ライフサイエンスコーパス: anterograde

1 We employed anterograde AAV1-directed axonal tracing to verify NAc C

2 on MTL structures, except to the extent that anterograde amnesia affects performance.

3 formation of long-term, declarative memory (anterograde amnesia), together with temporally graded re

4 e symptoms of temporal lobe and diencephalic anterograde amnesia.SIGNIFICANCE STATEMENT It has long b

5 medial temporal lobes can result in profound anterograde amnesic syndromes.

6 I, R, RT, RTp, and STGr using retrograde and anterograde anatomical tracers.

7 osome fine-tunes the precise balance between anterograde and intracellular retention elements that co

8 rocesses more broadly, triggering windows of anterograde and retrograde amnesia in healthy people.

9 irus particles in primary neurons to measure anterograde and retrograde axonal transport, demonstrati

10 m a thoracic inflammatory process results in anterograde and retrograde degeneration of axons, leadin

11 a slow directional motion state in both the anterograde and retrograde directions and a stationary s

12 All ALS-FUS variants impaired anterograde and retrograde FAT in squid axoplasm, wherea

13 sual cortex connectivity, substantially more anterograde and retrograde label was present in the hemi

14 Using anterograde and retrograde labeling, we found that a spa

15 on of an actin-dependent retrograde flow and anterograde and retrograde microtubule-dependent transpo

16 Anterograde and retrograde neuroanatomical tracing confi

17 ctionally, H(2)O(2) treatment inhibited both anterograde and retrograde protein transport, consistent

18 test this hypothesis, we performed bilateral anterograde and retrograde tectal tracing combined with

19 To address this issue, anterograde and retrograde tracers were placed, respecti

20 In cases in which anterograde and retrograde tracers were placed, respecti

21 In other experiments, anterograde and retrograde tracers were separately injec

22 Using small, discrete coinjections of anterograde and retrograde tracers within the thalamus a

23 l magnetic resonance imaging screen, we used anterograde and retrograde tracers, optogenetic and DREA

24 established by simultaneous co-injection of anterograde and retrograde tracers.

25 Anterograde and retrograde tracing experiments revealed

26 Anterograde and retrograde tracing identified the cortic

27 n the present report, we implemented in vivo anterograde and retrograde tracing techniques aiming to

28 rtical connections as the claustrum, we used anterograde and retrograde tracing techniques to elucida

29 to the entorhinal cortex was analyzed using anterograde and retrograde tracing techniques.

30 For this, we combined anterograde and retrograde tracing with immunohistochemi

31 edial, and ventromedial) by a combination of anterograde and retrograde tracing.

32 ave used viral, transgenic, and conventional anterograde and retrograde tract-tracing methods to bett

33 ance in sensory neurons between the rates of anterograde and retrograde trafficking of cargo destined

34 light on the cellular structures involved in anterograde and retrograde transmission and suggest a ke

35 e through Drosophila motoneuron terminals by anterograde and retrograde transport.

36 The anterograde and retrograde tubular carriers are both lar

37 and we provide a primer on currently applied anterograde and retrograde viral tracers with practical

38 s in retinal function as shown by histology, anterograde axon tracing, manganese-enhanced magnetic re

39 eview we summarize the literature supporting anterograde (axon to cell) spread of viral infection, de

40 of phosphoinositide 3-kinase (PI3K) reduces anterograde axonal trafficking of APP in hippocampal neu

41 vous system to body surfaces, referred to as anterograde axonal trafficking.

42 Virus was not released from the axons via anterograde axonal transport after infection of the cell

43 Here we demonstrate deficits in anterograde axonal transport of mitochondria in primary

44 four weeks in rats prevented degradation of anterograde axonal transport to the superior colliculus

45 oteins gE/gI and US9 initiate the process of anterograde axonal transport, ensuring that virus partic

46 d mice, indicating that paclitaxel inhibited anterograde axonal transport, whereas eribulin did not.

47 ew mechanisms for how gE/gI and US9 initiate anterograde axonal transport.

48 rly, suggestive of a putative dysfunction of anterograde axonal transport.

49 s diverse roles in cargo transport including anterograde (base to tip) trafficking in cilia.

50 In cortical axons, they normalized anterograde BDNF transport, restored retrograde BDNF tra

51 Therefore, activity-dependent anterograde capture is a major determinant of presynapti

52 nd delays the cell surface appearance of the anterograde cargo protein, VSVG.

53 microtubule-based kinesin-2 KIF3AC motor, an anterograde cargo transporter in neurons.

54 fall into two distinct classes containing 1) anterograde cargoes and clathrin clusters or 2) retrogra

55 re the retrograde membrane is, in itself, an anterograde carrier.

56 Because retrograde and anterograde communication exists between the nuclear and

57 data demonstrate that IFT52 is essential for anterograde complex integrity and for the biosynthesis a

58 of IFT74, IFT81, IFT88 and ARL13B, other key anterograde complex members.

59 The nucleo-cytoplasmic compartment exerts anterograde control on chloroplast gene expression throu

60 k showed that Unc-104 (a kinesin-3) is a key anterograde DCV motor.

61 Milton RNA interference had no influence on anterograde DCV runs, and detailed colocalization analys

62 Here we show that anterograde DCV transport requires the well-known mitoch

63 ed from basal capture by its selectivity for anterograde DCVs and its inhibition by overexpression of

64 These findings suggest attack-related anterograde degeneration rather than diffuse thalamic da

65 This pole-ward drift is facilitated by anterograde delivery of secretory cargo to the cell tip

66 rrectly" oriented MTs are transported in the anterograde direction away from the soma.

67 , viral capsids moved more frequently in the anterograde direction in axons, with an average velocity

68 tested primarily utilize the IFT path in the anterograde direction, differences are observed in the r

69 ma, and kinesins move cargo in the opposite, anterograde direction.

70 roteins are transported independently in the anterograde direction.

71 Anterograde double staining of the antennal afferents re

72 arization and synapse formation, followed by anterograde dynein-mediated transport and transfer of vi

73 Maintaining anterograde endosomal trafficking during pancreatitis ma

74 odynamic monitoring (AUM) uses physiological anterograde filling and, therefore, offers a longer and

75 turing at the tip and filopodia-guided actin anterograde flow with phagocytic cup formation, and (iii

76 stalled "tug-of-war" between retrograde and anterograde forces on the MT, providing an explanation f

77 lar transport through the Golgi occurs in an anterograde (from entry to exit) or retrograde fashion a

78 Anterograde HSV-based neuronal tracing initiated from GR

79 removal of KIF3 and IFT88, and KIF3-mediated anterograde IFT is responsible for photoreceptor transit

80 D1bLIC-GFP is transported with anterograde IFT particles to the flagellar tip, dissocia

81 mation, which matches the periodicity of the anterograde IFT-B train.

82 ed signaling in Chlamydomonas induced rapid, anterograde IFT-independent, cytoplasmic microtubule-dep

83 both kinesin-II and IFT dynein and regulates anterograde IFT.

84 e for IFT54 in binding the IFT motors during anterograde IFT.

85 iary disassembly in response to cessation of anterograde IFT: a slow shortening that is steady over t

86 he Mla system being retrograde (OM to IM) or anterograde (IM to OM).

87 ultiple sclerosis patient cohort revealed an anterograde increase of radial diffusivity in the anteri

88 Next, we used anatomic cases with anterograde injections in ACC/OFC to determine the exten

89 ing ARF6 activity in mature neurons restores anterograde integrin flow, allows transport into axons,

90 liary entry per se of SAG1 is independent of anterograde intraflagellar transport (IFT) [13], but the

91 Anterograde intraflagellar transport (IFT) is mediated b

92 ables ciliary assembly and maintenance as an anterograde intraflagellar transport (IFT) motor.

93 family motors that act jointly to carry out anterograde intraflagellar transport (IFT), ferrying car

94 IFT88, essential for anterograde intraflagellar transport (IFT), was signific

95 s in IFT52, which encodes a component of the anterograde intraflagellar transport complex.

96 R)-resident protein kinectin-1, controls the anterograde kinesin-1-dependent transport of the ER requ

97 o the ligation consistent with inhibition of anterograde (kinesin based) transport by paclitaxel.

98 Evidence has emerged that multiple anterograde kinesins can contribute to some transport pr

99 the injection into area 20a resulted in more anterograde label, whereas more retrograde label was obs

100 perior colliculus (SC) contained only sparse anterograde label.

101 Anterograde-labeled nerve endings were dispersed through

102 examined the distribution of retrograde and anterograde labeling after injecting tracers into one or

103 between neurons via synapses, explaining the anterograde labeling of neural circuits by H129-derived

104 rons, retrograde labeling of PL neurons, and anterograde labeling of PL.

105 ough homotopic, consists mainly of very weak anterograde labeling which was more widespread in area 2

106 ing bone were collected, processed to reveal anterograde labeling, and immuno-labeled with antibodies

107 aration between two major clusters which, by anterograde labeling, correspond to gustatory and somato

108 ending L5B pathway from the BC by dual-color anterograde labeling.

109 results identify CPT1C as a new regulator of anterograde LE/Lys transport in response to malonyl-CoA

110 Our study reveals an anterograde link between photoreceptor-mediated signalin

111 in addition to postulation of mechanisms for anterograde lipid transport from the inner to outer memb

112 autoinhibition, promoting kinesin-1-driven, anterograde lysosome transport.

113 retrograde dynein/dynactin motor complex in anterograde mbp mRNA transport and myelination in vivo.

114 or the retrograde dynein/dynactin complex in anterograde mbp mRNA transport.

115 How can anterograde membrane trafficking be modulated by physiol

116 ercise (RE) improves cognition, formation of anterograde memories, and mood, alongside enhancing hipp

117 ves after going on tangents, suggesting that anterograde memory impairment may have interfered with n

118 Participants then undertook an anterograde memory task of alcohol impairment when intox

119 articipants on task and reduce the burden on anterograde memory.

120 ysosomal membrane to couple lysosomes to the anterograde microtubule motor kinesin-1.

121 on of an actin filament array that specifies anterograde microtubule polymerization and guides these

122 While the mechanics and impact of anterograde mitochondrial movement toward axon terminals

123 Anterograde mitochondrial transport is mediated by the m

124 wed that loss of APC slowed the frequency of anterograde mitochondrial transport to the membrane.

125 Anterograde mitochondrial transport was less sensitive t

126 ptic nerve led to MRI detection of degrading anterograde Mn transport at the primary injury site and

127 bnormal Mn accumulation and gradually reduce anterograde Mn transport via specific Mn entry routes.

128 Here, we uncover a surprising role of the anterograde molecular motor UNC-104/KIF1A as a key regul

129 Using anterograde mono-trans-synaptic tracing, we elucidate ce

130 Time spent in anterograde motion was reduced; retrograde motion was sp

131 arry a temperature-sensitive mutation in the anterograde motor for IFT.

132 T1 and RHOT2, the adapter protein TRAK2, the anterograde motor Kif5B, and an effector of mitochondria

133 Although the anterograde motor kinesin KIF1B is involved in mbp mRNA

134 al is driven by direct interactions with the anterograde motor kinesin-1.

135 ar transport (IFT) machinery consists of the anterograde motor kinesin-II, the retrograde motor IFT d

136 teractions of cargo with a highly processive anterograde motor.

137 owed that predominance of 3R tau favored the anterograde movement of APP vesicles, increasing anterog

138 ic loop formed by circular membrane flow and anterograde movement of lipid vesicles, resulting in cel

139 vated cellular pathway acting to inhibit the anterograde movement of newly synthesized rhodopsin, is

140 ns than in wild type Hsp27 neurons, although anterograde movement velocities remained normal.

141 lay more frequent long-range retrograde than anterograde movement, with the endosomal levels of APPL1

142 protein (MBP), expression of which requires anterograde mRNA transport followed by local translation

143 al trafficking, make it a potential tool for anterograde neural circuitry tracing.

144 serve that neuronal gluconeogenesis promotes anterograde neuropeptide distribution from the soma to a

145 sed an approach combining cell-type-specific anterograde optogenetic excitation with single-cell reco

146 oups was studied following administration of anterograde or retrograde tracers into the PB.

147 We show that anterograde or retrograde vesicular transports are asymp

148 ploit both routes: viruses typically use the anterograde pathway for envelope formation prior to exit

149 The anterograde pathway, from the endoplasmic reticulum thro

150 gest that the Mla pathway may have a role in anterograde phospholipid transport.

151 c interactions with mlaA*, a mutant in which anterograde PL transport causes the inner membrane (IM)

152 Recently anterograde polysynaptic and monosynaptic tracers were d

153 required for distal axon degeneration via an anterograde pro-degenerative factor.

154 -survival Bcl-xL and Bcl-w and initiates the anterograde pro-degenerative program, highlighting the r

155 results uncover a novel function of CRK1 in anterograde protein trafficking and elucidate the mechan

156 dent kinase in Trypanosoma brucei, regulates anterograde protein trafficking by phosphorylating Sec31

157 rograde movement of APP vesicles, increasing anterograde run lengths and reducing retrograde runs and

158 Khc mutations had specific effects on anterograde run parameters, neuron-specific inhibition o

159 ues can now be extended to modulation of the anterograde secretory pathway.

160 idirectional capture by activity dependence, anterograde selectivity, and Fmr1 sensitivity.

161 reveal the framework of a nucleus-to-plastid anterograde signaling pathway by which phytochrome signa

162 AIS), controls retrograde (axon-to-soma) and anterograde (soma-to-axon) traffic of Tau.

163 We propose that the PRV anterograde sorting complex, gE/gI/US9, recruits KIF1A t

164 PRV mutants deficient in axonal sorting and anterograde spread, we identified the PRV US9/gE/gI prot

165 stem (SS) inflow from BAT to brain using the anterograde SS-specific transneuronal viral tract tracer

166 Anterograde sterol movement from STRIC is independent of

167 Lastly, we used an anterograde strategy for transynaptic targeting of Cre e

168 dopamine neuron axon terminals by impairing anterograde SV trafficking motor protein Unc104/KIF1A re

169 matrix protein family, was identified as an anterograde synaptic organizer in the nematode Caenorhab

170 The anterograde task did not reveal significant differences

171 in p14 sorting into AP1-coated vesicles for anterograde TGN-plasma membrane transport.

172 owing reactivation, the virus is transferred anterograde to the initial site of infection or to sites

173 nto the PB region to deliver a Cre-dependent anterograde tracer (synaptophysin-mCherry) in three diff

174 zing descending fibers from injections of an anterograde tracer in the rat ACC and OFC.

175 Injections of an anterograde tracer in the rPH confirmed these connection

176 Anterograde tracer injections in DEn revealed labeled te

177 An anterograde tracer was injected in the IC of CBA/Ca mice

178 ing expression of a virally encoded synaptic anterograde tracer, AAV-SynaptoTag, followed by 3D recon

179 Unilateral injections of dextran-biotin (anterograde tracer; 20% in saline, 50-100 nl) were made

180 using data from 461 systematically acquired anterograde-tracer injections into the right cortical an

181 the development of crossed projections using anterograde tracers and electron microscopy to explore t

182 Anterograde tracers identified complementary descending

183 this portion of the reticular formation with anterograde tracers in combination with injection of ret

184 Thus, we placed injections of retrograde or anterograde tracers into different IP subdivisions or th

185 Here, we placed injections of retrograde or anterograde tracers into LDTg, LHb, IP, and MnR.

186 this end, we injected rats aged P0-P28 with anterograde tracers into RSC.

187 administered a combination of retrograde and anterograde tracers into structures important for contex

188 Injections of anterograde tracers into the cortical areas identified b

189 Anterograde tracers were injected into the taste thalamu

190 biotinylated dextranamines as retrograde and anterograde tracers, respectively.

191 ed Phaseolus vulgaris-leucoagglutinin (PHAL) anterograde tracing and electron microscopy to shed ligh

192 ctions to the dLGN, Pv, and claustrum, using anterograde tracing and electron microscopy.

193 We used cell-type-specific anterograde tracing and optogenetic methods to selective

194 Finally, retrograde and anterograde tracing experiments identified the basilar p

195 Anterograde tracing experiments show that parasubicular

196 o maternal separation ELA were analyzed with anterograde tracing from basolateral amygdala (BLA) to P

197 Combined retrograde and anterograde tracing identified the paraventricular nucle

198 c manipulations, translational profiling and anterograde tracing identify a subset of distal intestin

199 Cell-specific anterograde tracing revealed that CCK(NTS) neurons provi

200 ointestinal (GI) tract, there have been many anterograde tracing studies of vagal afferent endings, b

201 In the present study, retrograde and anterograde tracing studies revealed a previously undesc

202 We used an anterograde tracing technique developed in our laborator

203 In this study, we have utilized an in vivo anterograde tracing technique to selectively label spina

204 Using an anterograde tracing technique, nulliparous female C57BL/

205 Here we use various retrograde and anterograde tracing techniques both in vivo and in vitro

206 nd aVTA, pVTA, and RMTg using retrograde and anterograde tracing techniques in the rat.

207 We performed conditional anterograde tracing using mice that express Cre recombin

208 We used anterograde tracing, viral-mediated gene silencing, func

209 Here, using focal trans-synaptic anterograde tracing, we show that the motor-action-relat

210 tic stroke of the motor cortex in mice using anterograde tracing.

211 TA through cell-type-specific retrograde and anterograde tracing.

212 ical and subcortical areas, as determined by anterograde tract tracing.

213 component analysis were applied in mouse to anterograde tract-tracing experiments available from the

214 f Chlamydomonas IFT54 resulted in diminished anterograde traffic of IFT and accumulation of IFT motor

215 s 261-275 of IFT54 reduced ciliary entry and anterograde traffic of IFT dynein with accumulation of I

216 d in multiple membrane trafficking pathways: anterograde traffic, recycling, and Golgi integrity.

217 d LTCC endocytosis; promotion of Cavalpha1.2 anterograde trafficking by blocking Kir/Gem-dependent se

218 Dendrites/axons require anterograde trafficking of mitochondria for local ATP sy

219 Molecular mechanisms governing the anterograde trafficking of nascent G protein-coupled rec

220 sphoinositide 3-kinase (PI3K) is involved in anterograde trafficking of the amyloid precursor protein

221 usion attachment protein receptor)-dependent anterograde trafficking pathway that requires multiple p

222 F1 activation by AMPK couples its control of anterograde trafficking to physiological cues; levels of

223 ceptors and a strategy for their release and anterograde trafficking to the lysosome.

224 To determine the role of pUS9 in anterograde trafficking, we analyzed the axonal transpor

225 ces pronounced alterations in retrograde and anterograde trafficking, which correlate with dramatic f

226 Anterograde trains split apart and IFT complexes mix wit

227 o the tip by kinesin-II as inactive cargo on anterograde trains.

228 Anterograde trans-synaptic degeneration across the later

229 for developing new safer and more effective anterograde trans-synaptic viral vectors for neural circ

230 ation and cancer cell invasion by preventing anterograde translocation and exocytosis of MT1-MMP.

231 ng mechanisms, to strongly support that AAV1 anterograde transneuronal spread is highly synapse speci

232 uits.SIGNIFICANCE STATEMENT The discovery of anterograde transneuronal spread of AAV1 generates great

233 9-based anterograde viral tracers.IMPORTANCE Anterograde transneuronal tracers derived from herpes si

234 9 (H129), including natural neurotropism and anterograde transneuronal trafficking, make it a potenti

235 Adeno-associated virus (AAV) exhibits anterograde transneuronal transport, however, the synapt

236 rotein in Rab6 depleted cells, we found that anterograde transport at 32 degrees C, permissive condit

237 PT1C) senses malonyl-CoA and enhances LE/Lys anterograde transport by interacting with the endoplasmi

238 growth cone during axon extension relies on anterograde transport by kinesin motors.

239 ed evidence of destabilization of additional anterograde transport complex components.

240 ce of IFT81 in the skeleton, its role in the anterograde transport complex, and expand the number of

241 ased P-Akt(S473) in response to PDGF-AA upon anterograde transport disruption.

242 evelopment, the mechanisms of cargo-specific anterograde transport during axon extension are only sta

243 that Rab6 is selectively required for rapid anterograde transport from the medial to trans Golgi.

244 Herpes simplex virus (HSV) anterograde transport in neuronal axons is vital, allowi

245 ore SVs arrive at the apex of A. nidulans by anterograde transport involving cooperation of kinesin-1

246 degeneration in the nerve lagged deficits in anterograde transport is consistent with progression in

247 Next, the anterograde transport of an adeno-associated virus expre

248 f an unphosphorylatable HTT decreased axonal anterograde transport of APP, reduced presynaptic APP le

249 se findings, there was a marked reduction in anterograde transport of BDNF in BACHD cortical neurons.

250 rs support that kinesin-1 contributes to the anterograde transport of capsids.

251 rus particles in the cytoplasm, which blocks anterograde transport of enveloped particles.

252 A 42% elevation in IOP over 28 weeks reduced anterograde transport of fluorescently-labeled cholera t

253 hat the expression of GFP-Rab43 arrested the anterograde transport of G(AE) in a Rab43-positive media

254 de antiapoptotic properties and facilitating anterograde transport of galactosylceramide from Golgi t

255 e results shed light into the mechanisms for anterograde transport of H129-derived tracer in axons an

256 Anterograde transport of HSV requires two membrane prote

257 Anterograde transport of late endosomes or lysosomes (LE

258 iligand sorting receptor responsible for the anterograde transport of lysosomal enzymes and substrate

259 novel role for the Kif1B-KBP complex in the anterograde transport of SCG10, which is necessary for p

260 that this defect results from disruption of anterograde transport of SCG10.

261 ingly, loss of retromer function impairs the anterograde transport of several SJ core components, rev

262 that KinA is the major kinesin mediating the anterograde transport of SVs.

263 )-dependent neuronal differentiation through anterograde transport of the NGF receptor TRKA.

264 Depletion of CRK1 abolished anterograde transport of the secretory protein and disru

265 eriod to allow sufficient time for selective anterograde transport of the tracer to nerve terminal en

266 nal cytoplasm, which can explain the reduced anterograde transport of unenveloped capsids and envelop

267 pesviruses, functions in both retrograde and anterograde transport of virion capsids, and plays criti

268 olgi membranes, as well as in retrograde and anterograde transport of virion capsids.

269 ich has neuron-specific effects, promote the anterograde transport of virus particles in neuronal axo

270 d that V1 corticotectal terminals labeled by anterograde transport primarily synapse (93%) on dendrit

271 ptic vesicle transport polarity by promoting anterograde transport processivity.

272 al approaches suggest a selective slowing of anterograde transport relative to 3 different marker pro

273 Anterograde transport through the Golgi has been explain

274 A or Rab6A' isoforms alone had any effect on anterograde transport through the Golgi suggesting that

275 and ixabepilone significantly inhibited the anterograde transport velocity of mitochondria in neuron

276 In contrast, photobleaching anterograde transport vesicles entering a bouton inhibit

277 transport) or from cell bodies to axon tips (anterograde transport).

278 Motor-dependent anterograde transport, a process that moves cytoplasmic

279 ent cisternae biochemically mature to ensure anterograde transport.

280 ere cisternae biochemically mature to ensure anterograde transport.

281 sal body, depleting kinesin-II available for anterograde transport.

282 component of the IFT-B complex essential for anterograde transport.

283 ctively increases capture of DCVs undergoing anterograde transport.

284 reased retrograde transport but no effect on anterograde transport.

285 baumannii mla mutants exhibit no defects in anterograde transport.

286 re highly expressed in the CNS and the major anterograde transporters of cargos, such as mitochondria

287 er, several outstanding questions remain for anterograde transsynaptic approaches in the field: (1) w

288 ere we describe trans-Tango, a technique for anterograde transsynaptic circuit tracing and manipulati

289 paratrigeminal nucleus were confirmed using anterograde transsynaptic conditional herpes viral traci

290 o-associated viruses (AAV1 and AAV9) exhibit anterograde transsynaptic spread properties.

291 ith an intersectional approach, AAV-mediated anterograde transsynaptic tagging can categorize neurons

292 These properties make AAV1 a promising anterograde transsynaptic tool for establishing a compre

293 tic neurons of transduced neurons, analogous anterograde transsynaptic tools for tagging postsynaptic

294 etrograde bias by a significant reduction of anterograde velocities.

295 QR11 dispersed Golgi organelles and impaired anterograde vesicle transport to the plasma membrane as

296 in was also shown to be required for optimal anterograde vesicular trafficking to the plasma membrane

297 igated with adeno-associated virus (AAV), an anterograde viral tracer.

298 modifications and improvements of H129-based anterograde viral tracers.IMPORTANCE Anterograde transne

299 Using anterograde viral tracing, we show that innervation of c

300 Using anterograde viral tract-tracing data provided by the All