ライフサイエンスコーパス: analgesic action

1 lead compound as a 5-HT(4)R antagonist with analgesic action.

2 Finally, PCTR1 showed potent analgesic action.

3 d compounds representing novel mechanisms of analgesic action.

4 pioid receptor as a major contributor to its analgesic action.

5 ha(2) adrenoceptor subtypes to produce their analgesic action.

6 2 in vivo, and thereby modulates its central analgesic actions.

7 itive antagonist of the NMDA receptor on the analgesic action and development of tolerance to the ana

8 lts in the development of tolerance to their analgesic action and the intensity of tolerance increase

9 lei in the brainstem is responsible for this analgesic action and which alpha(2) adrenoceptor subtype

10 ceptors; the central and peripheral sites of analgesic actions and side effects; endogenous and exoge

11 antagonism of NMDA receptors attenuates the analgesic action as well as development of tolerance to

12 duced release of norepinephrine mediates the analgesic action at alpha(2) adrenoceptors in the spinal

13 2-endomorphin-2 analog should produce longer analgesic actions at lower doses.

14 ropathic pain and augment opioid/cannabinoid analgesic actions by increasing the transcription of Opr

15 e nonsteroid anti-inflammatory drugs have no analgesic action in this test.

16 ar mechanisms underlying resolvins' distinct analgesic actions in mice are unclear.

17 theless, systemic [Dmt(1)]DALDA retained its analgesic actions in MOR-1 knockout animals and CXBK mic

18 demonstrated that A3AR agonists have potent analgesic actions in preclinical rodent models of neurop

19 spinal-projections from LC neurons can exert analgesic actions, it is not known whether they can act

20 nti-Il-1Ra antibody transiently reversed the analgesic action of CS.

21 c action and development of tolerance to the analgesic action of D-Ala2, Glu4 deltorphin II (deltorph

22 n as well as development of tolerance to the analgesic action of delta 2-opioid receptor agonist in t

23 MK-801 and LY 235959 also antagonized the analgesic action of deltorphin II.

24 d help us to understand the mechanism of the analgesic action of different classes of antidepressants

25 d K+ channels in thermal nociception and the analgesic action of morphine and other agents.

26 epinephrine (NE), as a possible mechanism of analgesic action of NO in the spinal cord.

27 e of the spinal and supraspinal sites in the analgesic action of systemic opioids remains uncertain.

28 10 min prior to U-50,488H did not modify the analgesic action of the latter.

29 to gabapentin and pregabalin, mediating the analgesic action of these drugs against neuropathic pain

30 We therefore suggest that the analgesic action of triptan can be attained specifically

31 erved on the development of tolerance to the analgesic action of U-50,488H in both the species.

32 eptor antagonists block the tolerance to the analgesic action of U-50,488H in rodents.

33 treatment of rats with LY235959 enhanced the analgesic action of U-50,488H.

34 Previously we demonstrated that the analgesic actions of alpha(2) adrenoceptor agonists are

35 nsitization is believed to contribute to the analgesic actions of capsaicin.

36 variants in a knockout model eliminates the analgesic actions of delta and kappa opioids and of alph

37 ose-dependent analgesia, and potentiated the analgesic actions of endomorphin-2, particularly on the

38 e exon 11 knockout mouse was normal, but the analgesic actions of heroin, M6G, and fentanyl were mark

39 In this assay, ibuprofen potentiated the analgesic actions of hydrocodone and oxycodone, shifting

40 o reduce the development of tolerance to the analgesic actions of MOR agonists.

41 Notably, Rgs9-2 in the NAc affects the analgesic actions of morphine as well as the development

42 tein alpha subunits differentially block the analgesic actions of mu-, delta-, and kappa-opioid agoni

43 al horn has been implicated in mediating the analgesic actions of neurosteroids.

44 epresent a relevant molecular target for the analgesic actions of neurosteroids.

45 opioid receptor (MOR) is responsible for the analgesic actions of opioid drugs as well as their unwan

46 Both rewarding and analgesic actions of opioids depend upon actions at the

47 s, thereby causing hyperalgesia and reducing analgesic actions of opioids.SIGNIFICANCE STATEMENT Opio

48 n mechanisms that modulate the rewarding and analgesic actions of oxycodone.

49 to antinociception by opioids, we tested for analgesic actions of Rf.

50 exons all block both spinal and supraspinal analgesic actions of the delta2 ligand [D-Ala2,Glu4]delt

51 rs enhances, in a dose-dependent manner, the analgesic actions of the mu analgesic morphine, the kapp

52 ntilation while, if possible, preserving the analgesic actions of the opioids.

53 e acute versus persistent pain settings, the analgesic actions of the SNRI duloxetine and the SSRI fl

54 nale of conserving the anti-inflammatory and analgesic actions of traditional nonsteroidal anti-infla

55 tenuated the development of tolerance to the analgesic actions of U-50,488H.

56 The 6TM variants are also involved in analgesic action through other drug classes, including d

57 cytochrome P450 (P450) activity in mu opioid analgesic action, we generated a mutant mouse with brain

58 rea (POA) to ascertain whether the steroids' analgesic actions were mediated by membrane actions in t