ライフサイエンスコーパス: anaphase-promoting complex

1 luding an A-type cyclin and a subunit of the anaphase promoting complex.

2 yzed by a massive enzyme machine, called the Anaphase Promoting Complex.

3 conveys lack of tension or attachment to the anaphase promoting complex.

4 l: the destruction box sequence bound to the anaphase-promoting complex.

5 transmitting a "wait anaphase" signal to the anaphase-promoting complex.

6 proteins that function as activators of the anaphase-promoting complex.

7 previous observations that Tax activates the anaphase-promoting complex.

8 ll cycle-associated E3-ubiquitin ligase, the anaphase-promoting complex.

9 tion and upregulation of E3 ubiquitin ligase anaphase-promoting complex 10 activity, which targeted E

10 ago, the first post-mitotic function of the anaphase-promoting complex, a major cell cycle-regulated

11 nd thereby promoting SPOP degradation by the anaphase-promoting complex activator FZR1.

12 reakdown, and provides an effective block to anaphase-promoting complex activity, and consequently th

13 erview of the function and regulation of the anaphase-promoting complex, an E3 ubiquitin ligase that

14 tion cascade that leads to inhibition of the anaphase promoting complex and cell cycle arrest.

15 se I and II, was dependent on myosin II, the anaphase promoting complex and separase, but did not req

16 The Anaphase Promoting Complex (APC) coactivator Cdh1 drives

17 int signaling, the role kinetochores play in anaphase promoting complex (APC) inhibition remains uncl

18 The anaphase promoting complex (APC) is a ubiquitin ligase t

19 repressed genes is Emi1, an inhibitor of the anaphase promoting complex (APC) which is degraded durin

20 Anaphase promoting complex (APC)-Cdh1 targets multiple m

21 ming of HURP action and its turnover via the anaphase promoting complex (APC)-proteasome system, ther

22 ndent protein kinase (Cdk) families, and the Anaphase Promoting Complex (APC).

23 y the microarray should be substrates of the anaphase promoting complex (APC).

24 ted by a meiosis-specific coactivator of the anaphase promoting complex (APC/C) E3 ubiquitin ligase,

25 Thereafter, the anaphase promoting complex (APC/C) is activated and chro

26 complex (MCC), which binds and inhibits the anaphase promoting complex (APC/C).

27 in B2 from destruction by the Cdh1-activated anaphase-promoting complex (APC(Cdh1)) and remains impor

28 Anaphase-promoting complex (APC) activation results in d

29 euploidy by coupling anaphase onset, through anaphase-promoting complex (APC) activation, with chromo

30 FZR1 is an anaphase-promoting complex (APC) activator best known fo

31 arrests cells at metaphase by inhibiting the anaphase-promoting complex (APC) and its coactivator Cdc

32 o the identification of many subunits of the anaphase-promoting complex (APC) associated with PHF8.

33 nce of ubiquitylation events mediated by the anaphase-promoting complex (APC) based on short redundan

34 pindle assembly checkpoint, which results in anaphase-promoting complex (APC) inhibition.

35 The Anaphase-Promoting Complex (APC) is an E3 ubiquitin liga

36 A pulse-driven CDK1-anaphase-promoting complex (APC) model corroborated thes

37 The ubiquitin ligase anaphase-promoting complex (APC) recruits the coactivato

38 the large, multisubunit E3 ubiquitin ligase anaphase-promoting complex (APC) that targets effector p

39 The Skp1-Cul1-F-box (SCF) and anaphase-promoting complex (APC) ubiquitin ligases targe

40 cells, revealing a link between CYP24A1 and anaphase-promoting complex (APC), a key cell cycle regul

41 We show that the activity of the anaphase-promoting complex (APC), an E3 that regulates t

42 directly inhibiting its interaction with the anaphase-promoting complex (APC), an E3 ubiquitin ligase

43 ctivity of the master regulator known as the anaphase-promoting complex (APC), brought about through

44 Cdh1, a coactivator of the anaphase-promoting complex (APC), is a potential tumor s

45 at Eco2, like sororin, is a substrate of the anaphase-promoting complex (APC), which ensures that pro

46 ing the metaphase-anaphase transition by the anaphase-promoting complex (APC), which recognizes the d

47 nt is the Cdc20 protein, which initiates the anaphase-promoting complex (APC)-dependent degradation o

48 -1-dependent early translocation followed by anaphase-promoting complex (APC)-dependent spindle rotat

49 ation pathways in yeast, including Rsp5- and anaphase-promoting complex (APC)-mediated pathways.

50 ies of cyclin-dependent kinase (Cdk) and the anaphase-promoting complex (APC).

51 neuploidy by restraining the activity of the anaphase-promoting complex (APC).

52 and Cdh1, the two mitotic activators of the anaphase-promoting complex (APC).

53 partly attributed to the inactivation of the anaphase-promoting complex (APC).

54 vator of an E3 ubiquitin ligase known as the anaphase-promoting complex (APC).

55 etochores into the cytoplasm, inhibiting the anaphase-promoting complex (APC).

56 show that MOAP-1 is a novel substrate of the anaphase-promoting complex (APC/C(Cdh1)) ubiquitin ligas

57 process is associated with its regulation of anaphase-promoting complex (APC/C) activity.

58 sely when substrates of the ubiquitin ligase anaphase-promoting complex (APC/C) are degraded.

59 lo-like kinase 1 (PLK1), transitions through Anaphase-promoting complex (APC/C) bound to Cell divisio

60 regulatory proteins by the large multimeric anaphase-promoting complex (APC/C) controls sister chrom

61 ning E3 ubiquitin ligase able to inhibit the anaphase-promoting complex (APC/C) directly.

62 Here, we report that the anaphase-promoting complex (APC/C) efficiently synthesiz

63 Geminin is targeted for degradation by the anaphase-promoting complex (APC/C) from anaphase through

64 The anaphase-promoting complex (APC/C) is a multimeric RING

65 The ubiquitin ligase anaphase-promoting complex (APC/C) is essential for cell

66 Ubiquitination by the anaphase-promoting complex (APC/C) is essential for prol

67 sequence motifs in several substrates of the anaphase-promoting complex (APC/C) that are required for

68 ctive interphase promoters(6,7), recruit the anaphase-promoting complex (APC/C) to specific transcrip

69 cycle protein 27 (Cdc27), a component of the anaphase-promoting complex (APC/C), as a novel interacti

70 o the mitotic spindle with activation of the anaphase-promoting complex (APC/C), the E3 ubiquitin lig

71 wed that LANA interacted physically with the anaphase-promoting complex (APC/C), thus promoting the d

72 progression requires the E3 ubiquitin ligase anaphase-promoting complex (APC/C), which uses the subst

73 lated ubiquitylation events catalyzed by the anaphase-promoting complex (APC/C).

74 inhibit Cdc20, the activating subunit of the anaphase-promoting complex (APC/C).

75 int complex (MCC), a potent inhibitor of the anaphase-promoting complex (APC/C).

76 tivation of the E2 Ube2S by its RING-E3, the anaphase-promoting complex (APC/C); while phosphorylatio

77 In eukaryotes, the anaphase-promoting complex (APC/C, also known as the cyc

78 vious studies implied that activation of the anaphase-promoting complex (APC/cyclosome) is involved i

79 We have identified the Cdh1-anaphase promoting complex as a putative E3 ligase that

80 This study implicates the anaphase-promoting complex as a mediator of MIWI ubiquit

81 eating a toggle switch for activation of the anaphase-promoting complex as embryonic cells exit mitos

82 tin ligase Cdc20-APC (cell division cycle 20-anaphase promoting complex) as a centrosomal substrate o

83 ese subprocesses are largely governed by the anaphase-promoting complex, Aurora B kinase, and kinesin

84 me decreased, resulting in an attenuation of anaphase-promoting complex/C ubiquitin ligase activity a

85 bundance is restricted to S phase in part by anaphase promoting complex Cdc20-homologue 1 (APC(Cdh1))

86 Anaphase-promoting complex Cdc20 (APC(Cdc20)) plays pivo

87 the major mitotic E3 ubiquitin ligase Cdc20-anaphase promoting complex (Cdc20-APC) regulates presyna

88 Among E3 ubiquitin ligases, Cdh1-anaphase promoting complex (Cdh1-APC) and Cdc20-APC have

89 The ubiquitin ligase Cdh1-anaphase promoting complex (Cdh1-APC) plays a key role i

90 ulatory subunit of the ubiquitin ligase Cdh1-anaphase-promoting complex (Cdh1-APC), profoundly impair

91 Here we show that Parkin interacts with anaphase promoting complex/cyclosome (APC/C) coactivator

92 The anaphase promoting complex/cyclosome (APC/C) controls un

93 is mediated by increased destruction by the anaphase promoting complex/cyclosome (APC/C) during meio

94 ta-independent-acquisition (DIA) data of the anaphase promoting complex/cyclosome (APC/C) during mito

95 The anaphase promoting complex/cyclosome (APC/C) E3 ligase c

96 at changes at kinetochores are essential for anaphase promoting complex/cyclosome (APC/C) inhibition.

97 The anaphase promoting complex/cyclosome (APC/C) is a large

98 Anaphase promoting complex/cyclosome (APC/C) is reported

99 The anaphase promoting complex/cyclosome (APC/C) mediates th

100 CDKs and the anaphase promoting complex/cyclosome (APC/C) restrict li

101 Assembly Checkpoint (SAC) that inhibits the Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin l

102 The SAC prevents the anaphase promoting complex/cyclosome (APC/C) ubiquitin l

103 matid pairs become bioriented, the E3 ligase anaphase promoting complex/cyclosome (APC/C) ubiquitylat

104 e chromosome segregation by inactivating the anaphase promoting complex/cyclosome (APC/C) until all c

105 , were found to physically interact with the anaphase promoting complex/cyclosome (APC/C)(Cdc20) and

106 cycle onset is controlled by activity of the Anaphase Promoting Complex/Cyclosome (APC/C), a multisub

107 are post-transcriptionally controlled by the Anaphase Promoting Complex/Cyclosome (APC/C), a specific

108 a female, meiosis-specific activator of the Anaphase Promoting Complex/Cyclosome (APC/C), an E3 ubiq

109 mitotic E3 ubiquitin ligase, known as Cdc20-anaphase promoting complex/cyclosome (APC/C), and stabil

110 xpression of the Cdc27 (APC3) subunit of the anaphase promoting complex/cyclosome (APC/C), which resu

111 MCC inhibits the ubiquitin ligase anaphase promoting complex/cyclosome (APC/C), whose acti

112 well-established substrate receptors for the Anaphase Promoting Complex/Cyclosome (APC/C).

113 factor (MPF) by inhibiting ubiquitin ligase anaphase promoting complex/cyclosome (APC/C).

114 T), a meiosis-specific form of the E3 ligase anaphase promoting complex/cyclosome (APC/C).

115 is an evolutionarily conserved regulator of anaphase promoting complex/cyclosome (APC/C).

116 MCC), which inhibits Cdc20 to inactivate the Anaphase Promoting Complex/Cyclosome (APC/C).

117 MAK is overexpressed, the binding of CDH1 to anaphase promoting complex/cyclosome decreased, resultin

118 tly in metaphase I if the Cortex form of the Anaphase Promoting Complex/Cyclosome is inactive.

119 of-function allele in an APC5 subunit of the anaphase promoting complex/cyclosome.

120 on and activation of the mitotic form of the anaphase-promoting complex/cyclosome (APC(Cdc20)).

121 Here, we show that inactivation of the anaphase-promoting complex/cyclosome (APC(Cdh1)) has the

122 Some RING E3s, including anaphase-promoting complex/cyclosome (APC), catalyze pol

123 uch E3 is the gigantic, multisubunit 1.2-MDa anaphase-promoting complex/cyclosome (APC), which contro

124 oint delays anaphase onset by inhibiting the anaphase-promoting complex/cyclosome (APC/C(Cdc20)) [2].

125 Activation of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) by C

126 ubiquitination activities of CDC20-activated anaphase-promoting complex/cyclosome (APC/C(CDC20)).

127 They arrest with hallmarks of defective anaphase-promoting complex/cyclosome (APC/C) activation,

128 efects in germinal vesicle breakdown (GVBD), anaphase-promoting complex/cyclosome (APC/C) activation,

129 pression is lost after differentiation, high anaphase-promoting complex/cyclosome (APC/C) activity de

130 Cdk1 play compensatory roles to suppress the anaphase-promoting complex/cyclosome (APC/C) activity ea

131 ntriole disengagement depend on separase and anaphase-promoting complex/cyclosome (APC/C) activity, w

132 checkpoint complex (MCC), which inhibits the anaphase-promoting complex/cyclosome (APC/C) and blocks

133 20, resulting in prolonged inhibition of the anaphase-promoting complex/cyclosome (APC/C) and delayed

134 Transient interactions between the anaphase-promoting complex/cyclosome (APC/C) and its act

135 o-EM and biochemistry show that the human E3 anaphase-promoting complex/cyclosome (APC/C) and its two

136 ukaryote with a semiopen mitosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of

137 CLIN A and CYCLIN B are ubiquitylated by the anaphase-promoting complex/cyclosome (APC/C) and then su

138 till occur for a considerable time after the anaphase-promoting complex/cyclosome (APC/C) becomes act

139 duration is determined by activation of the anaphase-promoting complex/cyclosome (APC/C) bound to it

140 The switch from activation of the anaphase-promoting complex/cyclosome (APC/C) by CDC20 to

141 , and TPX2 were rescued by inhibition of the anaphase-promoting complex/cyclosome (APC/C) by proTAME,

142 The differential regulation of anaphase-promoting complex/cyclosome (APC/C) coactivator

143 Here we show that Arabidopsis anaphase-promoting complex/cyclosome (APC/C) coactivator

144 The anaphase-promoting complex/cyclosome (APC/C) controls a

145 The ubiquitin ligase called the anaphase-promoting complex/cyclosome (APC/C) controls mi

146 ion of cell cycle regulatory proteins by the anaphase-promoting complex/cyclosome (APC/C) controls si

147 several means, including inactivation of the anaphase-promoting complex/cyclosome (APC/C) E3 ubiquiti

148 The anaphase-promoting complex/cyclosome (APC/C) E3 ubiquiti

149 HL associates with Cdh1, an activator of the anaphase-promoting complex/cyclosome (APC/C) E3 ubiquiti

150 tes recognition of mitotic substrates by the anaphase-promoting complex/cyclosome (APC/C) E3 ubiquiti

151 y-destroyed cyclins-Cyclins A and B-restrain anaphase-promoting complex/cyclosome (APC/C) function, w

152 Here, we demonstrate that the anaphase-promoting complex/cyclosome (APC/C) in complex

153 -D159, causes failure of inactivation of the anaphase-promoting complex/cyclosome (APC/C) in interpha

154 rrested at Metaphase II by Emi2, the meiotic anaphase-promoting complex/cyclosome (APC/C) inhibitor.

155 The anaphase-promoting complex/cyclosome (APC/C) is a cell c

156 The anaphase-promoting complex/cyclosome (APC/C) is a large

157 The anaphase-promoting complex/cyclosome (APC/C) is a large

158 The anaphase-promoting complex/cyclosome (APC/C) is a large

159 The anaphase-promoting complex/cyclosome (APC/C) is a large,

160 The anaphase-promoting complex/cyclosome (APC/C) is a massiv

161 The anaphase-promoting complex/cyclosome (APC/C) is a member

162 The anaphase-promoting complex/cyclosome (APC/C) is a protei

163 The anaphase-promoting complex/cyclosome (APC/C) is an E3 ub

164 The Anaphase-Promoting Complex/Cyclosome (APC/C) is an E3 ub

165 The Anaphase-Promoting Complex/Cyclosome (APC/C) is an essen

166 The anaphase-promoting complex/cyclosome (APC/C) is an essen

167 The anaphase-promoting complex/cyclosome (APC/C) is an evolu

168 The anaphase-promoting complex/cyclosome (APC/C) is an ubiqu

169 The anaphase-promoting complex/cyclosome (APC/C) is the E3 u

170 The anaphase-promoting complex/cyclosome (APC/C) is the ubiq

171 Proteasomal degradation of cyclin B by anaphase-promoting complex/cyclosome (APC/C) is, in part

172 The anaphase-promoting complex/cyclosome (APC/C) orchestrate

173 The anaphase-promoting complex/cyclosome (APC/C) promotes an

174 For example, the anaphase-promoting complex/cyclosome (APC/C) promotes th

175 The anaphase-promoting complex/cyclosome (APC/C) regulates s

176 ith abundance profiles most similar to known Anaphase-Promoting Complex/Cyclosome (APC/C) substrates

177 e we show that another ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C) targets Ams

178 get of the SAC is Cdc20, which activates the anaphase-promoting complex/cyclosome (APC/C) that trigge

179 i1/NuMA/Dynein-dynactin) network anchors the anaphase-promoting complex/cyclosome (APC/C) to the mito

180 The anaphase-promoting complex/cyclosome (APC/C) ubiquitin l

181 two-step destruction process mediated by the anaphase-promoting complex/cyclosome (APC/C) ubiquitin l

182 ostnatal deletion of Cdh1, a cofactor of the anaphase-promoting complex/cyclosome (APC/C) ubiquitin l

183 The checkpoint system acts on the Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin l

184 The anaphase-promoting complex/cyclosome (APC/C) ubiquitin l

185 0, and MAD2, directly binds and inhibits the anaphase-promoting complex/cyclosome (APC/C) until all c

186 The MCC inhibits the anaphase-promoting complex/cyclosome (APC/C) until the c

187 bub3Delta cells had impaired binding of the anaphase-promoting complex/cyclosome (APC/C) with its ac

188 An example is the anaphase-promoting complex/cyclosome (APC/C), a 13-subun

189 -B-Insensitive 4) are negative regulators of anaphase-promoting complex/cyclosome (APC/C), a multisub

190 MCC inhibits the anaphase-promoting complex/cyclosome (APC/C), a ubiquiti

191 Cdc20, a cofactor of the E3 ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C), accumulate

192 netochores by inhibiting the activity of the Anaphase-Promoting Complex/Cyclosome (APC/C), an E3 ubiq

193 Here we show that the anaphase-promoting complex/cyclosome (APC/C), an E3 ubiq

194 The anaphase-promoting complex/cyclosome (APC/C), an E3 ubiq

195 The anaphase-promoting complex/cyclosome (APC/C), an essenti

196 ense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to del

197 ation of the ANAPC1 gene, a component of the anaphase-promoting complex/cyclosome (APC/C), in all aff

198 A multi-subunit ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C), regulates

199 example, the cell cycle regulatory E3, human anaphase-promoting complex/cyclosome (APC/C), relies on

200 chromosomes and which binds and inhibits the anaphase-promoting complex/cyclosome (APC/C), the E3 ubi

201 two destruction boxes and is mediated by the anaphase-promoting complex/cyclosome (APC/C), whereas de

202 procal circuit with the cell cycle E3 ligase anaphase-promoting complex/cyclosome (APC/C), which also

203 Here, studying the 1.2-MDa E3 ligase anaphase-promoting complex/cyclosome (APC/C), which cont

204 gulated by multiple mechanisms including the anaphase-promoting complex/cyclosome (APC/C), which is t

205 es with the function of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C), which, tog

206 n the proteasome after ubiquitylation by the anaphase-promoting complex/cyclosome (APC/C)-cadherin 1

207 Together, our results indicate that anaphase-promoting complex/cyclosome (APC/C)-Cdh1 specif

208 nt cells in contrast to somatic cells, where anaphase-promoting complex/cyclosome (APC/C)-mediated pr

209 in Saccharomyces cerevisiae is regulated by anaphase-promoting complex/cyclosome (APC/C)-mediated pr

210 g proper bipolar chromosomal attachment with anaphase-promoting complex/cyclosome (APC/C)-mediated se

211 ction during M-phase exit is mediated by the anaphase-promoting complex/cyclosome (APC/C)-targeted ub

212 ate receptor CDT2/DTL, and components of the anaphase-promoting complex/cyclosome (APC/C).

213 assembles and inhibits the ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C).

214 ubules promote chromosome association of the anaphase-promoting complex/cyclosome (APC/C).

215 complex (MCC) inhibits the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C).

216 x (MCC), which inhibits the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C).

217 between Ubp15 and Cdh1, an activator of the anaphase-promoting complex/cyclosome (APC/C).

218 al domain required for ubiquitination by the Anaphase-Promoting Complex/Cyclosome (APC/C).

219 mitotic spindle, and a regulatory component, anaphase-promoting complex/cyclosome (APC/C).

220 checkpoint complex (MCC), which inhibits the anaphase-promoting complex/cyclosome (APC/C).

221 ase by targeting Cdc20, the activator of the anaphase-promoting complex/cyclosome (APC/C).

222 proteins inhibit Cdc20, an activator of the anaphase-promoting complex/cyclosome (APC/C).

223 ork that inhibits premitotic activity of the anaphase-promoting complex/cyclosome (APC/C).

224 MCC formation inhibits the anaphase-promoting complex/cyclosome (Cdc20-APC/C), ther

225 m mitosis to endoreduplication by modulating anaphase-promoting complex/cyclosome activity, which are

226 a diffusible inhibitor of APC/C(Cdc20) (the anaphase-promoting complex/cyclosome and its coactivator

227 ation of Drp1, catalyzed by the APC/C(Cdh1) (anaphase-promoting complex/cyclosome and its coactivator

228 The anaphase-promoting complex/cyclosome and its coactivator

229 At the first meiotic division, anaphase-promoting complex/cyclosome associated with Cdc

230 e Mad2 is converted into an inhibitor of the anaphase-promoting complex/cyclosome bound to its specif

231 This is achieved through inhibition of the anaphase-promoting complex/cyclosome by a kinetochore-de

232 CARP-1 also binds with anaphase-promoting complex/cyclosome co-activators Cdc20

233 proliferation, including most targets of the anaphase-promoting complex/cyclosome complex, a set of g

234 ligases, the Skp/cullin/F-box-containing and anaphase-promoting complex/cyclosome complexes.

235 ing from our screen, we demonstrate that the Anaphase-Promoting Complex/Cyclosome directly engages th

236 brid screen revealed CARP-1 binding with the anaphase-promoting complex/cyclosome E3 ubiquitin ligase

237 ndle assembly checkpoint remained active and anaphase-promoting complex/cyclosome function was inhibi

238 BubR1M that contribute to Cdc20 binding and anaphase-promoting complex/cyclosome inhibition: a destr

239 Cdc20 is an activator of the anaphase-promoting complex/cyclosome that initiates anap

240 a meiosis-specific targeting subunit of the anaphase-promoting complex/cyclosome that regulates mult

241 stl is required for the timely activation of anaphase-promoting complex/cyclosome to allow meiosis I

242 f endoreplication entrance by activating the anaphase-promoting complex/cyclosome to initiate the ubi

243 he G1 phase of the cell cycle is achieved by anaphase-promoting complex/cyclosome(Cdh1) (APC/C(Cdh1))

244 iated by the 1.2-MDa ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) and its coactivato

245 Here we demonstrate that APC/C (anaphase-promoting complex/cyclosome) enzyme is active i

246 ts the action of the ubiquitin ligase APC/C (Anaphase-Promoting Complex/Cyclosome) to degrade inhibit

247 CC is a critical checkpoint inhibitor of the anaphase-promoting complex/cyclosome, a ubiquitin ligase

248 The relevant ubiquitin ligase, the anaphase-promoting complex/cyclosome, also targets cycli

249 thway involving the mitotic kinase PLK1, the anaphase-promoting complex/cyclosome, and the proteasome

250 tor of DNA pre-RC, and Emi1, an inhibitor of anaphase-promoting complex/cyclosome, are elevated in Pl

251 y preventing degradation of cyclin B1 by the anaphase-promoting complex/cyclosome, but some cells eva

252 te and characterize recombinant forms of the anaphase-promoting complex/cyclosome, cohesin, and kinet

253 Likewise, Cdc20, an activator of the anaphase-promoting complex/cyclosome, is excluded from i

254 ic exit, MCPH1 isoforms were degraded by the anaphase-promoting complex/cyclosome-CDH1 E3 ligase comp

255 Anaphase-promoting complex/cyclosome-CDH1 target protein

256 bility of RNF157 during the cell cycle in an anaphase-promoting complex/cyclosome-CDH1-dependent mann

257 le ensuring timely activation of separase by anaphase-promoting complex/cyclosome-dependent degradati

258 x, and its association and inhibition of the anaphase-promoting complex/cyclosome.

259 of the checkpoint is the E3 ubiquitin ligase anaphase-promoting complex/cyclosome.

260 actions, causing premature activation of the anaphase-promoting complex/cyclosome.

261 chromatid segregation is independent of the anaphase-promoting complex/cyclosome.

262 e-independent failure of inactivation of the anaphase-promoting complex/cyclosome.

263 stributed throughout the cell to inhibit the anaphase-promoting complex/cyclosome.

264 ugating enzyme that donates ubiquitin to the anaphase-promoting complex/cyclosome.

265 rylation of cdk1 inhibited activation of the anaphase promoting complex degradation system, which was

266 ion mutant compromised for the kinesin-8 and anaphase-promoting complex-driven spindle-disassembly pa

267 ell cycle kinase Mps1, a known target of the anaphase-promoting complex E3, require Ufd2 enzyme.

268 WEE1 interacts with the anaphase promoting complex, functioning as a negative re

269 e groups that control the M phase, including anaphase-promoting complex genes, via aberrant transcrip

270 ve identified additional novel roles for the anaphase-promoting complex in diverse aspects of neurona

271 perspective on future investigations of the anaphase-promoting complex in neurobiology.

272 discuss the functions and mechanisms of the anaphase-promoting complex in neurogenesis, glial differ

273 The anaphase-promoting complex in partnership with its activ

274 and Nr4a receptors induce components of the anaphase-promoting complex, including ubiquitin-conjugat

275 independent of a conserved component of the anaphase-promoting complex, indicating a unique role for

276 The anaphase-promoting complex is required for similar steps

277 Here, we show that PANS1 targeting by the anaphase-promoting complex is required to trigger chromo

278 ION CYCLE16 (CDC16), a core component of the Anaphase Promoting Complex, is one of the key mediators

279 tween the actions of the E3 ubiquitin ligase anaphase-promoting complex or cyclosome (activated by th

280 lti-subunit E3 ubiquitin ligase known as the anaphase-promoting complex or cyclosome (APC/C [2]).

281 itionally, we found that Pim-1 regulates the anaphase-promoting complex or cyclosome (APC/C complex)

282 The anaphase-promoting complex or cyclosome (APC/C) is a con

283 The anaphase-promoting complex or cyclosome (APC/C) is a lar

284 The anaphase-promoting complex or cyclosome (APC/C) is a ubi

285 The anaphase-promoting complex or cyclosome (APC/C) is a ubi

286 The anaphase-promoting complex or cyclosome (APC/C) is an un

287 The anaphase-promoting complex or cyclosome (APC/C) is the u

288 The anaphase-promoting complex or cyclosome (APC/C), a multi

289 ed kinetochores during mitosis, inhibits the anaphase-promoting complex or cyclosome (APC/C), and del

290 role for a master cell-cycle regulator, the anaphase-promoting complex or cyclosome (APC/C), in the

291 ochores during prometaphase and inhibits the anaphase-promoting complex or cyclosome (APC/C), thus en

292 ed kinetochores and inhibits the Cdc20-bound anaphase-promoting complex or cyclosome (APC/C), to dela

293 have been depleted of known subunits of the anaphase-promoting complex or cyclosome (APC/C).

294 R1-Bub3, Mad2, and Cdc20, which inhibits the anaphase-promoting complex or cyclosome bound to Cdc20 (

295 and destabilization of Skp2 mediated by the anaphase-promoting complex or cyclosome bound to Cdh1 (A

296 ts the "wait anaphase" signal to inhibit the anaphase-promoting complex or cyclosome until all chromo

297 The anaphase-promoting complex, or cyclosome (APC/C), is a l

298 The anaphase-promoting complex, or cyclosome (APC/C), is a u

299 oach by isolating the complexes for the rice ANAPHASE PROMOTING COMPLEX SUBUNIT 10 (APC10) and CYCLIN

300 romiscuous E3 ligase inhibitor targeting the anaphase-promoting complex, which increases cell mitogen