ライフサイエンスコーパス: ampullary

1 cation of primary tumor (57% pancreatic, 22% ampullary, 17% distal bile duct, 3% duodenal), mean tumo

2 actuarial survival rates were pancreatic 5%, ampullary 25%, distal bile duct 21%, and duodenal 59%.

3 r actual survival rates were pancreatic 15%, ampullary 39%, distal bile duct 27%, and duodenal 59%.

4 ectomy for adenocarcinomas: 13 duodenal, 110 ampullary, 43 distal CBD, and 344 PDAC.

5 Most duodenal (61.5% [8 of 13]) and ampullary (51.8% [57 of 110]) cancers were intestinal ty

6 ts included in the primary analysis, 297 had ampullary, 96 had bile duct, and 35 had other cancers.

7 Ampullary adenocarcinoma (AAC) is widely seen as the bes

8 ich is a result of the different epitheliums ampullary adenocarcinoma can arise from (intestinal or p

9 ents who underwent pancreatoduodenectomy for ampullary adenocarcinoma in 9 European tertiary referral

10 Ampullary adenocarcinoma is a rare gastrointestinal canc

11 targeting serves as a potential therapy for ampullary adenocarcinoma patients.

12 ession of SFRP1 predicted poor prognosis for ampullary adenocarcinoma patients.

13 SFRP1 expression in ampullary adenocarcinoma was detected by immunohistochem

14 ration of SFPR1 gene and SFRP1 expression in ampullary adenocarcinoma was lower than that in other pe

15 ), in patients who underwent resection of an ampullary adenocarcinoma with curative intent.

16 -related genes in primary culture cells from ampullary adenocarcinoma, but SFRP1 expression was incre

17 g survival and recurrence after resection of ampullary adenocarcinoma.

18 tandard regimen for advanced small bowel and ampullary adenocarcinomas.

19 astic epithelial cells of the pancreatic and ampullary adenocarcinomas.

20 f the risk of progression to adenocarcinoma, ampullary adenomas should be treated.

21 Three more ampullary adenomas were detected using CAE compared to F

22 evaluating the role of endoscopy in managing ampullary adenomas.

23 lished, whereas in the more regularly firing ampullary afferents it is not.

24 In controls, when cut ampullary afferents reinnervate transplanted ampullary o

25 ations of beta-catenin were more frequent in ampullary and gallbladder carcinomas than in bile duct c

26 The ampullary and type I parampullary neurons possess dendri

27 r edge of the semicircular canals and to the ampullary and utricular walls.

28 ic alterations in 18 extrahepatic biliary, 9 ampullary, and 12 duodenal carcinomas.

29 Primary afferents from long ampullary canals (>3 cm) were more sensitive and had a l

30 lts showed pancreatic cancer (n = 282; 43%), ampullary cancer (n = 70; 11%), distal common bile duct

31 Independent predictors of OS in resected ampullary cancer were N-stage, perineural invasion, and

32 cholangiocarcinoma, gallbladder cancer, and ampullary cancer, exhibit poor prognosis.

33 ts (11 cholangiocarcinoma, 10 gallbladder, 4 ampullary cancers), the ORR is 16% (95% CI 4.5-36.1%).

34 Ampullary cannulation during ERCP was successful in all

35 a (33.4%), distal cholangiocarcinoma (8.7%), ampullary carcinoma (7.1%), duodenal carcinoma (4.0%), o

36 Factors predictive of improved survival in ampullary carcinoma include resection, negative margins,

37 clinicopathologic variables and survival of ampullary carcinoma was tested by the Kaplan-Meier metho

38 luding cholangiocarcinoma and gallbladder or ampullary carcinoma) with documented radiological diseas

39 In 123 patients presenting with ampullary carcinoma, 101 tumors (82.1%) were resected.

40 malignancies were distal cholangiocarcinoma, ampullary carcinoma, and neuroendocrine tumors.

41 t pancreaticobiliary diseased tissues (PDAC, ampullary carcinoma, cholangiocarcinoma, mucinous cystic

42 omas, 2 of 2 duodenal carcinomas, and 5 of 8 ampullary carcinomas (63%).

43 tromal compartments, a distinction absent in ampullary carcinomas and cholangiocarcinomas.

44 Ampullary carcinomas are highly malignant neoplasms that

45 eta (P = 0.03), and ER (P = 0.001), and than ampullary carcinomas at RAR beta (P = 0.02) and ER (P =

46 equencing and DNA copy-number analysis on 60 ampullary carcinomas resected from clinically well-chara

47 ast, the methylation profiles of biliary and ampullary carcinomas were not statistically different.

48 nal carcinomas are distinct from biliary and ampullary carcinomas, and that tumor-specific methylatio

49 To characterize somatic alterations in ampullary carcinomas, we performed whole-exome sequencin

50 survival (median, 43.6 months) were found in ampullary carcinomas.

51 In addition, Ksp-cadherin was found at UB ampullary cells next to developing outpouches, suggestin

52 e projection area of afferents from a single ampullary cluster.

53 2) was 60%, 19%, 15%, and 6% for pancreatic, ampullary, distal bile duct, and duodenal tumors, respec

54 ar survival is less likely for patients with ampullary, distal bile duct, and pancreatic primaries, i

55 Non-ampullary duodenal adenocarcinoma (NADC) is extremely ra

56 We reviewed our experience of 42 non-ampullary duodenal NETs managed at a single centre.

57 frequently by laparoscopy (31%), whereas in ampullary/duodenal cancer it was never found.

58 neuronal response properties in tuberous and ampullary electroreceptor afferents of the weakly electr

59 we show that lateral line placodes form both ampullary electroreceptors and mechanosensory neuromasts

60 Male stingrays use their ampullary electroreceptors to locate mates, but the effe

61 in the zone of ELL that receives input from ampullary electroreceptors, indicating markedly differen

62 The bigenic ampullary glands and vas deferens were extremely cystic,

63 enon that temporarily arrests oocytes at the ampullary-isthmic junction (AIJ) where fertilisation occ

64 tor of positive diagnosis on EUS, of finding ampullary lesion and pancreatic lesion on EUS.

65 ndergone ampullectomy for a suspected benign ampullary lesion.

66 The proposed management of benign ampullary lesions includes local resection (EA or SA) an

67 atients selected for ampullectomy for benign ampullary lesions, EA was found to have equivalent effic

68 mpared EA and SA for the treatment of benign ampullary lesions.

69 The nerve terminals, however, make large ampullary-like boutons on the receptor cells.

70 atic head and gallbladder cancers but not in ampullary malignancies.

71 latation in (67 out of 121) 55.4% cases with ampullary neoplasm being the commonest (29 out of 67 i.e

72 Innervated by a branch of the posterior ampullary nerve, the organ is covered by a cupula extend

73 s angular head velocity and stimulates canal ampullary nerves can improve vision by augmenting the ve

74 Two ampullary neurons are associated with each of the latera

75 type I and type II parampullary neurons, and ampullary neurons.

76 Those with intestinal-type duodenal, ampullary, or distal CBD adenocarcinomas had longer medi

77 Those with PB-type duodenal, ampullary, or distal CBD adenocarcinomas have survival s

78 receptive and our molecular understanding of ampullary organ development is rudimentary.

79 Overall, our results illuminate ampullary organ development, physiology and evolution.

80 These data suggest that Bmp5 promotes ampullary organ development, whereas Bmp signalling via

81 el predicted from skate (cartilaginous fish) ampullary organ electrophysiology.

82 Ampullary organ electroreceptors excited by weak cathoda

83 s, but the molecular mechanisms underpinning ampullary organ formation are understudied relative to n

84 r mechanistic understanding of neuromast and ampullary organ formation by elongating lateral line pla

85 tes opposing roles for Bmp signalling during ampullary organ formation.

86 H1 treatment shortly before the formation of ampullary organ primordia, supernumerary ampullary organ

87 Targeting ampullary organ-restricted Neurod4 did not yield any phe

88 We identify an ampullary organ-specific proneural transcription factor,

89 ine placode-derived system of electrosensory ampullary organs and mechanosensory neuromasts.

90 emonstrate a lateral line placode origin for ampullary organs and neuromasts.

91 er with the axolotl data, this confirms that ampullary organs are ancestrally lateral line placode-de

92 onic origins remain controversial: bony fish ampullary organs are derived from lateral line placodes,

93 hanosensory hair cells, flanked by fields of ampullary organs containing electroreceptors-modified ha

94 Both neuromasts and ampullary organs develop from lateral line placodes, but

95 of ampullary organ primordia, supernumerary ampullary organs developed.

96 r targeting mechanosensory-restricted Foxg1, ampullary organs formed within neuromast lines, suggesti

97 innervation of the incorrect end organ; (3) ampullary organs generate ampullary receptor cells altho

98 confirm the homology of electroreceptors and ampullary organs in cartilaginous and non-teleost bony f

99 Although ampullary organs in the axolotl (a representative of the

100 uestion the homology of electroreceptors and ampullary organs in the two lineages of jawed vertebrate

101 e sensory receptors nor the afferents of the ampullary organs label with these antibodies, and the af

102 of a subset reveals expression in developing ampullary organs of transcription factor genes critical

103 ferentiating in the center of the ridge, and ampullary organs on the flanks), or migration as collect

104 ossess a total of over 4000 electroreceptive ampullary organs scattered over the entire body.

105 hared gene expression between neuromasts and ampullary organs suggests that conserved molecular mecha

106 and afferent neurons for both neuromasts and ampullary organs, develop from lateral line placodes.

107 ctroreception is mediated by 'hair cells' in ampullary organs, distributed in fields flanking lines o

108 ed on the head by fields of electroreceptive ampullary organs, innervated by afferent neurons project

109 mechanosensory neuromasts and electrosensory ampullary organs, is a useful model for investigating th

110 When type I tuberous afferents reinnervate ampullary organs, receptor cells remain S-100- and parva

111 ampullary afferents reinnervate transplanted ampullary organs, they have characteristic calbindin-neg

112 0-injected sterlet embryos resulted in fewer ampullary organs.

113 nes that we found to be expressed in sterlet ampullary organs.

114 ia electroreceptors (modified hair cells) in ampullary organs.

115 3 and Gfi1 expression in both neuromasts and ampullary organs.

116 th advanced adenocarcinoma of small bowel or ampullary origin.

117 mucosal projections become more bulky in the ampullary portion, with the projections less present on

118 ect end organ; (3) ampullary organs generate ampullary receptor cells although innervated by tuberous

119 gh innervated by tuberous afferents; and (4) ampullary receptor cells can be trophically supported by

120 07, all (100%) originated in the fimbrial or ampullary region of the tube; six had an early (intraepi

121 Improved overall survival in ampullary relative to periampullary adenocarcinoma is du

122 ing from the crista and extending toward the ampullary roof.

123 e evaluated for the presence of bile duct or ampullary stones, as well as for biliary dilatation.

124 luated for the presence of bile duct stones, ampullary stones, the gallbladder and gallbladder stones

125 mical analysis of calreticulin in pancreatic/ampullary tumor tissue arrays using an isoform nonspecif

126 best therapeutic approach for patients with ampullary tumors and to determine methods to decrease co

127 ication of independent prognostic factors in ampullary tumors has been limited by small numbers of tu

128 Ampullary tumors, usually adenomas, are often encountere

129 as focused on the preoperative management of ampullary tumors, with a paper evaluating the role of en

130 Four patients had ampullary tumors.

131 pears to be an effective method for treating ampullary tumors.

132 Outcomes appear worse for ampullary tumours or those with co-occurring oncogenic T

133 cal dendrites and commissural cells, but the ampullary zone did not.

134 Mormyromast and ampullary zones of the ELL showed calretinin-like immuno