ライフサイエンスコーパス: amyloid precursor protein

1 t light and the soluble fraction beta of the amyloid precursor protein).

2 ations in presenilin 1, presenilin 2, or the amyloid precursor protein.

3 protein, phosphorylated tau 181, and soluble amyloid precursor protein.

4 s alpha-secretase of the Alzheimer's disease amyloid precursor protein.

5 imer disease-associated mutations within the amyloid precursor protein.

6 expressing familial AD-linked forms of human amyloid precursor protein.

7 d to increased proteolytic processing of the amyloid precursor protein.

8 n lipid-related processes and degradation of amyloid precursor proteins.

9 ovel object recognition test and stained for amyloid precursor protein, a DAI marker.

10 d with doxycycline (dox) to suppress further amyloid precursor protein/Abeta production, and at the s

11 hese observations, anterogradely transported amyloid precursor protein accumulated in ligated sciatic

12 Amyloid precursor protein accumulates within the periphe

13 This occurred prior to the appearance of amyloid precursor protein accumulation, an indicator of

14 ion on transmembrane proteins other than the amyloid precursor protein affects the nervous system is

15 e transmembrane alpha-helical portion of the amyloid precursor protein after the latter values were a

16 Sarm1(-/-) mice developed fewer beta-amyloid precursor protein aggregates in axons of the cor

17 We analysed soluble amyloid precursor protein alpha (sAPPalpha) and beta (sA

18 ant factors amyloid beta (Abeta) and soluble amyloid precursor protein-alpha (sAPPalpha) and present

19 Secreted amyloid precursor protein-alpha (sAPPalpha) has growth f

20 cilitate LTP.SIGNIFICANCE STATEMENT Secreted amyloid precursor protein-alpha (sAPPalpha) is a neurotr

21 to measure amyloid beta (Abeta) and soluble amyloid precursor protein-alpha (sAPPalpha), analytes ce

22 the absence of any changes in the amounts of amyloid precursor protein, amyloid-beta or synaptic prot

23 Furthermore, we observed increased levels of amyloid precursor protein and amyloid beta in PITRM1-kno

24 Amyloid precursor protein and endosomal-lysosomal dysfun

25 led increased phosphorylation of full-length amyloid precursor protein and its associated neurotoxic

26 a-secretase association with substrates like amyloid precursor protein and N-cadherin, but not with i

27 x that catalyzes the proteolytic cleavage of amyloid precursor protein and Notch.

28 ransgenic mouse model carrying mutated human amyloid precursor protein and presenilin 1 (APP/PS1-Tg).

29 Alzheimer's disease we used a double mutant amyloid precursor protein and presenilin 1 (APPswe/PSEN1

30 Methods: Nine wild-type (WT) mice and 9 amyloid precursor protein and presenilin 1 double-transg

31 expression of human familial AD mutations in amyloid precursor protein and presenilin 1 leads to sens

32 at initiates amyloidogenic processing of the amyloid precursor protein and which is a substrate for t

33 rane proteins such as EGF, betacellulin, the amyloid precursor protein, and CD23 from cells.

34 of AD, GR signaling pathways, processing of amyloid precursor protein, and enzymes involved in Tau p

35 generative diseases such as alpha-synuclein, amyloid precursor protein, and tau.

36 at bind a variety of proteins, including the amyloid precursor protein, and that mediate the assembly

37 Abeta43, a product of the proteolysis of the amyloid precursor protein APP, is related to Abeta42 by

38 d Swedish and Indiana mutations of the human amyloid precursor protein (APP mice) and WT mice.

39 kidney cells bearing the Swedish mutation of amyloid precursor protein (APP(sw) HEK cells) as a cellu

40 set Alzheimer's disease-causing mutations in amyloid precursor protein (APP(Swe)) and presenilin 1 (P

41 zheimer's disease, as they are produced from amyloid precursor protein (APP) along the endocytic path

42 HIV, brain region-specific up-regulation of amyloid precursor protein (APP) and Abeta (40 and 42) in

43 Previous studies have demonstrated that amyloid precursor protein (APP) and Abeta levels can be

44 SorLA interacts directly with the amyloid precursor protein (APP) and affects the processi

45 s the interaction between astrocyte-released amyloid precursor protein (APP) and death receptor-6 (DR

46 and increased Abeta production by modulating amyloid precursor protein (APP) and gamma-secretase leve

47 eavage product of the ubiquitously expressed amyloid precursor protein (APP) and is able to self-asso

48 ly onset AD, requires the extra gene copy of amyloid precursor protein (APP) and is specifically medi

49 We determined that full-length amyloid precursor protein (APP) and its beta-C-terminal

50 Amyloid precursor protein (APP) and its cleavage product

51 beta-Amyloid precursor protein (APP) and its cleaved products

52 Amyloid precursor protein (APP) and its extracellular do

53 cretase and gamma-secretase cleavages of the amyloid precursor protein (APP) and mediates a synergist

54 ha-, beta-, and gamma-secretases, cleave the amyloid precursor protein (APP) and modulate beta-amyloi

55 disease (fAD) results from mutations in the amyloid precursor protein (APP) and presenilin (PSEN1 an

56 ExNef caused a redistribution of amyloid precursor protein (APP) and Tau to lipid rafts a

57 ysosomal cysteine protease that cleaves both amyloid precursor protein (APP) and tau, mediating the a

58 beta due to a change in the approximation of amyloid precursor protein (APP) and the beta-site APP cl

59 es whether C-terminal fragments (CTF) of the amyloid precursor protein (APP) are present in cerebrosp

60 ally neurotoxic Abeta fragments derived from amyloid precursor protein (APP) at synapses may be a key

61 in cell and animal models to edit endogenous amyloid precursor protein (APP) at the extreme C-terminu

62 Cleavage of amyloid precursor protein (APP) by BACE-1 (beta-site APP

63 ta (Abeta) peptide, derived from cleavage of amyloid precursor protein (APP) by beta- and gamma-secre

64 and are formed by sequential cleavage of the amyloid precursor protein (APP) by beta-secretase (BACE)

65 eta is generated by a sequential cleavage of amyloid precursor protein (APP) by beta-secretase 1 (BAC

66 Cleavage of amyloid precursor protein (APP) by beta-secretase BACE1

67 ides derived from sequential cleavage of the amyloid precursor protein (APP) by beta-site APP cleavin

68 tion of Abeta peptide from the processing of amyloid precursor protein (APP) by clipping enzymes (bet

69 Cleavage of the amyloid precursor protein (APP) by gamma-secretase is a

70 and are formed by successive cleavage of the amyloid precursor protein (APP) by the beta and gamma se

71 Processing of amyloid precursor protein (APP) by the beta-secretase BA

72 Proteolytic processing of amyloid precursor protein (APP) C-terminal fragments (CT

73 dels of Alzheimer's disease suggest that the amyloid precursor protein (APP) can cause changes in syn

74 Prior work suggests that amyloid precursor protein (APP) can function as a proinf

75 Mutations in PSEN and the Amyloid Precursor Protein (APP) cause early-onset AD GSE

76 APP/PS1 Tg mice, the critical molecules for amyloid precursor protein (APP) cleavage and signaling p

77 al Alzheimer's disease (fAD) mutations alter amyloid precursor protein (APP) cleavage by gamma-secret

78 icits in AD.SIGNIFICANCE STATEMENT beta-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1

79 beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1

80 beta-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1

81 inesterase, butyrylcholinesterase, beta-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE-

82 Amyloid precursor protein (APP) derivative beta-amyloid

83 reviously that the Alzheimer-associated beta-amyloid precursor protein (APP) facilitates neuronal iro

84 Members of the amyloid precursor protein (APP) family participate in ma

85 's disease (AD) brain and the requirement of amyloid precursor protein (APP) for these effects.

86 haracterized by increases in DNA content and amyloid precursor protein (APP) gene copy number.

87 nsmembrane synaptic protein belonging to the amyloid precursor protein (APP) gene family.

88 of DS models that one extra copy of a normal amyloid precursor protein (APP) gene impairs lysosomal a

89 in AD, as compared to rodent Abeta, the rat Amyloid Precursor Protein (App) gene was mutated to prod

90 his hypothesis derives from mutations in the amyloid precursor protein (APP) gene.

91 The amyloid precursor protein (APP) harbors physiological ro

92 p family proteins.SIGNIFICANCE STATEMENT The amyloid precursor protein (App) has been intensively stu

93 The amyloid precursor protein (APP) has garnered considerabl

94 The amyloid precursor protein (APP) has long been appreciate

95 The function of the amyloid precursor protein (APP) in brain health remains

96 yloid beta (Abeta) peptides originating from amyloid precursor protein (APP) in the endosomal-lysosom

97 mediate amyloid beta (Abeta) formation from amyloid precursor protein (APP) in vitro To determine wh

98 ecretase (BACE1) initiates processing of the amyloid precursor protein (APP) into Abeta peptides, whi

99 retase is responsible for the proteolysis of amyloid precursor protein (APP) into short, aggregation-

100 a growing body of evidence suggests that the amyloid precursor protein (APP) intracellular C-terminal

101 retase component, the enzyme responsible for amyloid precursor protein (APP) intramembraneous cleavag

102 Amyloid precursor protein (APP) is a key player in Alzhe

103 The amyloid precursor protein (APP) is an ubiquitously expre

104 Amyloid precursor protein (APP) is associated with both

105 associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by beta-secre

106 Here, we reveal that the membrane-associated amyloid precursor protein (APP) is highly expressed in m

107 The beta-amyloid precursor protein (APP) is involved in Alzheimer

108 Amyloid precursor protein (APP) is involved in the patho

109 Amyloid precursor protein (APP) is predominantly express

110 Amyloid precursor protein (APP) is processed along the a

111 nce of earlier complications occurring while amyloid precursor protein (APP) is trafficking through t

112 and cortical slices from male wild-type and amyloid precursor protein (APP) knock-out (KO) mice to a

113 nked mutations in Presenilins (PSEN) and the amyloid precursor protein (APP) lead to production of lo

114 Proteolysis of the amyloid precursor protein (APP) liberates various fragme

115 ACH) and presenilin (PSH) hypotheses and the amyloid precursor protein (APP) matrix approach (AMA), o

116 lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that

117 For these cohorts, amyloid precursor protein (APP) metabolism, synaptic mar

118 Amyloid precursor protein (APP) metabolites (amyloid-bet

119 beta-secretase 1 (BACE-1) and BACE-1-cleaved amyloid precursor protein (APP) metabolites (secreted AP

120 -targeted replacement mice with mutant human amyloid precursor protein (APP) mice.

121 xpressing human genes such as those encoding amyloid precursor protein (APP) or presenilins (PSEN1 or

122 Amyloid precursor protein (App) plays a crucial role in

123 ly involvement of endosomes and lysosomes in amyloid precursor protein (APP) processing and clearance

124 of APOE varepsilon3/4 allele exhibit altered amyloid precursor protein (APP) processing, abnormally i

125 of the unfolded protein response and altered amyloid precursor protein (APP) processing.

126 excitatory synaptic alterations by promoting amyloid precursor protein (APP) processing.

127 Studies have suggested that amyloid precursor protein (APP) regulates synaptic homeo

128 and Abeta42 secretion, and the amount of the amyloid precursor protein (APP) secreted at the cell sur

129 Abeta is derived from amyloid precursor protein (APP) through sequential prote

130 oduce Abeta by the proteolytic processing of amyloid precursor protein (APP) through the endocytic pa

131 Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's disease (

132 The proteolytic cleavage of beta-amyloid precursor protein (APP) to form the amyloid beta

133 (AD) is associated with the cleavage of the amyloid precursor protein (APP) to produce the toxic amy

134 ns of alpha-syn-containing preparations into amyloid precursor protein (APP) transgenic mice (express

135 hat Abeta pathology and neuroinflammation in amyloid precursor protein (APP) transgenic mice are wors

136 rodissected neurons extracted from preplaque amyloid precursor protein (APP) transgenic rats were fou

137 Amyloid precursor protein (APP) was originally identifie

138 ng studies revealed that the dynamics of the amyloid precursor protein (APP) were significantly impai

139 in, and scyllo-inositol, in cells expressing amyloid precursor protein (APP) with the Osaka (E693Delt

140 laque pathology and astrogliosis in the male amyloid precursor protein (APP)(SWE) /presenilin 1 (PS1)

141 The amyloid precursor protein (APP), a key player in Alzheim

142 te products in the brain, possibly including amyloid precursor protein (APP), a marker of DAI.

143 in 4 (CNTN4) or one of its binding partners, amyloid precursor protein (APP), a subset of direction-s

144 transport of the Alzheimer's disease-related amyloid precursor protein (APP), although neuronal morph

145 Abeta is a cleavage product of the amyloid precursor protein (APP), and aberrant posttransl

146 cholesterol homeostasis and cleavage of the amyloid precursor protein (APP), and how this relationsh

147 laques resulting from abnormal processing of amyloid precursor protein (APP), and presence of neurofi

148 eferring to an interaction between DISC1 and amyloid precursor protein (APP), and to an association o

149 mory deficits as well as the upregulation of amyloid precursor protein (APP), BACE-1, a trending incr

150 erated through sequential proteolysis of the amyloid precursor protein (APP), first by the action of

151 els of total-Tau, phosphorylated-Tau (pTau), amyloid precursor protein (APP), GFAP, Iba1, alphaII-spe

152 oid-beta generation from its precursor, beta-amyloid precursor protein (APP), in a competitive manner

153 tide, a metabolite of sequential cleavage of amyloid precursor protein (APP), is a critical step in t

154 ition of amyloid-beta peptides, derived from amyloid precursor protein (APP), is a neuropathological

155 proteins linked to familial AD (FAD), mutant amyloid precursor protein (APP), or APP and presenilin (

156 eta), derived from proteolytic processing of amyloid precursor protein (APP), play a central role in

157 The amyloid precursor protein (APP), primarily known as the

158 use models overexpress mutant forms of human amyloid precursor protein (APP), producing high levels o

159 Similarly to the amyloid precursor protein (APP), PrP(C) is proteolytical

160 er impregnation and immunohistochemistry for amyloid precursor protein (APP), respectively.

161 ) peptide because of increased processing of amyloid precursor protein (APP), resulting in loss of sy

162 illar aggregates of peptide fragments of the amyloid precursor protein (APP), typically 40 or 42 resi

163 ilar to that of transgenic mice that express amyloid precursor protein (APP), which is duplicated in

164 tween these conditions may be constituted by amyloid precursor protein (APP), which plays a pivotal r

165 idue protein produced by the cleavage of the amyloid precursor protein (APP), which subsequently aggr

166 wn primarily for its initial cleavage of the amyloid precursor protein (APP), which ultimately leads

167 The amyloid precursor protein (APP), whose mutations cause A

168 The amyloid precursor protein (APP), whose mutations cause f

169 The protease beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1

170 It was recently suggested that beta-site amyloid precursor protein (APP)-cleaving enzyme 2 (BACE2

171 n that affects the Alzheimer's disease gene, amyloid precursor protein (APP).

172 eady shown for oAbeta, also oTau can bind to amyloid precursor protein (APP).

173 on of polypeptides that are derived from the Amyloid Precursor Protein (APP).

174 drogen bond strengths in the TM helix of the amyloid precursor protein (APP).

175 x Virus strikingly overlaps with that of the amyloid precursor protein (APP).

176 rt the generation of Abeta-peptides from the amyloid precursor protein (APP).

177 metabolism of the Alzheimer disease-related amyloid precursor protein (APP).

178 o acids long Abeta peptides derived from the amyloid precursor protein (APP).

179 quence in the extracellular E2 domain of the amyloid precursor protein (APP).

180 Using the amyloid precursor protein (APP)/presenilin 1 (PS1) trans

181 Here, we examined the impact of CXCR3 in the amyloid precursor protein (APP)/presenilin 1 (PS1) trans

182 Here we discovered that, in amyloid precursor protein (APP)/presenilin-1 (PS1) mice

183 well as an Alzheimer's disease mouse model, amyloid precursor protein (APP)/PSEN1dE9(+/-) (PS1) that

184 Down syndrome critical region 1 (DSCR1) and amyloid-precursor protein (APP), proteins upregulated in

185 /Down syndrome critical region 1 (DSCR1) and amyloid-precursor protein (APP), proteins upregulated in

186 ntracellular amyloidogenic proteins (amylin, amyloid precursor protein [APP], and amyloid-beta [Abeta

187 he diversion of the membrane-bound beta-site amyloid precursor protein-(APP) cleaving enzyme (BACE1)

188 on within the Kunitz inhibitor domain of the amyloid precursor protein (APPI) that incorporated a new

189 We have previously shown that the fly amyloid precursor protein (APPL) is required for memory

190 TgF344-AD) expressing disease-causing mutant amyloid precursor protein (APPsw) and presenilin-1 (PS1D

191 known that mutations in the gene coding for amyloid precursor protein are responsible for autosomal

192 e result of alterations in expression of the amyloid precursor protein, as confirmed by both immunost

193 Due to the fact that it also cleaves amyloid precursor protein, BACE1 is a therapeutic target

194 Here, we used a mouse model expressing human amyloid precursor protein bearing two familial mutations

195 SY5Y neuroblastoma cells expressing the beta-amyloid precursor protein (betaAPP) harboring the famili

196 's disease (AD) are tied to mutations in the amyloid precursor protein, but the cellular mechanisms t

197 ial forms of AD are tied to mutations in the amyloid precursor protein, but the cellular mechanisms t

198 Intramembrane cleavage of the beta-amyloid precursor protein C99 substrate by gamma-secreta

199 egion from >100 substrates, including Notch, amyloid precursor protein, cadherins, growth factors, an

200 accompanied by a decrease in BACE1-mediated amyloid precursor protein cleavage and amyloid-beta leve

201 nduce an "endosomal traffic jam" that drives amyloid precursor protein cleavage to amyloid-beta in en

202 ncoding RNA (miR-188-3p) targeting beta-site amyloid precursor protein cleaving enzyme (BACE)-1, a ke

203 sufficient to unleash a global and beta-site amyloid precursor protein cleaving enzyme 1 (bace-1) DNA

204 ide derivative, is a high-affinity beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhi

205 Mice were treated with a beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhi

206 Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a

207 beta-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is a

208 sion causes an increase in APP and beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) prot

209 S6K1 levels reduced translation of beta-site amyloid precursor protein cleaving enzyme 1 and tau, two

210 BACE1 (beta site amyloid precursor protein cleaving enzyme 1) is the rate

211 reporter gene driven by the BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) promoter, w

212 reduced translation of tau and the beta-site amyloid precursor protein cleaving enzyme 1, a key enzym

213 ro-amyloidogenic processing enzyme beta-site amyloid precursor protein cleaving enzyme 1, and both to

214 Furthermore, increased beta-site amyloid precursor protein-cleaving (APP-cleaving) enzyme

215 The beta-site amyloid precursor protein-cleaving enzyme (BACE1) is the

216 becestat is an orally administered beta-site amyloid precursor protein-cleaving enzyme 1 (BACE-1) inh

217 ADE levels of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE-1), ga

218 beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is b

219 inistration of an inhibitor of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) on A

220 gical substrate of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1)).

221 One major target has been the beta-site amyloid-precursor-protein-cleaving enzyme 1 (BACE-1), wi

222 iation is partially due to overexpression of amyloid precursor protein, encoded by APP, as a result o

223 Although brain amyloid precursor protein expression and amyloid beta pr

224 The amyloid precursor protein family (APP/APLPs) has essenti

225 pressing a shorter FE65 isoform able to bind amyloid precursor protein family members (APP, APLP1, AP

226 these rats, such as increased deposition of amyloid precursor protein fragments associated with the

227 ma-secretase complex that cleaves Abeta from amyloid precursor protein fragments.

228 s of the Alzheimer's disease (AD)-implicated amyloid precursor protein gene (APP) and comprehensively

229 Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a

230 t over-express the Swedish mutant human beta-amyloid precursor protein gene with G protein-coupled re

231 ocampal neurons and in mice expressing human amyloid precursor protein (hAPP mice), a model for famil

232 compared transgenic mice that express human amyloid precursor protein (hAPP) and patients with mild

233 humans with AD, aging mice expressing human amyloid precursor protein (hAPP) showed increased levels

234 cking in the axon of AD-related mutant human amyloid precursor protein (hAPP) transgenic (Tg) mouse n

235 e mortality and network dysfunction in human amyloid precursor protein (hAPP) transgenic mice, which

236 tors, in the brains of AD patients and human amyloid precursor protein (hAPP) transgenic mice.

237 odel of AD (transgenic mice expressing human amyloid precursor protein [hAPP]) and patients in the ea

238 TgCRND8 (Tg) transgenic mice express human amyloid precursor protein harboring the Swedish and Indi

239 e and monkeys, and accompanied by diminished amyloid precursor protein in monkeys.

240 s involved in anterograde trafficking of the amyloid precursor protein in neurons and in the secretio

241 iple similarities, strengthening the role of amyloid precursor protein in normal brain function and d

242 human induced neurons overexpressing mutant amyloid precursor protein in the background of APOE vare

243 l PDAPP mice, which overexpress mutant human amyloid precursor protein in the brain, exhibit two cryp

244 Overexpression of human amyloid precursor protein in transgenic mice induces hip

245 e of the Alzheimer's disease-associated beta-amyloid precursor protein in vitro and in human embryoni

246 and low sAPPbeta (a soluble beta fragment of amyloid precursor protein) in cerebrospinal fluid (CSF)

247 affected brain regions caused by cleavage of amyloid precursor protein into the pathogenic peptide am

248 Here we report that the amyloid precursor protein intracellular domain associate

249 Acting as synapse-to-nucleus messengers, amyloid precursor protein intracellular domain associate

250 ogical feature of AD, and endocytosis of the amyloid precursor protein is an important step in its su

251 We report that amyloid precursor protein is crucial for axonal pruning

252 ogy of Alzheimer's disease, it is clear that amyloid precursor protein is expressed in numerous cell

253 Here we demonstrate that amyloid precursor protein is involved in regulating the

254 cases, hippocampal levels of phosphorylated amyloid precursor protein, its pro-amyloidogenic process

255 n called "remapping." We tested remapping in amyloid precursor protein knockin (APP-KI) mice with imp

256 vine pancreatic trypsin inhibitor (BPTI) and amyloid precursor protein Kunitz protease inhibitor (APP

257 t to be primarily due to triplication of the amyloid precursor protein located on chromosome 21, the

258 he AD mouse model carrying human mutation of amyloid precursor protein (mhAPP) expressing human Abeta

259 Results: Aged mutant amyloid precursor protein mice with established disease

260 P = .01) and associative memory (P = .02) in amyloid precursor protein mice.

261 The amyloid precursor protein modulates alpha2A-adrenergic r

262 Amyloid precursor protein mutations falling within the a

263 ells via intracerebroventricular infusion in amyloid precursor protein/presenilin 1 (APP/PS1) double-

264 e effect of CLU on Abeta pathology using the amyloid precursor protein/presenilin 1 (APP/PS1) mouse m

265 content of mitochondrial 5-methylcytosine in amyloid precursor protein/presenilin 1 mice along with A

266 rt, liver, and brain tissues in a late-stage amyloid precursor protein/presenilin-1 (APP/PS-1) human

267 endosomes was coupled with reduced levels of amyloid precursor protein processing and Abeta productio

268 In the latter case, proteins related to amyloid precursor protein processing and secretion are S

269 sosome transport in regulating amyloidogenic amyloid precursor protein processing and support a model

270 These swellings contain high levels of amyloid precursor protein processing enzymes (BACE1 and

271 immunoreactivity without detectably altering amyloid precursor protein processing or extracellular Ab

272 Increased APP (amyloid precursor protein) processing causes beta-amyloi

273 itory fragment of Nogo-A is generated by the amyloid precursor protein protease BACE1 and presented o

274 ; however, its role in the processing of the amyloid precursor protein remains unknown.

275 Here, we have uncovered a role for soluble amyloid precursor protein (sAPP) as a vascular niche sig

276 soluble metabolites alpha and beta (soluble amyloid precursor protein (sAPP)alpha, sAPPbeta) and two

277 ), gamma-secretase, soluble Abeta42, soluble amyloid precursor protein (sAPP)beta, sAPPalpha, glial-d

278 ht chain (NFL), alpha-synuclein (alpha-syn), amyloid precursor protein soluble metabolites alpha and

279 smic reticulum retrograde transport, affects amyloid precursor protein subcellular localization, cell

280 teins, including those derived from the same amyloid precursor protein, such as Aeta or sAPPalpha, an

281 PPSwDI transgenic mice expressing human beta-amyloid precursor protein Swedish (Tg-SwDI), a model of

282 havioural signs, astrogliosis, deposition of amyloid precursor protein, synaptic loss and neuronal de

283 , we identified the protein interacting with amyloid precursor protein tail 1 (PAT1) as a potential p

284 Amyloid precursor protein/tetracycline transactivator mi

285 nsgenic mice expressing mutated forms of the amyloid precursor protein (Tg2576 mice).

286 young transgenic mice overexpressing mutated amyloid precursor protein (Tg2576), Abeta causes dysfunc

287 mice expressing the Swedish mutation of the amyloid precursor protein (tg2576).

288 ral transmembrane proteins, most notably the amyloid precursor protein that results in Abeta, a trans

289 protease complex involved in the cleavage of amyloid precursor proteins that lead to the formation of

290 efflux by lowering tau protein that traffics amyloid precursor protein to facilitate iron efflux.

291 (pTalpha) and has also been shown to cleave amyloid precursor protein to trigger its secretion.

292 Expression analysis of amyloid precursor protein transgenic mice also revealed

293 dated miRNA data using AD postmortem brains, amyloid precursor protein transgenic mice and AD cell li

294 Starting at 5 months of age, tet-off amyloid precursor protein transgenic mice were treated w

295 In Alzheimer amyloid precursor protein-transgenic mice and SH-SY5Y ce

296 Unexpectedly, ablation of CR3 in human amyloid precursor protein-transgenic mice results in dec

297 The human systemic amyloid precursor protein transthyretin (TTR) is known t

298 of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway.

299 ring AD-related mutations in presenilin-1 or amyloid precursor protein vs. isogenic gene corrected co

300 are caused by mutations in the gene encoding amyloid precursor protein, whose processing can result i