ライフサイエンスコーパス: anabolism

1 atch the stoichiometric demands of microbial anabolism.

2 sphorylation of elements thought to increase anabolism.

3 F treatment, where it precedes activation of anabolism.

4 on networks, promote catabolism and suppress anabolism.

5 stration of the hormone is required for bone anabolism.

6 tease inhibitors did not prevent lean tissue anabolism.

7 as predictive of the extent of intracellular anabolism.

8 lls show mTORC1 hyperactivation and enhanced anabolism.

9 f Treg expansion prevented GAHT-induced bone anabolism.

10 t carbon inputs and microbial catabolism and anabolism.

11 ulating lipid synthesis, an energy-demanding anabolism.

12 a link between hepatic ketogenesis and lipid anabolism.

13 tion direction decoupled from catabolism and anabolism.

14 olic reprogramming that sustains cancer cell anabolism.

15 ic program with increased mitobiogenesis and anabolism.

16 nd enthalpy for inflammatory and immune cell anabolism.

17 fractory to parathyroid hormone-induced bone anabolism.

18 pathway may be a new target to modulate bone anabolism.

19 ilitating a general shift from catabolism to anabolism.

20 preventing any increase in cellular protein anabolism.

21 omplete, understanding of BMP catabolism and anabolism.

22 ogic levels of butyrate restored PTH-induced anabolism.

23 ANKL-OPG axis, without interfering with bone anabolism.

24 f a greater ability to utilize nutrients for anabolism.

25 metabolic precursors that are essential for anabolism.

26 s a novel pharmacologic approach to skeletal anabolism.

27 an osteogenic environment with enhanced PTH anabolism.

28 abecular bone mass and increased PTH-induced anabolism.

29 use oncogenic mutations constitutively drive anabolism.

30 e supporting this novel approach to skeletal anabolism.

31 protein beverages designed to enhance muscle anabolism.

32 ced cancer and the window of possible muscle anabolism.

33 s fatty acid oxidation while promoting lipid anabolism.

34 nase that is obligate for insulin-stimulated anabolism.

35 may provide pharmacological targets for bone anabolism.

36 ilize a metabolic master regulator and drive anabolism.

37 ition before surgery while augmenting muscle anabolism after resection.

38 tose phosphate pathway (PPP) is critical for anabolism and biomass production.

39 panied by different effects on hepatic lipid anabolism and blood TG profiles.

40 ltered, indicating dissociation of cartilage anabolism and breakdown.

41 t (Saccharomyces cerevisiae), in which polyP anabolism and catabolism are well-characterized.

42 ar metabolism and control the switch between anabolism and catabolism by regulating lysosomal biogene

43 Circadian shifts in the balance between anabolism and catabolism control muscle growth rate in y

44 oskeletal pathoanatomy or from imbalances in anabolism and catabolism induced by pathophysiological f

45 and mutations in genes involved in vitamin D anabolism and catabolism might be of importance in VKH p

46 The anabolism and catabolism of myocardial triacylglycerol (

47 In contrast to skin melanosomes, anabolism and catabolism of pigments proceed within the

48 tate mRNA levels of 14 genes involved in the anabolism and catabolism of reactive oxygen species (ROS

49 ory factors and the imbalance between muscle anabolism and catabolism that develops with aging.

50 ke and utilization and direct the balance of anabolism and catabolism to ensure the appropriate use o

51 der this fundamental intertwining of protein anabolism and catabolism, and how it ultimately serves t

52 Pursuit, consisting of anabolism and catabolism, dominates when usable resource

53 atic controls regulating the balance between anabolism and catabolism, favoring accelerated cartilage

54 n cells, insulin and glucocorticoids promote anabolism and catabolism, respectively.

55 c and nonphysiologic loads leading to matrix anabolism and catabolism, respectively.

56 le activity of TOR complex 1 (TORC1) between anabolism and catabolism, thus controlling lifespan, dev

57 e energy substrate flux to coordinate tissue anabolism and catabolism.

58 ids, regulating the balance between cellular anabolism and catabolism.

59 t AcCoA and EP300 play pivotal roles in cell anabolism and catabolism.

60 suppressor that controls the balance between anabolism and catabolism.

61 n of strong oncogenic drivers promoting cell anabolism and cell cycle progression.

62 ivation of mTORC1 with downstream effects on anabolism and cell growth.

63 essential reactions such as ATP production, anabolism and cellular oxidation-reduction (redox) regul

64 ll this metabolic response but can result in anabolism and continued growth in ill children.

65 measurements, and in cellulo analysis of GAG anabolism and decorin glycosylation, we mapped the organ

66 es OS in the rat VP through elevation of ROS anabolism and diminution of antioxidant detoxification.

67 etabolic index incorporating glucose derived anabolism and FA uptake correlates linearly to the level

68 metabolites, leading to suppression of cell anabolism and growth, and marked autophagy.

69 vated energetic demand, such as during rapid anabolism and growth.

70 During anabolism and hypertrophy, UBR5 gene expression increase

71 uscle atrophy, recovery from atrophy/injury, anabolism and hypertrophy.

72 e atrophy, recovery from atrophy and injury, anabolism and hypertrophy.

73 ng translation initiation and muscle protein anabolism and is the focus of ongoing research.

74 rt that muscle IGF-I independently modulates anabolism and metabolism in an age-dependent manner, thu

75 proline metabolism between yeast (cytosolic anabolism and mitochondrial catabolism) and humans (excl

76 se it primarily to meet nitrogen demands for anabolism and nitrification.

77 ased adenosine triphosphate (ATP) to support anabolism and proliferation.

78 x kg(-1) x d(-1) may enhance muscle protein anabolism and provide a means of reducing the progressiv

79 The markedly lower anabolism and related cytostatic activity of dFdC in myc

80 me Escherichia coli operons that function in anabolism and represses others involved in catabolism.

81 abundance, nutrient-sensing pathways engage anabolism and storage, whereas scarcity triggers homeost

82 ity and energy balance influence both muscle anabolism and substrate metabolism, but whether circulat

83 he hypoxic response, lipid catabolism, lipid anabolism and the production of cell wall lipids.

84 d with anaplerotic central metabolism, lipid anabolism and the regeneration of oxidized cofactors.

85 ncrease the efficiency of EAA use for muscle anabolism and to lower the meal threshold for stimulatio

86 metabolites are utilized to support protein anabolism and turnover.

87 s of PP were a result of inhibition of lipid anabolism and, more specifically, the impairment of anab

88 naling has been recognized in promoting bone anabolism, and application of strain has been shown to i

89 ong-lasting inhibitory effect on feeding and anabolism, and pathophysiological processes increase mel

90 oxygen, with downstream actions on behavior, anabolism, and the cell cycle.

91 NMP4 functions to suppress bone anabolism, and we suggest that this occurs due to decrea

92 nt metastatic disease in TNBC exploits lipid anabolism as a metabolic vulnerability against CSCs in p

93 le approach for normalizing deranged protein anabolism associated with human diseases.

94 iofilm system, the dimensions of the zone of anabolism at the air interface ranged from 16 to 38 micr

95 uridine 5'-monophosphate from catabolism to anabolism avoiding futile cycling of key nutrients.

96 or different body-size scaling exponents for anabolism (biosynthesis potential), besides the commonly

97 s novel mechanism explains how CDK4 promotes anabolism by blocking catabolic processes (FAO) that are

98 ormonal regulation of amino acid and protein anabolism by coupling amino acid uptake and synthesis, a

99 n autophagic catabolism, how autophagy halts anabolism by degrading the protein synthesis machinery,

100 Further efficient anabolism by nucleotide kinases is compromised apparentl

101 plays an important role in PTH-induced bone anabolism by promoting T-cell production of Wnt10b and s

102 Mitochondrial metabolism supports T cell anabolism by providing key metabolites for macromolecule

103 The brain-gut axis is the effector of anabolism by regulating growth, feeding, and metabolism

104 fection allows for increased virulence lipid anabolism by the bacterium.

105 Drug uptake and anabolism by tumors are prerequisites of response to 5-f

106 entails reprogramming photoreceptors towards anabolism by upregulating the mechanistic target of rapa

107 is decreased in the elderly, muscle protein anabolism can nonetheless be stimulated by increased ami

108 ses can be classified into four broad fates: anabolism, catabolism, regulation of ferroptosis, and th

109 Besides contributing to anabolism, cellular metabolites serve as substrates or c

110 uals is suggested to restore the lean tissue anabolism characteristic of youth.

111 dense foods differentially stimulates muscle anabolism compared with protein-dense foods.

112 utrient oversupply and triacylglycerol (TAG) anabolism contribute to hepatic steatosis, little is kno

113 rigin, our results shed light on how glucose anabolism could have emerged in early life forms.

114 We further showed that high purine anabolism determines the sensitivity to DDR-targeting ag

115 We conclude that high efficiency of anabolism exemplified by this autotrophic cycle perfectl

116 ovide a stimulatory effect on muscle protein anabolism, favoring the retention of lean muscle mass wh

117 ew of eukaryotic NAD+ biosynthesis, that all anabolism flows through nicotinic acid mononucleotide, w

118 activity abolished the induction of protein anabolism genes by BMP2 treatment in vitro.

119 While their anabolism has been extensively unraveled through the stu

120 Due to more efficient microbial anabolism, high-quality litter may produce more microbia

121 and how periostin expression influences bone anabolism, however, remains unknown.

122 genes associated with human skeletal muscle anabolism, hypertrophy and epigenetic memory.

123 The thesis that EPA impacts on anabolism, immune function, and clinical outcomes post-e

124 Omega-3 (n-3) fatty acids stimulate protein anabolism in animals and might therefore be useful for t

125 abolites suggests a shift from catabolism to anabolism in cicaprost-treated Th2 cells.

126 signaling in osteocytes is critical for full anabolism in cortical bone, but tempers bone gain in can

127 las) can improve nutrient intake and promote anabolism in critically ill infants.

128 a typical protein-containing diet on muscle anabolism in middle-to-older aged adults is unknown.

129 amino acid availability limits postexercise anabolism in older individuals.

130 reduction potentials, driving catabolism and anabolism in opposite directions.

131 Msx2 exerts bone anabolism in part by reducing Dkk1 expression and enhanc

132 hexia, but the potential for skeletal muscle anabolism in patients with advanced cancer is unproven.

133 Our results reveal a central role of purine anabolism in regulating DDR, which could be therapeutica

134 hat aerobic exercise restores muscle protein anabolism in response to insulin by improving vasodilati

135 Our objective was to measure muscle protein anabolism in response to Leu and its metabolite HMB.

136 cle is more advantageous for skeletal muscle anabolism in response to resistance exercise.

137 mplex 1 (mTORC1) is the central regulator of anabolism in skeletal muscle.

138 AAs largely determined protein anabolism in splanchnic bed by stimulating PS and decrea

139 of an actual protein-rich food to stimulate anabolism in the young and the elderly has not been expl

140 To target lipid anabolism in tumor cells specifically, it is important t

141 metallothionein blockade on skeletal muscle anabolism in vitro and in vivo We found that concomitant

142 pamycin (mTOR) complex 1-regulated metabolic anabolism, including increased SREBP-regulated lipid syn

143 Factors that affect muscle anabolism, including protein intake, also affect bone ma

144 lude that exogenous HMB induces acute muscle anabolism (increased MPS and reduced MPB) albeit perhaps

145 d therefore stimulates appetite and enhances anabolism, indicating that TCMCB07 is a promising drug c

146 liferation requires nutrients to support the anabolism inherent in clonal expansion.

147 mal metabolic balance between catabolism and anabolism is altered.

148 High purine anabolism is associated with unique somatic mutational s

149 Nutrient stimulation of muscle protein anabolism is blunted with aging and may contribute to th

150 quired for parathyroid hormone-mediated bone anabolism, KDM4B depletion accelerated bone loss and mar

151 t tomatidine stimulated mTORC1 signaling and anabolism, leading to accumulation of protein and mitoch

152 of macromolecules for energy production) and anabolism (macromolecule synthesis from bio-precursors)

153 estrates adaptive responses, including lipid anabolism, metabolic reprogramming, increases in protein

154 r long term through microbial catabolism and anabolism, mostly due to uncoupled research on litter de

155 TORC1 senses amino acid abundance to promote anabolism, mTORC2 responds to declining glutamine catabo

156 In anabolism, neither clinical symptoms nor biochemical sig

157 g process in which mTORC1, the gatekeeper of anabolism, occupies a privileged regulatory position.

158 d protein expression, energy metabolism, and anabolism occur in the absence of a stable endosymbiotic

159 sed exposure to 5-FU and, in turn, increased anabolism of 5-FU to cytotoxic nucleotides, resulting in

160 may be feasible to measure the transport and anabolism of [18F]FU in tumors by kinetic modeling and P

161 recharging bottom seawater, suggesting that anabolism of inorganic carbon may be a potential strateg

162 activity of 5-fluorouracil (5-FU) and in the anabolism of its oral prodrug, capecitabine, through the

163 id metabolism encompasses the catabolism and anabolism of lipids, and is fundamental for the maintena

164 ction of OPP on Staphylococcus: OPP inhibits anabolism of many amino acids and highly downregulates t

165 ome P-450 systems, which allow catabolism or anabolism of unusual compounds.

166 central to an energy sensor that determines anabolism or catabolism depending on local sucrose avail

167 ration product (Col2-3/4m), as indicators of anabolism or catabolism.

168 en, and triggers responses that either boost anabolism or suppress catabolism.

169 injury demonstrated an impairment in muscle anabolism, persistent expression of genes that promote e

170 Enhancing anabolism promoted neuronal survival and function and co

171 stically, we discover that increasing purine anabolism promotes epitranscriptomic dysregulation of DN

172 lores leukemia metabolic circuitries feeding anabolism, redox potential, and energy required for tumo

173 ORC1 signaling, causing defective amino acid anabolism, reduced T reg cell proliferation, and a rampa

174 r, the mechanisms by which NO modulates bone anabolism remain largely unclear.

175 es, namely the induction of autophagy, while anabolism remains unchanged.

176 inding protein-3 as an index of nutrition or anabolism requires knowledge of its relationship to nonn

177 es the expression of genes involved in lipid anabolism, secretion, and redox metabolism, in response

178 s dispensable for BMP2 to induce the protein anabolism signature, which instead critically depends on

179 nes as mineralization related versus protein anabolism signatures of osteoblasts.

180 ed organic matter fraction through microbial anabolism, suggesting that mineral association plays an

181 s and attenuated PTH-induced trabecular bone anabolism, supporting the positive function of macrophag

182 dioprotection, the balance of catabolism and anabolism, the concept of mitochondrial quality control,

183 by both IGF-1 and BMP-7 greatly potentiated anabolism through complementary and synergistic mechanis

184 ther iPTH induces Wnt10b production and bone anabolism through direct activation of the parathyroid h

185 cidate the complex role of periostin on bone anabolism, through the regulation of Sost, Wnt-beta-cate

186 entary pathways to ATF4 expression, allowing anabolism to be finely tuned to amino acid availability.

187 nd protein synthesis, signaling a shift from anabolism to catabolism in response to Abeta deposition.

188 get proteins, triggering a global shift from anabolism to catabolism.

189 creases and leads to a metabolic switch from anabolism to catabolism.

190 (mechanistic target of rapamycin) stimulates anabolism to expand cellular mass, whereas nutrient and

191 the response of muscle protein synthesis and anabolism to insulin.

192 lism of these antibiotic-tolerant cells from anabolism to oxidative phosphorylation.

193 Inorganic pyrophosphatases are required for anabolism to take place in all living organisms.

194 The efficient anabolism to the diglutamate analogue and the lack of de

195 cinoma, suggesting similar elevations in the anabolism-to-catabolism ratio.

196 ites once considered solely in catabolism or anabolism turn out to have key regulatory functions.

197 bute to energy sensing and the disruption of anabolism under conditions of nutrient oversupply.

198 and parathyroid hormone (PTH)-dependent bone anabolism using murine models of targeted myeloid-lineag

199 notypes were associated with enhanced tendon anabolism via an increase in tendon-specific transcripti

200 In both nephrotic and control subjects anabolism was due to a suppression of whole-body protein

201 proteins involved in lipid and carbohydrate anabolism was increased in the presence of ethanol, a re

202 Simultaneously, both catabolism and anabolism were probed by coincubation with BODIPY-FL lab

203 GAAC pathway may facilitate insulin-mediated anabolism when exogenous amino acids are limiting.

204 nometabolism toward enhanced catabolism over anabolism, whereas LDLR-overexpressing microglia also un

205 e androgen receptor (AR) ligands that induce anabolism while having reduced effects in reproductive t

206 mechanical signals - promote bone and muscle anabolism while limiting formation and expansion of fat

207 tion of AMPK, nor differential activation of anabolism with the manipulation of endurance exercise in

208 Submaximal insulin can promote muscle anabolism without eliciting a hypoglycemic response.