ライフサイエンスコーパス: antagonistic

1 eration, and may be additive, synergistic or antagonistic.

2 )-receptors are coexpressed and are mutually antagonistic.

3 e cytarabine combination with tivantinib was antagonistic.

4 ection and the BMP/SMAD pathway are mutually antagonistic.

5 ates that the fbRF and the ffRF are mutually antagonistic.

6 interactions, which are both beneficial and antagonistic.

7 rol by seasonal cues is mediated by mutually antagonistic action of aspen orthologs of the flowering

8 d that a bifunctional approach combining the antagonistic action of SERMs with a targeted (*)NO relea

9 ability and behavioral plasticity, and their antagonistic actions are balanced within a dynamic range

10 messenger cyclic (c)AMP are regulated by the antagonistic actions of the canonical G protein -> adeny

11 hat the pathogenic mechanisms include direct antagonistic actions on glycine receptors.

12 mpounds were screened for both agonistic and antagonistic activities against a panel of 168 G protein

13 ect, the novel compound 4 (V2a) demonstrated antagonistic activities against hypocretin (orexin) rece

14 old of 11i yielded compounds with high CXCR7 antagonistic activities and balanced ADMET properties.

15 o and out of the nucleus is regulated by the antagonistic activities of both a peptide-encoded N-term

16 Under dehydration in plants, antagonistic activities of histone 3 lysine 4 (H3K4) met

17 elucidated, this process is known to rely on antagonistic activities of plus end- and minus end-direc

18 Analysis of the agonistic and antagonistic activities of the resulting products agains

19 tested for their TLR7 or TLR8 agonistic and antagonistic activities.

20 Compounds showed antagonistic activity for ERbeta (IC(50)(ERbeta) = 0.2-2

21 eners (2 fM to 2 muM) exhibited agonistic or antagonistic activity in a THR reporter cell line.

22 nalyzed its IL-33-binding affinity and IL-33 antagonistic activity in cultured cells and mice.

23 This antagonistic activity is crucial for maintaining the req

24 e acetylation homeostasis, maintained by the antagonistic activity of histone acetyltransferases (HAT

25 ering the molecular functions underlying the antagonistic activity of this yeast.

26 that the default mode network (DMN) exhibits antagonistic activity with dorsal attention (DAN) and sa

27 H(2) O(2) formation with concomitant loss of antagonistic activity.

28 isolated, of which 77 exhibited significant antagonistic activity.

29 The analysis of transcription shows that the antagonistic adaptive mutations repress a stringent resp

30 eases driven by multiple cytokines, a single antagonistic agent such as a mAb to IL-1R3 is a therapeu

31 These findings point to antagonistic allostery in ISRIB action on eIF2B, culmina

32 by food deprivation, thus selecting between antagonistic amine actions on motoneurons.

33 There was an even distribution of antagonistic and agonistic effect directions among the s

34 tively, we comprehensively characterized the antagonistic and cooperative contributions of H2A.Z and

35 Here, we experimentally tested how antagonistic and facilitative pairwise interactions with

36 lex ecological responses (that is, additive, antagonistic and synergistic effects).

37 er able to discriminate between synergistic, antagonistic, and additive interactions.

38 ukocytes under short-term immunotherapy with antagonistic anti-CD40 antibody 2C10R4, rapamycin, solub

39 m has been perturbed by irradiation or by an antagonistic anti-ckit antibody, only a small fraction o

40 Here, we have identified novel antagonistic anti-PD-1 Abs not blocking the PD-1-PDL-1 i

41 Classical antagonistic antibodies (Abs) targeting PD-1, such as pe

42 th tumor necrosis factor receptor II (TNFR2) antagonistic antibody protected mice by significantly re

43 MM-131 is a purely antagonistic antibody that blocks ligand-dependent and l

44 rine signaling and may explain resistance to antagonistic antibody therapies targeting receptors at t

45 t all interspecies interactions studied were antagonistic, as S. aureus exoproducts were shown to res

46 mplex transcriptional network, with mutually antagonistic Bcl6-Blimp1 as a core regulatory axis.

47 To this end, we investigated an inducible antagonistic behavior in multiple isolates of the order

48 Given the antagonistic behavior of commensal bacteria toward their

49 ells as the plausible cause of the inducible antagonistic behavior.

50 motor neurons (MNs) generate two distinct or antagonistic behaviors remains an open question.

51 Our results suggest that aspects of antagonistic behaviors to both conspecifics and brood pa

52 molecular modelling, we show an interplay of antagonistic binding effects of PtdIns(3,4,5)P(3) and ot

53 e of temporally delayed coordination between antagonistic brain networks.

54 We identified caspase-2 as the antagonistic caspase that downregulates IFN-I production

55 o chemokine receptors allows coordination of antagonistic cell behaviors, promoting a self-resolving

56 content might be partly responsible for the antagonistic cellular antioxidant property seen in some

57 er nonsynonymous to synonymous rate ratio in antagonistic changing environments than in the correspon

58 ion and that these 2 elements are engaged in antagonistic coevolution despite the fact that TART-A is

59 Sexually antagonistic coevolution is predicted to lead to the div

60 Antagonistic coevolution with selfish genetic elements (

61 inked to direct inhibition of the invader by antagonistic communities (antibiosis), and to a lesser d

62 promoted G(q) activation due to its 5-HT(2C) antagonistic component.

63 over Streptomyces' arsenal of signaling and antagonistic compounds.

64 the CC-trapping, GRPR-targeted agonistic and antagonistic constructs led to an approximately 2-fold i

65 localized outside introns are not under this antagonistic control.

66 pinning(12,13), exhibit both synergistic and antagonistic cooperativity depending on the inhibitor co

67 rystal growth modifiers is expected, but the antagonistic cooperativity of haematin inhibitors is not

68 e combination of autoactivation and mutually antagonistic cross talk between GTPases, along with the

69 ciprocity, which is encoded in the model via antagonistic cross-diffusivities, provides a generic mec

70 cate that EphrinB2 is a critical effector of antagonistic Dll4 and Jag1 functions in arterial morphog

71 ther identified corresponding synergistic or antagonistic drug combinations.

72 ability to rapidly identify synergistic and antagonistic drug interactions can potentially alter the

73 tures of Ca(v)1.1 in complex with archetypal antagonistic drugs, nifedipine, diltiazem, and verapamil

74 Antagonistic dynamics can also occur between RNAPs from

75 ribing RNAPs display either collaborative or antagonistic dynamics over long distances (>2 kb) throug

76 .g., pollination, seed dispersal) as well as antagonistic (e.g., herbivory, parasitism) interactions.

77 mechanism involving ubiquitination and three antagonistic E3 ubiquitin ligases: Grr1 and Ptr1 maintai

78 We observed the antagonistic effect by a decrease in singlet oxygen gene

79 Scanning electron microscopy confirmed the antagonistic effect of SFC addition on extrudate porosit

80 The observed antagonistic effect of the A allele on propranolol's eff

81 ipotent stem cell-derived cardiomyocyte, its antagonistic effect on myocardial regeneration, and its

82 ormone abscisic acid signaling, whereas this antagonistic effect was blocked in younger rosette leave

83 ic lipopeptides could be responsible for the antagonistic effect, despite what is often reported.

84 , presence of the three hydrocolloids had an antagonistic effect.

85 to evaluate additive and/or synergistic (or antagonistic) effect of vaccine-induced antibodies.

86 We suggest that mutations with antagonistic effects between males and females have driv

87 melanoma cell lines, resulted in short-term antagonistic effects consistent with in vivo findings.

88 groups and showed different synergistic and antagonistic effects in combination with clindamycin.

89 s on the two traits in poor environments but antagonistic effects in rich environments.

90 We also highlight that synergistic and antagonistic effects occur concurrently, and the final l

91 Antagonistic effects of FBFs are mediated by their disti

92 )ethane (DDT) and its metabolites had mainly antagonistic effects on all of the receptors, except for

93 conferring flooding resistance, but lacking antagonistic effects on growth.

94 sized to involve the linkage of factors with antagonistic effects on male and female function.

95 Thus, MEF8 has two antagonistic effects on mitochondrial editing: stimulato

96 Some QR has correlated or antagonistic effects on multiple diseases.

97 ated biphenyls (PCBs) had both agonistic and antagonistic effects on PPARG and GR, and mainly antagon

98 und that metals exerted various and sometime antagonistic effects on the reaction catalyzed by CntM:

99 ble for better understanding synergistic and antagonistic effects relevant for stabilizing aqueous di

100 Additionally, synergistic effects turn into antagonistic effects when soil fauna are absent or litte

101 ocarbon phase, can have both synergistic and antagonistic effects, depending on their molecular struc

102 nts, and/or sex- and environment-specific or antagonistic effects.

103 , studies in boreal regions show significant antagonistic effects.

104 Nonlinear (including synergistic and antagonistic) effects among global change drivers were r

105 sm in a ternary protocell network capable of antagonistic enzyme-mediated interactions.

106 gonistic effects on PPARG and GR, and mainly antagonistic, except for PCB153, effects on THRB.

107 ally, in important biological contexts these antagonistic factors are co-expressed and target overlap

108 ersus combinatory effects of synergistic and antagonistic factors on chromatograph area.

109 vasoactive intestinal peptide have mutually antagonistic fbRF and ffRF, similar to excitatory neuron

110 g T cells; these interactions fed two nested antagonistic feedback circuits that regulated interleuki

111 istently underestimated in nature due to the antagonistic fitness effects of mutations in changing en

112 We find that the ratio between these antagonistic forces establishes the range of filament in

113 cross replicate populations, consistent with antagonistic frequency-dependent selection, (iii) genomi

114 Furthermore, they have similar or antagonistic function depending on genes.

115 regulation of pattern formation and have an antagonistic function to Wnt signaling in Hydra.

116 the Nup98-Rae1 complex and abolishes its IFN antagonistic function.

117 ufacturing of structural materials combining antagonistic functional properties.

118 stic behavior may underlie variable and even antagonistic functions during inflammation or cancer, ye

119 utants, showing that PANS1 and SEPARASE have antagonistic functions in vivo.

120 nd progerin, products of the Lmna gene, have antagonistic functions on energy metabolism and life spa

121 h proteins target the same receptor but have antagonistic functions, virus infection depends on a pro

122 nhibits NF-kappaB activation among its other antagonistic functions.

123 reases in mutualistic fungi and increases in antagonistic fungi that were strongest on the least fert

124 teromer can explain previous results showing antagonistic galanin-opioid interactions and offers a ne

125 ns using data from experiments simulating an antagonistic game between an Attacker and a Blocker.

126 ocampal neurons; however, the identity of an antagonistic GAP remains elusive.

127 ndings reveal the molecular mechanism of the antagonistic gene paralogs RH1 and RH2 in determining an

128 d the systematic characterization of extreme antagonistic gene-drug interactions, which can be used t

129 nt genetic variance and heritability, and an antagonistic genetic correlation with some animal perfor

130 nomic location, and evolutionary dynamics of antagonistic genetic variants.

131 Here, we investigate how contractions of antagonistic groups of muscles are intersegmentally coor

132 ng in expansion of H3K36me2 and shrinkage of antagonistic H3K27me3 domains.

133 ntracellular positioning mechanism involving antagonistic Hippo signaling and cyclin E.

134 plying space-for-time substitution, a strong antagonistic (i.e. dampening) interaction between sportf

135 evaluated for antibiotic susceptibility and antagonistic impacts on other pathogenic bacteria.

136 on in the p85 mutant lens, demonstrating the antagonistic interaction between FGF-induced MAPK and PD

137 -3 and SKN-1a are proposed to regulate cross-antagonistic interaction between opioids and pheromones

138 , we highlight recent findings regarding the antagonistic interaction between PRR and ELABELA/apelin,

139 Contrary to the second hypothesis, an antagonistic interaction between warming and nutrient en

140 ash and LNS treatments for HAZ, but found an antagonistic interaction for stunting (OR: 1.55; 95% CI:

141 egulation, we present the immune Synergistic/Antagonistic Interaction Learner (iSAIL).

142 d Factor 1 (which included Fn), exhibited an antagonistic interaction with Hp in relation to all-caus

143 nteraction rate functions that can stabilize antagonistic interactions and destabilize mutualistic on

144 Such antagonistic interactions are commonplace in cells and c

145 In complex mixtures of up to 12 odorants, antagonistic interactions are stronger and more prevalen

146 However, antagonistic interactions between chemo-drugs and photos

147 atching other thaumarchaeal iMGE, suggesting antagonistic interactions between coexisting MGE and sym

148 These data suggest that coevolutionary antagonistic interactions between Fusarium and Streptomy

149 of documented importance for mutualistic and antagonistic interactions between plants, pollinators, a

150 Synergistic and antagonistic interactions between stimuli play major rol

151 These extreme antagonistic interactions constitute gene-environment an

152 Antagonistic interactions drive host-virus evolutionary

153 in freely breathing mice, we find widespread antagonistic interactions in binary odor mixtures.

154 Antagonistic interactions in biological systems, which o

155 Synergistic/antagonistic interactions occur when the combination has

156 Sex determination in mammals is governed by antagonistic interactions of two genetic pathways, imbal

157 Furthermore, GATA4 and TBX5 showed antagonistic interactions on an Ryr2 enhancer.

158 resident community interactions promoted and antagonistic interactions suppressed invasions both in t

159 e spatial variation of their mutualistic and antagonistic interactions using two multilayer networks,

160 n aqueous medium, while both synergistic and antagonistic interactions were seen in liposome medium.

161 Yet, this interpretation ignores extreme antagonistic interactions wherein an otherwise deleterio

162 rematode parasites, the larvae of which have antagonistic interactions with S. mansoni in their share

163 The networks of multiple synergistic and antagonistic interactions within oral biofilms give rise

164 tectures would correspond to mutualistic and antagonistic interactions, respectively.

165 icult to distinguish between mutualistic and antagonistic interactions.

166 multispecies mixtures of microorganisms with antagonistic interactions.

167 maintenance then involves complementary and antagonistic interplay between apical and basal polarity

168 Together, the results suggest a complex antagonistic interplay between the control of ARPP-16 by

169 ealed a neuronal maturation context-specific antagonistic interplay between the transcriptional repre

170 -plant relationship based on mutualistic and antagonistic life-history traits.

171 T2) is a context-dependent TIE2 agonistic or antagonistic ligand that induces diverse responses in ca

172 , TEK (TEK receptor tyrosine kinase) and its antagonistic ligand, ANGPT2 (angiopoietin-2).

173 tween the sex-determining locus and sexually antagonistic loci, and leads to the degeneration of the

174 nsverse muscles and inhibitory inputs to the antagonistic longitudinal muscles.

175 rane- and intracellular-targeting AMPs in an antagonistic manner.

176 mine the structure-activity relationship and antagonistic mechanism on TRPM2 using whole-cell patch c

177 ial structure are affected by cooperative or antagonistic microbes.

178 In the antagonistic migration assay, a population of fluidlike

179 n of two monolayers of different cells in an antagonistic migration assay.

180 We reproduce the experimentally observed antagonistic migration assays by assuming that a fractio

181 al deletion, or due to overexpression of the antagonistic miRNA let-7g, suppressed Akt-mTOR complex 1

182 and synaptic pathologies in Fmr1-KO mice are antagonistic, mitigating circuit dysfunction, and hence

183 control CP1-3, dedicated hubs integrate the antagonistic mitogenic and DNA damage signals, regulatin

184 Mutually antagonistic molecular signals ensure ovary versus testi

185 Here we report a therapeutic antagonistic monoclonal antibody, 3P10, that targets GFR

186 A phosphopeptide bearing the antagonistic motif (AVPI) to the inhibitors of apoptotic

187 hich is associated with high coactivation of antagonistic muscle groups.

188 In physiological movements of large limbs, antagonistic muscle passive torque is generally negligib

189 he pattern of co-activation of agonistic and antagonistic muscles changed based on whether passive fo

190 edback into task-dependent co-contraction of antagonistic muscles.

191 spontaneously occurring, pigmentless, weakly antagonistic mutant derivative.

192 Antagonistic natural selection pressures are likely invo

193 NF-alpha) stimulation, confirming the immune-antagonistic nature of this sequestration.

194 differ substantially between mutualistic and antagonistic networks.

195 ysiological effects different, and sometimes antagonistic, of their binding to AT(1)R.

196 DHP compounds exhibit chirality-specific antagonistic or agonistic effects.

197 two species (be it mutualistic, competitive, antagonistic, or neutral) may switch to a different clas

198 teractions with these organelles lead to the antagonistic outcomes.

199 coli O26:H11, and Staphylococcus aureus with antagonistic P. aeruginosa.

200 tion on PIF activity, rather than a parallel antagonistic pathway.

201 The pervasiveness of antagonistic pathways is necessarily matched by an equal

202 ent LUXendin645, a far-red fluorescent GLP1R antagonistic peptide label.

203 PR3 silencing in DCs or pretreatment with an antagonistic peptide restores IL-12 and induces IL-10 ex

204 cing of FPR3 in DCs and pretreatment with an antagonistic peptide were used to assess the function of

205 these CC-trapping agents into agonistic and antagonistic pharmacophores targeting the gastrin-releas

206 In this article we detail the antagonistic philosophies behind two quantitative approa

207 er via perturbation of GA signaling, the ABA antagonistic phytohormone, nor through interference with

208 genes with sex- and environment-specific or antagonistic pleiotropic allelic effects.

209 h as late-life-specific deleterious effects, antagonistic pleiotropic effects on early and late-age f

210 is of fitness trade-offs, a concept known as antagonistic pleiotropy (AP).

211 large effect), as well as little evidence of antagonistic pleiotropy (few trait correlations and QTL

212 to become deleterious soon after because of antagonistic pleiotropy and hindering their fixations re

213 g variation and de novo mutations; shown how antagonistic pleiotropy and temporally varying selection

214 ongest evidence to date for a gene having an antagonistic pleiotropy effect on human cognitive functi

215 eral lines of evidence supporting a model of antagonistic pleiotropy in the DNA damage response where

216 n hosts indicating that positive rather than antagonistic pleiotropy is pervasive.

217 their evolution that avoid or compensate for antagonistic pleiotropy may limit access to certain futu

218 ons evolved was explained by amelioration of antagonistic pleiotropy through epistasis(13,14,20-22).

219 flict between germline and soma, relevant to antagonistic pleiotropy, an evolutionary process underly

220 er benefits to the organisms that bear them, antagonistic pleiotropy, the importance of pre-existing

221 biology for survival of deleterious genes is antagonistic pleiotropy.

222 to specific instances of both agonistic and antagonistic pleiotropy.

223 The classic genetic explanation is antagonistic pleiotropy: genes underlying the generalism

224 P2X1 antagonistic potency was assessed in 1321N1 astrocytoma

225 imidamide group significantly attenuated K18 antagonistic potency.

226 Compounds 1a and 2a showed alpha4beta2 antagonistic properties while behaved as full agonists o

227 set of fluorescent KOR-selective probes with antagonistic properties.

228 in the presence or absence of two viral IFN antagonistic proteins.

229 these hypotheses are predicated on mutually antagonistic Rac-Rho signaling, Rac-mediated protrusion

230 ted predation, and increased temperature are antagonistic, rather than synergistic or additive, for a

231 group ring finger (Pcgf) 2/ Pcgf5, displayed antagonistic regulation between the placenta and brain.

232 electrical output to sleep need(4), via the antagonistic regulation of two potassium conductances: t

233 lated OXI1 We conclude that OXI1 and DAD are antagonistic regulators of cell death through modulating

234 ula, providing a multidimensional paralogous-antagonistic regulatory paradigm for fine-tuning pattern

235 We report an antagonistic relationship between endosomal F-actin asse

236 enetics CRISPR-Cas9 screen, we identified an antagonistic relationship between LSD1 and the non-canon

237 This suggests an antagonistic relationship between UTX and FGFR3.

238 The first calcium binding site showed an antagonistic relationship towards the other two.

239 vealed quantitative imbalances in TFs' cross-antagonistic relationships that underlie lineage determi

240 How the SAC meets these potentially antagonistic requirements is unclear.

241 lor signaling, with a circuitry that enables antagonistic responses between long (L)- and medium (M)-

242 d pest populations, our results suggest that antagonistic responses resulting from a combination of i

243 processed in the brain through generation of antagonistic responses to different wavelengths.

244 otype, which may have evolved to balance the antagonistic RETN effects on pathogen protection vs. met

245 plet populations for exploring beneficial or antagonistic roles in microbial cocultivation systems, a

246 th synthesized from GTP molecules, they play antagonistic roles in regulating the cell cycle.

247 We suggest that A-type lamins and SUN2 play antagonistic roles in the modulation of profibrotic sign

248 s tumor suppressor gene microenvironment has antagonistic roles in tumorigenesis, by accelerating dev

249 ependent response of microglia, and proposes antagonistic roles of TREM2 in Abeta- versus tau-mediate

250 The surprising antagonistic roles of two closely related E3 ubiquitin l

251 and females in opposite directions [sexually antagonistic (SA) polymorphisms] are the main selective

252 However, sexually antagonistic selection (SAS) may promote diversity by se

253 opulations with differing levels of sexually antagonistic selection for colour, we also show that sex

254 n are consistent with the idea that sexually antagonistic selection may have played a role in favorin

255 of adaptive phenotypes because of potential antagonistic selection on correlated traits, or, alterna

256 of recombination suppression, including (1) antagonistic selection, (2) association of additional fu

257 Under sexually antagonistic selection, mechanisms are expected to evolv

258 m to evolve under what is hypothesised to be antagonistic selection.

259 iA and reciprocal regulation of the mutually antagonistic signaling proteins, SasA and CikA.

260 The use of 'cross-antagonistic' signalling to trap pluripotent stem cell i

261 mately 230 chromosomal clusters of candidate antagonistic single nucleotide polymorphisms (SNPs).

262 luence substrate selectivity on functionally antagonistic sites in PERIOD that directly control circa

263 Characterising antagonistic SNPs functionally, we find a large excess o

264 ansmission in pumas may primarily be via non-antagonistic, social interactions between adult conspeci

265 ate functional responses to novel classes of antagonistic stimuli remain poorly understood.

266 these traits were less pronounced, implying antagonistic stressor effects on morphological traits.

267 alized thalamic reticular neurons, including antagonistic subpopulations.

268 nce of both synergistic (CRISPR evasion) and antagonistic (superinfection exclusion) interactions wit

269 We also detected a loss of antagonistic surround in several RGC subtypes.

270 They have small receptive fields and strong antagonistic surrounds.

271 ive effects and 33% resulted in interactive (antagonistic, synergistic, opposing or reversal) effects

272 EL-bound Golgi state, and in complex with an antagonistic synthetic nanobody (sybody).

273 logical scenarios, creating a phenologically antagonistic system.

274 The contextual agonistic and antagonistic Tie2 ligand ANGPT2 is believed to be exclus

275 Furthermore, BdES43 was antagonistic to BdFTL2 in flowering initiation in a tran

276 Once soil microbes were confirmed to be antagonistic to C. elegans, they were tested for pathoge

277 nvestigated if PLE DNA replication itself is antagonistic to ICP1 replication.

278 ficient for nodulation, whereas cytokinin is antagonistic to lateral root development, with cre1 show

279 the molecular motifs that are synergistic or antagonistic to M1 agonism, which we have prospectively

280 set of mAbs that are non-functional, or even antagonistic to neutralizing antibodies.

281 om interactions also occur as oral yeast are antagonistic to some oral bacteria, while numerous mutua

282 nscriptional profiling, we implicate IRF2 as antagonistic to stemness and show that it binds and regu

283 r component of the innate immune response is antagonistic to the bactericidal activities of antibioti

284 Although long thought to be antagonistic to translation, discovery of the 5' to 3' c

285 h enrichment for bacterial species that were antagonistic toward R. solanacearum.

286 ed to population variation in the key female antagonistic trait (spine length, a defence against male

287 ess, population covariation between sexually antagonistic traits remained substantial and significant

288 rentiation disrupted the balance between two antagonistic transcription factor modules.

289 ription result in the co-expression of these antagonistic transcription factors in the majority of ha

290 Th2-antagonistic type1 IFN signalling may play a key role in

291 Remarkably, antagonistic variants are associated with multiple signa

292 also assess the evolutionary persistence of antagonistic variants by examining extant polymorphism i

293 Based on our results, we propose that antagonistic variation accumulates because of constraint

294 icted to harbour elevated levels of sexually antagonistic variation due to asymmetries in the heritab

295 ct resolution capable of protecting sexually antagonistic variation while avoiding the homozygous let

296 n resolve this conflict and protect sexually antagonistic variation, but they accumulate deleterious

297 the X chromosome is a hot spot for sexually antagonistic variation.

298 osable elements (TEs) and their hosts can be antagonistic, where TEs evolve to avoid silencing and th

299 lly for uptake of Se by B. edulis, which was antagonistic with As and Pb in the soil.

300 alpha-dependent VHL(-/-) ccRCC cells and not antagonistic with HIF-2alpha inhibition in HIF-2alpha-in