as a cluster of four amphipathic helices (two alphaE and two AI helices) at t

106 Here we show that N-terminal amphipathic helices ahA and ahB in PspA HD1 are function

107 by the hydrophobic packing of the conserved amphipathic helices alpha1 and alpha3.

108 line 25 is involved in sequential use of the amphipathic helices and ahA-IM interaction.

109 moting structural motifs, such as wedge-like amphipathic helices and crescent-shaped BAR domains, are

110 observations of the degree of tubulation by amphipathic helices and variation of the free energy of

111 Furthermore, we show that amphipathic helices are dispensable in forming protein s

112 The amphipathic helices enable PspA to switch from a low-ord

113 actions of the tau MBD are mediated by short amphipathic helices formed within each of the MBD repeat

114 demonstrates the importance of including the amphipathic helices in future experimental and theoretic

115 is generic, operating even in the absence of amphipathic helices in the BAR domain, and could in prin

116 curvature generation, for IMDs we find that amphipathic helices inhibit membrane shape transitions,

117 does not occur until endophilin inserts its amphipathic helices into lipid bilayers, supporting an a

118 imuthal angles are observed, positioning the amphipathic helices of all three peptides with the charg

119 onserved across all HCV isolates, as well as amphipathic helices of many pathogens and apolipoprotein

120 the M2 construct, revealing the role of the amphipathic helices on this transition and shedding ligh

121 These include the use of amphipathic helices or sheets, hydrophobic loops, myrist

122 cement results in a loss of stability of the amphipathic helices TH1-3 and the hydrophobic core helix

123 The structure reveals that the CT folds into amphipathic helices that wrap around the C-terminal end

124 termed AD1 and AD2, which fold to form short amphipathic helices upon binding to TAZ1 and TAZ2 wherea

125 Single molecule imaging of eGFP-PspA and its amphipathic helices variants in live Escherichia coli ce

126 Two amphipathic helices within the Naa60 C terminus bind the

127 deling predicts two DNA-binding domains, two amphipathic helices, and an in-plane membrane anchor in

128 r and aromatic interactions with neighboring amphipathic helices.

129 membrane insertion (also called wedging) of amphipathic helices.

130 oA and MLXIPL/ChREBP bind LDs via C-terminal amphipathic helices.

131 n/Rvs (BAR) domain and deep insertion of its amphipathic helices.

132 We trace this ability to an amphipathic helix (AH) located on the C-terminus of Cdc1

133 Yop1p) and identified a C-terminal conserved amphipathic helix (APH) that, on its own, interacts stro

134 gion in the C terminus containing a putative amphipathic helix (APH).

135 ain capped by a short sequence containing an amphipathic helix (Cap domain).

136 ted by reversible membrane binding of a long amphipathic helix (domain M).

137 tured peptide, whereas promoter C encodes an amphipathic helix (Kal-C-helix).

138 rdered domains flanking a 12-amino acid-long amphipathic helix (residues Gln-62-Leu-73) that together

139 ir of positively charged residues within the amphipathic helix (the basic amino acid PI(4,5)P2 pincer

140 also other GPCR cargoes, must release their amphipathic helix 8 from the membrane to be recognized b

141 nd-binding pocket and by the presence of the amphipathic helix 8.

142 -sensitive manner between a membrane-binding amphipathic helix and a soluble degradation-prone segmen

143 n Doa10 yeast degron, Deg1, also contains an amphipathic helix and exhibits 42% amino acid similarity

144 In contrast, the IFITM3 amphipathic helix and its amphipathic properties were re

145 allisation inhibition activity linked to its amphipathic helix and that it enhances the DMSO cryopres

146 eracts with anionic lipid membranes using an amphipathic helix at its unique N-terminus.

147 eal a similar fold to Cu(+)-ATPases, with an amphipathic helix at the membrane interface.

148 The resultant stabilization of the amphipathic helix deep in the bilayer interface facilita

149 our simulations indicate that the C-terminal amphipathic helix does not significantly change the prot

150 Molecular dynamics simulations of an amphipathic helix embedded in a lipid bilayer indicate t

151 HDX-MS identifies an N-terminal amphipathic helix essential for membrane association.

152 The hNaa60 protein contains an amphipathic helix following its GNAT domain that may con

153 Thus, reversible alphaS amphipathic helix formation and dynamic multimerization

154 alphaS vesicle binding via membrane-induced amphipathic helix formation, and '3K' further enhances t

155 This work deciphers how the CCT regulatory amphipathic helix functions as a silencing device.

156 ics simulations-suggest that alpha-tubulin's amphipathic helix H10 is responsible for peripheral bind

157 Serine scan mutagenesis of the N-Cap amphipathic helix identified Leu-15, Ile-18, and Ile-19

158 ate an essential role in this process for an amphipathic helix in CIDEA, which facilitates embedding

159 her, our results support a model whereby the amphipathic helix in SM N100 attaches reversibly to the

160 Furthermore, we showed that an amphipathic helix in the C-terminal cytosolic tail of RH

161 Contrary to N-BAR domains, where amphipathic helix insertion is known to promote its memb

162 ating that the hydrophobic face of the N-Cap amphipathic helix interacts with a surface-exposed hydro

163 This amphipathic helix is aligned nearly parallel to the memb

164 Our data demonstrate that the N-Cap amphipathic helix is critical for channel stability and

165 fferent M2 domains show that the cytoplasmic amphipathic helix is necessary and sufficient for NGC ge

166 e occupancy of the canonical position of the amphipathic helix is reduced to various extents in many

167 An N-terminal membrane-binding amphipathic helix is required for LC3B lipidation under

168 ort a mechanistic model where the C-terminal amphipathic helix is stabilized by an intramolecular sal

169 ependently of these recycling pathways by an amphipathic helix is viable and polarizes spontaneously

170 An amphipathic helix located at the C-terminus of Tts1 is i

171 ions of charged residues located in the TatA amphipathic helix lock TatA in an assembled state, sugge

172 A favorable N-capping arrangement prior to amphipathic helix may result in the highest hydrophobici

173 r, when the PAS domain is present, the N-Cap amphipathic helix must also be present for channels to t

174 attenuated IFITM3 restriction and converted amphipathic helix mutants into infection enhancers.

175 it tunnel, is auto-inhibited by a C-terminal amphipathic helix occluding its hydrophobic binding groo

176 Recently, we showed that the N-terminal amphipathic helix of Arl3, but not that of Arl2, regulat

177 a stepwise model in which the amino-terminal amphipathic helix of GTP-bound Sar1 stably penetrates th

178 The N-terminal amphipathic helix of NS5A bound specifically to PI(4,5)P

179 The interactions between the juxtamembrane amphipathic helix of one monomer and its neighboring mon

180 ein VI-specific antibodies, we show that the amphipathic helix of protein VI contributes to capsid st

181 opy analyses to show that the amino-terminal amphipathic helix of SecA and the ribosomal protein uL23

182 We show that the amphipathic helix of the adenovirus internal protein VI

183 On calcium binding, an amphipathic helix of the C-terminal domain binds to the

184 f unrelated adaptors, interact with the same amphipathic helix of the dynein light intermediate chain

185 d lipids in the membrane, and the N-terminal amphipathic helix of the monomers not only acts as a mem

186 endoplasmic reticulum-localizing, N-terminal amphipathic helix of viperin is specifically required fo

187 5 was observed to bind to cardiolipin via an amphipathic helix on its N terminus.

188 G vesicles, the first demonstration that the amphipathic helix on its own is capable of this effect.

189 structures reveal a well-ordered N-terminal amphipathic helix preceding a putative transmembrane hel

190 embrane-binding module, a membrane-inducible amphipathic helix present in a previously undescribed lo

191 l3 and other Arf proteins with an N-terminal amphipathic helix require GTP loading for the interactio

192 5 or residues on the hydrophobic face of the amphipathic helix strongly attenuated palmitoylation and

193 We demonstrate that HAfp23 is a new class of amphipathic helix that functions by leveraging the negat

194 n some cases, a BAR domain also possesses an amphipathic helix that inserts into the membrane to indu

195 peptide binds with residues 3-11 forming an amphipathic helix that makes contact with the antibody f

196 dynamics and circular dichroism revealed an amphipathic helix within this 12-residue region.

197 rved between cholesterol and residues in the amphipathic helix, accounting for cholesterol binding ad

198 res revealed that this domain is a five-turn amphipathic helix, and the invariant tryptophan forms a

199 the palmitoylation insertion, containing an amphipathic helix, contributes to the PI-binding pocket

200 ression of a novel, phosphoinositide-binding amphipathic helix, Kalrn promoter usage is expected to a

201 embrane-inserting, curvature-sensing/driving amphipathic helix, the existence and properties of which

202 opathy analysis suggests that it can form an amphipathic helix, which is ideal for lipid membrane int

203 tes with the cell membrane via an N-terminal amphipathic helix, which is necessary for function.

204 hydrophobic targeting signal displaces this amphipathic helix, which then acts as a protective lid o

205 erminal transmembrane (TM) residues, near an amphipathic helix, without requiring a cholesterol recog

206 brane rigidity in a glycine-95-dependent and amphipathic helix-dependent manner.

207 anes through a highly evolutionary conserved amphipathic helix-forming (AH) motif encoded by exon 5.

208 facilitating membrane insertion of the Arf1 amphipathic helix.

209 induced by the hydrophobic void beneath the amphipathic helix.

210 and membrane insertion of the M domain as an amphipathic helix.

211 which include the lateral movement of a key amphipathic helix.

212 oils are peptide structures constructed from amphipathic heptad repeats.

213 ,d-aza-Thr(8),Arg(10)-teixobactin reveals an amphipathic hydrogen-bonded antiparallel beta-sheet dime

214 Here we describe the stabilization of the amphipathic L4F peptide through fusion to a high molecul

215 An amphipathic lid loop from the nitrilase domain interacts

216 of CCT1, to remove the predicted C-terminal amphipathic lipid binding domain, produced a constitutiv

217 The translocation of the amphipathic lipid II across the cytoplasmic membrane is

218 The intrinsic amphipathic lipid packaging sensor (ALPS) motif within H

219 3 lipidation through the curvature-targeting amphipathic lipid packing sensor (ALPS) motif of ATG14.

220 up133(NTD) contains a structurally conserved amphipathic lipid packing sensor motif, confirmed by lip

221 roperties of the Golgi resembles that of the amphipathic lipid-packing sensor (ALPS) motif of GMAP-21

222 Thr-87 is located within an amphipathic lipid-packing sensor (ALPS) motif, which par

223 mes with lipid order-sensitive proteins like amphipathic lipid-packing sensor and alpha-synuclein was

224 OS, the structural characterization of these amphipathic lipids has largely focused on elucidation of

225 rage and metabolism, and it was assumed that amphipathic lipids simply served a passive structural ro

226 We introduce a rationale of helical amphipathic lockers that differentiates autonomously fol

227 We propose that it is the amphipathic locking of interfacing helices prior to bind

228 plexes, we hypothesized that accumulation of amphipathic, long-chain acyl-CoA (LC-CoA) metabolites st

229 Because of the presence of amphipathic LPS molecules, the OM behaves as an effectiv

230 IL26 is a unique amphipathic member of the IL10 family of cytokines that

231 t that self-assembled enantiomerically pure, amphipathic metallohelicies inhibited ice growth at just

232 Lanosterol is an amphipathic molecule enriched in the lens.

233 ulosis, and the extracellular export of this amphipathic molecule likely accounts for the known virul

234 ophobic steroid nucleus and polar groups are amphipathic molecules.

235 Oleosin has short amphipathic N- and C-terminal peptides flanking a conser

236 Here we quantitatively demonstrate that the amphipathic N-terminal H0 helix of endophilin is importa

237 We show here that the strongly amphipathic N-terminal helix of CPn0678 mediates binding

238 tational approaches, we demonstrate that the amphipathic N-terminal helix of MscL acts as a crucial s

239 trum of bactericidal activity resulting from amphipathic nature and membrane-permeabilizing propertie

240 Protein-protein interactions and the amphipathic nature of GGPP suggest metabolite channeling

241 Here, the true amphipathic nature of pristine graphene flakes is demons

242 Our working hypothesis posited that the amphipathic nature of the C-terminal alpha-helix (Thr(60

243 This indicates that the amphipathic nature of the C-terminal alpha-helix was dis

244 Based on the amphipathic nature of the critical helix it may probe th

245 The amphipathic nature of the lipid molecule (hydrophilic he

246 diverse polypeptides require them to have an amphipathic nature, and this is achieved by a diverse ra

247 ive channel opening, as the target for these amphipathic neurotoxins.

248 moting its assembly to a water-soluble, less amphipathic oligomer variant with reduced ability to pen

249 binding cassette transporters that transport amphipathic or hydrophobic substrates in a detergent-fre

250 Moreover, we show that the HD1 amphipathic pattern is required to induce membrane dynam

251 covalently attached Rose Bengal (RB) to the amphipathic peptide (AMP) C(KLAKLAK)(2) and determined t

252 emonstrated that a melittin-derived cationic amphipathic peptide combined with siRNA targeting the p6

253 ports the extensive investigation of a novel amphipathic peptide composed of repeating RALA units cap

254 also called LAH4-A4, a short histidine-rich amphipathic peptide derived from the LAH4 family of DNA

255 WLBU2 is an engineered cationic amphipathic peptide designed to maximize antimicrobial a

256 that block heterochiral analogs of the model amphipathic peptide KFE8 (Ac-FKFEFKFE-NH(2)), composed o

257 teraction between SLBs and PEP1, a synthetic amphipathic peptide resembling a segment of the nonstruc

258 termed A-ZIP53 that has a glutamic acid-rich amphipathic peptide sequence attached to N-terminal of b

259 Thus, the amphipathic peptide sequences become available to disrup

260 e report structure-guided optimization of an amphipathic peptide, arenicin-3, originally isolated fro

261 When combined with amphipathic peptide-based plasmid DNA delivery, these bi

262 siFKBPL with RALA; a novel, cationic 30 mer amphipathic peptide.

263 on-dependent curvature sensing mechanisms in amphipathic peptides and challenge existing theories of

264 This phenomenon can be reproduced with amphipathic peptides as short as three amino acids.

265 tatic interactions provided by short, basic, amphipathic peptides can be harnessed to drive RNA bindi

266 In addition to its biological activity, amphipathic peptides such as L4F are likely candidates t

267 universal approach to express many cationic amphipathic peptides that are normally toxic and would k

268 l peptides (AMPs) are generally cationic and amphipathic peptides that show potential applications to

269 es in mice and hamsters indicated that these amphipathic polymers offer a valuable tool for high-yiel

270 the inner leaflet of the OM with a central, amphipathic pore.

271 rface pressure as surface area decreases and amphipathic products transiently accumulate at the lipop

272 My own passion for the unique amphipathic properties of lipids led me to seek other, n

273 ntrast, the IFITM3 amphipathic helix and its amphipathic properties were required for virus restricti

274 cated apolipoprotein A-I, which serves as an amphipathic proteic 'shield' that sequesters the IMP fro

275 n the lipids and the hydrophobic face of the amphipathic protein alpha-helix.

276 T(H)17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria vi

277 uce both small lipid-associated peptides and amphipathic proteins that allow growth across water:air

278 veolin scaffolding domain (CSD), a conserved amphipathic region implicated in interactions with signa

279 share an amino-terminal 11-mer repeat (11mr) amphipathic region suggested to be involved in LD target

280 positively charged residues, and an adjacent amphipathic region that can bind membranes in either a d

281 hin the conduction pathway framed by helical amphipathic regions (termed membrane-associated (MA) hel

282 gical activity was diminished, indicating an amphipathic requirement for activity in cells.

283 The rationale offers structurally balanced amphipathic scaffolds to advance the exploitation of fun

284 It is composed of a 17-amino-acid amphipathic segment (Htt17), an amyloidogenic segment of

285 Amphipathic sequences displayed increased antimicrobial

286 g charge-clustered variants, suggesting that amphipathic sequences may be desirable in nature to allo

287 lipid-dependent Slo1 gating may explain how amphipathic signaling molecules and pharmacologically ac

288 serines adjacent to aromatic residues in the amphipathic SRR.

289 flakes to be utilized as stabilizers with an amphipathic strength that depends on the edge-to-surface

290 Specifically, a seventeen-residue amphipathic stretch (N17) that is directly N-terminal to

291 atm (Tatm3x) with an elongated alpha-helical amphipathic structure enhances transduction activity and

292 tion, as determined by NMR, showed that this amphipathic structure matches the polar/apolar interface

293 mino acid composition can adopt two distinct amphipathic structures: A classic horizontal helix (hori

294 o-Schiller (SS) peptides comprise a class of amphipathic tetrapeptides that are efficacious toward a

295 inding site in TAP1 to the polar face of the amphipathic TM helix TM9 and identify key residues that

296 n octasaccharide fragment leads to a helical amphipathic topography that may affect the thermal hyste

297 hich involves formation of an intermolecular amphipathic two- or three- strand antiparallel beta shee

298 metry for the qualitative detection of model amphipathic viral peptide on a screen-printed electrode.

299 activity; they are somewhat hydrophobic and amphipathic, with a propensity to interact with the inte

300 al peptide (CAP) sequences are predominantly amphipathic, with only ca. 2% containing four or more co