ライフサイエンスコーパス: analgesia

1 s and diminish cooling-mediated pain relief (analgesia).

2 use of volatile anaesthetic, and opioids for analgesia.

3 volatile anaesthetic sevoflurane and opioid analgesia.

4 ng inhibitory circuit mediating opioid-based analgesia.

5 e veteran population affects intra-operative analgesia.

6 anisms underlying exercised-induced pain and analgesia.

7 d their activation there produces meaningful analgesia.

8 horn, a principal site of action for opiate analgesia.

9 luding brain regions mediating addiction and analgesia.

10 elective NaV1.7 inhibitors produced profound analgesia.

11 n, and schizophrenia, as well as in pain and analgesia.

12 s the activity of these neurons and produces analgesia.

13 R can modulate side effects without altering analgesia.

14 rimary outcome evaluated was intra-operative analgesia.

15 e than males to produce comparable levels of analgesia.

16 erity of withdrawal without affecting opiate analgesia.

17 ub of key brainstem structures to endogenous analgesia.

18 brainstem structure implicated in endogenous analgesia.

19 nsively in humans for general anesthesia and analgesia.

20 during infection, leading to pain, itch, or analgesia.

21 n shown to be effective adjuncts to narcotic analgesia.

22 te a biological brake to opioid drug-induced analgesia.

23 n smoke inhalation under deep anesthesia and analgesia.

24 ia, 5236 (58.2%) with specific preprocedural analgesia.

25 echanisms promoting pain vs. those dampening analgesia.

26 in nociceptors might enable ligand-dependent analgesia.

27 nfusion failed to reverse meditation-induced analgesia.

28 protein muOR signalling is thought to confer analgesia.

29 ficantly reduces the need for periprocedural analgesia.

30 ental absence and use of continuous sedation/analgesia.

31 anted delta, kappa1, and alpha2 actions from analgesia.

32 fect of active drug interfering with placebo analgesia.

33 the weak-opioid group, because of inadequate analgesia.

34 after correcting for modeled placebo-related analgesia.

35 patients diminishes modeled placebo-related analgesia.

36 heat perception, cold hyperalgesia, and cold analgesia.

37 eling of euphoria, anxiolysis, sedation, and analgesia.

38 gonist, bicuculline, disrupted A3AR-mediated analgesia.

39 gnificantly increased and prolonged morphine analgesia.

40 is both necessary and sufficient for IBNtxA analgesia.

41 related to pain were not affected by placebo analgesia.

42 ons that prevented KOR-mediated aversion and analgesia.

43 prevent respiratory depression while sparing analgesia.

44 for premedication, sedation, anxiolysis and analgesia.

45 section, and is reported to provide neonatal analgesia.

46 asonable option for early postoperative oral analgesia.

47 pared with active controls, such as epidural analgesia.

48 tors are ameliorated by regional anaesthesia-analgesia.

49 lacental weight <500 g and especially labour analgesia.

50 general anaesthesia (sevoflurane) and opioid analgesia.

51 ic resection is often achieved with epidural analgesia.

52 vs 1.2 +/- 0.2, p = 0.006) and required less analgesia (0% vs 10%, p = 0.03) immediately after PLB in

53 Among women assigned regional anaesthesia-analgesia, 102 (10%) recurrences were reported, compared

54 0), but the NSAID group required more rescue analgesia (26.3% vs 38.1%; rate ratio, 2.1; 95% CI, 1.3-

55 e and avoidance learning [2], and endogenous analgesia [3].

56 ions given were intravenous fluids 57 (21%), analgesia 49 (25%) and antibiotics 40 (20%).

57 2379 (26.4%) were performed with continuous analgesia, 5236 (58.2%) with specific preprocedural anal

58 vs 14.4%; P < 0.001), and patient-controlled analgesia (56.5% vs 22.8%; P < 0.001).

59 s in pain response ("offset-analgesia"; mean analgesia: 85%, n = 20 subjects).

60 Observations: Regional analgesia, acetaminophen, nonsteroidal anti-inflammatory

61 care for supportive care and pain management-analgesia, adjunct therapies, radiotherapy, surgery, sys

62 Receipt of analgesia administration (any and opioid) by race.

63 d the frequency of both opioid and nonopioid analgesia administration using complex survey weighting.

64 hippocampus gyrus connectivity predicts drug analgesia after correcting for modeled placebo-related a

65 system contributes not only to acetaminophen analgesia against acute pain but also against inflammato

66 m with regards to the mechanisms of CIPN and analgesia against CIPN remains unclear.

67 roduce their effects (loss of consciousness, analgesia, amnesia, and immobility) remain an unsolved m

68 1043 were assigned to regional anaesthesia-analgesia and 1065 were allocated to general anaesthesia

69 56 patients assigned to regional anaesthesia-analgesia and 456 (52%) of 872 patients allocated to gen

70 59 patients assigned to regional anaesthesia-analgesia and 89 (10%) of 870 patients allocated to gene

71 functional responses to opioids in models of analgesia and addiction.

72 on and function of RGS proteins in models of analgesia and addiction.

73 vel of motor incoordination at the effective analgesia and anti-scratch doses.

74 EGF receptor Type 2 signaling in rats causes analgesia and blocks opioid tolerance.

75 time-dynamic pulses (TDPs) leads to improved analgesia and compared the effects of SCS using conventi

76 Tolerance and OIH counteract opioid analgesia and drive dose escalation.

77 ectively preserving the efficacy of morphine analgesia and eliminating tolerance.

78 .6%) patients had pain requiring intravenous analgesia and Fc-SEMS had to be removed because of unbea

79 uits responsible for systemic opioid-induced analgesia and hyperalgesia remain unclear.

80 radoxical behavioural responses: early-phase analgesia and late-phase mechanical allodynia which requ

81 te that sleep disruption diminishes morphine analgesia and modulates reward processing.

82 ve recently developed, alongside appropriate analgesia and monitoring.

83 the spinal cord, are crucial for both opioid analgesia and opioid-induced hyperalgesia.

84 The Opiates produce analgesia and other adverse effects through activation o

85 article reviews mechanisms underlying opioid analgesia and other opioid actions.

86 as systemic high-dose morphine (HDM)-induced analgesia and priming are neither TLR4 nor PKCepsilon de

87 DM-induced hyperalgesia and priming, whereas analgesia and priming induced by HDM were unaffected.

88 nd evaluation of a chemical probe exhibiting analgesia and reduced opioid-induced side effects.

89 at end of life, specifically in relation to analgesia and related medicines (for side-effect managem

90 and peripheral biological effects, including analgesia and respiratory depression, but these may not

91 many opiate-like behavioral effects such as analgesia and reward, it does not lead to tolerance or w

92 ntaneous Breathing Trials; "C" for Choice of Analgesia and Sedation; "D" for Delirium Assess, Prevent

93 pressed in primary sensory neurons in opioid analgesia and suggest new strategies to increase the eff

94 gents and analgesics; length of sedation and analgesia and total doses of sedatives and analgesics.

95 may alter opioid-mediated effects, including analgesia and withdrawal symptoms.

96 M, 3 mg/kg) increased nociceptive threshold (analgesia) and induced priming, neither of which was att

97 Opioid tolerance (increased dose needed for analgesia) and opioid-induced hyperalgesia (paradoxical

98 hat underlie both their therapeutic effects (analgesia) and their adverse effects (addiction and over

99 ssment score), interventions (e.g., sedation/analgesia), and ICU characteristics (e.g., size).

100 nd puncture followed by fluid resuscitation, analgesia, and antibiotics.

101 y genes known to be involved in nociception, analgesia, and antidepressant drug actions.

102 ciceptive afferents could be used to produce analgesia, and if so, how.

103 R4 and signaling via PKCepsilon, HDM-induced analgesia, and priming are neither TLR4 nor PKCepsilon d

104 RGS9-2 complexes negatively control morphine analgesia, and promote the development of morphine toler

105 cally involved in the modulation of pain and analgesia, and represent a candidate mechanism for the d

106 tors curtail immune-driven peripheral opioid analgesia, and sigma-1 antagonism produces local opioid

107 inistered intraoperatively for postoperative analgesia, and some evidence suggests that ketamine prev

108 After adoption of the multimodal analgesia approach for a colorectal ERAS pathway, most p

109 s responsible for clinically relevant opioid analgesia are uncertain.

110 ly beneficial effects of KOR agonists (e.g., analgesia) are predominantly mediated by heterotrimeric

111 ols have questioned the position of epidural analgesia as the optimal method of pain management after

112 ting in rostral ventromedial medulla promote analgesia associated with exercise.

113 We demonstrate that 33 provides greater analgesia at lower doses, and does not possess the sever

114 prostaglandin E synthase 1 (mPGES-1) confers analgesia, attenuates atherogenesis, and fails to accele

115 inal wound catheters plus patient-controlled analgesia (AWC-PCA).

116 ipheral nerve blocks, and local infiltration analgesia benefit patients after total knee and total hi

117 s, induced JF-NP-26-mediated light-dependent analgesia both in neuropathic and in acute/tonic inflamm

118 While anti-NGF antibodies have demonstrated analgesia both preclinically and in patients, the mechan

119 Pain control is as effective as epidural analgesia, but could be favored based upon recovery para

120 ls of acute nociceptive pain, indicated that analgesia by acetaminophen involves an indirect activati

121 n important site of the cannabinoid-mediated analgesia by acetaminophen.

122 Neurotensin exerts potent analgesia by acting at both NTS1 and NTS2 receptors, whe

123 and sigma-1 antagonism produces local opioid analgesia by enhancing the action of EOPs of immune orig

124 tudy was to study the tolerability of opioid analgesia by performing a network meta-analysis (NMA) of

125 Here, we show that pregnancy analgesia can produce a complete cessation of chronic pa

126 s regulated by RGS proteins in addiction and analgesia circuits.

127 no significant effect on orthodontic pain or analgesia consumption during initial alignment with fixe

128 6764 (75.2%) heelsticks were performed with analgesia (continuous and/or specific).

129 The intensity and duration of on-demand analgesia could be adjusted by varying the intensity and

130 ortion of care periods with optimal sedation-analgesia, defined as being free from excessive sedation

131 imination of RGS7 enhanced reward, increased analgesia, delayed tolerance, and heightened withdrawal

132 To characterize sedation, analgesia, delirium, and mobilization practices in patie

133 o develop a mechanism-based understanding of analgesia devoid of the influence of anesthetics or rest

134 esthesia, and no patient required additional analgesia during this period.

135 Importance: Epidural analgesia (EA) is used as an adjunct procedure for posto

136 nful electrical stimulation in mediating the analgesia effect of BreEStim.

137 ptor antagonist, interferes with acupuncture analgesia, even at a low dose.

138 st that T cells are a mediator of the opioid analgesia exhibited during pregnancy.SIGNIFICANCE STATEM

139 er (MACE2) was able to induce longer lasting analgesia following subcutaneous administration.

140 promising strategy to achieve non-addictive analgesia for multiple pain conditions.

141 ated with the lack of specific preprocedural analgesia for this procedure.

142 fluctuations between disruption by pain and analgesia from a competing task.

143 By subtracting away linearly modeled placebo analgesia from duloxetine response, we uncovered in 6/19

144 uishing the pathways involved in MOR-induced analgesia from its side effects.

145 ty to KOR agonist-induced hypolocomotion and analgesia-G protein signaling-dependent behaviors; a ven

146 This pregnancy-related analgesia has been demonstrated for acute pain in rats.

147 eripheral nerve block and local infiltration analgesia have become more favorable.

148 or component ERAS pathways is opioid-sparing analgesia; however, the effect on postoperative pain and

149 e evaluated conditioned place preference for analgesia in 44 calves disbudded or sham-disbudded 6 hou

150 infiltration is an alternative for epidural analgesia in abdominal surgery but studies have shown co

151 neurons suppresses nociception and promotes analgesia in an animal model of inflammatory pain.

152 ive for GlyT2 and have been shown to provide analgesia in animal models of pain with minimal side eff

153 ycine transporter GlyT2 (SLC6A5) and provide analgesia in animal models of pain.

154 nto the spinal cord and dramatically reduces analgesia in both female and male Nav1.7-null mutant mic

155 the efficacy of NGF inhibition as a form of analgesia in chronic pain states including osteoarthriti

156 ial assessed whether the Targeting Effective Analgesia in Clinics for HIV (TEACH) intervention improv

157 Racial disparities in use of analgesia in emergency departments have been previously

158 Finally, compound 6 produces potent analgesia in experimental models of acute and persistent

159 te that sleep disruption attenuates morphine analgesia in humans and suggest that sleep disturbed mal

160 vated peripheral opioid receptors to produce analgesia in inflamed rat paws without major side effect

161 Here, we analyzed acetaminophen analgesia in mice of either sex with inflammatory pain a

162 nduced prolactin secretion and in tail-flick analgesia in mice.

163 t support for the centrality of personalized analgesia in modern perioperative care.

164 d inhibitor produced potent and long-lasting analgesia in mouse models of incisional wound and inflam

165 granted greater efficacy in blunting heroin analgesia in murine behavioral models compared to the H(

166 Intraplantar injection of PD-L1 evoked analgesia in naive mice via PD-1, whereas PD-L1 neutrali

167 investigated the current use of sedation or analgesia in neonatal ICUs (NICUs) in European countries

168 orphine consumption using patient-controlled analgesia in pairwise comparisons between the 4 groups (

169 hort study of the management of sedation and analgesia in patients in NICUs.

170 in GABAA receptor signaling modulate opioid analgesia in persistent inflammation.

171 mine is a leading medication used to provide analgesia in pre-hospital and hospital settings.

172 comes, present evidence supporting nonopioid analgesia in transplant surgery, and briefly address the

173 ffer the first example of optical control of analgesia in vivo using a photocaged mGlu5 receptor nega

174 gnificantly increased and prolonged morphine analgesia in vivo.

175 t sleep condition by drug interaction on the analgesia index (95% CI - 0.57, - 0.001).

176 The primary outcome was the analgesia index, calculated as the change in cold presso

177 correlation between PTSD and intra-operative analgesia, intra-operative time, and anesthesia type for

178 nt exercise protocols, show exercise-induced analgesia involves activation of central inhibitory path

179 Although morphine analgesia is independent of these 6TM mu receptor isofor

180 unknown whether mindfulness-meditation-based analgesia is mediated by endogenous opioids.

181 ains unknown if mindfulness-meditation-based analgesia is mediated by opioids, an important considera

182 However, animal studies indicate that PAG analgesia is mediated largely via caudal brainstem struc

183 e the notion that clinically relevant opioid analgesia is mediated mostly by centrally expressed MORs

184 aths, an alternative method of post-surgical analgesia is needed.

185 Multimodal analgesia is readily available and the evidence is stron

186 This pregnancy-related analgesia is reversible by intrathecal administration of

187 Opioid-induced analgesia is strongly enhanced and analgesic tolerance i

188 Multimodal postoperative analgesia is widely used but lacks evidence of benefit.

189 intravenous, multimodal, patient-controlled analgesia (IV-PCA) could be noninferior to multimodal th

190 esia (TEA) to intravenous patient-controlled analgesia (IV-PCA) for pain control over the first 48 ho

191 The mechanisms underlying capsaicin-induced analgesia likely involve reversible ablation of nocicept

192 General anesthesia (GA) can produce analgesia (loss of pain) independent of inducing loss of

193 Despite their role in analgesia, loss of the 6TM variants were not involved wi

194 was associated with effective post-operative analgesia, major reductions in in-hospital consumption o

195 assuring fetal status, history of CS, labour analgesia, maternal age >=35 and gestation >40 weeks.

196 d large decrements in pain response ("offset-analgesia"; mean analgesia: 85%, n = 20 subjects).

197 7 [95% CI, -20.3 to -0.8]), and breakthrough analgesia (median, 322.5 vs 405.3 ug morphine equivalent

198 In addition to analgesia, modulatory effects of EA on spinal sympatheti

199 (N = 106) or intravenous patient-controlled analgesia (N = 34).

200 hows that anesthetics activate an endogenous analgesia neural ensemble in the central nucleus of the

201 al direct current stimulation (tDCS)-induced analgesia, neuromodulation occurs through a top-down pro

202 g non-operative vaginal deliveries, epidural analgesia, non-reassuring fetal heart rate, meconium in

203 ave not yet fully recapitulated the dramatic analgesia observed in Nav1.7-null subjects.

204 Analgesia of 11, 22, and 26 was evaluated in the mouse f

205 d painful thermal stimuli following hypnotic analgesia on their own hand, but also when they viewed p

206 In addition to analgesia, opioids produce opioid-induced hyperalgesia (

207 bation to either nonsedation with sufficient analgesia or light sedation with a daily wake-up call du

208 Phenomena such as placebo analgesia or pain relief through distraction highlight t

209 .62, P = 0.047), and application of epidural analgesia (OR, 1.81, P = 0.

210 use of continuous or intermittent sedation, analgesia, or neuromuscular blockers, pain assessments,

211 he effect of intervention was independent of analgesia (P = 0.883).

212 1.50 minutes to the first patient-controlled analgesia; P < .001; I2 = 19%).

213 nvestigated this issue within an attentional analgesia paradigm with brainstem-optimized fMRI and ana

214 n our study population, regional anaesthesia-analgesia (paravertebral block and propofol) did not red

215 d by computer to either regional anaesthesia-analgesia (paravertebral blocks and propofol) or general

216 duration of the block, need for supplemental analgesia, patient and operator satisfaction, and compli

217 Patient-controlled analgesia (PCA) is an "on-demand" system which allows pa

218 en feasible, pre-/intra-operative multimodal analgesia, postoperative multimodal analgesia, postopera

219 ltimodal analgesia, postoperative multimodal analgesia, postoperative nausea and vomiting prophylaxis

220 understanding of the degree of variation in analgesia practice and patient-reported pain between hos

221 to characterize patient-reported outcomes of analgesia practices in a population-based surgical colla

222 agement requires dissemination of multimodal analgesia practices.

223 f daily sedation interruption and a sedation/analgesia protocol was reported by 51% and 39%, respecti

224 nd pregabalin, are recommended in multimodal analgesia protocols for acute postoperative pain managem

225 m pain of the lidocaine with the longer-term analgesia provided.

226 cation has the potential to improve sedation-analgesia quality and patient safety in mechanically ven

227 The sedation-analgesia quality data feedback did not improve quality

228 tion programme; regular feedback of sedation-analgesia quality data; and use of a novel sedation-moni

229 on alone (two ICUs), education plus sedation-analgesia quality feedback (two ICUs), education plus RI

230 Providing sedation-analgesia quality feedback to ICUs did not appear to imp

231 By contrast, sedation-analgesia quality feedback was poorly understood and tho

232 We assessed patients' sedation-analgesia quality for each 12 h period of nursing care,

233 The RI monitoring seemed to improve sedation-analgesia quality, but inconsistent adoption by bedside

234 not seem to alter other measures of sedation-analgesia quality.

235 three interventions to improve sedation and analgesia quality: an online education programme; regula

236 ond hypothesis was that regional anaesthesia-analgesia reduces persistent incisional pain.

237 to patient and surgeon success, the optimal analgesia regimen in HPB surgery remains controversial.

238 , 1.3) and 0.24 (0.04, 1.36) for overall and analgesia-related complications, respectively.

239 Management of delivery, including type of analgesia, requires a multidisciplinary approach and dep

240 neuronal firing to modulate morphine-induced analgesia, reward, and withdrawal.

241 aline-paired one, suggesting that they found analgesia rewarding.

242 Intersubject analgesia scores correlated to activity within a distinc

243 Thus, epidural analgesia should be the preferred method for the managem

244 However, black patients received opioid analgesia significantly less frequently than white patie

245 ding the medullary targets of the endogenous analgesia system, and offer new insights into the centra

246 en vagal sensory pathways and the endogenous analgesia system, potentially important for understandin

247 O), regions known to regulate the endogenous analgesia system.

248 noninferior to multimodal thoracic epidural analgesia (TEA) in patients undergoing open liver surger

249 mized trial was to compare thoracic epidural analgesia (TEA) to intravenous patient-controlled analge

250 he castration of piglets without anaesthesia/analgesia, the pig industry is searching for a mode of a

251 lthough, most heelsticks were performed with analgesia, this was not systematic.

252 Here we show that inducing analgesia through hypnosis leads to decreased responses

253 READD activation produced a ligand-dependent analgesia to heat in vivo and a decrease in neuronal fir

254 ive signaling, which may also enhance opioid analgesia, to help to alleviate the enormous burden of p

255 MOR endocytosis and determine its effects on analgesia, tolerance and dependence.

256 ed behavior and a battery of tests to assess analgesia, tolerance, and physical dependence to morphin

257 cing behaviors to morphine without affecting analgesia, tolerance, and withdrawal.

258 ors in OA synovia indicates a new target for analgesia treatments.

259 e surgery is lower with regional anaesthesia-analgesia using paravertebral blocks and the anaesthetic

260 roved opioid therapeutic window, notably for analgesia versus respiratory depression, is a result of

261 o display an improved therapeutic window for analgesia versus respiratory depression.

262 t improve therapeutic window for MOR-induced analgesia versus respiratory depression.

263 e efficacious for the affective component of analgesia versus the reflexive component and is devoid o

264 ropic P2X receptors while adenosine mediates analgesia via activation of metabotropic P1 receptors.

265 The use of patient-controlled analgesia was also reduced among patients who received l

266 e model, the increased lack of preprocedural analgesia was associated with female sex, term birth, hi

267 Morphine analgesia was diminished threefold under FA, relative to

268 Morphine analgesia was not altered, and neither was physical depe

269 Sham mindfulness meditation-induced analgesia was not correlated with significant neural act

270 rmal and mechanical pain thresholds in vivo; analgesia was observed for 3 days after a single systemi

271 Epidural analgesia was observed to be superior to PCA for pain co

272 During the baseline period, optimal sedation-analgesia was present for 5150 (56%) care periods.

273 xmedetomidine vs propofol, only breakthrough analgesia was significantly different (median, 328.8 vs

274 Epidural analgesia was used in 66% of controls and in none of the

275 Antinociception (analgesia) was measured as the latency to remove the tai

276 HDM-induced priming, but not analgesia, was markedly attenuated in both saporin-treat

277 To identify their involvement in endogenous analgesia, we used brainstem optimized, whole-brain imag

278 r sensitization, withdrawal and supra-spinal analgesia were facilitated, consistent with a tonic inhi

279 effects of vasopressin on expectancy-induced analgesia were significantly larger than those observed

280 estricted NaV1.7 inhibitors can only produce analgesia when administered in combination with an opioi

281 reverse morphine-induced, centrally mediated analgesia when given intravenously.

282 Children receive more analgesia when ordered around the clock compared to as r

283 re the need for periinterventional on-demand analgesia when water for injection (WFI) was replaced wi

284 One example is placebo analgesia, where expecting low pain causes a painful sti

285 tant) pregnant mice do not exhibit pregnancy analgesia, which can be rescued with the adoptive transf

286 al using a well-established model of placebo analgesia while controlling for sex differences.

287 g tolerance and may prolong effective opioid analgesia while reducing opioid dependence.

288 d no improvement in overall optimal sedation-analgesia with education (OR 1.13 [95% CI 0.86-1.48]), b

289 ic advantage in terms of producing effective analgesia with fewer adverse effects has driven the desi

290 zed to 1 of 4 groups receiving postoperative analgesia with IV acetaminophen or placebo every 6 hours

291 FST provides analgesia with modest to moderate increased risk of lowe

292 oximately half of the participants exhibited analgesia with placebo treatment.

293 nce by the neuromodulatory process to induce analgesia with potential relevance for patient stratific

294 delta-opioid receptor (DOR) produces similar analgesia with reduced side effects.

295 significant improvement in optimal sedation-analgesia with RI monitoring (odds ratio [OR] 1.44 [95%

296 s for a brainstem triumvirate in attentional analgesia: with the PAG activated by attentional load; s

297 um duration, cognitive decline, breakthrough analgesia within the first 48 hours, and ICU and hospita

298 Most women with MBC require opioid analgesia within the first month after diagnosis.

299 benzoyl-6beta-naltrexamide) mediate a potent analgesia without many undesirable effects.

300 the mechanisms of electroacupuncture induced analgesia would benefit chronic pain conditions such as