ライフサイエンスコーパス: anesthetic

1 arlson comorbidity index, and treatment with anesthetics).

2 ration of paravertebral musculature with the anesthetic.

3 ears after it was approved as an intravenous anesthetic.

4 ess despite continuous exposure to a general anesthetic.

5 the greater and lesser occipital nerves with anesthetics.

6 side effects associated with conventional IV anesthetics.

7 s system function and the actions of general anesthetics.

8 e fifth transmembrane domain (S5) in sensing anesthetics.

9 animals resistant to systemically delivered anesthetics.

10 at potentiates the effect of delivered local anesthetics.

11 thal genetic condition triggered by volatile anesthetics.

12 re used in the residual determination of the anesthetic 2-phenoxyethanol in fish fillets, to ensure f

13 s targets and putative mechanisms of general anesthetics across biology and identify key substrates t

14 e review the behavioral endpoints of general anesthetics across species and propose the isolation of

15 An alternative hypothesis proposes that anesthetics act on one or more brainstem or diencephalic

16 th lipid- and protein-mediated mechanisms of anesthetic action are scrutinized, focusing on the behav

17 describe a robust larval zebrafish model of anesthetic action, from sedation to general anesthesia.

18 own as the unitary lipid-based hypothesis of anesthetic action, has been challenged by evidence for d

19 that the modulated receptor theory of local anesthetic action, which confines local anesthetic bindi

20 A new study shows that anesthetics activate an endogenous analgesia neural ense

21 Here we exploit the observation that pungent anesthetics activate mammalian but not Drosophila TRPA1.

22 These noxious anesthetics activate transient receptor potential ankyri

23 In vivo experiments also demonstrate overt anesthetic activity in both tadpoles and rats with a pot

24 e recent fall history) to receive EEG-guided anesthetic administration (n = 614) or usual anesthetic

25 nding does not support the use of EEG-guided anesthetic administration for this indication.

26 adults undergoing major surgery, EEG-guided anesthetic administration, compared with usual care, did

27 and calcium imaging at one minute after the anesthetic administration.

28 mice, which was about two minutes after the anesthetic administration.

29 re complications after subconjunctival local anesthetics administration.

30 usceptibility mutations triggered by gaseous anesthetic, affecting both central and peripheral advers

31 s of initiating brexanolone infusion without anesthetic agent reinstatement in the following 24 hours

32 lness, escalating and constant levels of two anesthetic agents (experiment 1, n = 39), and during sle

33 ciousness level, consistent across different anesthetic agents and sleep.

34 ystem development and are being developed as anesthetic agents and treatments for psychiatric disease

35 Epidemiological studies suggest exposures to anesthetic agents and/or sedative drugs (AASDs) in child

36 Intravenous anesthetic agents are associated with cardiovascular ins

37 Furthermore, because anesthetic agents have the unique ability to reversibly

38 channels, which are putative targets for the anesthetic agents, as well as advancements in high-perfo

39 ian TRPA1 residues into dTRPA1 recapitulates anesthetic agonism.

40 For example, the local anesthetics ambroxol and lidocaine block both Na(V)1.7 a

41 We also examine recent studies of local anesthetic and antiepileptic drug binding to a sodium ch

42 nylphenyl) barbituric acid (R-mTFD-MPAB), an anesthetic and GABAAR potentiator, has been shown to inh

43 n hypothesis, or why the lipophilicity of an anesthetic and its potency are generally proportional.

44 lopregnanolone (F(4)N(3)Bzoxy-AP), a general anesthetic and photoreactive allopregnanolone analog tha

45 neuroactive steroids, and various GABAergic anesthetic and sedative drugs.

46 endent manner, which were abolished by local anesthetic and selective A-fiber blockade.

47 nostic related groups codes, blood pressure, anesthetics and narcotics administered, surgical and ane

48 a broad range of chemically diverse general anesthetics and related nonanesthetics on lipid bilayer

49 Our structural analysis using photoactivable anesthetics and rigid docking simulation showed that iso

50 other relevant channels sensitive to general anesthetics and, as shown here, to barbiturates, at clin

51 swab compression, 27% used a subconjunctival anesthetic, and 31% used an anesthetic gel.

52 -azipropofol activates TRPA1 like the parent anesthetic, and identify two photolabeled residues (V954

53 d for medical purposes, most typically as an anesthetic, and recent studies support its use in the tr

54 a group of gases including anesthetics, non-anesthetics, and anesthetic/convulsants on tubulin dynam

55 erse group of 3alpha-OH steroids that act as anesthetics, anti-epileptics, and anti-depressants.

56 terial hypertension) and is an off target of anesthetics, antiparkinsonian drugs, and selective serot

57 f GABA(A) receptors (GABA(A)Rs) with in vivo anesthetic, anxiolytic, and anti-convulsant effects.

58 ient's anxiety to the point that intravenous anesthetic/anxiolytic medications were discontinued and

59 Although anesthetics appear to activate microglia, the increased

60 Inhaled anesthetics are a chemically diverse collection of hydro

61 Propofol, etomidate, and barbiturate anesthetics are allosteric coagonists at pentameric alph

62 General anesthetics are both neuroprotective and neurotoxic with

63 Inhalational anesthetics are bronchodilators with immunomodulatory ef

64 been no empirical demonstration that general anesthetics are capable of functional quantum interactio

65 Anesthetics are generally associated with sedation, but

66 The sums of the anesthetic-associated Deltalog(d) values for sets of M2-

67 val zebrafish respond to inhalational and IV anesthetics at concentrations similar to mammals.

68 he potential binding mode of noxious general anesthetics at TRPA1.

69 se range of noxious and non-noxious volatile anesthetics, at clinically relevant concentrations, inhi

70 ic ligand-gated ion channels, the details of anesthetic binding and channel modulation are still deba

71 Val-136 and adjacent residues may mediate anesthetic binding and stabilize an open state regulated

72 because the mutations impaired both abutting anesthetic binding effects and positive cooperativity be

73 ocal anesthetic action, which confines local anesthetic binding effects to the channel pore, should b

74 lations presented herein demonstrate a novel anesthetic binding site in GLIC that is accessed through

75 harmacologically distinct classes of general anesthetic binding sites in the alpha1beta3gamma2 GABA(A

76 resent a computational study identifying two anesthetic binding sites in the transmembrane domain of

77 fication through structural determination of anesthetic binding sites, details of receptors and ion c

78 g effects and positive cooperativity between anesthetic binding sites.

79 n TREK1 TM2, TM3, and TM4 that contribute to anesthetic binding.

80 genized the residue Val-136, which lines the anesthetic-binding cavity, its flanking residues (132 to

81 ed anesthetics through binding at a putative anesthetic-binding cavity.

82 Fentanyl is well characterized as an anesthetic, but the basic physiological effects of fenta

83 This is the first illustration that anesthetics can affect the binding of nucleic acids to t

84 generally associated with sedation, but some anesthetics can also increase brain and motor activity-a

85 e lines of evidence demonstrate that general anesthetics can co-opt the neural circuits regulating ar

86 first experimental evidence that halogenated anesthetics can directly undergo quantum interaction mec

87 future studies to further determine whether anesthetics can induce behavioral hyperactivity via incr

88 es indicate that early postnatal exposure to anesthetics can lead to lasting deficits in learning and

89 Postconditioning with inhalational anesthetics can reduce ischemia-reperfusion brain injury

90 anesthetic administration (n = 614) or usual anesthetic care (n = 618).

91 g contractions, bladder pressure slopes) and anesthetic (change in heart rate [DeltaHR], average hear

92 Here we show that inhaled anesthetics (chloroform and isoflurane) activate TREK-1

93 e, and geographic location did not influence anesthetic choice for IVI.

94 these findings suggest the possibility that anesthetic choice may modulate the outcome in patients o

95 s will facilitate appropriate study-specific anesthetic choices.

96 en considerable focus on the hypothesis that anesthetics co-opt the neural mechanisms regulating slee

97 nding of the mechanisms of action of general anesthetics, coincident with progress in structural biol

98 Median end-tidal volatile anesthetic concentration was significantly lower in the

99 Intraoperative measures included anesthetic concentration, EEG suppression, and hypotensi

100 ut changes spontaneously at a fixed level of anesthetic concentration.

101 ombines wakefulness with clinically relevant anesthetic concentrations in the brain.

102 Anesthetic concentrations in the membrane are high (10-1

103 ry (derived from mean end-tidal inhalational anesthetic concentrations).

104 were treated with volatile sedation using an anesthetic conserving device and isoflurane, and 322 rec

105 hypercapnia occurred more frequently during anesthetic conserving device use (6.4% vs 0%; p = 0.021)

106 ng of PaCO2 is necessary during sedation via anesthetic conserving device.

107 including anesthetics, non-anesthetics, and anesthetic/convulsants on tubulin dynamics.

108 al vision and visual movements but bilateral anesthetic corneas.

109 provide a survey of the effects of different anesthetics, demonstrating that short exposure to diethy

110 e anesthetic sevoflurane is a common general anesthetic derived from ether as a prototype.

111 ats (n = 7) during stepwise reduction of the anesthetic desflurane (6%, 4%, 2%, and 0%).

112 We previously reported that volatile anesthetics directly bound to TLR2 and TLR4 and attenuat

113 High inhalational anesthetic dose of 1.20 (1.13-1.30) (median [interquarti

114 Converging evidence suggests a single sub-anesthetic dose of the N-methyl-D-aspartate receptor ant

115 ught to determine the effect of inhalational anesthetic dose on risk of severe postoperative respirat

116 Additionally, high inhalational anesthetic dose was associated with lower 30-day mortali

117 dings challenge the assumption of monotonic, anesthetic dose-dependent behavior of cortical neuron po

118 Intraoperative use of higher inhalational anesthetic doses is strongly associated with lower odds

119 ty of psychiatric disorders when used at sub-anesthetic doses, but the neural mechanisms underlying i

120 e 3 [interquartile range, 2-4]), 24 received anesthetic drug infusions for seizure control.

121 cular mechanisms of antiarrhythmic and local anesthetic drug interactions with hNa(V)1.5 and will be

122 the deactivation of NsVBa, whereas the local anesthetic drug lidocaine was shown to antagonize NsVBa

123 ions (10-15 Hz) induced by the commonly used anesthetic drug propofol are synchronized between the th

124 support for the antidepressant effect of an anesthetic drug, ketamine, by Inverse-Frequency Analysis

125 results of preclinical studies suggest that anesthetic drugs administered to neonatal animals cause

126 oss and return of consciousness regulated by anesthetic drugs and physiological sleep are used as mod

127 ousness remains unclear, and whether diverse anesthetic drugs and sleep share a common neural pathway

128 oundational implications for biology because anesthetic drugs are effective in organisms ranging from

129 Knowing that anesthetic drugs can pose immunomodulatory effects, it w

130 ures (p = 0.0077), and in those who required anesthetic drugs for seizure control (p = 0.0035).

131 fractoriness, use of mechanical ventilation, anesthetic drugs for seizure control, and medical compli

132 tal and 90-day mortality, whereas the use of anesthetic drugs for seizure control, mechanical ventila

133 ugh the rho1 receptor is insensitive to many anesthetic drugs that modulate the heteromeric GABA(A) r

134 the interactions of antiarrhythmic and local anesthetic drugs with hNa(V)1.5.

135 (A) receptors as the primary targets of most anesthetic drugs, but how these compounds produce parado

136 is were used to determine whether the use of anesthetic drugs, mechanical ventilation, Status Epilept

137 Use of anesthetic drugs, medical complications, and mechanical

138 an effective dose equivalent of inhalational anesthetics during surgery (derived from mean end-tidal

139 General anesthetics during surgery are presumed to block pain by

140 e intensity and duration of irradiation, the anesthetic effect can be modulated.

141 The macromolecular prodrug has no anesthetic effect itself unless irradiated with a low-po

142 These results suggest that (1) anesthetic effect on spike rate is distinct from sleep,

143 generally presumed monotonic, dose-dependent anesthetic effect on the brain.SIGNIFICANCE STATEMENT Re

144 an intravenous anesthetic that produces its anesthetic effect, largely via the GABAA receptor in the

145 henotype has been shown connecting PLD to an anesthetic effect.

146 lly relevant concentrations, indicating that anesthetic effects on ion channel function are not bilay

147 d the critical roles of neuronal networks in anesthetic effects on memory and consciousness.

148 mption of ethanol, mechanisms underlying its anesthetic effects remain uncertain.

149 conscious) or drug-related (anesthetic vs no anesthetic) effects.

150 type A receptor (GABA(A)R) could have potent anesthetic efficacy with limited cardiovascular effects.

151 Unlike the clinically approved GABAergic anesthetic etomidate, the chemical structure of our N-ar

152 activation was not attenuated by intravenous anesthetics, except for a high concentration of propofol

153 ane, desflurane) and i.v. (propofol) general anesthetics excite peripheral sensory nerves to cause pa

154 cted states of consciousness during constant anesthetic exposure revealed that activity of the thalam

155 which are thus vulnerable to perturbation by anesthetic exposure.

156 , minimal alveolar concentration of volatile anesthetic, fatigue, active time, and respiratory functi

157 %) underwent a procedure while under general anesthetic for diagnostic purposes.

158 ice setting did not seem to impact choice of anesthetic for IVI significantly.

159 ane site (TM2) that inhibits dissociation of anesthetic from the TM1 site and is consistent with the

160 to network function and suggest that general anesthetics - from single cells to complex brains - crea

161 Lengthy use of general anesthetics (GAs) causes neurobehavioral deficits in the

162 General anesthetics (GAs) exert their effects through endogenous

163 Several general anesthetics (GAs) produce pain or irritation upon admini

164 nts as a hypermetabolic response to volatile anesthetic gases, where susceptible persons may develop

165 subconjunctival anesthetic, and 31% used an anesthetic gel.

166 C) and 1% preservative-free lidocaine (as an anesthetic) has gained popularity for its use in trabecu

167 lthough immunomodulatory effects of volatile anesthetics have been growingly appreciated, the molecul

168 We conclude that general anesthetics have minimal effects on bilayer properties a

169 but causal investigations of potent inhaled anesthetics have not been conducted.

170 modulators such as barbiturates and steroid anesthetics have provided insight into the modes of acti

171 General anesthetics have revolutionized medicine by facilitating

172 tracameral combination of 2 mydriatics and 1 anesthetic (ICMA, Mydrane) for cataract surgery in patie

173 ocols to regulatory the use of menthol as an anesthetic in aquaculture.

174 tion-based and individual-based responses to anesthetics in mice and zebrafish.

175 Despite the common use of sedatives and anesthetics in the acute phase of TBI management, their

176 Local anesthetics in the form of creams, gels and sprays have

177 How the brain dynamics change during anesthetic-induced altered states of consciousness is no

178 ately involved in modulating spontaneous and anesthetic-induced changes in arousal.

179 A recent hypothesis proposes that anesthetic-induced changes in ion channel function resul

180 to derive log(d) parameters proportional to anesthetic-induced channel modulating energies (where d

181 amining the response of these neurons during anesthetic-induced loss of consciousness.

182 d the understanding of the neuronal basis of anesthetic-induced state of unconsciousness.

183 us functional recovery is possible following anesthetic-induced unconsciousness and the intermediate

184 espite decades of research, the mechanism of anesthetic-induced unconsciousness remains incompletely

185 fragmented spiking pattern is a signature of anesthetic-induced unconsciousness, and (3) the paradoxi

186 , 38%, 34%, respectively, in anticipation of anesthetic induction (Figure; p<0.05).

187 rgic or glutamatergic neurons does not alter anesthetic induction or recovery time.

188 0 seconds before, during, and after a common anesthetic induction procedure (cage squeeze followed by

189 below baseline levels within 1 minute after anesthetic induction.

190 = 167) or placebo (n = 168) initiated after anesthetic induction.

191 ow that both noxious and non-noxious general anesthetics inhibit agonist-evoked transient receptor po

192 We conclude that anesthetics inhibit TRPA1 by interacting at a site disti

193 these residues into Drosophila TRPA1 confers anesthetic inhibition.

194 annel sensitive, a channel that is otherwise anesthetic insensitive.

195 , has been challenged by evidence for direct anesthetic interactions with a range of proteins, includ

196 Some evidence for anesthetic interactions with the cytoskeleton exists, bu

197 ral pressure that arise from partitioning of anesthetics into the bilayer.

198 tigate the efficacy of intraperitoneal local anesthetic (IPLA) on pain after acute laparoscopic appen

199 c, with restoration occurring only after the anesthetic is discontinued.

200 Generally the protein target for anesthetics is assumed to be neuronal membrane receptors

201 The subconjunctival anesthesia with local anesthetics is considered as a low-risk procedure allowi

202 preferential interactions given by volatile anesthetics is quite poor.

203 Ketamine, a dissociative anesthetic, is experiencing a clinical resurgence as a f

204 In septic mice, the commonly used volatile anesthetic isoflurane attenuated the production of 5-lip

205 Different from volatile anesthetic isoflurane, sevoflurane exposure significantl

206 Volatile anesthetics isoflurane and sevoflurane directly target a

207 Our reporter assay showed that volatile anesthetics isoflurane and sevoflurane increased the act

208 The binding sites of volatile anesthetics isoflurane and sevoflurane were located near

209 concentration-response of TASK-3 to several anesthetics (isoflurane, desflurane, sevoflurane, haloth

210 exposed mouse pups to a prototypical general anesthetic, isoflurane (ISO, 1.5% for 3 hr), at three ea

211 The general anesthetic ketamine has been repurposed by physicians as

212 omputational methods can be used to identify anesthetic lead compounds devoid of specific side effect

213 d a nonunitary relationship with the current anesthetic level.

214 urally related to the Na(+) channel-blocking anesthetic lidocaine, is used to treat LQT3 patients.

215 General anesthetics may control cell survival via their effects

216 Sevoflurane, a commonly used anesthetic, may cause agitation in patients.

217 gn safer ones, despite important advances in anesthetic mechanisms research.

218 hod was applied to residual determination of anesthetic menthol in fish.

219 Recent evidence suggests that anesthetics might cause persistent deficits in cognitive

220 on by aryl sulfonamides and by classic local anesthetics might show an interaction mediated by their

221 omparisons of distinct site contributions to anesthetic modulation because the mutations impaired bot

222 widely attributed to suppressive actions of anesthetic molecules distributed by the systemic circula

223 hesized that a new class of intravenous (IV) anesthetic molecules that is highly selective for the sl

224 rch into mechanisms of LOC and the design of anesthetic monitoring devices.

225 Because of their roles as general anesthetics, n-alcohols are perhaps the best-studied amp

226 tly known modulators of GABA function (e.g., anesthetics, neurosteroids or ethanol).

227 ugs of abuse (methamphetamine and fentanyl), anesthetics, neurotoxins, the pesticide paraquat, and he

228 ate the effect of a group of gases including anesthetics, non-anesthetics, and anesthetic/convulsants

229 the pharmacological effects of commonly used anesthetics nor with methadone, naloxone, oxycodone, or

230 All mutations reduced the log(d) values for anesthetics occupying both abutting and nonabutting pock

231 The effects of general anesthetics on apoptosis and autophagy are closely integ

232 l evidence informing the distinct effects of anesthetics on metastasis of breast cancers through chan

233 ould be critical to understand the impact of anesthetics on sepsis pathophysiology.

234 study sets the foundation for the effect of anesthetics on TLR9 and will pave the way for future stu

235 upon tissue injury, we examined the role of anesthetics on TLR9 function.

236 n these data that sedation with inhalational anesthetics outside of the operating room may likewise h

237 agent-specific differences in urodynamic and anesthetic parameters in cats will facilitate appropriat

238 The GABAergic anesthetics pentobarbital and propofol were also effecti

239 ns in a manner that is correlated with their anesthetic potency.

240 We injected the local anesthetic procaine [15, 17, 18] into the mushroom body

241 All currently available general anesthetics produce potentially deadly side effects.

242 Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuat

243 The anesthetic propofol elicits many different spectral prop

244 The intravenous anesthetic propofol is a full agonist (maximal P(Open,pe

245 activated and potentiated by the intravenous anesthetic propofol.

246 Furthermore, the results indicate that the anesthetics propofol and pentobarbital interact with par

247 asal activity with the allosterically acting anesthetics propofol, pentobarbital, or alfaxalone.

248 e cortex, and postconditioning with volatile anesthetics provides neuroprotective actions that depend

249 s consistent with the high concentrations of anesthetics required to achieve clinical effects.

250 wild type)] for M2-15' mutations abutting an anesthetic's biochemically established binding sites wer

251 on method that permitted localization of the anesthetic-sensitive neurons with much improved spatial

252 Individual differences in anesthetic sensitivity and stochastic fluctuations in re

253 hesia and suggest PA helps set thresholds of anesthetic sensitivity in vivo.

254 udy investigated whether PreCon with inhaled anesthetic sevoflurane (SF-PreCon) remains cardioprotect

255 The volatile anesthetic sevoflurane is a common general anesthetic de

256 The volatile anesthetic sevoflurane reduces neutrophil apoptosis via

257 al differentiation and its interactions with anesthetic sevoflurane, miRNA and GSK-3beta.

258 ite continuous administration of the general anesthetic sevoflurane.

259 Interestingly, we show that anesthetics share with the antagonist A-967079 a potenti

260 dulating energies (where d is the allosteric anesthetic shift factor).

261 ant Deltalog(d) values qualitatively reflect anesthetic site occupancy patterns.

262 drugs that bind selectively to intersubunit anesthetic sites.

263 Unlike cationic derivatives of local anesthetic sodium channel blockers like QX-314, this cat

264 y in diverse physiological functions such as anesthetic sparing, and working memory enhancement.

265 ep and wakefulness actually do influence the anesthetic state in vivo.

266 wakefulness does not substantively influence anesthetic state transitions.

267 The anesthetic state was assessed by quantifying responses t

268 e complete mechanistic underpinnings for the anesthetic state.

269 Unresponsive anesthetic states and verified sleep stages, where a sub

270 General anesthetics, such as chloroform, isoflurane, diethyl eth

271 General anesthetics suppress CNS activity by modulating the func

272 lecular motors have received no attention as anesthetic targets.

273 cular prodrug (P407-CM-T) in which the local anesthetic tetracaine (T) is attached to the polymer pol

274 recover more slowly from certain injectable anesthetics than other dog breeds.

275 Dexmedetomidine is an anesthetic that alters the level of arousal by selective

276 mal bupivacaine is a novel extended-duration anesthetic that has recently been used for local infiltr

277 Propofol is an intravenous anesthetic that produces its anesthetic effect, largely

278 An on-demand anesthetic that would only take effect when needed and w

279 ., anxiolytics, anticonvulsants, and general anesthetics) that act as positive allosteric modulators

280 ion of brexanolone response during and after anesthetic third-line agent (TLA) weaning.

281 channel function is activated by halogenated anesthetics through binding at a putative anesthetic-bin

282 Preoperative anesthetic time was shorter in the AWC-PCA group, 49 min

283 ropofol is the most widely used i.v. general anesthetic to induce and maintain anesthesia.

284 Finally, asymmetric binding patterns of anesthetic to the channel were found to promote an iris-

285 complicate the ability to appropriately dose anesthetics to each individual.

286 Even with co-administration of local anesthetics, traditional injection still causes pain to

287 tinues or recurs despite 24 hours or more of anesthetic treatment.

288 Catalytically dead PLD2 robustly blocks anesthetic TREK-1 currents in whole-cell patch-clamp rec

289 First, the effect of lidocaine, a local anesthetic used for human skin biopsy, on B. burgdorferi

290 ed question of interest focused on choice of anesthetic used for IVI.

291 The role of anesthetics used during surgery in cancer metastasis and

292 annels are known to be modulated by volatile anesthetic (VA) drugs and play important roles in clinic

293 (conscious vs unconscious) or drug-related (anesthetic vs no anesthetic) effects.

294 The anesthetic was immediately reversed with atipamezole, an

295 amics and the top task performance while the anesthetic was still being infused.

296 For 100 y, anesthetics were speculated to target cellular membranes

297 fects of isoflurane, a commonly-used general anesthetic, which was delivered to newborn rabbits.

298 Fentanyl is an anesthetic with a high bioavailability and is the leadin

299 For anesthesia, 14% used a topical anesthetic with cotton swab compression, 27% used a subc

300 and scientific interest in developing local anesthetics with prolonged durations of effect from sing

301 cally induced wakefulness in the presence of anesthetic, with restoration occurring only after the an