ライフサイエンスコーパス: angiogenic activity

1 ADAMTS-1 is also known to exhibit anti-angiogenic activity.

2 n of the signaling mechanisms underlying its angiogenic activity.

3 n of the signaling mechanisms underlying its angiogenic activity.

4 l-tRNA synthetase (T2-TrpRS) has potent anti-angiogenic activity.

5 thymosin beta4 is an essential site for its angiogenic activity.

6 pondin type-1 repeats which can exhibit anti-angiogenic activity.

7 motif of thymosin beta4 is essential for its angiogenic activity.

8 pear to be significantly contributing to the angiogenic activity.

9 ould reverse the aging-associated decline in angiogenic activity.

10 umulation of VEGF mRNA and hypoxia-dependent angiogenic activity.

11 ) and its deletion mutant tum-5 possess anti-angiogenic activity.

12 e increased expression of macrophage-derived angiogenic activity.

13 collagen) was identified as possessing anti-angiogenic activity.

14 s and has previously been shown to stimulate angiogenic activity.

15 ntify peptide sequence(s) which possess anti-angiogenic activity.

16 thrombospondin 1 expression, and suppressed angiogenic activity.

17 JRA synovium is characterized by high angiogenic activity.

18 es within the peptide did not alter the anti-angiogenic activity.

19 lecules have been identified to possess anti-angiogenic activity.

20 ell proliferation but necessary for the anti-angiogenic activity.

21 d neurotoxin and onconase, all of which lack angiogenic activity.

22 membrane assay, it was found to have potent angiogenic activity.

23 and in vivo assays revealed that leptin has angiogenic activity.

24 icrovascular endothelial cell hemostatic and angiogenic activity.

25 ition of both tumor cell growth and secreted angiogenic activity.

26 es in secreted protein levels and in overall angiogenic activity.

27 specimens resulted in enhanced tumor-derived angiogenic activity.

28 is, whereas TNF-alpha has both pro- and anti-angiogenic activity.

29 an endothelial-specific mitogen with potent angiogenic activity.

30 ine in tumor-associated vascular density and angiogenic activity.

31 glycoprotein known for its proapoptotic and angiogenic activity.

32 hausted T-cells, in addition to high stromal angiogenic activity.

33 outstanding importance to control their pro-angiogenic activity.

34 agonism/antagonism of GPCR ligands, and anti-angiogenic activity.

35 of full-length tissue factor, which exhibits angiogenic activity.

36 as histamine and serotonin, might also have angiogenic activity.

37 to produce numerous isoforms that differ in angiogenic activity.

38 Ferritin binds to HKa and blocks its anti-angiogenic activity.

39 g that anti-CLEC14A antibodies may have anti-angiogenic activity.

40 nesis in the endometrium, likely by reducing angiogenic activity.

41 lood vessels, consistent with its known anti-angiogenic activity.

42 CD34(+) cell-depleted mononuclear cells had angiogenic activity.

43 genitor cells, have been reported to possess angiogenic activity.

44 wth factor, resulting in increased paracrine angiogenic activity.

45 D5) both have been shown to have potent anti-angiogenic activity.

46 ogenesis assay, sorafenib showed potent anti-angiogenic activity.

47 antiapoptotic effect while lacking a general angiogenic activity.

48 ells does not impede their elevated in vitro angiogenic activity.

49 e Stat3 inhibitor, on IFNalpha-mediated anti-angiogenic activity.

50 might quantitatively reflect tumor mass and angiogenic activity.

51 g resulted in decreased VEGF-A synthesis and angiogenic activity.

52 as been shown to have both antimicrobial and angiogenic activities.

53 has potent, HIF-1-independent oncogenic and angiogenic activities.

54 elopment, as well as harboring pro- and anti-angiogenic activities.

55 t of activated macrophages that has indirect angiogenic activities.

56 equirements of CYR61 with respect to its pro-angiogenic activities.

57 Y2 receptor (Y2R)-mediated proliferative and angiogenic activities.

58 ommunication and vascular endothelial cells' angiogenic activities.

59 -EGF including cancer cell proliferation and angiogenic activities.

60 e arrest and with both proapoptotic and anti-angiogenic activities.

61 teinase inhibitor with anti-inflammatory and angiogenic activities.

62 er T cell (TH1) immune stimulation, and anti-angiogenic activities.

63 ed to be the receptor that mediates its anti-angiogenic activities.

64 ity (mean decrease 76 +/- 13%, P < 0.01) and angiogenic activity (5 of 5 samples affected) of later w

65 These findings provide novel insights into angiogenic activities and molecular mechanisms of YKL-40

66 thalidomide or ATN-161 significantly reduced angiogenic activity and associated tissue histopathology

67 down miR-126-3p from CD34Exo abolished their angiogenic activity and beneficial function both in vitr

68 ound macrophages was paralleled by decreased angiogenic activity and collagen synthesis.

69 ntegrin) results in diminished expression of angiogenic activity and CXC chemokines compared with con

70 kine (or platelet factor 4) with potent anti-angiogenic activity and differed only in three amino aci

71 eavage of CgA by thrombin abrogated its anti-angiogenic activity and generated fragments (lacking the

72 which can regulate prostate cancer growth by angiogenic activity and growth-promoting effects.

73 d pair in lung cancer is associated with the angiogenic activity and level of CXC chemokine expressio

74 inhibition of tumor growth, tumor-associated angiogenic activity and neovascularization, and spontane

75 rowth factor-A expression and enhances their angiogenic activity and reduces cardiomyocytes and endot

76 into core/shell nanodrugs with combined anti-angiogenic activity and significantly reduced anticoagul

77 rPAI-1(23), that possesses significant anti-angiogenic activity and stimulates high levels of apopto

78 ProAgio also has anti-angiogenic activity and strongly inhibits growth of tumo

79 portion of nonsmall cell lung cancer-derived angiogenic activity and support tumorigenesis.

80 ical to Ang in this segment still lacks both angiogenic activity and the capacity to inhibit Ang.

81 VEGF was initially discovered due to its angiogenic activity and therefore named "vascular endoth

82 dium nitrite therapy can selectively augment angiogenic activity and tissue perfusion in the murine h

83 ctly upon endothelial cells to stimulate pro-angiogenic activities, and induces angiogenesis in vivo.

84 rowth factor (VEGF), characterization of its angiogenic activity, and demonstration that its expressi

85 oliferative chemotactic properties and their angiogenic activity, and suggest a physiological role fo

86 is a major contributor to macrophage-derived angiogenic activity, and that activation by hypoxia, lac

87 mechanisms of cellular immortalization; (6) angiogenic activity; and (7) the ability to invade surro

88 Thus, besides its angiogenic activity, angiogenin also plays a role in can

89 models, but the molecular basis of their pro-angiogenic activity are largely unknown.

90 The consequences of modulation of angiogenic activity are therefore context dependent.

91 e cellular mechanisms underlying 12(R)-HETrE angiogenic activity are unexplored.

92 to Ang and inhibits its ribonucleolytic and angiogenic activities as potently as mAb 26-2F.

93 This imbalance correlated with angiogenic activity as assessed by the corneal micropock

94 tent effector of fluid volume regulation and angiogenic activity, as a novel placental target of PCBs

95 tein is functionally important in tumor cell angiogenic activity, as demonstrated by the reduction of

96 These results suggest that the angiogenic activity attributed to VEGF may be due in par

97 is 28.9-kDa protein may be the source of the angiogenic activity because it is the predominant protei

98 cular function and circulating biomarkers of angiogenic activity before and after the onset of preecl

99 Moreover, differences in the pro-angiogenic activity between blood circulating and tumor

100 odular secreted glycoprotein, possesses anti-angiogenic activity both in vitro and in vivo.

101 cells secrete exosomes that have independent angiogenic activity both in vitro and in vivo.

102 lling endothelial inflammatory responses and angiogenic activities by retaining expression of TNFR-1

103 rgillus fumigatus that is known for its anti-angiogenic activity by binding to human methionine amino

104 minoguanidine (1 mmol/L) block production of angiogenic activity by MPMs and RAW cells.

105 ning 28 bridges endothelial inflammation and angiogenic activity by retaining expression of TNFR1 and

106 ng and angiogenic factor, exerts much of its angiogenic activity by up-regulating expression of TR3/N

107 rt here that human VEGF-A exerts much of its angiogenic activity by up-regulating the expression of T

108 fibronectin were the most potent inducers of angiogenic activity compared with tissue culture plastic

109 y study showed increased uptake in AVMs with angiogenic activity, compared with surrounding tissue wi

110 ite-dependent ischemic tissue blood flow and angiogenic activity consistent with nitrite reduction to

111 Serum markers of angiogenic activity did not provide insight into rh-Endo

112 ve thinned skull windows to study a burst of angiogenic activity during cerebrovascular development i

113 t IL-8 plays a significant role in mediating angiogenic activity during tumorigenesis of human NSCLC,

114 fect the in vitro chemotactic or the in vivo angiogenic activity early wound samples (POD 0).

115 Finally, K5-N,OS(H) hampers the angiogenic activity exerted in vitro and in vivo by huma

116 erved in K40Q, establishing that the loss of angiogenic activity for this derivative is directly attr

117 hemotactic activity of endothelial cells and angiogenic activity found in RA synovial tissue homogena

118 and ENA-78 are important contributors to the angiogenic activity found in the inflamed RA joint.

119 ) integrin, promotes CXC chemokine-dependent angiogenic activity from monocytes.

120 Moreover, Tat21-40 possesses potent angiogenic activity, further underscoring its role in HI

121 ased angiogenesis, the mechanism of the anti-angiogenic activity has not been determined.

122 eptor through which T2-TrpRS exerts its anti-angiogenic activity has not previously been identified.

123 tively significant antiangiogenic and slight angiogenic activities in a microvascular sprouting assay

124 through integrin alphavbeta3 to promote pro-angiogenic activities in activated endothelial cells.

125 tumor promoter induced higher mitogenic and angiogenic activities in Ikkalpha+/- than in Ikkalpha+/+

126 and secreted EVs had hypoxia-protective, pro-angiogenic activities in in vitro assays.

127 ta3 and impaired in alphavbeta3-mediated pro-angiogenic activities in vascular endothelial cells, inc

128 lity of MC(TC)LUVA to alter endothelial cell angiogenic activities in vitro and ex vivo.

129 Flt-1 and KDR ribozymes also exhibited anti-angiogenic activity in a rat corneal pocket assay of VEG

130 e show that irradiation induces survival and angiogenic activity in a subset of radioresistant lung c

131 ar endothelial growth factor (VEGF) mediates angiogenic activity in a variety of estrogen target tiss

132 ibute to tumor progression through their pro-angiogenic activity in addition to immunosuppressive fun

133 rmine whether IL-8 plays a role in mediating angiogenic activity in atherosclerosis.

134 ed MR imaging may prove useful in estimating angiogenic activity in carcinomas.

135 uggest that GPR35 suppresses OXSR1-dependent angiogenic activity in ECs, contributing to poor angioge

136 ctivity, as demonstrated by the reduction of angiogenic activity in fibrosarcoma cell culture medium

137 llular matrix, are important determinants of angiogenic activity in health and disease.

138 n important additional factor that regulates angiogenic activity in IPF.

139 nd IP-10 are important factors that regulate angiogenic activity in IPF.

140 rom six RA SFs significantly inhibited their angiogenic activity in Matrigel plug assays (P < 0.05).

141 ly involved in the microenvironment and anti-angiogenic activity in NPC development.

142 Furthermore, angiogenic activity in PC-3 tumor homogenates was attrib

143 ore, sorafenib has a strong antitumoral and -angiogenic activity in the 5T33MM mouse model leading to

144 (designated EDM-TTF-1(+)) displayed an anti-angiogenic activity in the endothelial cell tube formati

145 The angiogenic activity in the lung was significantly decrea

146 owered hypoxia-sensitive gene expression and angiogenic activity in the MHC-II(lo) TAM subset.

147 activity for endothelial cells in vitro and angiogenic activity in the rat cornea in vivo than did n

148 nic activity in the epidermis, and decreased angiogenic activity in the skin stroma.

149 inhibited vessel development and suppressed angiogenic activity in transgenic zebrafish models.

150 reduced tumor growth in vivo and reduced the angiogenic activity in tumor homogenates.

151 IL-8-neutralizing antibodies attenuate their angiogenic activity in vitro and in vivo.

152 s and endothelial cells, displayed increased angiogenic activity in vitro, and enhanced the formation

153 regulated VEGF mRNA expression and decreased angiogenic activity in vitro.

154 GF mRNA expression and resulted in increased angiogenic activity in vitro.

155 er, and demonstrated the positive effects of angiogenic activity in vivo as well as in vitro.

156 TPO also had an angiogenic activity in vivo in the chorioallantoic membr

157 To reflect angiogenic activity in vivo, we selected a model using w

158 members have been shown to have potent anti-angiogenic activity in vivo.

159 Macrophages are an important source of angiogenic activity in wound healing, cancer, and chroni

160 Angiogenic activity increased again upon transformation

161 and H2 fully retain alphavbeta3-mediated pro-angiogenic activities, indicating that these mutants are

162 The sustained, pro-angiogenic activities induced by eVEGF-38 and eVEGF-53 s

163 in vivo was also demonstrated by the lack of angiogenic activity induced by ELR(+) CXC chemokines in

164 The rPAI-1(23) anti-angiogenic activity inhibits FGF2 pro-angiogenic functio

165 It is suggested that 12(R)-HETrE's angiogenic activity involves the activation of NF-kappaB

166 al in cell adhesion, and therefore, the anti-angiogenic activity is attributed exclusively to alpha(v

167 tor A (VEGF-A) is present in the cornea, its angiogenic activity is impeded by being bound to a solub

168 Anti-angiogenic activity is induced in the tumor cells by low

169 Lack of angiogenic activity is not due to an antiangiogenic fact

170 of VEGF-B on injured nerves and its lack of angiogenic activity makes VEGF-B a suitable therapeutic

171 ies, respectively) and demonstrated a marked angiogenic activity measured as the total length of spro

172 When tested on other angiogenic activities mediated by VEGF, survivin antisen

173 poxia and may act to inhibit hypoxia-induced angiogenic activity mediated by vascular endothelial gro

174 Both the chemotactic and angiogenic activities of CYR61 can be blocked by specifi

175 ese integrins differentially mediate the pro-angiogenic activities of CYR61.

176 ability of the endothelium; we elucidate the angiogenic activities of the endothelia and differential

177 clusters that reflected the tumorigenic and angiogenic activities of the respective TMEs.

178 lear translocation of angiogenin abolish the angiogenic activities of these factors.

179 ly inhibited the vascular permeabilizing and angiogenic activities of VPF/VEGF.

180 nd that VEGF mediates, at least in part, the angiogenic activity of 12(R)-HETrE.

181 The anti-angiogenic activity of A-LHU was investigated both in vi

182 se findings provide a mechanism for the anti-angiogenic activity of ADAMTS1 and describe a novel modu

183 kringle conformation in maintaining the anti-angiogenic activity of angiostatin.

184 Paracrine angiogenic activity of APCs from IRKO mice was impaired

185 Additionally, we show that the anti-angiogenic activity of arresten is potentially mediated

186 Our results showed that the angiogenic activity of asTF is mediated via hypoxia-indu

187 ng led to a significant reduction in the pro-angiogenic activity of beta-catenin.

188 y, demonstrating that IL-6 supports the anti-angiogenic activity of Bev by suppressing Ang1 expressio

189 ambled sequence, C16S, which antagonizes the angiogenic activity of bFGF and of C16 by binding to the

190 The low angiogenic activity of CD271+ MSCs and improved early st

191 In vitro, CD34(+) exosomes replicated the angiogenic activity of CD34(+) cells by increasing endot

192 rnative helix conformation enhances the anti-angiogenic activity of CXCL4L1 by reducing the glycosami

193 Neutralizing anti-MIP-2 Abs inhibited the angiogenic activity of day 16 bleomycin-treated lung spe

194 role of TRIM28 in inflammatory responses and angiogenic activity of ECs for the first time.

195 s support the notion that CXCR2 mediates the angiogenic activity of ELR(+) CXC chemokines in a precli

196 , possibly because of the stimulation of the angiogenic activity of endothelial cells.

197 d miR-486-5p or silenced MMP19 increased the angiogenic activity of endothelial cells; however, mediu

198 We recently reported impaired angiogenic activity of endothelial colony-forming cells

199 We propose that ferritin blocks the anti-angiogenic activity of HKa by reducing binding of HKa to

200 ly mediated by blunted expression as well as angiogenic activity of inflammatory cytokines.

201 trol, may represent a mechanism for the anti-angiogenic activity of K5.

202 demonstrates that VEGF is essential for the angiogenic activity of Lcn2.

203 The angiogenic activity of mini TyrRS can be opposed by anti

204 To investigate the in vivo angiogenic activity of placenta growth factor (PIGF) and

205 mechanistic basis for understanding the anti-angiogenic activity of semaphorin as well as the physica

206 s not affect tumor cell growth in vitro, the angiogenic activity of sICAM-1 produced by sense ICAM-1

207 The angiogenic activity of SMOC-2 was also examined in exper

208 show that in breast cancer patients the pro-angiogenic activity of TEM increased drastically from bl

209 tudy explores the fate of EETs with COX, the angiogenic activity of the primary metabolites formed, a

210 hesion in the human vasculature and the anti-angiogenic activity of the RGD-alpha3NC1 domain.

211 They decreased the angiogenic activity of the tumor cells, and they caused

212 in, a requirement not essential for the anti-angiogenic activity of this domain.

213 It also does not influence the angiogenic activity of this protein.

214 The anti-angiogenic activity of thrombospondin-1 and pigment epit

215 Our results support the angiogenic activity of TPO, and suggest that it may have

216 the present study, we confirm that the anti-angiogenic activity of tumstatin and tum-5 is independen

217 ely, these experiments suggest that the anti-angiogenic activity of tumstatin is localized to a 25-am

218 In the present study, the anti-angiogenic activity of tumstatin was localized to the pu

219 the main human receptor responsible for the angiogenic activity of VEGF.

220 ypothesis that inflammatory processes induce angiogenic activity possibly contributory to brain AVM i

221 In addition, angiogenic activity present in the conditioned media of

222 Angiogenic activity produced by hypoxia and lactate-trea

223 antibody, which also neutralizes most of the angiogenic activity produced by IFNgamma/LPS-activated M

224 This angiogenic activity represented endothelial cell sprouti

225 ed chemical carcinogen-induced mitogenic and angiogenic activities, repressing tumor progression and

226 fy angiogenin (ANG), a ribonuclease with pro-angiogenic activity, secreted by osteoclasts as a key fa

227 by the striking anti-proliferative and anti-angiogenic activity specific to mini TrpRS.

228 proteins with antiapoptotic, mitogenic, and angiogenic activities, suggesting that drug-induced sene

229 ty, compared with surrounding tissue without angiogenic activity, suggesting that (68)Ga-RGD PET/CT i

230 The evidence that sICAM-1 has angiogenic activity suggests a possible role linking inf

231 These findings, together with its angiogenic activity, support a role for CCN3 in cutaneou

232 atrigel (MG(FN-)) induced significantly less angiogenic activity than CM from monocytes cultured on c

233 anti-MIP-1alpha contained significantly less angiogenic activity than control wound homogenates (27%

234 he recombinant TM ectodomain exhibited lower angiogenic activity than did the recombinant TM domains

235 as lacking GATA-2 secrete significantly less angiogenic activity than wild-type placentas as measured

236 is a nuclear protein with both mitogenic and angiogenic activity that is highly expressed in the deve

237 media from IPF-PFs demonstrated constitutive angiogenic activity that was attributable, in part, to I

238 co-cultured with NCM460-NK-1R cells induced angiogenic activity that was inhibited by CCN1 silencing

239 ery of vascular-specific growth factors with angiogenic activity, there has been a significant effort

240 es demonstrate that IL-8 expression enhances angiogenic activity through the induction of matrix meta

241 d to contribute via mitogenic, survival, and angiogenic activities to HHV-8-associated Kaposi's sarco

242 re best known for their powerful mitotic and angiogenic activities toward endothelial cells.

243 Beside its anti-angiogenic activity, TSP2 also suppressed the production

244 rin-dependent mechanism, leading to specific angiogenic activities (tubule formation, cell migration,

245 ovascular endothelial cells and improved BMC angiogenic activity under high glucose condition.

246 ) differentiate into PACs and possess robust angiogenic activity under ischemic conditions.

247 y, we discovered that opticin possesses anti-angiogenic activity using a murine oxygen-induced retino

248 control wound homogenates (27% positive for angiogenic activity versus 91% positive in the control g

249 d function of endogenous E2F1: regulation of angiogenic activity via p53-dependent transcriptional co

250 The contribution of IL-8 to net angiogenic activity was assessed using the rat cornea mi

251 This increased angiogenic activity was associated with increased expres

252 Functional angiogenic activity was associated with VEGF-A levels in

253 model to demonstrate that senescent cardiac angiogenic activity was depressed (2 of 17 allografts we

254 This angiogenic activity was inhibited by a monoclonal antibo

255 The anti-angiogenic activity was localized to amino acids 54-132

256 ed from IPF tissue specimens, tissue-derived angiogenic activity was markedly reduced or enhanced, re

257 ed from IPF tissue specimens, tissue-derived angiogenic activity was markedly reduced.

258 Interestingly, such pro-angiogenic activity was not associated with progression

259 To evaluate IL-15 for possible angiogenic activity, we assessed the ability of recombin

260 Proliferation and angiogenic activities were associated with peaks II and

261 ate, and IFNgamma/LPS-activated MPMs express angiogenic activity, whereas normoxic, nonactivated MPMs

262 of calcitonin in PC-3M cells increased their angiogenic activity, whereas the silencing of calcitonin

263 TIMP-2 possesses two distinct types of anti-angiogenic activities which can be uncoupled from each o

264 ceptor, CXCR2, resulted in the inhibition of angiogenic activity, which suggests that CXCL1 signaling

265 specific laminin gamma1-chain peptides have angiogenic activity with potential therapeutic applicati