ライフサイエンスコーパス: antagonist

1 coagulants (heparin or switched to vitamin K antagonist).

2 onal degeneration, are mitigated by an H(3)R antagonist.

3 lly available, potent, and selective hGnRH-R antagonist.

4 dies using CP-101,606, an established GluN2B antagonist.

5 by a pair of rationally designed agonist and antagonist.

6 or but not by an angiotensin II AT1 receptor antagonist.

7 apparent K(D) of 50 nm and behaves as an AhR antagonist.

8 nselective acetylcholine muscarinic receptor antagonist.

9 relevant dose/schedule of any IL-17-receptor antagonist.

10 d IL-1alpha but low amounts of IL-1 receptor antagonist.

11 ferator-activated receptor gamma (PPARgamma) antagonist.

12 two classes of estrogen receptor-alpha (ER) antagonists.

13 e same effects were not seen with other NMDA antagonists.

14 ncer patients that are not sensitive to HER2 antagonists.

15 tified for the classification of ER agonists/antagonists.

16 d this protective effect was abrogated by IP antagonists.

17 n compounds on the ER, either as agonists or antagonists.

18 aluated a series of novel triazole-based S1R antagonists.

19 ed to identify novel, small-molecule hGnRH-R antagonists.

20 gical evaluation of pyroglutamide-based P2X7 antagonists.

21 SPINK1-positive subtype, are treated with AR-antagonists.

22 We recently developed a brain-permeable EP2 antagonist 1 (TG6-10-1), which displayed anti-inflammato

23 he muscarinic acetylcholine receptor (mAChR) antagonist 2 was synthesized and studied for their affin

24 with or without prior exposure to TNF-alpha antagonists, (2) comparative efficacy and safety of biol

25 tion of a highly potent and selective TLR7/8 antagonist (27) with in vivo efficacy.

26 on OAC (direct anticoagulants: 26, vitamin K antagonists: 4), with no differences in baseline-procedu

27 Patients were treated with vitamin K antagonists (48.4%), parenteral heparins (27.7%), and di

28 s P2X4 WT mice treated with a selective P2X4 antagonist (5-BDBD) were protected against ischemic AKI.

29 1 participants who used neither agonists nor antagonists, 5 participants who used opioid agonists (wi

30 duced by EFS were reduced by an Ano1 channel antagonist, abolished by DAU 5884, and unaffected by AF-

31 Thus, vitamin K antagonists act through mimicking the key interactions a

32 chanisms mediating receptor-inactivating KOR antagonist action and advance medication development for

33 has potentiating, inhibitory, or competitive antagonist activity on GABA(A)Rs.

34 predictive models for binding, agonist, and antagonist activity predictions.

35 CD8(+) T cells were detected with the IL-4R antagonist adjuvanted strategy compared to the unadjuvan

36 ric residues in one dimer arm retaining high antagonist affinity.

37 and Vpu was consequently chosen again as an antagonist against human BST-2 in the context of HIV-1.

38 examined the bioactivities of the identified antagonists against Aedes, the third major genus of the

39 found that the alpha3beta4* nAChR-selective antagonist alpha-conotoxin AuIB almost completely abolis

40 also able to selectively displace the CXCR4 antagonists AMD3100 and AMD3465 from the liver.

41 itabine alone or in combination with a CXCR4 antagonist (AMD3100) or hedgehog inhibitor (GDC-0449) di

42 tentiation was eliminated by the competitive antagonist AMG-21629, the NADPH oxidase assembly inhibit

43 istics related to use of opioid agonists and antagonists among people receiving outpatient addiction

44 Ex vivo, addition of the IL-1 receptor antagonist anakinra to whole blood reduced staphylococca

45 early in the disease with the IL-1 receptor antagonist, anakinra.

46 Evaluate the Safety of Apixaban vs Vitamin K Antagonist and Aspirin vs Aspirin Placebo in Patients Wi

47 ing domperidone, a peripheral dopamine D2/D3 antagonist and common anti-emetic, at a dose (10 mg) tha

48 escued in acinar cells treated with a Piezo1 antagonist and in acinar cells from mice with genetic de

49 Agouti-related protein (AgRP), an MC3R/MC4R antagonist and MC4R inverse agonist, contains an exposed

50 asymmetric total synthesis of Merck's hNK(1) antagonist and three of its stereoisomers was accomplish

51 Treatment with Nifedipine (Ca(2+) antagonist and vasodilator) prevented cocaine-induced CB

52 ion of beta-cells were blocked by a 5-HT(3)R antagonist and were enhanced by increasing serotonin lev

53 Muscarinic M(3) receptor antagonists and inverse agonists displaying high affinit

54 orts the use of diuretics, mineralocorticoid antagonists and lifestyle interventions.

55 eceptors on which NMDA acts as a competitive antagonist, and high affinity homomeric glycine activate

56 yl-D-aspartate receptor (NMDAR) glycine site antagonist, and of 4-chloro-3-hydroxyanthranilic acid (4

57 nists elicited higher repellency than single antagonists, and binding competition assays suggested th

58 made it resistant to inactivation by the LPL antagonists angiopoietin-like protein 3 (ANGPTL3) or ANG

59 reduce body weight were reversed by a GFRAL-antagonist antibody.

60 Histamine H1 receptor antagonists (antihistamines) are recommended as adjuncti

61 e, the potent anticancer activities of NR4A1 antagonists are also accompanied by enhanced antitumor i

62 why in vivo combinations of BCL-2 and MCL-1 antagonists are more effective when concurrent rather th

63 Potent C3aR antagonists are now available for interrogating C3a rece

64 state cancers resistant to androgen receptor antagonists are still susceptible to nontoxic BRD9 inhib

65 Subtype-selective OX1R antagonists are valuable tools to further investigate th

66 oglial cell line, reinforcing the use of EP2 antagonists as anti-inflammatory agents.

67 olix, an oral gonadotropin-releasing hormone antagonist, as compared with those of leuprolide are not

68 Previously, bupropion was shown to be an antagonist at homopentameric 5-HT type 3A receptors.

69 ight odors tested acted as both agonists and antagonists at different receptors.

70 Pre-treatment with SKF-83566, a D1 receptor antagonist, attenuated GBP-induced CPP.

71 r antagonist MK-801 and the GABA(A) receptor antagonist bicuculline methiodide while recording cellul

72 or (MOR) agonist/delta-opioid receptor (DOR) antagonist bicyclic core peptidomimetics with promising

73 gy calculations, and provide new insights on antagonist binding to the A(2A) AR, an emerging target i

74 Intramuscular application of an NMDAR antagonist blocked the acquisition/maintenance of the le

75 B12 and FA bind AhR directly as competitive antagonists, blocking AhR nuclear localization, XRE bind

76 ed Vaccinia Ankara Virus (MVA)-gag pol-IL-4R antagonist boost followed by an i.m SOSIP-gp140 boost.

77 e report cryo-EM structures of TRPC6 in both antagonist-bound and agonist-bound states.

78 hese hybrid models were based on an inactive antagonist-bound hA(1)AR structure for the upper part of

79 he optimization of NBD-11021, an HIV-1 gp120 antagonist, by developing a new and novel analogue, NBD-

80 EDNR antagonists can be repurposed to improve drug delivery i

81 The RGS4 antagonist CCG203769 attenuated AHR induced by allergen

82 The CCR2 antagonist CCX872 increased median survival as a monothe

83 ary system, T(RM) are identified through S1P antagonist CD69 and expression of integrins CD103/beta7

84 t co-administration of histamine H1 receptor antagonist, cetirizine, and cysteinyl-leukotriene recept

85 her than synergistic effects of the specific antagonist combinations on ORco function.

86 Awakening by the alpha2-adrenergic antagonist completely eliminated this intermediate state

87 Besides selective P2X1 antagonists, compounds with ancillary P2X4 and/or P2X7 r

88 is a nonsteroidal mineralocorticoid receptor antagonist currently in phase III clinical trials for th

89 blocked by bath applying a competitive NMDAR antagonist (DCPP-ene) or by an NMDAR channel blocker app

90 ated by application of the K(v)1.1 selective antagonist, Dendrotoxin-K, in several L-DRG subclasses (

91 Moreover, the TLR7 antagonists depicted excellent selectivity against TLR8.

92 al for optimizing the SS-RJW100 scaffold for antagonist design.

93 (3)R yet identified, providing new leads for antagonist development.

94 nel blockers, and mineralocorticoid receptor antagonists did not achieve significant reductions over

95 on from GluK1 homotetramers, indicating that antagonist dissociation proceeds in a nonuniform and coo

96 ignaling by activating expression of the Wnt antagonist DKK1.

97 and PS exposure, which was inhibited by its antagonist Dooku1 and the PIEZO1 inhibitor GsMTx4, consi

98 that the inhibition of ESRPs can suppress AR-antagonist-driven tumor invasion.

99 are clues for the finding of a usable h-P2X7 antagonist drug.

100 dministration-approved AMPA receptor (AMPAR) antagonist, during a follow-on 24-hour vEEG to investiga

101 d new fluorescent ligands based on the mu-OR antagonist E-p-nitrocinnamoylamino-dihydrocodeinone (CAC

102 Binary mixtures of specific antagonists elicited higher repellency than single antag

103 d by applying the mineralocorticoid receptor antagonist eplerenone.

104 arch suggests the mineralocorticoid receptor antagonist, eplerenone, is effective for treating CSCR;

105 Oral P2Y(12) receptor antagonists exhibit delayed onset of platelet inhibition

106 lutionary arms races and suggests that BST-2 antagonists exist in some avian viruses.

107 growth factor-beta1/SMAD 2/3 pathway and its antagonist follistatin.

108 s the noncovalent binding of beta-ionone, an antagonist for G protein activation.

109 acts as slowly diffusing and insurmountable antagonist for G(q) protein activation and in particular

110 ng the potential benefits of 5-HT2C receptor antagonists for both reduction of motor side effects of

111 nsport, and the therapeutic promise of TRPV4 antagonists for patients with TRPV4-related neurodegener

112 Antagonists for the ATP-gated ion channel receptor P2X1

113 g the partial agonist tamoxifen and the pure antagonist fulvestrant, affect the tumor stroma has not

114 2B)AR, with a number of potent and selective antagonists further confirmed by functional cyclic adeno

115 sent just below crypts that secretes the BMP antagonist Gremlin1.

116 olitis on mice, in comparison with reference antagonist GSK1370319A.

117 The administration of a specific TRPV4 antagonist, GSK2193874, in elastase-treated WT mice and

118 (2+)](i)) and that application of the Piezo1 antagonist, GsMTx4, completely blocked this change.

119 Use of PPIs and histamine 2-receptor antagonists (H2RA) during the year before the index date

120 rticipants who used opioid agonists (without antagonists) had lower microbiota diversity, Bacteroides

121 effects of a single dose of the D2 receptor antagonist haloperidol on temporal discounting and choic

122 ne precursor L-dopa, 2 mg of the D2 receptor antagonist haloperidol, and placebo.

123 , we found that an affinity matured nanobody antagonist has comparable antihypertensive activity to t

124 th schizophrenia to determine whether opioid antagonists have therapeutic efficacy on positive, negat

125 Cases had higher levels of IL-1 receptor antagonist (IL-1Ra) at all time points leading up to fir

126 Naturally-occurring IL-1 receptor antagonist (IL-1Ra) binds and blocks the IL-1 receptor-1

127 The IL-1 receptor antagonist (IL-1Ra) has emerged as a pivotal player in t

128 6alpha, IL-36beta, and IL-36gamma), receptor antagonists (IL-1Ra, IL-36Ra), and 2 anti-inflammatory c

129 amoxifen acts as an antiestrogen and ERalpha antagonist in breast cancer but also on the membrane ERa

130 ed as part of the Mineralocorticoid Receptor Antagonist in Type 2 Diabetes (MIRAD) trial, which rando

131 nd pufferfish VKOR-like, with substrates and antagonists in different redox states.

132 ants (DOACs) have largely replaced vitamin K antagonists in many indications for anticoagulation.

133 odels of HCC with the clinical failure of AR antagonists in patients with advanced HCC by evaluating

134 tracerebroventricular (ICV) galanin receptor antagonists in prior studies precluded defining a causal

135 tudy highlights the role of viral interferon antagonists in shaping the kinetics and magnitude of the

136 , whereas the majority of them acted as zfPR antagonists in U2OS-zfPR.

137 E inhibitors, and mineralocorticoid receptor antagonists increase ACE2 receptor expression, it has be

138 idate and sulpiride, a selective D2 receptor antagonist, increased cognitive motivation more for part

139 IL-17 antagonists induce impressive clinical benefits in psori

140 elationship screening cascade based on a new antagonist-induced dissociation NMR assay, called the we

141 with either saline or BQ-123 (ET(A) receptor antagonist) infusion following a 2-week withdrawal of an

142 The tested antagonists inhibited the function of Ae. aegypti ORco e

143 sted that this enhanced repellence is due to antagonist interaction with distinct ORco sites.

144 in myriad autoimmune disorders, but no TLR7 antagonist is available for clinical use to date.

145 Inactivation of these CoV interferon antagonists is a rational approach for generating candid

146 As a secreted antagonist, it inhibits the effect of BMP2/4 on adipose

147 Divergent responses to the K-channel antagonist, kappaM-conopeptide RIIIJ (RIIIJ), reliably i

148 effect of a NMDAR PAM (rapastinel) or NMDAR antagonist, ketamine on NMDAR function and disinhibition

149 fficacy of the N-methyl-D-aspartate receptor antagonist, ketamine, for treating major depressive diso

150 ox, nifedipine, or the adenosine receptor 2A antagonist KW6002.

151 restriction, and genetic loss of viral IFN-I antagonists leads to virus attenuation.

152 d neurophysiological deficits using GABA(A)R antagonists led to hypothesize an excessive activity of

153 ures of the receptors in complex with 10 new antagonist ligands from diverse chemotypes are presented

154 nalyse in vivo signalling interplay, a CCK-1 antagonist (lorglumide) was intraperitoneally injected i

155 The angiotensin-II antagonist losartan is a promising candidate that has en

156 nity with CCR5 co-receptor than the standard antagonist Maraviroc.

157 ophagitis, whereas the neurokinin-1 receptor antagonist maropitant citrate is licensed as an antiemet

158 uggest that GFRAL neutralising antibodies or antagonists may provide a co-treatment opportunity for p

159 y and restricted biodistribution of nanobody antagonists may provide a path for treating hypertensive

160 combined beta-blocker and renin-angiotensin antagonist medication rates increased from 60.7% to 72.8

161 ns in subjective responses to alcohol (e.g., antagonist medication).

162 examined if combined treatment with the NMDA antagonist memantine and the opioid antagonist naltrexon

163 etaARs occluded PF-PC LTP, while the beta1AR antagonist metoprolol blocked PF-PC LTP, which was also

164 est that the enhanced mosquito repellency by antagonist mixtures is due to additive rather than syner

165 We administered the NMDA receptor antagonist MK-801 and the GABA(A) receptor antagonist bi

166 cated by short-term treatment with the NMDAR antagonist MK-801, suggesting that they arise from acute

167 BN), and the N-methyl-D-aspartic acid (NMDA) antagonist MK801-in mouse and rat models of focal cerebr

168 tirizine, and cysteinyl-leukotriene receptor antagonist, montelukast, as well as between baseline and

169 treatment using a mineralocorticoid receptor antagonist (MRA) and with longitudinal systolic BP.

170 ree drug classes (mineralocorticoid receptor antagonists [MRAs], angiotensin receptor-neprilysin inhi

171 uctions with edoxaban were seen in vitamin K antagonist naive patients, patients with CHADS(2) scores

172 Conversely, the antagonist, naloxone, was predicted to have prosurvival

173 the benzomorphans, and the classic mu opioid antagonists, naloxone, naltrexone, and nalmefene.

174 MCAM (0.1-0.32 mg/kg) or the opioid receptor antagonist naltrexone (0.001-0.032 mg/kg) was injected p

175 the NMDA antagonist memantine and the opioid antagonist naltrexone, when compared with naltrexone alo

176 The effects of two new ethylene antagonists namely 1H-cyclopropabenzene (BC) and 1H-cycl

177 been proposed to bind to the noncompetitive antagonist (NCA) site in the pore of the receptor channe

178 eptor agonist 3-chloropropanoic acid and the antagonist NCS-382 had no effects on glucagon secretion

179 viruses with inactive versions of interferon antagonist nonstructural protein 1 (nsp1), nsp15, and ns

180 inactive versions of three viral interferon antagonists, nonstructural proteins 1, 15, and 16, resul

181 tor-inactivating kappa opioid receptor (KOR) antagonists, norbinaltorphimine (norBNI), produces prolo

182 Intrathecal injection of oxytocin receptor antagonist not only attenuates ejaculation but also affe

183 Tamoxifen is an antagonist of estrogen receptor (ERalpha), a transcripti

184 sulphide (NaHS); NaHS plus glibenclamide, an antagonist of K(ATP) opening (NaHS Glib), and Glib alone

185 dimers, MNT is considered a transcriptional antagonist of MYC.

186 d the safety and efficacy of tradipitant, an antagonist of NK1R, in patients with idiopathic or diabe

187 down; (2) antagonists of TRPV4 channels; (3) antagonist of P2Y(1) receptors for ATP; and (4) inhibito

188 Sprouty 1 (SPRY1) is an antagonist of receptor tyrosine kinases.

189 orixafor is an oral small molecule selective antagonist of the CXCR4 receptor that increases mobiliza

190 GB001 is an oral antagonist of the prostaglandin D2 receptor that may inh

191 agonist for the nuclear receptor RORc and an antagonist of the sphingosine-1-phosphate receptor-1-via

192 as completely abolished by pretreatment with antagonists of both acid-sensing ion channels and transi

193 ogical conditions, and specific agonists and antagonists of catecholamines are available for the trea

194 tes of the rat brainstem were blocked by (1) antagonists of connexin channels, connexin 43 (Cx43) blo

195 cised tissue) or in vivo (in animals), using antagonists of opioid receptors to infer endogenous pept

196 e discovered multiple nanobodies that act as antagonists of the angiotensin II type 1 receptor (AT1R)

197 t GnRHR function and are neither agonist nor antagonists of the GnRHR cognate receptor, a feature req

198 transmembrane current that was inhibited by antagonists of the mechanogated channel Piezo1, Rutheniu

199 Designing potent and selective antagonists of these receptors, especially of kainate re

200 he mode of action of the numerous allosteric antagonists of this important drug target.

201 peptide Gap26, or Cx43 gene knock-down; (2) antagonists of TRPV4 channels; (3) antagonist of P2Y(1)

202 nsights into their functions as mediators or antagonists of vascular diseases in vivo.

203 n if causal, the effect of beta-adrenoceptor antagonists on the risk of Parkinson's disease would be

204 riasis using vorapaxar, an FDA-approved PAR1 antagonist, on explanted lesional skin from patients wit

205 In vitro, V2R antagonists OPC31260 and Tolvaptan, or V2R gene silencin

206 clinically irrelevant and possess intrinsic antagonist or agonist activity.

207 e blocked by co-infusion of an AMPA receptor antagonist or an anti-BDNF neutralizing antibody.

208 inhibition with a nanoparticle-delivered AHR antagonist or an inhibitor developed for human use limit

209 ally by BAPTA, and externally by a Ca(V) 1.3 antagonist or iberiotoxin.

210 ntly reduced by a selective and potent TRPV1 antagonist or is completely abolished in Trpv1 null mice

211 trophils, suggesting that serotonin-receptor antagonists or serotonin reuptake inhibitors could repre

212 atment of these cell lines with 5HTR2A/2B/2C antagonists or TPH1 inhibitor decreased 5HT levels as we

213 Treatment with icatibant (bradykinin-B2-antagonist) or anakinra (interleukin-1-antagonist) reduc

214 ng: (1) L-368899 (an oxytocin receptor [OTR] antagonist) or by (2) bicuculline (a preferent GABA(A) r

215 on of either dextromethorphan (NMDA receptor antagonist) or placebo across two sessions in a double-b

216 neutralizing antibodies against chemokines, antagonists, or control antibodies.

217 and Drug Administration (FDA)-approved IL-1R antagonist; or parthenolide, a caspase-1 and nuclear fac

218 The advent of non-vitamin K antagonist oral anticoagulants, which attenuate fibrin f

219 Production of RANKL and its competitive antagonist osteoprotegerin (OPG) were analyzed by ELISA,

220 uclear factor kappa B ligand (RANKL) and its antagonist osteoprotegerin (OPG) were measured prospecti

221 struct mathematical models of ER agonist and antagonist pathways to prioritize chemicals for endocrin

222 the identification of ZmPep5a as a potential antagonist peptide able to competitively inhibit the act

223 s, protease activated receptor 2 agonist and antagonist peptides, and a tryptase-neutralizing mAb on

224 cts on signals elicited by the NMDA-receptor antagonists phencyclidine (PCP) and ketamine.

225 e widely used GABA receptor type A (GABA(A)) antagonist picrotoxinin, TETS has been proposed to bind

226 red a gonadotropin-releasing hormone agonist/antagonist plus aromatase inhibitor.

227 inhibitor) versus triple therapy (vitamin K antagonist plus aspirin and P2Y12 inhibitor) in patients

228 ascular endothelial growth factor receptor 2 antagonist-plus docetaxel was previously reported to imp

229 ndoline system significantly improved GnRH-R antagonist potencies across several species, mandatory f

230 ntrast, aquaretic drugs (such as vasopressin antagonists) predominantly cause water excretion, which

231 inant Fowl Pox Virus (FPV)-gag pol env-IL-4R antagonist prime, intramuscular (i.m.) recombinant Modif

232 c dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant

233 pinal cell responses whereas the D2 receptor antagonist raclopride increased the response amplitude.

234 roidal, selective mineralocorticoid receptor antagonist, reduced albuminuria in short-term trials inv

235 in-B2-antagonist) or anakinra (interleukin-1-antagonist) reduces disease activity in patients.

236 r systemic administration of an EP2 receptor antagonist relieves multiple deleterious consequences of

237 potent, non-acidic, allosteric P2X1 receptor antagonists reported to date.

238 for non-metastatic PC with androgen receptor antagonists, respectively.

239 olix, an oral gonadotropin-releasing hormone antagonist resulting in rapid, reversible suppression of

240 -binding domain in complex with the ZK168281 antagonist, revealing that the ligand prevents optimal f

241 induced DPP4 expression is blocked by the GR antagonist RU-486 and by GR siRNA transfection and that

242 mutant mice with the glucocorticoid receptor antagonist RU486 restored KLF15 and POX expression level

243 eating PGRB-overexpressing mice with the PGR antagonist RU486 stalled tumor growth and decreased the

244 unteers of either sex who received the NMDAR antagonist S-ketamine in a placebo-controlled, double-bl

245 cacy and Safety Trial of Oral GABA(A) alpha5 antagonist S44819 after Recent ischemic Event (RESTORE B

246 nation of olanzapine and the opioid receptor antagonist samidorphan is under development for the trea

247 use it is abrogated by the 5-HT(2B)-specific antagonist SB204741.

248 Here, we describe a novel SUCNR1 antagonist scaffold discovered by high-throughput screen

249 of homozygous mouse pups with NMDA receptor antagonists significantly delayed the onset of lethal se

250 ontrast, a clinically used S1P(1) functional antagonist, siponimod, conferred minimal renal protectio

251 activation being blocked by an hPXR-specific antagonist, SPA70; 3) does not activate mouse PXR; 4) de

252 Thus, we expanded P2Y(14)R antagonist structure-activity relationship, introducing

253 targeting FPR1 by a selective small molecule antagonist, such as ICT12035, can provide a new avenue f

254 ngosine-1-phosphate (S1P) receptor 1 (S1PR1) antagonists, such as FTY720/fingolimod, used clinically

255 herapeutic strategies utilizing agonists and antagonists targeting nucleic acid sensors to treat infe

256 Here, we present the design of a novel TRPM2 antagonist, tatM2NX, which prevents ligand binding and T

257 an effective L-type Ca(2+) channel (Cav1.2) antagonist that directly inhibits calcium influx and smo

258 by the addition of small molecule S6K1/MDM2 antagonists that could have clinical benefit.

259 onstrates that inactivating a dominant viral antagonist, the coronavirus endoribonuclease, dramatical

260 dent mutations in one of two different viral antagonists, the deubiquitinase (DUB) within nonstructur

261 se to V2R-selective vasopressin agonists and antagonists, the response to CRISPR-mediated deletion of

262 fate to induce colitis and/or gavage with an antagonist to MIR200C-3p (antagomiR-200C) or the nonspec

263 Recent work shows that binding of antagonists to these receptors is complex, with strong d

264 anipulation of nAChRs by reversibly applying antagonists to two receptor types, alpha7 and alpha4beta

265 severe CRS is managed with the IL-6 receptor antagonist tocilizumab with or without corticosteroids,

266 EPC markers are observed in the tumors of AR-antagonists treated mice, and in a subset of NEPC patien

267 ATF3 deletion improves the effect of ADORA1 antagonist treatment of melanoma and NSCLC xenografts.

268 551-evoked pain is relatively insensitive to antagonist treatment.

269 c Function Heart Failure With an Aldosterone Antagonist) trial participants (n = 379) using a Multipl

270 herein the identification of bispecific RBP4 antagonist-TTR tetramer kinetic stabilizers.

271 citonin gene-related peptide (CGRP) receptor antagonist under investigation for treatment of migraine

272 's disease associated with beta-adrenoceptor antagonists use can be explained by reverse causation be

273 Here, we show that clinically relevant antagonists used for treating autoimmune conditions can

274 Here we screen 39 potential A(3)R, antagonists using agonist-induced inhibition of cAMP.

275 trexate, cyclosporine, tacrolimus, TNF-alpha antagonists, vedolizumab, tofacitnib, or ustekinumab, ei

276 The BCL-2 antagonist venetoclax is highly effective in multiple my

277 d less bleeding with apixaban than vitamin K antagonist (VKA) and with placebo than aspirin.

278 tion of prior anticoagulation with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs)

279 Vitamin K antagonists (VKAs), although commonly used to reduce thr

280 ancy, and anticoagulation (LMWH or vitamin K antagonists [VKAs]) should be continued until 6 weeks af

281 xanthine oxidase inhibitor or IL-1 receptor antagonist was administered during RSV infection.

282 Introduction of NMDA receptor antagonists was correlated with a decrease in seizure bu

283 Because FRZB is a Wnt antagonist, we assessed beta-catenin, the canonical tran

284 the in vivo applicability of this novel TLR7 antagonist, we demonstrated its excellent efficacy in pr

285 Using BAPTA loading and selective receptor antagonists, we found that Ca(2+) mobilization downstrea

286 nce to BCL-2 (venetoclax) and MCL-1 (S63845) antagonists, we identify common principles of resistance

287 ct either as agonists or as inverse agonists/antagonists were discovered.

288 Because some of the identified antagonists were previously shown to strongly repel Anop

289 on-competitive N-methyl-D-aspartate receptor antagonist, which produces rapid and long-lasting antide

290 minants for distinguishing CB2 agonists from antagonists, which are supported by a pair of rationally

291 ), an orally administered Toll-like receptor antagonist widely used in lupus including during pregnan

292 Methocinnamox (MCAM), a mu opioid receptor antagonist with a long duration of action, attenuates he

293 Moreover, tatM2NX is a potent antagonist with an IC(50) of 396 nM.

294 We found that UBP-310, a kainate receptor antagonist with high selectivity for GluK1 subunits, red

295 that the combination of a dopamine receptor antagonist with radiation enhances the efficacy of RT in

296 einforce the beta-turn resulted in our first antagonist with subnanomolar potency in AgrC-I, while an

297 an oral lutenizing-hormone-releasing hormone antagonist with superior endocrine and tolerability prof

298 nomolar affinity for its receptor, designing antagonists with an extended confirmation and multiple p

299 studies, we have developed several novel EP2 antagonists with improved water solubility, brain penetr

300 These included four dopamine D2 receptor antagonists, with D2 receptors having previously been su

301 hether gepants, small molecule CGRP receptor antagonists, worsen cerebral ischemia.