ライフサイエンスコーパス: angiotensinogen

1 ompletely, compensate for excess circulating angiotensinogen.

2 ensin-converting enzyme inhibitor or lacking angiotensinogen.

3 suppressed the expression of vasoconstrictor angiotensinogen.

4 on of fat-derived peptides (PAI-1 by 4-fold, angiotensinogen 3-fold, leptin 2-fold, resistin 4-fold,

5 pression of renal renin (50 %, P < 0.01) and angiotensinogen (40 %, P < 0.05) gene expression.

6 entified several vasoactive genes, including angiotensinogen, a constituent of the renin-angiotensin

7 targets in the DrugBank database, including angiotensinogen, a target of sparsentan (dual antagonist

8 eleased by the enzyme renin from the tail of angiotensinogen-a non-inhibitory member of the serpin fa

9 n PE at altitude than at sea level, yet PRR, angiotensinogen (AGT) and AT1R proteins were all increas

10 The main precursor of RAS is angiotensinogen (Agt) and this system is often linked to

11 We examine herein angiotensinogen (AGT) as a candidate gene to help elucid

12 al proximal tubular cells (RPTCs) suppresses angiotensinogen (Agt) expression, and attenuates systemi

13 cific renin and glial- and neuronal-specific angiotensinogen (AGT) expression.

14 tes) with two, three, and four copies of the angiotensinogen (Agt) gene (Vpr-Agt-2, Vpr-Agt-3, and Vp

15 oid 2-related factor 2 (Nrf2) stimulation of angiotensinogen (Agt) gene expression and the developmen

16 onucleoprotein F (hnRNP F) overexpression on angiotensinogen (Agt) gene expression, hypertension, and

17 ressure, we sequenced a 6.8 kb region of the angiotensinogen (AGT) gene in 29 male Nigerians with hig

18 k factor for cardiovascular disease, and the angiotensinogen (AGT) gene locus is associated with huma

19 ugh previous studies have suggested that the angiotensinogen (AGT) gene locus is involved in human es

20 Using a transgenic mouse harboring an angiotensinogen (AGT) gene modified for Cre-mediated del

21 ork showed that TGF-beta1 potently increases angiotensinogen (AGT) gene mRNA in primary human lung fi

22 riants in the RREB1 gene, a repressor of the angiotensinogen (AGT) gene previously associated with ki

23 We find that K-Ras(G12V) activates the angiotensinogen (AGT) gene promoter and promotes AGT pro

24 on among the M235T and T174M variants of the angiotensinogen (AGT) gene, plasma AGT, and hypertension

25 hisms in the 5' flanking region of the human angiotensinogen (AGT) gene, the -20 and -217 polymorphis

26 used to examine the cellular localization of angiotensinogen (AGT) in the brain.

27 In the brain, angiotensinogen (AGT) is expressed in astrocytes and in

28 Angiotensinogen (AGT) is the precursor of one of the mos

29 The oxidation status of angiotensinogen (AGT) may have a critical role in pre-ec

30 iated Ang II uptake and stimulation of renal angiotensinogen (AGT) mRNA and protein expression.

31 Renal inflammation modulates angiotensinogen (AGT) production in renal proximal tubul

32 The angiotensinogen (AGT) promoter G(-6) allele lowers trans

33 ntisense oligonucleotide (ASO) that inhibits angiotensinogen (Agt) synthesis to lisinopril in adult c

34 In the pituitary, the mRNA levels for angiotensinogen (AGT) were increased by 45% following es

35 osomal regions containing genes for the ACE, angiotensinogen (AGT), and angiotensin II type 1 recepto

36 such as angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and angiotensin receptor type I (

37 cluding angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and the type 1 (AT1) and type 2 (

38 The levels of immunoreactive angiotensinogen (AGT), angiotensin I (AngI), and angiote

39 Plasma renin, angiotensinogen (AGT), angiotensin II (Ang II), aldoster

40 ingle-nucleotide polymorphisms (SNPs) in the angiotensinogen (AGT), angiotensin receptor 1 (AGTR1), a

41 leotide polymorphisms (SNPs) at renin (REN), angiotensinogen (AGT), angiotensin-converting enzyme (AC

42 Angiotensinogen (AGT)-deficient mice die shortly after b

43 we explored the role of genetic variants of angiotensinogen (AGT, M235T), ACE (I/D), and angiotensin

44 ta, epidermal growth factor receptor [EGFR], angiotensinogen [AGT]) were tested in urine (Ur) and per

45 Xenograft growth, the renin-angiotensinogen aldosterone-system, and the calcium-vita

46 ine CC-4, angiotensin-converting enzyme, and angiotensinogen, although the direction of effect was re

47 or-alpha, interleukin-6, C-reactive protein, angiotensinogen and adiponectin).

48 pe results in increased tissue expression of angiotensinogen and Ang II.

49 Angiotensinogen and AngI also generated the same effect,

50 nt with Cap increased the expression of RAS (angiotensinogen and angiotensin II receptor), insulin si

51 large increases in plasma concentrations of angiotensinogen and angiotensin peptides (Ang II, III, I

52 lemia was associated with increased systemic angiotensinogen and angiotensin peptides, which were red

53 tribution of mast cells, and the presence of angiotensinogen and angiotensin-converting enzyme in man

54 Inasmuch as myocardial interstitium contains angiotensinogen and angiotensin-converting enzyme, and b

55 h the findings demonstrating the presence of angiotensinogen and angiotensinogen mRNA in proximal tub

56 f p53 was associated with an accumulation of angiotensinogen and AT(1) and enhanced production of ang

57 s diuretics did significantly reduce urinary angiotensinogen and beta2-microglobulin excretion.

58 Research on a link between angiotensinogen and essential hypertension illustrates a

59 a significant decrease in circulating human angiotensinogen and markedly blunted the pressor respons

60 ute significantly to the circulating pool of angiotensinogen and provide proof-of-principle that the

61 rting enzyme locus on chromosome 17, nor the angiotensinogen and renin loci on chromosome 1, with eit

62 blot analyses showed increased expression of angiotensinogen and renin protein at 16 to 24 hours of s

63 the angiotensin II type 1 receptor, while RV angiotensinogen and renin remained unchanged.

64 eed, they express renin, the renin receptor, angiotensinogen, and angiotensin-converting enzyme by mR

65 ("visceral white"), including the resistin, angiotensinogen, and chemerin genes, in addition to indu

66 Increased intracellular levels of Ang II, angiotensinogen, and renin were observed by confocal mic

67 sequence (St domain) in the promoter of the angiotensinogen (ANG) gene and consequently upregulate t

68 Angiotensinogen (ANG) is the specific substrate of the r

69 ding region to produce a nonsecreted form of angiotensinogen [Ang(-S)Exp].

70 53 was characterized by upregulation of Bax, angiotensinogen, Ang type 1 (AT(1)) receptors, and Ang I

71 lung, manifested by the induction of renin, angiotensinogen, angiotensin II and angiotensin receptor

72 dietary salt and increased plasma levels of angiotensinogen, angiotensin II, and aldosterone.

73 wn to stimulate expression of the endogenous angiotensinogen, angiotensin-converting enzyme, and endo

74 We have used RT-PCR to identify mRNA for angiotensinogen, angiotensin-converting enzyme, and the

75 Angiotensinogen-, angiotensin-converting enzyme-, and an

76 ma and liver protein using a polyclonal anti-angiotensinogen antibody demonstrated two specific immun

77 ure or plasma angiotensin II (AII), renin or angiotensinogen (Ao) concentrations.

78 p53 modulates transcription of angiotensinogen (Aogen) and AT(1) receptors in myocytes,

79 pression of p53-dependent genes; quantity of angiotensinogen (Aogen), AT(1), and Bax decreased, where

80 Additionally, p53 DNA binding to angiotensinogen (Aogen), AT1 receptor, and Bax was marke

81 On this basis, p53 DNA binding activity to angiotensinogen (Aogen), bax, and the AT1 receptor was d

82 ance, and renal mRNA levels of its precursor angiotensinogen are increased 2-fold in B-129/Sv-4A11(+/

83 tions of AngII, as well as angiotensin I and angiotensinogen, are much greater than can be explained

84 ls of myo-inositol, 4-guanidinobutanoate and angiotensinogen as downstream effectors of several kidne

85 p53 binding to the promoter of angiotensinogen, AT1 receptor, and Bax also increased.

86 Expression of angiotensinogen, AT1 receptor, p53, and Bax increased an

87 Angiotensin I (Ang I) was generated from angiotensinogen by cathepsin D in the presence of normal

88 II derived from local synthesis of renin and angiotensinogen can cause an elevation in blood pressure

89 ell death pathways (Solute carrier family 2, Angiotensinogen, CD14) and mitochondrial reactive oxygen

90 tensin II (Ang II) receptors, we mutated the angiotensinogen cDNA by removing the signal sequence-enc

91 WT-p90RSK-Tg mice, suggesting an increase of angiotensinogen cleavage and subsequent RAS activation i

92 n, pyruvate kinase isozymes M1/M2 isoform 3, angiotensinogen, complement C4-A isoform 1, and compleme

93 Although HG did not affect the rate of angiotensinogen conversion, it decreased expression of a

94 The virus binds to angiotensinogen converting enzyme 2 (ACE2), which mediat

95 otype is virtually identical to that seen in angiotensinogen-deficient (Agt-/-) and angiotensin-conve

96 Wild-type (Agt+/+) and homozygous angiotensinogen deletion mutant (Agt-/-) littermates wer

97 The angiotensinogen-derived precursor, Ang I, is cleaved eit

98 es demonstrate that extra-hepatic sources of angiotensinogen do not contribute significantly to the c

99 ssociated with preeclampsia, we investigated angiotensinogen expression in the first trimester uterus

100 further show that repression of resistin and angiotensinogen expression involves recruitment of CtBP1

101 paralleled by incrementally increased liver angiotensinogen expression.

102 Clinical trials are ongoing targeting angiotensinogen for the treatment of hypertension and he

103 five genetically determined levels of mouse angiotensinogen gene (Agt) expression covering the range

104 nked to differential expression of the human angiotensinogen gene (AGT) gene and hypertension, but th

105 then use conditional genetic deletion of the angiotensinogen gene (Agt) to test whether production in

106 o determine whether common haplotypes in the angiotensinogen gene (AGT), the renin gene, the angioten

107 peptides, but brain-specific deletion of the angiotensinogen gene (Agt), which encodes the lone precu

108 having zero to four functional copies of the angiotensinogen gene (Agt).

109 hose found in mutant mice homozygous for the angiotensinogen gene (Agt-/-), indicating that major bio

110 rrying a gene-targeted deletion of the mouse angiotensinogen gene (mAgt).

111 e- and cell-specific expression of the human angiotensinogen gene and normally produce and process th

112 reduction on renin release, renal renin and angiotensinogen gene expression and the role played by a

113 We conclude that increased NF-kappaB and angiotensinogen gene expression are associated with R-FS

114 Intra-graft angiotensinogen gene expression was significantly elevat

115 t suppressed basal levels of renal renin and angiotensinogen gene expression; (b) acute reduction of

116 generated transgenic mice containing a human angiotensinogen gene flanked by loxP sites (hAGT(flox)).

117 ogic consequences of tissue-specific loss of angiotensinogen gene function in vivo, we constructed an

118 The human angiotensinogen gene has a C/A polymorphism located at -

119 -I reduces the basal expression of the human angiotensinogen gene in liver cells.

120 renin-angiotensin system of mice having one angiotensinogen gene inactivated.

121 tion in the mice having only one copy of the angiotensinogen gene is greater than twice wild-type.

122 They are hypertensive, and expression of the angiotensinogen gene is increased in their subcutaneous

123 his transgenic mouse model is that the human angiotensinogen gene is inserted into the mouse genome a

124 Angiotensinogen gene is primarily expressed in the liver

125 Therefore, we investigated whether the angiotensinogen gene might be similarly implicated in th

126 vity of reporter constructs containing human angiotensinogen gene promoter (with nucleoside A at -20)

127 sion of reporter constructs containing human angiotensinogen gene promoter.

128 ods) revealed no evidence for linkage of the angiotensinogen gene to hypertension.

129 r alpha (TNFalpha), is a potent activator of angiotensinogen gene transcription in hepatocytes by act

130 mouse model generated by targeting the human angiotensinogen gene upstream of the mouse HPRT locus by

131 S (ACE gene, Angiotensin II receptor 1 gene, Angiotensinogen gene) in 233 liver transplant recipients

132 gen genes can functionally replace the mouse angiotensinogen gene, and provides proof in principle th

133 evidence that individual differences in the angiotensinogen gene, the precursor of the vasoactive ho

134 Previously, the angiotensinogen gene, which encodes the key substrate fo

135 d in tissue-specific expression of the human angiotensinogen gene.

136 ed to single-nucleotide polymorphisms in the angiotensinogen gene.

137 ransgenic for both the human renin and human angiotensinogen genes (RA+) exhibit appropriate tissue-

138 e studies establish that the human renin and angiotensinogen genes can functionally replace the mouse

139 consisting of both the human renin and human angiotensinogen genes to study further the role played b

140 ice containing a PAC transgene and the human angiotensinogen (hAGT) gene (P+/A+) are moderately hyper

141 The human angiotensinogen (hAGT) gene has polymorphisms in its 2.5

142 ating the acute-phase induction of the human Angiotensinogen (hAGT) gene in hepatocytes.

143 ting acute-phase response (APR) of the human angiotensinogen (hAGT) gene in hepatocytes.

144 ed protein (KAP) promoter fused to the human angiotensinogen (HAGT) gene with the goal of specificall

145 containing the human renin (HREN) and human angiotensinogen (HAGT) genes were bred to mice heterozyg

146 EN) and bred them with mice expressing human angiotensinogen (hAGT) under the control of the same pro

147 Although angiotensinogen has long been regarded as a passive subs

148 Furthermore, male and female mice lacking angiotensinogen have normal fertility, indicating that a

149 lts had higher urinary mRNA levels of renin, angiotensinogen, IL-18 and CTGF.

150 vels of calprotectin, von Willebrand factor, angiotensinogen, IL8, IL15, IP10, TNFalpha, and decrease

151 lpha, nuclear factor-kappaB (NF-kappaB), and angiotensinogen in 60 biopsies from 27 pediatric renal t

152 tion may not affect intracellular sorting of angiotensinogen in a qualitative manner, it leads to a q

153 The expression of angiotensinogen in liver increased fivefold 3 hours afte

154 usly reported that adipose overexpression of angiotensinogen in mice (Agt-Tg) induces obesity, in par

155 Selective deletion of angiotensinogen in renal tubules ameliorated the patholo

156 Despite markedly reducing angiotensinogen in the blood, eliminating Agt from hepat

157 II) stimulate the synthesis and secretion of angiotensinogen in the proximal tubule, which provides s

158 y defined, but include enhanced formation of angiotensinogen, increased sodium reabsorption, and incr

159 nogen upregulation and remodeling of cardiac angiotensinogen interaction networks in P21 Kcne2(-/-) m

160 prises a biochemical cascade that hydrolyzes angiotensinogen into several different bioactive peptide

161 In human decidua, angiotensinogen is expressed only in spiral artery smoot

162 The epidemiology of angiotensinogen is not well defined, particularly its re

163 e we show that the reduced unbridged form of angiotensinogen is present in the circulation in a near

164 Angiotensinogen is the glycoprotein precursor of one of

165 Angiotensinogen is the most upstream precursor of the re

166 Angiotensinogen is the proximal precursor of the angiote

167 Angiotensinogen is the sole precursor of angiotensin pep

168 ation was observed using plasma samples from angiotensinogen-knockout mice.

169 ypothesize that adipose tissue enrichment of angiotensinogen leads to activation of inflammatory casc

170 th R-30P showed a tendency to lowered plasma angiotensinogen level (1563 ng of ANG I/ml (range 1129-1

171 compared to the sedentary group (Sed) (renal angiotensinogen level: Sed vs. Mod-Ex, 1.101 +/- 0.077 v

172 Dose-dependent decreases in serum angiotensinogen levels and 24-hour ambulatory blood pres

173 RNA interference therapeutic, reduced serum angiotensinogen levels and systolic blood pressure (SBP)

174 Significant differences in angiotensinogen levels are present between sexes and eth

175 receiving zilebesiran had decreases in serum angiotensinogen levels that were correlated with the adm

176 to determine the relationship of circulating angiotensinogen levels to ethnicity, sex, BP, incident h

177 Plasma angiotensinogen levels were measured in 5,786 participan

178 n was also attenuated in kidneys with URC as angiotensinogen levels were reduced.

179 Angiotensinogen levels were significantly higher in fema

180 specific deletion of Agt reduced circulating angiotensinogen levels without reducing thirst or sodium

181 ing that chronic overexpression of renin and angiotensinogen locally in the brain can result in hyper

182 The angiotensinogen M235T polymorphism in humans is linked t

183 eatures (TGA-PE, female transgenic for human angiotensinogen mated to male transgenic for human renin

184 lity that increases in circulating or tissue angiotensinogen may cause an increase in blood pressure

185 ed to determine whether augmented intrarenal angiotensinogen may contribute to the enhanced renal ang

186 Toll-like receptor 4 (TLR4) and angiotensinogen messenger ribonucleic acid (mRNA) were m

187 ssociated with a common molecular variant of angiotensinogen (Met235Thr).

188 y in the transgenic alpha-myosin heavy chain-angiotensinogen mice causes prominent changes in hypertr

189 is revealed the absence of full-length human angiotensinogen mRNA and protein in the liver but not th

190 Angiotensinogen mRNA and protein levels in kidney cortex

191 that chronic AngII infusion increases renal angiotensinogen mRNA and protein levels, thus contributi

192 Human angiotensinogen mRNA has two in-phase translation initia

193 strating the presence of angiotensinogen and angiotensinogen mRNA in proximal tubule cells, the data

194 circulating AngII levels increase intrarenal angiotensinogen mRNA levels, which may contribute to the

195 espite similar increases in cardiac TLR4 and angiotensinogen mRNA over 8 to 16 h.

196 This occurs after LPS increases TLR4 and angiotensinogen mRNA, but proximal to AT(1) receptor act

197 Renal and hepatic expression of angiotensinogen mRNA, which was examined by semiquantita

198 ological block of AT1R and in the absence of angiotensinogen or TRPC6 channels.

199 induction of left ventricular hypertrophy in angiotensinogen-overexpressing transgenic mice harboring

200 a potential 20-HETE dependence of intrarenal angiotensinogen production and ANGII receptor type 1 act

201 d whether thirst and sodium appetite require angiotensinogen production in astrocytes or hepatocytes.

202 s indicate that SHR have enhanced intrarenal angiotensinogen production that contributes to increased

203 bind to a sequence motif (St-domain) in the angiotensinogen promoter to activate its transcription i

204 inkage disequilibrium with a mutation in the angiotensinogen promoter, G(-6)A, which leads to elevate

205 Importantly, we demonstrated that angiotensinogen protein and functional angiotensin II wa

206 Although there was no detectable human angiotensinogen protein in plasma, it was evident in the

207 or 64-kD), renal (52-kD), or hepatic (52-kD) angiotensinogen protein levels; however, there was a sig

208 induction of PRECE was confirmed with serial angiotensinogen protein reduction after perfusion in WT-

209 expression of the highly glycosylated 64-kD angiotensinogen protein, of almost fourfold (densitometr

210 The level of expression of angiotensinogen, renin, ACE, and AT(1A) genes was low in

211 expression, it did not block upregulation of angiotensinogen, renin, and ACE genes by stretch.

212 ely inhibited Ang II-induced upregulation of angiotensinogen, renin, and ACE genes, as well as stretc

213 s with Ang II also upregulated expression of angiotensinogen, renin, and ACE genes, whereas it downre

214 four renin-angiotensin system gene regions (angiotensinogen, renin, angiotensin I-converting enzyme,

215 ffect of mechanical stretch on expression of angiotensinogen, renin, angiotensin-converting enzyme (A

216 of the longer and the shorter form of native angiotensinogen, respectively.

217 nal cells in culture with human prorenin and angiotensinogen resulted in increased generation of angi

218 g insulin (insulin resistance), and elevated angiotensinogen (salt retention).

219 romoter of the gene encoding its prohormone, angiotensinogen, serves as the target site for activated

220 By transplanting angiotensinogen signal peptide onto green fluorescence p

221 tation at the -30 amino acid position of the angiotensinogen signal peptide, in which an arginine is

222 lele occurs in the liver, the main tissue of angiotensinogen synthesis.

223 olonged duration of action, inhibits hepatic angiotensinogen synthesis.

224 NA interference therapeutic, targets hepatic angiotensinogen synthesis.

225 nvolved the genes governing the structure of angiotensinogen, the substrate in the renin reaction.

226 e loci affecting BP variation are known (eg, angiotensinogen), there are likely to be novel signals t

227 ive reduction in the net secretion of mature angiotensinogen through decreased translocation or incre

228 ose that this redox-responsive transition of angiotensinogen to a form that will more effectively rel

229 stem that permit intracellular processing of angiotensinogen to Ang II and that Ang II generated intr

230 ils 1) converts both human angiotensin I and angiotensinogen to angiotensin II; 2) expresses angioten

231 Activating (pro)renin for conversion of Angiotensinogen to Angiotensin makes ATP6AP2 attractive

232 system by cleaving its only known substrate angiotensinogen to angiotensin.

233 ed with transgenic mice overexpressing human angiotensinogen to determine if there was a chronic comp

234 ally, we demonstrate the oxidative switch of angiotensinogen to its more active sulphydryl-bridged fo

235 We localized angiotensinogen transcription in uterine decidua using i

236 port, we describe the development of a human angiotensinogen transgenic mouse model generated by targ

237 d putative ion channel targets, namely AT1R, angiotensinogen, transient receptor potential channel 6

238 script transcriptomics, we uncovered cardiac angiotensinogen upregulation and remodeling of cardiac a

239 .80), while in females the same increment in angiotensinogen was associated with 0.97 mm Hg higher sy

240 tions, a standard deviation increment in log-angiotensinogen was associated with 2.61 mm Hg higher sy

241 However, expression of renin and angiotensinogen was not increased in MHCsTNF mice compar

242 Angiotensinogen was selected because of the putative lin

243 Equivalent relative differences in angiotensinogen were associated with greater differences

244 ee system, we found that two forms of native angiotensinogen were generated by alternative initiation

245 tutively secreted proteins IgG, albumin, and angiotensinogen, when added to the assays, remain predom

246 to produce ANGI from proximal tubule-derived angiotensinogen, which is then converted into ANGII by l

247 were utilized to examine the associations of angiotensinogen with BP, prevalent hypertension, and inc

248 our 4.4 A structure of the complex of human angiotensinogen with renin.