ライフサイエンスコーパス: amyloid precursor

1 iques, as applied to the transmembrane human amyloid precursor C99 protein in this medium.

2 pidly detecting small molecules that bind to amyloid precursors, identifying the interacting protein

3 Amyloid precursor-like protein 1 (APLP1) is a transmembr

4 The amyloid precursor-like protein 1 (APLP1) is a type I tra

5 Amyloid precursor-like protein 2 (APLP2) and sortilin we

6 exchanged for its homologous domain from the amyloid precursor-like protein 2.

7 d Swedish and Indiana mutations of the human amyloid precursor protein (APP mice) and WT mice.

8 kidney cells bearing the Swedish mutation of amyloid precursor protein (APP(sw) HEK cells) as a cellu

9 set Alzheimer's disease-causing mutations in amyloid precursor protein (APP(Swe)) and presenilin 1 (P

10 zheimer's disease, as they are produced from amyloid precursor protein (APP) along the endocytic path

11 HIV, brain region-specific up-regulation of amyloid precursor protein (APP) and Abeta (40 and 42) in

12 Previous studies have demonstrated that amyloid precursor protein (APP) and Abeta levels can be

13 SorLA interacts directly with the amyloid precursor protein (APP) and affects the processi

14 s the interaction between astrocyte-released amyloid precursor protein (APP) and death receptor-6 (DR

15 and increased Abeta production by modulating amyloid precursor protein (APP) and gamma-secretase leve

16 eavage product of the ubiquitously expressed amyloid precursor protein (APP) and is able to self-asso

17 ly onset AD, requires the extra gene copy of amyloid precursor protein (APP) and is specifically medi

18 We determined that full-length amyloid precursor protein (APP) and its beta-C-terminal

19 Amyloid precursor protein (APP) and its cleavage product

20 beta-Amyloid precursor protein (APP) and its cleaved products

21 Amyloid precursor protein (APP) and its extracellular do

22 cretase and gamma-secretase cleavages of the amyloid precursor protein (APP) and mediates a synergist

23 ha-, beta-, and gamma-secretases, cleave the amyloid precursor protein (APP) and modulate beta-amyloi

24 disease (fAD) results from mutations in the amyloid precursor protein (APP) and presenilin (PSEN1 an

25 ExNef caused a redistribution of amyloid precursor protein (APP) and Tau to lipid rafts a

26 ysosomal cysteine protease that cleaves both amyloid precursor protein (APP) and tau, mediating the a

27 beta due to a change in the approximation of amyloid precursor protein (APP) and the beta-site APP cl

28 es whether C-terminal fragments (CTF) of the amyloid precursor protein (APP) are present in cerebrosp

29 ally neurotoxic Abeta fragments derived from amyloid precursor protein (APP) at synapses may be a key

30 in cell and animal models to edit endogenous amyloid precursor protein (APP) at the extreme C-terminu

31 Cleavage of amyloid precursor protein (APP) by BACE-1 (beta-site APP

32 ta (Abeta) peptide, derived from cleavage of amyloid precursor protein (APP) by beta- and gamma-secre

33 and are formed by sequential cleavage of the amyloid precursor protein (APP) by beta-secretase (BACE)

34 eta is generated by a sequential cleavage of amyloid precursor protein (APP) by beta-secretase 1 (BAC

35 Cleavage of amyloid precursor protein (APP) by beta-secretase BACE1

36 ides derived from sequential cleavage of the amyloid precursor protein (APP) by beta-site APP cleavin

37 tion of Abeta peptide from the processing of amyloid precursor protein (APP) by clipping enzymes (bet

38 Cleavage of the amyloid precursor protein (APP) by gamma-secretase is a

39 and are formed by successive cleavage of the amyloid precursor protein (APP) by the beta and gamma se

40 Processing of amyloid precursor protein (APP) by the beta-secretase BA

41 Proteolytic processing of amyloid precursor protein (APP) C-terminal fragments (CT

42 dels of Alzheimer's disease suggest that the amyloid precursor protein (APP) can cause changes in syn

43 Prior work suggests that amyloid precursor protein (APP) can function as a proinf

44 Mutations in PSEN and the Amyloid Precursor Protein (APP) cause early-onset AD GSE

45 APP/PS1 Tg mice, the critical molecules for amyloid precursor protein (APP) cleavage and signaling p

46 al Alzheimer's disease (fAD) mutations alter amyloid precursor protein (APP) cleavage by gamma-secret

47 icits in AD.SIGNIFICANCE STATEMENT beta-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1

48 beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1

49 beta-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1

50 inesterase, butyrylcholinesterase, beta-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE-

51 Amyloid precursor protein (APP) derivative beta-amyloid

52 reviously that the Alzheimer-associated beta-amyloid precursor protein (APP) facilitates neuronal iro

53 Members of the amyloid precursor protein (APP) family participate in ma

54 's disease (AD) brain and the requirement of amyloid precursor protein (APP) for these effects.

55 nsmembrane synaptic protein belonging to the amyloid precursor protein (APP) gene family.

56 of DS models that one extra copy of a normal amyloid precursor protein (APP) gene impairs lysosomal a

57 in AD, as compared to rodent Abeta, the rat Amyloid Precursor Protein (App) gene was mutated to prod

58 his hypothesis derives from mutations in the amyloid precursor protein (APP) gene.

59 The amyloid precursor protein (APP) harbors physiological ro

60 p family proteins.SIGNIFICANCE STATEMENT The amyloid precursor protein (App) has been intensively stu

61 The amyloid precursor protein (APP) has garnered considerabl

62 The amyloid precursor protein (APP) has long been appreciate

63 The function of the amyloid precursor protein (APP) in brain health remains

64 yloid beta (Abeta) peptides originating from amyloid precursor protein (APP) in the endosomal-lysosom

65 mediate amyloid beta (Abeta) formation from amyloid precursor protein (APP) in vitro To determine wh

66 ecretase (BACE1) initiates processing of the amyloid precursor protein (APP) into Abeta peptides, whi

67 retase is responsible for the proteolysis of amyloid precursor protein (APP) into short, aggregation-

68 a growing body of evidence suggests that the amyloid precursor protein (APP) intracellular C-terminal

69 retase component, the enzyme responsible for amyloid precursor protein (APP) intramembraneous cleavag

70 Amyloid precursor protein (APP) is a key player in Alzhe

71 The amyloid precursor protein (APP) is an ubiquitously expre

72 Amyloid precursor protein (APP) is associated with both

73 associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by beta-secre

74 Here, we reveal that the membrane-associated amyloid precursor protein (APP) is highly expressed in m

75 Amyloid precursor protein (APP) is involved in the patho

76 Amyloid precursor protein (APP) is predominantly express

77 Amyloid precursor protein (APP) is processed along the a

78 nce of earlier complications occurring while amyloid precursor protein (APP) is trafficking through t

79 and cortical slices from male wild-type and amyloid precursor protein (APP) knock-out (KO) mice to a

80 nked mutations in Presenilins (PSEN) and the amyloid precursor protein (APP) lead to production of lo

81 Proteolysis of the amyloid precursor protein (APP) liberates various fragme

82 ACH) and presenilin (PSH) hypotheses and the amyloid precursor protein (APP) matrix approach (AMA), o

83 lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that

84 For these cohorts, amyloid precursor protein (APP) metabolism, synaptic mar

85 Amyloid precursor protein (APP) metabolites (amyloid-bet

86 beta-secretase 1 (BACE-1) and BACE-1-cleaved amyloid precursor protein (APP) metabolites (secreted AP

87 -targeted replacement mice with mutant human amyloid precursor protein (APP) mice.

88 xpressing human genes such as those encoding amyloid precursor protein (APP) or presenilins (PSEN1 or

89 Amyloid precursor protein (App) plays a crucial role in

90 ly involvement of endosomes and lysosomes in amyloid precursor protein (APP) processing and clearance

91 of APOE varepsilon3/4 allele exhibit altered amyloid precursor protein (APP) processing, abnormally i

92 of the unfolded protein response and altered amyloid precursor protein (APP) processing.

93 excitatory synaptic alterations by promoting amyloid precursor protein (APP) processing.

94 Studies have suggested that amyloid precursor protein (APP) regulates synaptic homeo

95 and Abeta42 secretion, and the amount of the amyloid precursor protein (APP) secreted at the cell sur

96 Abeta is derived from amyloid precursor protein (APP) through sequential prote

97 oduce Abeta by the proteolytic processing of amyloid precursor protein (APP) through the endocytic pa

98 Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's disease (

99 The proteolytic cleavage of beta-amyloid precursor protein (APP) to form the amyloid beta

100 (AD) is associated with the cleavage of the amyloid precursor protein (APP) to produce the toxic amy

101 ns of alpha-syn-containing preparations into amyloid precursor protein (APP) transgenic mice (express

102 hat Abeta pathology and neuroinflammation in amyloid precursor protein (APP) transgenic mice are wors

103 rodissected neurons extracted from preplaque amyloid precursor protein (APP) transgenic rats were fou

104 Amyloid precursor protein (APP) was originally identifie

105 ng studies revealed that the dynamics of the amyloid precursor protein (APP) were significantly impai

106 in, and scyllo-inositol, in cells expressing amyloid precursor protein (APP) with the Osaka (E693Delt

107 laque pathology and astrogliosis in the male amyloid precursor protein (APP)(SWE) /presenilin 1 (PS1)

108 The amyloid precursor protein (APP), a key player in Alzheim

109 te products in the brain, possibly including amyloid precursor protein (APP), a marker of DAI.

110 in 4 (CNTN4) or one of its binding partners, amyloid precursor protein (APP), a subset of direction-s

111 transport of the Alzheimer's disease-related amyloid precursor protein (APP), although neuronal morph

112 Abeta is a cleavage product of the amyloid precursor protein (APP), and aberrant posttransl

113 cholesterol homeostasis and cleavage of the amyloid precursor protein (APP), and how this relationsh

114 laques resulting from abnormal processing of amyloid precursor protein (APP), and presence of neurofi

115 eferring to an interaction between DISC1 and amyloid precursor protein (APP), and to an association o

116 mory deficits as well as the upregulation of amyloid precursor protein (APP), BACE-1, a trending incr

117 erated through sequential proteolysis of the amyloid precursor protein (APP), first by the action of

118 els of total-Tau, phosphorylated-Tau (pTau), amyloid precursor protein (APP), GFAP, Iba1, alphaII-spe

119 oid-beta generation from its precursor, beta-amyloid precursor protein (APP), in a competitive manner

120 tide, a metabolite of sequential cleavage of amyloid precursor protein (APP), is a critical step in t

121 ition of amyloid-beta peptides, derived from amyloid precursor protein (APP), is a neuropathological

122 proteins linked to familial AD (FAD), mutant amyloid precursor protein (APP), or APP and presenilin (

123 eta), derived from proteolytic processing of amyloid precursor protein (APP), play a central role in

124 The amyloid precursor protein (APP), primarily known as the

125 use models overexpress mutant forms of human amyloid precursor protein (APP), producing high levels o

126 Similarly to the amyloid precursor protein (APP), PrP(C) is proteolytical

127 ) peptide because of increased processing of amyloid precursor protein (APP), resulting in loss of sy

128 illar aggregates of peptide fragments of the amyloid precursor protein (APP), typically 40 or 42 resi

129 ilar to that of transgenic mice that express amyloid precursor protein (APP), which is duplicated in

130 tween these conditions may be constituted by amyloid precursor protein (APP), which plays a pivotal r

131 idue protein produced by the cleavage of the amyloid precursor protein (APP), which subsequently aggr

132 wn primarily for its initial cleavage of the amyloid precursor protein (APP), which ultimately leads

133 The amyloid precursor protein (APP), whose mutations cause A

134 The amyloid precursor protein (APP), whose mutations cause f

135 The protease beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1

136 It was recently suggested that beta-site amyloid precursor protein (APP)-cleaving enzyme 2 (BACE2

137 n that affects the Alzheimer's disease gene, amyloid precursor protein (APP).

138 eady shown for oAbeta, also oTau can bind to amyloid precursor protein (APP).

139 on of polypeptides that are derived from the Amyloid Precursor Protein (APP).

140 drogen bond strengths in the TM helix of the amyloid precursor protein (APP).

141 x Virus strikingly overlaps with that of the amyloid precursor protein (APP).

142 rt the generation of Abeta-peptides from the amyloid precursor protein (APP).

143 metabolism of the Alzheimer disease-related amyloid precursor protein (APP).

144 o acids long Abeta peptides derived from the amyloid precursor protein (APP).

145 quence in the extracellular E2 domain of the amyloid precursor protein (APP).

146 Using the amyloid precursor protein (APP)/presenilin 1 (PS1) trans

147 Here, we examined the impact of CXCR3 in the amyloid precursor protein (APP)/presenilin 1 (PS1) trans

148 Here we discovered that, in amyloid precursor protein (APP)/presenilin-1 (PS1) mice

149 well as an Alzheimer's disease mouse model, amyloid precursor protein (APP)/PSEN1dE9(+/-) (PS1) that

150 on within the Kunitz inhibitor domain of the amyloid precursor protein (APPI) that incorporated a new

151 We have previously shown that the fly amyloid precursor protein (APPL) is required for memory

152 TgF344-AD) expressing disease-causing mutant amyloid precursor protein (APPsw) and presenilin-1 (PS1D

153 SY5Y neuroblastoma cells expressing the beta-amyloid precursor protein (betaAPP) harboring the famili

154 ocampal neurons and in mice expressing human amyloid precursor protein (hAPP mice), a model for famil

155 compared transgenic mice that express human amyloid precursor protein (hAPP) and patients with mild

156 humans with AD, aging mice expressing human amyloid precursor protein (hAPP) showed increased levels

157 cking in the axon of AD-related mutant human amyloid precursor protein (hAPP) transgenic (Tg) mouse n

158 e mortality and network dysfunction in human amyloid precursor protein (hAPP) transgenic mice, which

159 tors, in the brains of AD patients and human amyloid precursor protein (hAPP) transgenic mice.

160 he AD mouse model carrying human mutation of amyloid precursor protein (mhAPP) expressing human Abeta

161 Here, we have uncovered a role for soluble amyloid precursor protein (sAPP) as a vascular niche sig

162 ), gamma-secretase, soluble Abeta42, soluble amyloid precursor protein (sAPP)beta, sAPPalpha, glial-d

163 nsgenic mice expressing mutated forms of the amyloid precursor protein (Tg2576 mice).

164 young transgenic mice overexpressing mutated amyloid precursor protein (Tg2576), Abeta causes dysfunc

165 mice expressing the Swedish mutation of the amyloid precursor protein (tg2576).

166 ntracellular amyloidogenic proteins (amylin, amyloid precursor protein [APP], and amyloid-beta [Abeta

167 odel of AD (transgenic mice expressing human amyloid precursor protein [hAPP]) and patients in the ea

168 hese observations, anterogradely transported amyloid precursor protein accumulated in ligated sciatic

169 Amyloid precursor protein accumulates within the periphe

170 This occurred prior to the appearance of amyloid precursor protein accumulation, an indicator of

171 e transmembrane alpha-helical portion of the amyloid precursor protein after the latter values were a

172 Sarm1(-/-) mice developed fewer beta-amyloid precursor protein aggregates in axons of the cor

173 We analysed soluble amyloid precursor protein alpha (sAPPalpha) and beta (sA

174 Furthermore, we observed increased levels of amyloid precursor protein and amyloid beta in PITRM1-kno

175 Amyloid precursor protein and endosomal-lysosomal dysfun

176 led increased phosphorylation of full-length amyloid precursor protein and its associated neurotoxic

177 a-secretase association with substrates like amyloid precursor protein and N-cadherin, but not with i

178 x that catalyzes the proteolytic cleavage of amyloid precursor protein and Notch.

179 ransgenic mouse model carrying mutated human amyloid precursor protein and presenilin 1 (APP/PS1-Tg).

180 Methods: Nine wild-type (WT) mice and 9 amyloid precursor protein and presenilin 1 double-transg

181 expression of human familial AD mutations in amyloid precursor protein and presenilin 1 leads to sens

182 at initiates amyloidogenic processing of the amyloid precursor protein and which is a substrate for t

183 Abeta43, a product of the proteolysis of the amyloid precursor protein APP, is related to Abeta42 by

184 known that mutations in the gene coding for amyloid precursor protein are responsible for autosomal

185 Here, we used a mouse model expressing human amyloid precursor protein bearing two familial mutations

186 Intramembrane cleavage of the beta-amyloid precursor protein C99 substrate by gamma-secreta

187 accompanied by a decrease in BACE1-mediated amyloid precursor protein cleavage and amyloid-beta leve

188 nduce an "endosomal traffic jam" that drives amyloid precursor protein cleavage to amyloid-beta in en

189 ncoding RNA (miR-188-3p) targeting beta-site amyloid precursor protein cleaving enzyme (BACE)-1, a ke

190 sufficient to unleash a global and beta-site amyloid precursor protein cleaving enzyme 1 (bace-1) DNA

191 ide derivative, is a high-affinity beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhi

192 Mice were treated with a beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhi

193 Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a

194 beta-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is a

195 sion causes an increase in APP and beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) prot

196 S6K1 levels reduced translation of beta-site amyloid precursor protein cleaving enzyme 1 and tau, two

197 BACE1 (beta site amyloid precursor protein cleaving enzyme 1) is the rate

198 reporter gene driven by the BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) promoter, w

199 reduced translation of tau and the beta-site amyloid precursor protein cleaving enzyme 1, a key enzym

200 ro-amyloidogenic processing enzyme beta-site amyloid precursor protein cleaving enzyme 1, and both to

201 Although brain amyloid precursor protein expression and amyloid beta pr

202 The amyloid precursor protein family (APP/APLPs) has essenti

203 pressing a shorter FE65 isoform able to bind amyloid precursor protein family members (APP, APLP1, AP

204 these rats, such as increased deposition of amyloid precursor protein fragments associated with the

205 ma-secretase complex that cleaves Abeta from amyloid precursor protein fragments.

206 s of the Alzheimer's disease (AD)-implicated amyloid precursor protein gene (APP) and comprehensively

207 t over-express the Swedish mutant human beta-amyloid precursor protein gene with G protein-coupled re

208 TgCRND8 (Tg) transgenic mice express human amyloid precursor protein harboring the Swedish and Indi

209 e and monkeys, and accompanied by diminished amyloid precursor protein in monkeys.

210 s involved in anterograde trafficking of the amyloid precursor protein in neurons and in the secretio

211 iple similarities, strengthening the role of amyloid precursor protein in normal brain function and d

212 human induced neurons overexpressing mutant amyloid precursor protein in the background of APOE vare

213 l PDAPP mice, which overexpress mutant human amyloid precursor protein in the brain, exhibit two cryp

214 Overexpression of human amyloid precursor protein in transgenic mice induces hip

215 e of the Alzheimer's disease-associated beta-amyloid precursor protein in vitro and in human embryoni

216 affected brain regions caused by cleavage of amyloid precursor protein into the pathogenic peptide am

217 Here we report that the amyloid precursor protein intracellular domain associate

218 Acting as synapse-to-nucleus messengers, amyloid precursor protein intracellular domain associate

219 ogical feature of AD, and endocytosis of the amyloid precursor protein is an important step in its su

220 We report that amyloid precursor protein is crucial for axonal pruning

221 ogy of Alzheimer's disease, it is clear that amyloid precursor protein is expressed in numerous cell

222 Here we demonstrate that amyloid precursor protein is involved in regulating the

223 n called "remapping." We tested remapping in amyloid precursor protein knockin (APP-KI) mice with imp

224 vine pancreatic trypsin inhibitor (BPTI) and amyloid precursor protein Kunitz protease inhibitor (APP

225 t to be primarily due to triplication of the amyloid precursor protein located on chromosome 21, the

226 Results: Aged mutant amyloid precursor protein mice with established disease

227 P = .01) and associative memory (P = .02) in amyloid precursor protein mice.

228 The amyloid precursor protein modulates alpha2A-adrenergic r

229 Amyloid precursor protein mutations falling within the a

230 endosomes was coupled with reduced levels of amyloid precursor protein processing and Abeta productio

231 In the latter case, proteins related to amyloid precursor protein processing and secretion are S

232 sosome transport in regulating amyloidogenic amyloid precursor protein processing and support a model

233 These swellings contain high levels of amyloid precursor protein processing enzymes (BACE1 and

234 immunoreactivity without detectably altering amyloid precursor protein processing or extracellular Ab

235 itory fragment of Nogo-A is generated by the amyloid precursor protein protease BACE1 and presented o

236 ; however, its role in the processing of the amyloid precursor protein remains unknown.

237 smic reticulum retrograde transport, affects amyloid precursor protein subcellular localization, cell

238 PPSwDI transgenic mice expressing human beta-amyloid precursor protein Swedish (Tg-SwDI), a model of

239 , we identified the protein interacting with amyloid precursor protein tail 1 (PAT1) as a potential p

240 ral transmembrane proteins, most notably the amyloid precursor protein that results in Abeta, a trans

241 efflux by lowering tau protein that traffics amyloid precursor protein to facilitate iron efflux.

242 (pTalpha) and has also been shown to cleave amyloid precursor protein to trigger its secretion.

243 Expression analysis of amyloid precursor protein transgenic mice also revealed

244 dated miRNA data using AD postmortem brains, amyloid precursor protein transgenic mice and AD cell li

245 Starting at 5 months of age, tet-off amyloid precursor protein transgenic mice were treated w

246 The human systemic amyloid precursor protein transthyretin (TTR) is known t

247 of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway.

248 ring AD-related mutations in presenilin-1 or amyloid precursor protein vs. isogenic gene corrected co

249 and low sAPPbeta (a soluble beta fragment of amyloid precursor protein) in cerebrospinal fluid (CSF)

250 Increased APP (amyloid precursor protein) processing causes beta-amyloi

251 t light and the soluble fraction beta of the amyloid precursor protein).

252 ovel object recognition test and stained for amyloid precursor protein, a DAI marker.

253 the absence of any changes in the amounts of amyloid precursor protein, amyloid-beta or synaptic prot

254 rane proteins such as EGF, betacellulin, the amyloid precursor protein, and CD23 from cells.

255 of AD, GR signaling pathways, processing of amyloid precursor protein, and enzymes involved in Tau p

256 generative diseases such as alpha-synuclein, amyloid precursor protein, and tau.

257 at bind a variety of proteins, including the amyloid precursor protein, and that mediate the assembly

258 e result of alterations in expression of the amyloid precursor protein, as confirmed by both immunost

259 Due to the fact that it also cleaves amyloid precursor protein, BACE1 is a therapeutic target

260 's disease (AD) are tied to mutations in the amyloid precursor protein, but the cellular mechanisms t

261 ial forms of AD are tied to mutations in the amyloid precursor protein, but the cellular mechanisms t

262 egion from >100 substrates, including Notch, amyloid precursor protein, cadherins, growth factors, an

263 iation is partially due to overexpression of amyloid precursor protein, encoded by APP, as a result o

264 cases, hippocampal levels of phosphorylated amyloid precursor protein, its pro-amyloidogenic process

265 teins, including those derived from the same amyloid precursor protein, such as Aeta or sAPPalpha, an

266 havioural signs, astrogliosis, deposition of amyloid precursor protein, synaptic loss and neuronal de

267 are caused by mutations in the gene encoding amyloid precursor protein, whose processing can result i

268 he diversion of the membrane-bound beta-site amyloid precursor protein-(APP) cleaving enzyme (BACE1)

269 ant factors amyloid beta (Abeta) and soluble amyloid precursor protein-alpha (sAPPalpha) and present

270 Secreted amyloid precursor protein-alpha (sAPPalpha) has growth f

271 cilitate LTP.SIGNIFICANCE STATEMENT Secreted amyloid precursor protein-alpha (sAPPalpha) is a neurotr

272 to measure amyloid beta (Abeta) and soluble amyloid precursor protein-alpha (sAPPalpha), analytes ce

273 Furthermore, increased beta-site amyloid precursor protein-cleaving (APP-cleaving) enzyme

274 The beta-site amyloid precursor protein-cleaving enzyme (BACE1) is the

275 becestat is an orally administered beta-site amyloid precursor protein-cleaving enzyme 1 (BACE-1) inh

276 ADE levels of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE-1), ga

277 beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is b

278 inistration of an inhibitor of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) on A

279 gical substrate of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1)).

280 In Alzheimer amyloid precursor protein-transgenic mice and SH-SY5Y ce

281 Unexpectedly, ablation of CR3 in human amyloid precursor protein-transgenic mice results in dec

282 ations in presenilin 1, presenilin 2, or the amyloid precursor protein.

283 protein, phosphorylated tau 181, and soluble amyloid precursor protein.

284 s alpha-secretase of the Alzheimer's disease amyloid precursor protein.

285 imer disease-associated mutations within the amyloid precursor protein.

286 expressing familial AD-linked forms of human amyloid precursor protein.

287 d to increased proteolytic processing of the amyloid precursor protein.

288 d with doxycycline (dox) to suppress further amyloid precursor protein/Abeta production, and at the s

289 ells via intracerebroventricular infusion in amyloid precursor protein/presenilin 1 (APP/PS1) double-

290 e effect of CLU on Abeta pathology using the amyloid precursor protein/presenilin 1 (APP/PS1) mouse m

291 content of mitochondrial 5-methylcytosine in amyloid precursor protein/presenilin 1 mice along with A

292 rt, liver, and brain tissues in a late-stage amyloid precursor protein/presenilin-1 (APP/PS-1) human

293 Amyloid precursor protein/tetracycline transactivator mi

294 Down syndrome critical region 1 (DSCR1) and amyloid-precursor protein (APP), proteins upregulated in

295 /Down syndrome critical region 1 (DSCR1) and amyloid-precursor protein (APP), proteins upregulated in

296 One major target has been the beta-site amyloid-precursor-protein-cleaving enzyme 1 (BACE-1), wi

297 protease complex involved in the cleavage of amyloid precursor proteins that lead to the formation of

298 n lipid-related processes and degradation of amyloid precursor proteins.

299 Similar to other amyloid precursors, the formation of CRES amyloids corre

300 locate across the outer membrane as unfolded amyloid precursors through a secretion system.