ライフサイエンスコーパス: ancestral

1 ata might support a similarly broadly active ancestral ABCE model of floral organ determination in ea

2 The ancestral acquisition of this enzyme, and the subsequent

3 ions in amino acid sequences lead to loss of ancestral activity and functional diversification of pro

4 We obtained up to 10(4)-fold increases in ancestral activity with various asymmetrical trade-offs

5 domain that serves as a major determinant of ancestral activity.

6 early innovation state by selecting for its ancestral activity.

7 Ancestral adaptations in crop wild relatives can provide

8 We observed complex patterns of ancestral admixture and putative-damaging and novel vari

9 s to quantify the error in the estimation of ancestral admixture proportions under various conditions

10 lcohol metabolizing activity compared to the ancestral allele G (ADH1B*1).

11 ded SNP frequency spectra (that is, when the ancestral alleles of the SNPs are unknown) of thousands

12 ogressed sequences reintroduced thousands of ancestral alleles that were lost in Eurasian populations

13 , the tuatara provides key insights into the ancestral amniotes(2,4).

14 This is consistent with a mosaic of ancestral and derived osteological characters in the hin

15 acement is linked to the transition from two ancestral and functionally distinct TIM complexes, found

16 in the transition states of the low-affinity ancestral and high-affinity human NCBD/CID interactions.

17 Ancestral and novel chemical defenses in Erysimum thus a

18 late in the history of eudicots and that the ancestral Antirrhinum had an active H gene and restricte

19 pically associated with transitions from the ancestral arbuscular mycorrhizal (AM) to the alternative

20 liverwort genus Lejeunea with estimation of ancestral areas of origin and testing if sexual system a

21 stantly related clades that reside in a more ancestral Asian clade with high amounts of genetic diver

22 Ancestral Astyanax are found in surface rivers and deriv

23 ytologically homomorphic and evolved from an ancestral autosome pair in association with a shift from

24 ack from ultraviolet (UV) sensitivity to the ancestral avian violet sensitivity, thus improving visua

25 LO2 arose by duplication, has maintained the ancestral B-class function in specifying petal and stame

26 ate representation of individuals of diverse ancestral backgrounds in these studies may undercut thei

27 pic novelty: exaptation and co-opting of the ancestral bauplan, the quasi-independence of the interfa

28 ependent incursions into the water column by ancestral benthic lineages in all major oceanic basins.

29 17 ancestral chordate linkage groups (and 19 ancestral bilaterian groups) by fusion, rearrangement an

30 onserved developmental toolkit and traces of ancestral bilaterian linkage.

31 me-wide research, and investigates the cross-ancestral biological contributions to cocaine use disord

32 ugh the combination of haplotype clustering, ancestral birth origin analysis, and local ancestry infe

33 32,000 individuals in the US using genetic, ancestral birth origin, and geographic data from the Nat

34 Small ancestral body size suggests that the extreme rarity of

35 ve selection on hearing-related genes in the ancestral branch of bats, which is indicative of larynge

36 NRs suggests that activity regulation is not ancestral but was gained after the first subclasses dive

37 is evolved multiple times independently from ancestral C(3) photosynthesis in a broad range of flower

38 merged via proposed gene duplication from an ancestral Ca(V)1/2 type channel.

39 potential contained within the genome of the ancestral cell.

40 on across precipitation gradients, acting on ancestral cereal grain size regulators, underlies seed m

41 c, consistent with sound production being an ancestral character for mochokids.

42 of the amniote intervertebral joint through ancestral character state reconstruction.

43 ollusc phylogeny and offer new insights into ancestral character states of major mollusc clades.

44 and diverse vertebrates are derived from 17 ancestral chordate linkage groups (and 19 ancestral bila

45 ermis in cephalochordates (and presumably in ancestral chordates) contrast with vertebrate sensory ne

46 d methods showed limited ability to identify ancestral clone sequences present in tumor samples corre

47 When ancestral clones harbor EGFR mutations, truncal mutation

48 Different globin genes from this ancestral cluster evolved in the current NPRL3-linked HB

49 act formation in the transition state of the ancestral complex and more heterogeneous transient inter

50 ilaginous endoskeletons, long considered the ancestral condition for all jawed vertebrates (gnathosto

51 It has been argued that the common ancestral condition likely resembles the nonmarginal, ra

52 to second cousins, seem paradoxical because ancestral correlations decay rapidly.

53 Furthermore, lampreys express only a single, ancestral corticosteroid receptor (CR).

54 e highest population of goats, as the likely ancestral country for BTV emergence and dispersal worldw

55 raphy(3,6,7) and divergence times(1,8-10) of ancestral crown birds remain unanswered.

56 rowth; for example, a gill) on the leg of an ancestral crustacean.

57 hytochromes have been proposed to arise from ancestral cyanobacterial genes via endosymbiotic gene tr

58 Reconstructed ancestral cytochrome P450 enzymes tend to have variable

59 rst structural evaluation of a reconstructed ancestral cytochrome P450, revealing key features that a

60 the mutational preferences of limited common ancestral descent, such as in the case of influenza type

61 domains, NCBD and CID, likely emerged in an ancestral deuterostome organism as a low-affinity intera

62 d relatively quiescent tumor precursors with ancestral diploid/2N genomes and normal Pten/chr19 are o

63 g in the late Miocene, along with a possible ancestral distribution of the Hengduan Mountains and adj

64 6 novel loci, emphasizing the importance of ancestral diversity and phenotype resolution in this era

65 legal, and social implications of increasing ancestral diversity in genetic studies of cardiometaboli

66 uals making up nearly 30%, MVP's substantial ancestral diversity surpasses that of other large bioban

67 Estimates of ancestral effective population sizes (N (e) ) confirm th

68 pituitary arising through interactions of an ancestral endoderm-derived proto-pituitary with newly ev

69 Using an ancestral enzyme, we obtain the first structure of an AD

70 array of eukaryotic lineages, suggesting an ancestral EPR-1 was a component of a primitive Polycomb

71 furrow formation that was already present in ancestral eukaryotes.

72 manipulation will provide insights into the ancestral eukaryotic lifeforms, general eukaryote cell b

73 r understanding of the true potential of the ancestral eukaryotic toolkit.

74 Motile male gametes (sperm cells) are an ancestral eukaryotic trait that has been lost in several

75 igrations back to Africa, predominately from ancestral Europeans, and gene flow into Neanderthals fro

76 In the clade G6, an ancestral exCNL has lost its N-terminal domains in the c

77 Thus, if expression shifts, ancestral expression in some organs induces a strong pro

78 hift expression as organisms evolve, but how ancestral expression influences altered descendant expre

79 resegmentation is a tetrapod novelty, or an ancestral feature of jawed vertebrates, we tested the re

80 findings resolve axial resegmentation as an ancestral feature of the jawed vertebrate body plan.

81 ing the evolution of Euglenozoa, focusing on ancestral features generally considered parasite-specifi

82 sequences of both FMO1 and FMO4, denoted as ancestral flavin-containing monooxygenase (AncFMO)1 and

83 We propose these characteristics as ancestral for all jawed vertebrates.

84 We suggest that M.EcoGII may represent an ancestral form of these enzymes, as its activity is inde

85 show that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on

86 sophila and other organisms may relate to an ancestral form, in which multiple functions or regulator

87 We first identify ancestral forms still present in Vibrio cholerae, Pseudo

88 distinct secondary structure elements in the ancestral forms that may contribute to their thermostabi

89 Phylogenetic analysis and ancestral fruit-type reconstruction suggest independent

90 ed that males failed to mate, confirming the ancestral function of this gene in male sexual behavior.

91 yophytes, and their evolutionary origins and ancestral function remain poorly understood.

92 ced back to prebilaterian species, but their ancestral function(s) are unknown.

93 Thus, in order to investigate how ancestral functions are retained or lost post-duplicatio

94 nsion, and it is unclear how or at what rate ancestral functions are retained or partitioned among co

95 e two teff subgenomes have partitioned their ancestral functions based on divergent expression across

96 s revealed that HOXA1 has retained essential ancestral functions of Labial, while HOXB1 and HOXD1 hav

97 nversion and/or repair after the breakage of ancestral gene clusters.

98 In this work, we pinpoint an ancestral gene giving rise to a new toxin and functional

99 into the role of fungal association and the ancestral gene repertoire in the early evolution of land

100 ting proteins but the evolutionary path from ancestral gene to novel protein is challenging to trace,

101 of the function or expression pattern of the ancestral gene.

102 by functional specialization of a duplicated ancestral gene.

103 in the human Y chromosome losing 97% of its ancestral genes while gene content and order remain high

104 han genes: complete sequence divergence from ancestral genes, such that homologues are not readily de

105 ent genomic characters evolved from a shared ancestral genetic architecture.

106 Ancestral genetic differences may contribute to these as

107 Ancestral genetic exchange between members of many impor

108 hat it is immotile in vitro, probably due to ancestral genetic loss.

109 equisite for accurate interpretations of the ancestral genetics of this population.

110 s the most common type in East Asia, and its ancestral genome appears not to have spread outside East

111 Consequently, solving ancestral genome inference problems constitutes a task o

112 challenges, we provide two contributions for ancestral genome inference.

113 , they provide a novel practical approach to ancestral genome reconstruction, which combines the adva

114 d provides additional molecular clues on the ancestral genome reduction associated with adaptation to

115 By controlling the ancestral genome, horizontally acquired genes are respon

116 Reconstructing ancestral genomes is one of the central problems present

117 genomes, we analyze the gene content of the ancestral genomes of the last common ancestor of land pl

118 inspire the reconstruction of preduplicated ancestral genomes, referred to as the genome halving pro

119 of genome rearrangements between extant and ancestral genomes.

120 thyroid hormone on both the male and female ancestral germ lines.

121 o reveal two hidden species of an engineered ancestral GFP-like protein LEA, involving semi-trapped p

122 ved twice, and independently, from different ancestral globin proteins.

123 e genus Erysimum (Brassicaceae) produce both ancestral glucosinolates and evolutionarily novel carden

124 icate that a mushroom body morphology is the ancestral ground pattern, from which the domed hemiellip

125 tations of their predictive ability in other ancestral groups.

126 Septin proteins evolved from ancestral GTPases and co-assemble into hetero-oligomers

127 1*03:01, and HLA-DQB1*02:01), related to the ancestral haplotype 8.1, were significantly associated w

128 colony social organization suggests that the ancestral haplotypes have been eroded by recombination,

129 on in the face of rare recombination between ancestral haplotypes.

130 i and Candida parapsilosis indicates loss of ancestral HIR-associated centromeres and establishment o

131 Enriched integration of histone H3.3, the ancestral histone H3 variant, is a general feature of dy

132 Africa, the ancestral home of all modern humans, is the most informa

133 rodimeric cis-PTases have evolved from their ancestral, homodimeric forms to fulfill their function i

134 We inferred that goats are the ancestral hosts for BTV but are less likely to be import

135 Our results suggest that ancestral human populations were highly polygynous, that

136 supports the hypothesis that longer LTL was ancestral in humans.

137 conserved between any thrips species and the ancestral insect mitochondrial genome.

138 s across Panarthropoda support the view that ancestral integrative circuits crucial to action selecti

139 PhyA substrate, suggesting some retention of ancestral interactions.

140 d locomotion did not arise until loss of the ancestral 'L-shaped' humerus in the crown group, setting

141 des robust support for selenocysteine as the ancestral ligand for the Mo/W atom.

142 , where sex differences are focused in deep, ancestral limbic regions involved in the control of repr

143 ven an antibody of interest and its inferred ancestral lineage, which branches in the tree are likely

144 H(2)S in sulfide spring P. mexicana but not ancestral lineages from nonsulfidic habitats due to conv

145 tuberculosis epidemics, whereas TbD1-intact "ancestral" lineages tend to be restricted to specific ge

146 Europe was also identified as the ancestral location for most internal nodes of the VZV ph

147 verted orientation compared to that at their ancestral locus.

148 The ancestral long-tailed spinal nerve configuration was hyp

149 15 F2 descendants on the paternal lineage of ancestral male and female T3-overexposed mice revealed,

150 first evolved some 500 million years ago in ancestral marine chordates.

151 ds included principal component analysis for ancestral matching and adjusting for population stratifi

152 Here, we employed trans-ancestral meta-analysis using data from European and Eas

153 nventional view is that methanogenesis is an ancestral metabolism of the class Thermoplasmata.

154 very similar and can be used to reconstruct ancestral miRNA repertoires.

155 h indiscriminate sexual behaviour may be the ancestral mode of sexual reproduction.

156 e duplication, diversification dynamics, and ancestral morphologies, and found that after early genom

157 reehopper and a leafhopper that retains more ancestral morphology.

158 vant model systems for probing nonclassical, ancestral neurohormone functions.

159 endent dispersal and strong predation in the ancestral niche coupled with the lack of it in the new n

160 adily detectable; and de novo emergence from ancestral non-genic sequences, such that homologues genu

161 plausible prebiotic syntheses of potentially ancestral noncanonical nucleotides may be of great impor

162 veness is underlain by both amplification of ancestral nutrition-responsive gene expression and recru

163 Amaranth (Amaranthus hypochondriacus) is an ancestral nutritional grain and good source of bioactive

164 date between 2,440 and 100 cal BP, from two ancestral Ohlone sites in Central California.

165 ional developmental stages to the end of the ancestral ontogeny.

166 s genome coming from each population and its ancestral origin along the chromosome of an admixed popu

167 galanin, spexin and kisspeptin have a common ancestral origin and their pathophysiological roles are

168 Nevertheless, the novel SARS-CoV-2 of bat ancestral origin emerged to infect humans in Wuhan, Chin

169 conserved in herpesviruses suggesting their ancestral origin.

170 generated a mutation in the single zebrafish ancestral pad gene, padi2, that results in a loss of det

171 in almost all extant representatives-from an ancestral pair of pre-ocular (protocerebral) appendages

172 Comparative gene analysis supported the ancestral pairings of CSF1R/IL34 and CSF3R/CSF3, and the

173 Examination of trans-ancestral pathways reflect the well-defined role for int

174 The tuatara and some geckos reverted to the ancestral persisting notochord.

175 which involves manganese-oxide production by ancestral photosystems, later followed by down-sizing of

176 The ancestral phylogenetic position of the West Beringian gr

177 Ancestral phylogenetic reconstruction and sequence simil

178 l plasmids are amalgamations of at least one ancestral plasmid and a bacteriophage.

179 The transfer of ancestral plastid genomes into mitochondrial genomes to

180 oth species, it is estimated that 35% of the ancestral plastid genomes were transferred to mitochondr

181 durum, and common wheat, suggesting that the ancestral Pm41 was restricted to its place of origin and

182 ot show an increase in net biotic adaptation:ancestral, polyculture- and monoculture-evolved populati

183 blocks, including a two-fragment form of the ancestral polymerase ribozyme.

184 Phylogenetic analysis indicates ancestral polymorphic architecture (both "baggy" and "co

185 in which shared ancestry results from either ancestral polymorphism or introgression among taxa.

186 tion in this group was likely facilitated by ancestral polymorphism resulting from early co-option of

187 pecific gene flow and the presence of shared ancestral polymorphisms, particularly those maintained b

188 ographic history of the outgroup species and ancestral population and estimate that at least 20% of n

189 ct for the sizes of the outgroup species and ancestral population.

190 a high frequency of recessive lethals in the ancestral population.

191 nd on the patterns of plasticity harbored by ancestral populations before a change in the environment

192 requencies and LD patterns from a variety of ancestral populations enables researchers to better unde

193 ores based on association data from distinct ancestral populations improved IBD prediction for every

194 variation in predator-induced plasticity in ancestral populations of Daphnia It is unlikely that the

195 ry informative markers (AIMs) from reference ancestral populations.

196 formative markers and accurately classifying ancestral populations.

197 tial differences in allele frequency between ancestral populations.

198 proportion of their ancestry from each of 4 ancestral populations.

199 Brachypodium distachyon) with the AZ in the ancestral position and one (Setaria viridis) with the AZ

200 The ancestral position of the AZ was reconstructed.

201 or hematologic malignancies, initiated by an ancestral precursor that gives rise to the parallel evol

202 multiple instances of introgression between ancestral primate lineages.

203 ng and other bonding mechanisms available in ancestral primate societies.

204 em may be reminiscent of the architecture of ancestral, primitive nervous systems.

205 gene clusters are descendants from a common ancestral progenitor.

206 dmixture proportions into further subsets of ancestral proportions in the ancestors.

207 uplication historical substitutions into the ancestral protein is sufficient to cause strong tetramer

208 The ancestral protein of IRF3 and 7 seemed to possess the DP

209 By applying ancestral protein reconstruction and biochemical assays

210 Here we use ancestral protein reconstruction and biophysical assays

211 such, we hereby reconstructed the mammalian ancestral protein sequences of both FMO1 and FMO4, denot

212 mutual information to the reconstruction of ancestral protein states.

213 it possible not only to predict sequences of ancestral proteins but also to identify thousands of mut

214 cal comparison of the modern and resurrected ancestral proteins.

215 the crown-group genera, but not in the most ancestral Pseudoturritis genome.

216 We propose that the ancestral pterosaur diet was dominated by invertebrates

217 a context when climate change forced growing Ancestral Puebloan populations to exploit water resource

218 ce for five drought events that impacted the Ancestral Puebloan society between ~ AD 150 and 950.

219 Divergence time estimation, ancestral range estimation, and diversification analyses

220 from 27 sites scattered across the species' ancestral range in sub-Saharan Africa, revealing previou

221 nsorial antennae in Mandibulata derived from ancestral raptorial forms.

222 The molecular mechanisms by which one ancestral rDNA set is selected for silencing remain uncl

223 ying newly developed statistical methods for ancestral recombination graph inference and machine-lear

224 eatures derived from inferred gene trees and ancestral recombination graphs (ARGs).

225 evolution of RGS-Galpha selectivity through ancestral reconstruction and demonstrates how naturally

226 We utilise ancestral reconstruction approaches together with phylog

227 Ancestral reconstruction methods can place species-speci

228 Their inclusion in gene tree-aware ancestral reconstructions reveals an intermediate stage

229 horizontally acquired gene that controls an ancestral regulator, thereby promoting bacterial virulen

230 ly acquired genes are typically regulated by ancestral regulators.

231 tion, holds that a DNA sequence producing an ancestral regulatory activity also becomes the template

232 atory gene ssrB is necessary to activate the ancestral regulatory system PhoP/PhoQ of Salmonella ente

233 While PolD has an ancestral RNA polymerase catalytic core, its active site

234 DNA replication through the evolution of an ancestral RNAP two-barrel catalytic core.

235 abnormal cuticle composition, suggesting an ancestral role for PHYTOCHROME-mediated, light-stimulate

236 e in heterochromatin function, suggesting an ancestral role of this mark in transposon silencing.

237 Our study illuminates ancestral roles of the TOR-LARP1-5'TOP metabolic regulat

238 erlap more duplicated genes retained from an ancestral salmonid autotetraploidization event than expe

239 The persistence of Sb along with the ancestral SB haplotype through multiple speciation event

240 was terrestrial, this evidence suggests that ancestral scorpions were likely capable of forays onto l

241 n be traced to neurocognitive mechanisms and ancestral selection pressures.

242 possibly horizontal gene transfer after the ancestral separation of the two lineages.

243 mized vaccine inserts, being identical to an ancestral sequence and one mutation away from the consen

244 analyzed this allosteric network by means of ancestral sequence reconstruction (ASR), which is an in

245 We combined ancestral sequence reconstruction and empiric deconstruc

246 Our findings demonstrate that ancestral sequence reconstruction can efficiently identi

247 912) used ancestral sequence reconstruction to identify historical

248 Here, we use ancestral sequence reconstruction to resurrect ancestors

249 Moreover, we believe their ancestral sequence reconstruction would be consistent wi

250 ace evolution by sequence-based phylogeny or ancestral sequence reconstruction.

251 We anticipated that ancestral-sequence reconstruction could help us identify

252 V DNA concentrations and HIV divergence from ancestral sequences in tissues.

253 our results provide compelling evidence that ancestral similarities in territorial signals are mainta

254 ts confirm previous work in finding that the ancestral Sino-Tibetans first split into Sinitic and Tib

255 articular the reconstruction of the myriapod ancestral situation-for future research to improve under

256 l characters underlie the transition from an ancestral sound to a derived electric discharge producin

257 identify eastern Europe as the most probable ancestral source region for the Chagyrskaya toolmakers,

258 castes, tribal groups have very high Ancient Ancestral South Indian (AASI) contributions.

259 genomics is the reconstruction of genomes of ancestral species based on genomes of extant species.

260 ic and functional analysis revealed that the ancestral species lost the gene for a de novo methylase,

261 a primitive trait inherited from an arboreal ancestral species rather than proof of engagement in arb

262 d voluntary control of jaw oscillations from ancestral species, but added voluntary control of vocali

263 ome duplication, when a novel gene repressed ancestral spine programming.

264 ly, we show that the lamprey CR expresses an ancestral, spironolactone-as-agonist structural motif an

265 Ancestral state estimation on the most complete Cucurbit

266 We did this by using an ancestral state reconstruction analysis calculating maxi

267 First, our ancestral state reconstruction of habitat preference, us

268 Ancestral state reconstructions across this ant-plant cl

269 Ancestral state reconstructions indicate that genome rea

270 Ancestral state reconstructions on our preferred phyloge

271 Phylogenetic analyses indicated that the ancestral state was a non-diapausing forest species, and

272 r reduction from an inferred nine-chromosome ancestral state: (a) chromosome breakage followed by los

273 Through an ancestral-state reconstruction of composition and ultras

274 etic recombination hotspot selection from an ancestral static pattern near genes towards a flexible p

275 ructures, but instead evolved from existing, ancestral structures.

276 by tandem duplication and divergence of the ancestral Sub1C gene in that order.

277 ional or protein networks as well as by more ancestral subcellular localization.

278 nt maize genotypes to phylogenetically infer ancestral symptom intensities and check for phylogenetic

279 feeding in Anopheles involves repurposing an ancestral thermoreceptor from non-blood-feeding Diptera.

280 rise to an extreme genomic asymmetry that is ancestral to all extant eukaryotes.

281 was the very first self-replicator directly ancestral to all life?

282 developmental programs in animals, probably ancestral to almost half of the animal phyla, and theref

283 gle origin of a pillar-erect hip morphology, ancestral to Eucrocopoda that preceded later development

284 veloped in a shoot-like fashion, potentially ancestral to extant seed plant reproductive shoots.

285 AML, myelodysplastic syndrome or CH that is ancestral to the AML, and independent or newly emerging

286 ggests the presence of an ancient mechanism, ancestral to the evolution of reptiles and mammals, that

287 delineate these modes of invasion by merging ancestral, topographic, and phenotypic information from

288 ot toxins, that likely evolved from a single ancestral toxin gene.

289 ndicative of laryngeal echolocation being an ancestral trait in this clade.

290 ty to human ACE2 receptors, appears to be an ancestral trait shared with bat viruses and not one acqu

291 we have named A, B, and C, with A being the ancestral type according to the bat outgroup coronavirus

292 ervation that reversed evolution back to the ancestral type is difficult.

293 specific major perfume compound, whereas the ancestral variant in E. viridissima is broadly tuned to

294 introgression reintroduced thousands of lost ancestral variants with gene regulatory activity and tha

295 Yet few studies have directly assessed ancestral variation in plasticity and tracked phenotypic

296 monomorphic species, we then investigate how ancestral variation, hybridization, and independent evol

297 Our findings suggest a hypothesis for ancestral vertebrate trunk myogenic patterning and how i

298 ike (S) protein variant D614G supplanted the ancestral virus worldwide, reaching near fixation in a m

299 neutralization properties, compared with the ancestral wild-type virus.

300 gene yellow, the novel spot enhancer and the ancestral wing blade enhancer.