ライフサイエンスコーパス: anion transporter

1 principal canalicular multispecific organic anion transporter.

2 s an important function of the renal organic anion transporter.

3 th the putative functioning of pendrin as an anion transporter.

4 yeast pcCMT, STE14, and the mammalian band 3 anion transporter.

5 y its interaction with the classical organic anion transporter.

6 fectively limited to the "classical" organic anion transporter.

7 as well as 15-20% deficiency of band 3, the anion transporter.

8 is-catechol (3) functions as a transmembrane anion transporter.

9 ll conserved family of genes that all encode anion transporters.

10 particular with mammalian organic cation and anion transporters.

11 ext of recent findings on the selectivity of anion transporters.

12 selective inhibitors of other mitochondrial anion transporters.

13 ructural fold typical of the SLC26 family of anion transporters.

14 y for the rational design of drugs to target anion transporters.

15 ancer activity as applications of artificial anion transporters.

16 ltration and tubular secretion using organic anion transporters.

17 e trivalent bismuthenium cations as chloride anion transporters.

18 four members of the SLC17 family of organic anion transporters.

19 cal applications for synthetic transmembrane anion transporters.

20 er hydrogen and halogen bond-based synthetic anion transporters.

21 st examples of pH-switchable nonelectrogenic anion transporters.

22 prises both Cl(-) channels and H(+) -coupled anion transporters.

23 ns are a ubiquitous superfamily of secondary anion transporters.

24 Human organic anion transporter 1 (hOAT1) belongs to a superfamily of

25 Human organic anion transporter 1 (hOAT1) plays a critical role in the

26 ls transfected stably with the human organic anion transporter 1 (hOAT1), the hypothesis that hOAT1 c

27 ne stably transfected with the human organic anion transporter 1 (hOAT1).

28 n renal library and designated human organic anion transporter 1 (hOAT1).

29 anionic substrates, the human renal organic anion transporter 1 (hOATI) is capable of transporting t

30 Organic anion transporter 1 (OAT1) mediates the body disposition

31 Organic anion transporter 1 (OAT1), expressed at the basolateral

32 Organic anion transporter 1 (OAT1), originally identified as NKT

33 kinetic interaction of ligands with organic anion transporter 1 (OAT1).

34 affected by the in vivo deletion of organic anion transporter 1 (Oat1, Slc22a6, originally NKT), a m

35 Organic anion transporter 1 (OAT1/SLC22A6) is a drug transporter

36 [down-regulated in adenoma (DRA) or putative anion transporter 1 (PAT1)] exchange in the brush border

37 mportantly, both hOAT1 and rat renal organic anion transporter 1 (rROAT1) mediated saturable, probene

38 (hMATE1/2-K), but not for the renal organic anion transporter 1 and 3 (hOAT1/3).

39 substrates for the renal basolateral organic anion transporter-1 (Oat1) from rat kidney.

40 Notably, organic anion transporter-1 (OAT1) knockout mice expressed a sim

41 Organic anion transporter-1 (OAT1) mediates the body disposition

42 Organic anion transporter-1 (OAT1) mediates the body's dispositi

43 teroidal anti-inflammatory drugs) is organic anion transporter-1 (OAT1), originally identified as NKT

44 their secretion by up-regulating the organic anion transporter-1 (OAT1).

45 ulated in adenoma (Dra) or Slc26a6, putative anion transporter-1 (Pat-1).

46 Putative anion transporter-1 (PAT1, SLC26A6) plays a key role in

47 -)/HCO(3)(-) exchangers, studies of putative anion transporter-1 knockout (KO) mice find little contr

48 O) mice find little contribution of putative anion transporter-1 to basal or cAMP-stimulated secretio

49 lls that were transfected with human organic anion transporter-1 were used.

50 Organic anion transporter 2 (OAT2 or SLC22A7) plays an important

51 e (Cyp7a1) and the Na(+)-independent organic anion transporter 2 (Oatp2).

52 major regulator of the Na+-dependent organic anion transporter 2.

53 und in the kidneys mediated by human organic anion transporter 3 (hOAT3) was hypothesized as a contri

54 l nervous system (CNS) riboflavin by organic anion transporter 3 (OAT-3), highlighting the need for a

55 a targeted disruption of the murine organic anion transporter 3 (Oat3) gene.

56 In this study, mice lacking organic anion transporter 3 (Oat3) had a 10 to 15% lower BP than

57 decrease in the expression level of organic anion transporter 3 (SLC22a8).

58 Human organic anion transporter 4 (hOAT4) belongs to a superfamily of

59 identified was SLC22A9 that encodes organic anion transporter 7 (OAT7).

60 e view of developing selective transmembrane anion transporters, a series of phosphonium boranes of g

61 ressed elevated amounts of the multispecific anion transporter ABCC3.

62 The band 3 proteins function as anion transporters, acid base regulators, C02 transporte

63 t kinetics have been examined in erythrocyte anion transporter AE1 that has been chemically modified

64 e founding member of a unique gene family of anion transporters (ALMTs) that mediate the efflux of or

65 chanistic insights into different classes of anion transporters and a new approach to achieve voltage

66 n the design of small-molecule transmembrane anion transporters and focuses on the progress so far in

67 Prestin is a member of the SLC26 family of anion transporters and is responsible for electromotilit

68 rstanding biological activities of synthetic anion transporters and potentially the uncoupling mechan

69 solute carrier (SLC) family 26, that encodes anion transporters and related proteins.

70 f many membrane proteins such as glucose and anion transporters and the erythropoietin receptor.

71 t the versatility of synthetic transmembrane anion transporters and to convince chemists to look beyo

72 on prestin, a member of the SLC26 family of anion transporters and utilizes the electric energy avai

73 cholate cotransporter, multispecific organic anion transporter, and P-glycoprotein) were also determi

74 Transmembrane anion transporters (anionophores) have potential for new

75 e also provide evidence that the most potent anion transporters are able to induce apoptosis in human

76 Several organic cation and anion transporters are expressed in the CPE cells, but h

77 Notably the best anion transporters are highly selective for transport of

78 d changes in fluidity and hence, activity of anion transporters, are monitored by fluorescence spectr

79 n to enhance the activity of known synthetic anion transporters as a result of a higher mobility.

80 ABA binds specifically to Band 3 (the RBC anion transporter), as determined by labeling of RBC mem

81 Further, the anion transporter band 3 was implicated as the counterio

82 the erythrocyte membrane; these include the anion transporter (band 3: Diego and Wright antigens), t

83 ts interaction with ankyrin and adducin, the anion transporter, band 3 (AE1), contributes prominently

84 or a high beta-carotene diet on aging of the anion transporter, band 3, in lymphocytes and brain.

85 olase to the N-terminus of human erythrocyte anion transporter, band 3, inhibits enzyme activity.

86 ciparum and Sendai virus, and along with the anion transporter, band 3, may contribute to the mechani

87 tyrosine phosphorylation of the erythrocyte anion transporter, band 3, triggers membrane destabiliza

88 Anion transporters based on small molecules have receive

89 al, and comparisons with GlpT show that both anion transporters bind substrates within equivalent dom

90 strate here that the activity of a synthetic anion transporter can be controlled through changes in t

91 We previously localized the anion transporter ClC-3 to polymorphonuclear leukocytes

92 hly motile PMN functions, suggested that the anion transporters, ClC-3 and ICl(swell), are involved i

93 1) and the canalicular multispecific organic anion transporter (cMOAT or MRP2) are ATP-binding casset

94 (MRP) and canalicular multispecific organic anion transporter (cMOAT) are closely related mammalian

95 the liver canalicular multispecific organic anion transporter (cMOAT) protein.

96 (MRP)1 and canalicular multispecific organic anion transporter (cMOAT)/MRP2 are ATP-binding cassette

97 strate for canalicular multispecific organic anion transporter [cMOAT]).

98 ve been identified such as the multispecific anion transporter, cMOAT, bile acid transporters, ion-mo

99 These results identify an organic anion transporter composed of a putative seven-helix TM

100 series of easy-to-make fluorinated tripodal anion transporters containing urea and thiourea groups h

101 hese coupled (stoichiometric) and uncoupled (anion) transporter currents is poorly understood, transp

102 as a target in the development of synthetic anion transporters despite natural fluoride transport ch

103 acid binding proteins (L-FABP), and organic anion transporters--determine the distribution, accumula

104 Pendrin is an anion transporter encoded by the PDS/Pds gene.

105 sport proteins that includes the rat sulfate-anion transporter (encoded by Sat-1; 29% amino acid sequ

106 ndependently correlated with hepatic organic anion transporter expression.

107 endrin and prestin both belong to a distinct anion transporter family called solute carrier protein 2

108 Si transporter, belong to an uncharacterized anion transporter family having a significant identity w

109 ember 1 (Slc10a1) and solute carrier organic anion transporter family member (Slco) 1a1 and 1b2, resp

110 ight chain (FTL), and solute carrier organic anion transporter family member 2B1 (SLCO2B1), in the bl

111 brane protein prestin, a member of the SLC26 anion transporter family, is responsible for the voltage

112 otein, prestin, which evolved from the SLC26 anion transporter family, underlies the OHC's voltage-de

113 ucture-function relationships of the organic anion transporter family.

114 ucture-function relationships of the organic anion transporter family.

115 of organic anions by a member of the organic anion transporter family.

116 nous molecular motors evolved from the SLC26 anion transporter family.

117 is taken up by tubular cells through organic anion transporters, followed by conversion to a highly f

118 development of small-molecule lipid-bilayer anion transporters for potential future use in channel r

119 the presence of distinctly different organic anion transporters for the efflux of VPA at the parenchy

120 CLC anion transporters form dimers that function either as C

121 previously cloned a cDNA encoding an organic anion transporter from mouse kidney (mOAT).

122 vement and morphology of PMNs lacking normal anion transporter function.

123 These cells had organic anion transporter function.

124 m on chloride anions suggests that selective anion transporters function as important components of t

125 Although recessive mutations in the anion transporter gene SLC26A4 are known to be responsib

126 associated with polymorphisms in the organic anion transporter gene SLCO1B1 (P = 2.1 x 10(-11)).

127 hitectures, while the study of transmembrane anion transporters has flourished from almost nothing in

128 The medical applications of synthetic anion transporters have been widely explored, especially

129 o the natural product prodigiosin, synthetic anion transporters have low-to-modest H(+) /Cl(-) sympor

130 s the protein from the closely related SLC26 anion transporters, highlighting the basis for evolution

131 Human organic anion transporter hOAT1 belongs to a superfamily of orga

132 Human organic anion transporter hOAT1 plays critical roles in the body

133 The human organic anion transporter (hOAT1) is a key component in the rena

134 n the functional maturation of human organic anion transporter hOAT4.

135 In contrast to the organic anion transporters identified to date, a transport activ

136 mbrane-associated protein; cMOAT, an organic anion transporter implicated in multidrug resistance; an

137 e studies indicate that pendrin is an apical anion transporter in intercalated cells of CCDs and has

138 s reveal that pendrin, a clinically relevant anion transporter in the thyroid, ear, kidney, and lungs

139 Prodigiosin is one of the most potent anion transporters in lipid bilayer membranes reported t

140 The molecular identity and regulation of anion transporters in PTs is unknown.

141 Organic anion transporters in the kidney proximal tubule play an

142 rect evidence implicating one of the organic anion transporters in the uptake of a mercuric conjugate

143 d circumstantial evidence implicates organic anion transporters in these processes.

144 ed in the presence of probenecid, an organic anion transporter inhibitor.

145 Clcn3(-/-) PMNs and human PMNs treated with anion transporter inhibitors demonstrated impaired chemo

146 (2)17betaG indicates that it is a lipophilic anion transporter involved in phase III (cellular extrus

147 Prestin, a member of the SLC26A family of anion transporters, is a polytopic membrane protein foun

148 This conductance is independent of the anion transporter mechanism.

149 Ci-Slc26aalpha acts as an anion transporter, mediating the electrogenic exchange o

150 ional modification of a mouse kidney organic anion transporter (mOAT), in a mammalian cell system, CO

151 protein (P-gp) and the multispecific organic anion transporter (MOAT), the liver-specific homologue o

152 rt in COS-7 cells expressing a mouse organic anion transporter (mOAT1), suggesting an important role

153 characterize functional activity of organic anion transporter (Oat) 3, P-glycoprotein (P-gp), breast

154 enous stimulation of proximal tubule organic anion transporter (OAT) and organic cation transporter (

155 In vivo studies implicate the organic anion transporter (OAT) family as a pivotal component of

156 ent of the contributions of specific organic anion transporter (OAT) family members to detoxification

157 clude two "drug" transporters of the organic anion transporter (OAT) family: OAT1 (SLC22A6, originall

158 le cells by the basolateral membrane organic anion transporters (Oat) 1 and Oat3.

159 Renal organic anion transporters (OAT) are known to mediate the excret

160 Organic anion transporters (OAT) play essential roles in the bod

161 The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8) hav

162 in vivo studies have established the organic anion transporters OAT1 (SLC22A6, NKT) and OAT3 (SLC22A8

163 The organic anion transporters OAT1 (SLC22A6, originally identified

164 cation transporters (OCT2 and OCT3), organic anion transporter (OAT1), and monoamine transporters wer

165 re plant Primula macrocalyx with the organic anion transporters (OAT1 and OAT3) and microorganisms le

166 ransporter (LAT1) used by leucine to organic anion transporters (OAT1 and OAT3) and the monocarboxyla

167 The multispecific organic anion transporters, OAT1 (SLC22A6) and OAT3 (SLC22A8), t

168 The organic anion transporter OAT4 (SLC22A11) and organic anion tran

169 and transport function of olfactory organic anion transporter, Oat6, in comparison with the more bro

170 Organic anion transporters (OATs) and organic cation transporter

171 Organic anion transporters (OATs) are believed to mediate the ce

172 Organic anion transporters (Oats) are located in the barrier epi

173 ty acid binding proteins (FABPs) and organic anion transporters (OATs) have been identified as import

174 Studies of the organic anion transporters (Oats) have focused mainly on their i

175 Given the selective expression of organic anion transporters (OATs) in renal proximal tubular cell

176 he proximal tubule-specific drug and organic anion transporters (OATs) OAT1 (SLC22a6) and OAT3 (SLC22

177 Organic anion transporters (OATs) play a critical role in the ha

178 Organic anion transporters (OATs) play a pivotal role in the cle

179 e cloning of multiple genes encoding organic anion transporters (OATs), the study of organic anion se

180 creted by the recently characterized organic anion transporters (OATs), which are expressed in proxim

181 Organic anion transporters (OATs, SLC21) are important in the ex

182 Organic anion transporters (OATs, SLC22) interact with a remarka

183 Here, we show that the multispecific organic anion transporters of drugs, OAT1 (SLC22A6 or NKT) and O

184 in which, in common with other mitochondrial anion transporters of known sequence and function, displ

185 amilies, most notably the organic cation and anion transporters of the solute carrier family (SLC22),

186 s suggest that GmN70 and LjN70 are inorganic anion transporters of the symbiosome membrane with enhan

187 orted that expression of the epithelial cell anion transporter pendrin is markedly increased in respo

188 Anion transporters play a vital role in cellular process

189 Organic anion transporters play an essential role in eliminating

190 t associations were with SNPs in the organic anion transporter polypeptide, SLCO1B1.

191 Rat organic anion transporter polypeptide1 (Oatp1) is known to trans

192 Members of the Organic Anion Transporter Polypeptides (OATP) are integral membr

193 ssociated protein 2 (Mrp2/Abcc2), an organic anion transporter present in the apical membrane of hepa

194 sociated protein 2 (Mrp2, Abcc2), an organic anion transporter present in the apical membrane of hepa

195 ain, which was possibly modulated by organic anion transporters present at the blood-brain barrier.

196 inocytes expressed the organic anion organic anion transporter protein (OATP) 2B1 transporter.

197 urocholate cotransporter protein and organic anion transporter protein 1.

198 ely taken up by a sodium-independent organic anion transporter protein-1B1 (OATP1B1) exclusively expr

199 The molecular identity of this anion transporter remains unknown.

200 smembrane conductance regulator (CFTR) is an anion transporter required for epithelial homeostasis in

201 AtALMT12, AtTMEM16 and AtCCC as the putative anion transporters responsible for these currents.

202 GLUT1, the glucose transporter; SLC4A1, the anion transporter; RhAG, the Rh-associated glycoprotein;

203 GLUT1, the glucose transporter; SLC4A1, the anion transporter; RhAG, the Rh-associated glycoprotein;

204 The rat organic anion transporter, rOAT3, mediates the transport of orga

205 ansport of organic anions by the rat organic anion transporter, rOAT3.

206 the STAS domain from the SulP/SLC26 putative anion transporter Rv1739c of Mycobacterium tuberculosis.

207 tile prestin orthologs, while functioning as anion transporters, should be much less sensitive to mem

208 l as organic cation transporters and organic anion transporters Slc22a1 (Oct1), Slc22a2 (Oct2), Slc22

209 A role of the anion transporter SLC26A1 (Sat1) for sulfate reabsorptio

210 The epithelial anion transporter SLC26A9 contributes to airway surface

211 Prestin is structurally similar to the anion transporter Slc26a9.

212 deled, based on structural data from related anion transporters (SLC26Dg and UraA), to have a 7 + 7 i

213 Recent studies have implicated roles for the anion transporter, SLC4A1, and the Rh-associated glycopr

214 ed STAS domains of the ubiquitous SulP/SLC26 anion transporter superfamily have until recently remain

215 by URAT1 (SLC22A12), a member of the organic anion transporter superfamily.

216 stin', the molecule is a member of the SLC26 anion transporter superfamily.

217 f SLC26A7 was inhibited by all inhibitors of anion transporters tested, 4,4'-diisothiocyanostilbene-2

218 ealed that the catenanes were more effective anion transporters than the constituent macrocycles, wit

219 We conclude that NaDC-1 is an electrogenic anion transporter that accepts either Na+ or Li+ as coup

220 These results identify an anion transporter that functions in stomatal opening and

221 Human MRP4 (ABCC4, MOAT-B) is a lipophilic anion transporter that is able to confer resistance to n

222 We conclude that MRP8 is an amphipathic anion transporter that is able to efflux cAMP and cGMP a

223 Slc26a9 is a recently identified anion transporter that is abundantly expressed in gastri

224 family member A9 (SLC26A9) is an epithelial anion transporter that is assumed to contribute to airwa

225 ClC-3, an anion transporter that is primarily found in intracellul

226 oatp1 is an hepatic sinusoidal organic anion transporter that mediates uptake of various struct

227 he expression of rOat2 (Slc22a7), an organic anion transporter that regulates, in part, the transfer

228 ere are many other applications of synthetic anion transporters that are often overlooked.

229 Mammalian SLC26 proteins are membrane-based anion transporters that belong to the large SLC26/SulP f

230 amily of putative membrane-localized sulfate/anion transporters that contain a sulfate transporter do

231 Synthetic anion transporters that facilitate transmembrane H(+) /C

232 Prestin is a member of the SLC26 family of anion transporters that is responsible for outer hair ce

233 secretion, as well as the potential role of anion transporters that may be saturated by a high paraa

234 In this report, we introduce synthetic anion transporters that operate with chalcogen bonds.

235 V)azanes give them applications as synthetic anion transporters through phospholipid layers.

236 The mechanisms that target organic anion transporters to different domains of the ileal ent

237 The application of anion transporters to the potential future treatment of

238 onal response of proximal organic cation and anion transporters was independent of GFR.

239 inity and transport mechanisms of four other anion transporters, we show that the lack of uniport and

240 late cotransporter and multispecific organic anion transporter were more profoundly diminished.

241 SLC26A9 is a member of the SLC26 family of anion transporters, which is expressed at high levels in

242 er hOAT1 belongs to a superfamily of organic anion transporters, which play critical roles in the bod

243 (hOAT1) belongs to a superfamily of organic anion transporters, which play critical roles in the bod

244 es for the canalicular multispecific organic anion transporter whose activity has recently been assoc

245 e solute carrier 26 (SLC26) transporters are anion transporters with diverse substrate specificity.

246 related to MRP, cMOAT, and the yeast organic anion transporter YCF1.

247 Prestin belongs to the SLC26 family of anion transporters yet is the only member capable of dis