ライフサイエンスコーパス: antibacterial

1 ustry to take actions in the quest for novel antibacterials.

2 npoint a novel target for development of new antibacterials.

3 Our findings revealed that VitC wield antibacterial action in dose-time dependent manner with

4 ance in every sample, corroborating with the antibacterial action of nanoZnO.

5 e acetic acid-solubilized chitosan possessed antibacterial activities against 3 single-species biofil

6 ibitors, several hit series eliciting potent antibacterial activities against Enterobacteriaceae and

7 ack of VDR in Paneth cells leads to impaired antibacterial activities and consequently increased infl

8 rial topoisomerase inhibitors with promising antibacterial activities and potencies, which thus repre

9 Synthetic methods, antibacterial activities and relative binding affinities

10 ve properties with special emphasis on their antibacterial activities and to support their uses as na

11 Our results indicate that nanopillars' antibacterial activities may be mediated by oxidative st

12 se the hypocholesterolaemic, antioxidant and antibacterial activities of fenugreek seeds.

13 e roles in enhancing the recruitment and the antibacterial activities of neutrophils in a manner that

14 We show genetically that the antibacterial activities of the compounds against efflux

15 The antibacterial activities of the dicarbonyl compounds gly

16 on, antioxidant, anti-lipid peroxidation and antibacterial activities were improved.

17 any studies have tried to summarize NPs with antibacterial activities, a comprehensive review with ri

18 o increase its own production and to enhance antibacterial activities, including the release of oxyge

19 ijoa leaf extracts with high antioxidant and antibacterial activities.

20 ows it with superior nuclease properties and antibacterial activities.

21 h as teratogenic, cytotoxic, phytotoxic, and antibacterial activities.

22 , also resulting in a higher antioxidant and antibacterial activities.

23 ophil recruitment, and potentiation of their antibacterial activities.

24 assessed for DNA gyrase inhibition, and the antibacterial activity across Gram-positive and Gram-neg

25 ideromycin natural product that shows potent antibacterial activity against clinically important path

26 sions that accumulate in E. coli and possess antibacterial activity against high-priority Gram-negati

27 ave been further exploited in photocatalytic antibacterial activity against methicillin-resistant Sta

28 re, one CAPH, Pentyl-P14 exhibited excellent antibacterial activity against multiple strains of patho

29 This material has strong antibacterial activity against periodontal pathogens suc

30 ion of a potent analogue, PK150, that showed antibacterial activity against several pathogenic strain

31 thod and related multifactorially with their antibacterial activity against Staphylococcus aureus and

32 ly, the antibacterial assay reveals a strong antibacterial activity against the tested Gram-positive

33 g structural information to achieve improved antibacterial activity against wild-type E. coli.

34 Ultimately, their antibacterial activity analysis against some food pathog

35 t screening commercial kinase inhibitors for antibacterial activity and found the anticancer drug sor

36 ficant components in honey: three related to antibacterial activity and linked to phenolic compounds;

37 tic use prior to the hospital visit using an antibacterial activity assay.

38 he old tuberculosis drug pyrazinamide exerts antibacterial activity by acting as a target degrader, a

39 ed to highlight plant-derived compounds with antibacterial activity by focusing on their growth inhib

40 Capuramycin displays a narrow spectrum of antibacterial activity by targeting bacterial translocas

41 These results indicate the spectrum of antibacterial activity can be altered by controlling the

42 Here, we report remarkable antibacterial activity enhancement via halogen substitut

43 phenoloxidase, involved in melanization, and antibacterial activity for humoral immunity.

44 gh dose, improvements in both solubility and antibacterial activity in vivo were prioritized early on

45 We show that antibacterial activity is modulated by the presence of o

46 and simulated intestinal fluid (SIF), on the antibacterial activity of auranofin were investigated.

47 Furthermore, the antibacterial activity of ES24 is equivalent to or bette

48 This study aimed to evaluate the antibacterial activity of eugenol and its derivatives al

49 Moreover, to the best of our knowledge, the antibacterial activity of GO and MGO against Listeria in

50 )O(2) and gluconic acid is essential for the antibacterial activity of honey.

51 H(2)O(2) over time, which in turn boosts the antibacterial activity of honey.

52 The superior antibacterial activity of necklace 1 against both standa

53 , eliciting caspase-4 recruitment, enhancing antibacterial activity of polymyxin B, and blocking the

54 The antibacterial activity of the compounds was assessed usi

55 The antibacterial activity of the obtained polymers is mainl

56 The antibacterial activity of the peptides was determined ag

57 nhibitor cells (PICs) that direct the potent antibacterial activity of the type VI secretion system (

58 The antiribosomal and antibacterial activity of these derivatives is briefly p

59 model, we demonstrate for the first time the antibacterial activity of Vibrio vulnificus Type 6 secre

60 oxazole scaffold with improved Gram-positive antibacterial activity relative to previously described

61 n in mice, the underlying mechanisms of this antibacterial activity remain unclear.

62 Interestingly, ES24 shows antibacterial activity toward clinically relevant strain

63 The antibacterial activity was assessed using the inhibition

64 ges (hAMs) were infected with S. aureus, and antibacterial activity was assessed.

65 Their antibacterial activity was evaluated against the multire

66 dize to SMX after oxygen exposure, and their antibacterial activity was significantly decreased compa

67 Auranofin's in vitro antibacterial activity was stable in the presence of hig

68 BF4) powder provided immediate and long-term antibacterial activity without cytotoxic effect against

69 mpounds is further discussed regarding their antibacterial activity, biosynthesis, structure-activity

70 s were evaluated for immediate and long-term antibacterial activity, cytotoxicity, polymerization beh

71 ts specific localization and its established antibacterial activity, Gga-AvBD11 appears to play a pro

72 eta-lactamase inhibitor relebactam has broad antibacterial activity, including against carbapenem-res

73 ctamases and the potentiation of beta-lactam antibacterial activity, indicating that DBO functionaliz

74 The roles of T6SSs in antibacterial activity, type-1 fimbriae expression, cell

75 chitin derivatives are characterized by high antibacterial activity, which is comparable with that of

76 Hydrogen peroxide plays a key role in honey antibacterial activity.

77 anthraquinones generated in this work showed antibacterial activity.

78 ard polymer parts and reveal the mode of the antibacterial activity.

79 s exhibit enhanced antifouling potential and antibacterial activity.

80 e clusters were synthesized and screened for antibacterial activity.

81 nding peptides while in many cases retaining antibacterial activity.

82 ald's eyesalve', and showed it had promising antibacterial activity.

83 network capable of predicting molecules with antibacterial activity.

84 icle size, which gives a series of different antibacterial activity.

85 icles with variable size and give controlled antibacterial activity.

86 inhibitors with potent in vivo and in vitro antibacterial activity.

87 TCA within micelles crucially improved their antibacterial activity.

88 the compounds presented clinically effective antibacterial activity.

89 IR, acceptable biocompatibility and moderate antibacterial activity.

90 occurring nucleoside inhibitors with potent antibacterial activity.

91 eria, signaling that another effector(s) has antibacterial activity.

92 nstrated that the dressings exhibited potent antibacterial activity.

93 ce 1 containing Cu and Pt metals with strong antibacterial activity.

94 C (VitC), a natural antioxidant as powerful antibacterial agent against multidrug-resistant (MDR), b

95 tivity showed that CC extract is a potential antibacterial agent.

96 indicating its potential as a cross-species antibacterial agent.

97 dant activities, but it was not effective as antibacterial agent.

98 is approach to prepare racemic linezolid, an antibacterial agent.

99 en developed without the use of any external antibacterial agents and surface treatments.

100 Novel antibacterial agents are needed to address the emergence

101 The antibacterial agents currently in clinical development a

102 d that cells treated with josamycin or other antibacterial agents exhibited impaired oxidative phosph

103 continued need for innovation and new-class antibacterial agents in order to provide effective thera

104 in pathogens necessitates the development of antibacterial agents inhibiting underexplored targets in

105 predominantly used for invasive candidiasis, antibacterial agents posing the highest risk for Clostri

106 ocycle provide a new class of broad-spectrum antibacterial agents with activity against MDR Gram-nega

107 undamental importance to efforts to discover antibacterial agents.

108 interactions and are established targets for antibacterial agents.

109 zed cells only to josamycin but not to other antibacterial agents.

110 cell surface represents a distinct class of antibacterial agents.

111 en identified as an appealing new target for antibacterial agents.

112 of small molecules, including nutrients and antibacterial agents.

113 re successfully developed and proven to have antibacterial and anti-inflammatory properties for the t

114 was proceeded by investigating the in vitro antibacterial and anti-inflammatory properties of the hy

115 Antibacterial and anti-melanosis properties of all extra

116 e development of biomimetic nanovaccines for antibacterial and anticancer applications is discussed,

117 The highest antibacterial and antifungal activities were attributed

118 the extracts presented in vitro antioxidant, antibacterial and antifungal activities, whereas no toxi

119 fied in pig leukocytes with a broad-spectrum antibacterial and antiviral activity, and a low rate of

120 function in innate immune cells to regulate antibacterial and antiviral responses downstream of phag

121 cterial pathogen lies at the intersection of antibacterial and antiviral responses.

122 cooking combined with herbs and/or beer - on antibacterial and coccidiostat drugs stability and bioac

123 Paecilomyces variotii produces the antibacterial and cytotoxic ( M)-viriditoxin (1) togethe

124 tural products from fungi exhibit a range of antibacterial and cytotoxicity activities, and can poten

125 Antibacterial and enzyme potency assessments in the pres

126 Particularly, EOs exhibit pronounced antibacterial and food preservative properties that repr

127 The phenolic profile, antioxidant, antibacterial and hepatotoxic properties were analyzed.

128 ivatives were conceived and characterized by antibacterial and membrane permeabilization assays, X-ra

129 l envelope of the bacterium may identify new antibacterials and new adjuvants that preserve the effic

130 Chitosan is a biodegradable, antibacterial, and nontoxic biopolymer used in a wide ra

131 In this work, a set of biomimicking, antibacterial, and sensing sutures based on the regenera

132 Clofoctol, an antibacterial antibiotic, has been reported to upregulat

133 d the number of immune compromised patients, antibacterial antibiotics that disrupt the microbiome, a

134 ts and pharmaceuticals, including antiviral, antibacterial, anticancer and cardiac drugs(6,7).

135 e bacterium Escherichia coli, but no further antibacterial, antifungal nor cytotoxic effects.

136 medical devices for the delivery of various antibacterial, antifungal, and antiviral therapeutics.

137 Cyclic peptides are reported to have antibacterial, antifungal, and other bioactivities.

138 , antitumoral or chemopreventive, antiviral, antibacterial, antifungal, antiparasitic, and neuroprote

139 the cationic N-terminal domain in mediating antibacterial, antiparasitic, and antiinvasive activitie

140 pare cavity-crosslinked polymer networks for antibacterial applications.

141 Finally, the antibacterial assay reveals a strong antibacterial activ

142 manized bacterial ribosomes and of extensive antibacterial assays with wild-type and resistant Gram n

143 g is a method to classify target pathways of antibacterials based on how bacteria respond to treatmen

144 ntal ligament (PDL) cells on nanofibers, and antibacterial capabilities of nanofibers were evaluated

145 their antioxidant activity as well as their antibacterial capacity.

146 pulation was recently shown to have superior antibacterial capacity.

147 ely as an intercalating poison, and that the antibacterial ciprofloxacin can poison yeast topoisomera

148 spirocyclic architecture and represent a new antibacterial class of bacterial DNA gyrase and topoisom

149 ting cross-resistance both within and across antibacterial classes limits the activity of many of the

150 int themselves with bacteriophages and their antibacterial components and, specifically, with methods

151 the identification and development of novel antibacterial compounds and other pharmacological agents

152 ZINC15 database, our model identified eight antibacterial compounds that are structurally distant fr

153 The material demonstrated marked antibacterial contact properties and, in ex-vivo studies

154 ceived antibacterials (p & 0.01) and had > 3 antibacterial courses (p & 0.01).

155 receptor (LXR) activation, inflammation and antibacterial defense in P47S macrophages.

156 e importance of the GBP-caspase-4 pathway in antibacterial defense.

157 inflammatory state characterized by elevated antibacterial defenses and reduced investment in antivir

158 ysis demonstrated wide use of broad-spectrum antibacterials, despite a paucity of evidence for bacter

159 Antibacterial DOT/1000pd ranged from 345 to 776 (2.2-fol

160 Antibacterial drug development activity rebounded substa

161 derivatives have the potential to be used in antibacterial drug development in strains carrying the N

162 Antibacterial drug development programs initiated in the

163 ial fatty-acid synthesis and is a target for antibacterial drug development.

164 Emerging trends in the field of antibacterial drug discovery from plants are also discus

165 ABP symptoms, and not receiving any nonstudy antibacterial drug for current CABP episode.

166 A review of the clinical antibacterial drug pipeline was recently published, but

167 endpoint failures were receipt of non-study antibacterial drug therapy and loss to follow-up.

168 niae or Staphylococcus aureus, have received antibacterial drug therapy prior to randomization, and h

169 in MODIFY I/II trial participants receiving antibacterial drug treatment for CDI.

170 al admissions, attendant costs, and unneeded antibacterial drug use, much of which would otherwise be

171 olymer synthesis, identified new targets for antibacterial drugs and informed synthetic biology appro

172 A critical question is whether enough new antibacterial drugs are being discovered and developed.

173 % with median development times for approved antibacterial drugs increasing to 8.2 years.

174 lication of this concept to the screening of antibacterial drugs that act at the major bacterial targ

175 idly, requiring urgent identification of new antibacterial drugs that are effective against multidrug

176 t for the discovery and development of novel antibacterial drugs to address the critical medical need

177 , which could guide the development of novel antibacterial drugs to combat infections with multidrug-

178 w drug applications (INDs) for new, systemic antibacterial drugs under active development between 198

179 encapsulation efficiencies (EE) (95-98%) and antibacterial effect against E. coli and L. innocua due

180 ple model system was used to investigate the antibacterial effect of, and possible synergies between,

181 , and Streptococcus gordonii, they exhibited antibacterial effect only in acidic medium, which prelim

182 resin adhesives (TA@RAs) with pH-responsive antibacterial effect to reduce the occurrence of seconda

183 Meanwhile, the stability of antibacterial effect was confirmed via a 5-d pH-cycling

184 zation of the conditioned medium aborted the antibacterial effect.

185 ated mice were characterized as host defense antibacterial effector cells.

186 ted the interplay between MAIT cell-mediated antibacterial effector functions and the humoral immune

187 Type VI secretion systems (T6SSs) deliver antibacterial effector proteins between neighboring bact

188 These antibacterial effectors are invariably encoded with immu

189 We show that antibacterial effects can be identified and classified i

190 mic impact and the reported regenerative and antibacterial effects of mesenchymal stem cell (MSCs), w

191 Desirable antibacterial effects, bone regeneration potential, and

192 peroxide is necessary but not sufficient for antibacterial effects.

193 el was used to compare costs and outcomes of antibacterial envelope (TYRX) use adjunctive to standard

194 incremental cost-effectiveness ratio of the antibacterial envelope compared with standard-of-care wa

195 As a prespecified objective, we evaluated antibacterial envelope cost-effectiveness compared with

196 Infection rates, antibacterial envelope effectiveness, infection treatmen

197 Prevention), adjunctive use of an absorbable antibacterial envelope resulted in a 40% reduction of ma

198 The absorbable antibacterial envelope was associated with a cost-effect

199 th aptamers, as a vehicle for delivering the antibacterial enzyme lysozyme in a specific and efficien

200 des difficile-specific phages and identified antibacterial enzymes whose activity is confirmed both i

201 Here we report the design, synthesis, and antibacterial evaluation of group A streptogramin antibi

202 The antibacterial evaluations demonstrated that the dressing

203 In summary, we identify a surprising gain of antibacterial function due to loss of BMAL1 in macrophag

204 macrophages are important for modulating the antibacterial function of neutrophils and play an import

205 ed IFN-gammaR signaling in AMs impairs their antibacterial function, thereby enabling otherwise nonin

206 Mucosal antibacterial gene expression was assessed by PCR Array.

207 acterial profiles were linked to the colonic antibacterial gene expression.

208 ible role of allergy-like type 2 immunity in antibacterial host defense.

209 vertebrates, the role of mammalian IL-17D in antibacterial immunity has not been established.

210 s antibiotic treatment while preserving lung antibacterial immunity in mice.

211 mediated inverse modulation of antiviral and antibacterial immunity may allow bacteria and viruses to

212 ctor arm of vaccine-induced humoral adaptive antibacterial immunity.

213 validity of this model to investigate human antibacterial immunity.

214 sts can recognize QSMs to trigger responsive antibacterial immunity.

215 This has inspired the design of antibacterial implant surfaces with insect-wing mimetic

216 e desirable over traditional, broadly acting antibacterials in several contexts.

217 eclined to an 11-year low, and the number of antibacterial INDs initiated with the FDA from 2010-2019

218 abolically process myeloid cells and advance antibacterial inflammation.

219 als to metabolically reprogram monocytes for antibacterial inflammation.

220 Lactoperoxidase (LPO) is one of the major antibacterial ingredients in milk and an extensively emp

221 l to be used in the development of bio-based antibacterial ingredients.

222 oducts (NPs) represent a promising source of antibacterial lead compounds that could help fill the dr

223 ction, the adaptive immune system suppresses antibacterial macrophage activation, whereas the innate

224 However, the understanding of the underlying antibacterial mechanism is incomplete.

225 gold (Au)NPs are synthesized to explore the antibacterial mechanism of non-translocating AuNPs.

226 stribution and ease of access, their various antibacterial modes of action, and the proven clinical e

227 rough the discovery of structurally distinct antibacterial molecules.

228 cetamol, i.e., 4-aminophenol (4-AP), and two antibacterials, namely, cefadroxil (CFD, beta-lactam ant

229 The development of new antibacterial nanostructured surfaces shows excellent pr

230 velopment of a series of CRISPR-Cas13a-based antibacterial nucleocapsids, termed CapsidCas13a(s), cap

231 ntestinal symptoms may allow a more targeted antibacterial or a diet-based approach to treatment.

232 lthcare facility visits (p = 0.05), received antibacterials (p & 0.01) and had > 3 antibacterial cour

233 can kill bacteria through a diverse range of antibacterial pathways and exogenous surfactant can impr

234 latory molecules are intricately involved in antibacterial pathways and how they shape susceptibility

235 for design and modification of pore-forming antibacterial peptides or toxins.

236 es of bone cement formulations with enhanced antibacterial performance have been developed through th

237 nt additives that can be used to enhance the antibacterial performance of the bone cement whilst main

238 alloys could broaden the current palette of antibacterial platforms for metals.

239 5-position, with the goals of increasing the antibacterial potency without sacrificing selectivity be

240 Ch-ZnO@gal films possess significant antibacterial potential and strong antioxidant behavior

241 y both with GO and MGO, interfering with the antibacterial potential and the degradation kinetics ind

242 brings to the forefront key findings on the antibacterial potential of plant NPs for consideration i

243 In antibacterial practices by photodynamic treatment, bacte

244 Antibacterial prescriptions for patients testing negativ

245 rojects and has found, as of 1 May 2019, 407 antibacterial projects from 314 institutions.

246 re as determined by NMR, exhibited increased antibacterial properties comparable to standard-of-care

247 With its unprecedented proregenerative, antibacterial properties coupled with favorable mechanic

248 cycles have been studied for their promising antibacterial properties due to their action on differen

249 re, we present a new approach to introducing antibacterial properties into AM, using Laser Sintering,

250 method of enhancing the cell penetrating and antibacterial properties of cationic amphiphilic polypro

251 ogens due to their antiviral, antifungal and antibacterial properties, and are considered potential t

252 ity, catheter injectability, retrievability, antibacterial properties, and biological activity to pre

253 Both extracts showed antibacterial properties, but the best results were achi

254 All extracts showed promising antibacterial properties, polyphenoloxidase inhibitory a

255 curring quinones can also be cytotoxins with antibacterial properties.

256 f the azido pharmacophore, but preserves its antibacterial properties.

257 We present a CPG for systemic antibacterial prophylaxis administration in pediatric ca

258 inical practice guideline (CPG) for systemic antibacterial prophylaxis administration in pediatric pa

259 anel made a weak recommendation for systemic antibacterial prophylaxis for children receiving intensi

260 Systemic antibacterial prophylaxis is one approach that can be us

261 ndations against the routine use of systemic antibacterial prophylaxis were made for children undergo

262 on of the AM population to provide prolonged antibacterial protection.

263 eversible pH-responsive and non-drug release antibacterial resin adhesives ingeniously overcome the d

264 With the increasing antibacterial resistance in typhoidal Salmonella and the

265 Antibacterial resistance is a great concern and requires

266 omatis play important roles in infection and antibacterial resistance transmission, but no US Food an

267 ntibacterial therapies to sustainably combat antibacterial resistance.

268 essive reprogramming away from TCR-dependent antibacterial responses towards innate-like functionalit

269 ways, essential for respective antiviral and antibacterial responses, is common in previously immunoc

270 nosa would impair host translation and block antibacterial responses.

271 hich binds TB virulence factors and controls antibacterial responses.

272 which suggests that melatonin might play an antibacterial role against this bacterium and gram-negat

273 planation of the greater potency and broader antibacterial spectrum of activity of temporin L over au

274 We envision that our antibacterial strategy based on utilization of sacrifici

275 A new antibacterial strategy for Ti has been developed without

276 Phage therapy is a promising alternative antibacterial strategy.Objectives: To evaluate the effic

277 Antibacterial studies with these four analogs revealed t

278 hiamine, the anti-cancer drug bleomycin, the antibacterial sulfathiazole and the antiviral nitazoxani

279 oward the development of a new generation of antibacterial surfaces, particularly in the current era

280 We determined antibacterial susceptibility using microbroth dilution a

281 ish embryos, we are able to design optimized antibacterial systems (Ti-Mg and Ti-Mg-3wt% Zn) that can

282 These results show that LpxA is a promising antibacterial target and imply the advantages of targeti

283 coccal Tfp and thereby, identify a potential antibacterial target.

284 icular host tissues and represent attractive antibacterial targets.

285 Antibacterial testing performed with live/dead staining

286 d to identify novel targets for copper-based antibacterial therapeutics.

287 nown as bacteriophages (phages) as potential antibacterial therapeutics.

288 at value in the development of new and novel antibacterial therapies in this era of emerging antibiot

289 the novel approaches to result in effective antibacterial therapies to sustainably combat antibacter

290 "source" control, and can guide duration of antibacterial therapy in septic patients.

291 The use of bacteriophages (phages) for antibacterial therapy is under increasing consideration

292 ns, promoting future biointerface design for antibacterial therapy.

293 ize intercellular cohesion loss for accurate antibacterial therapy.

294 Therefore, during infection antibacterial treatment may relieve bacterial imposed nu

295 and receipt (yes or no) of allowed previous antibacterial treatment.

296 Current methods for evaluation of antibacterial treatments in clinics and in vitro systems

297 nderlying mechanisms is crucial for devising antibacterial treatments.

298 CT &0.25 ng/ml, LFA could reduce unnecessary antibacterial use by 77%.

299 This is largely attributable to decreased antibacterial use, from 704 (95% CI 686-722) to 544 (95%

300 We show here that antibacterial zinc (Zn) and copper (Cu) species greatly