ライフサイエンスコーパス: antibiotic resistance

1 e population dynamics, such as the spread of antibiotic resistance.

2 s to a rapid spread of virulence factors and antibiotic resistance.

3 tion decision must consider implications for antibiotic resistance.

4 and contributes to the spread of traits like antibiotic resistance.

5 ) is critically needed to counter widespread antibiotic resistance.

6 antially reduce gonorrhea incidence, despite antibiotic resistance.

7 d infections and a major concern in terms of antibiotic resistance.

8 plications for protein design and combatting antibiotic resistance.

9 ced costs and eliminate risks of propagating antibiotic resistance.

10 t without risk, including adverse events and antibiotic resistance.

11 ay offer novel avenues to slow the spread of antibiotic resistance.

12 , which acts as a barrier and contributes to antibiotic resistance.

13 n that Gram-negative organisms may adopt for antibiotic resistance.

14 ass azithromycin distributions may propagate antibiotic resistance.

15 particularly in the current era of emerging antibiotic resistance.

16 eded to address the looming global crisis of antibiotic resistance.

17 vaded detection in plate-based assessment of antibiotic resistance.

18 olecules and contributes to the emergence of antibiotic resistance.

19 eutically without promoting the evolution of antibiotic resistance.

20 ome instances, rRNA modifications can confer antibiotic resistance.

21 ug target in the fight against the increased antibiotic resistance.

22 e used to identify targets to select against antibiotic resistance.

23 poB can be a mutational mechanism generating antibiotic resistance.

24 ng of cell wall muropeptides, with a link to antibiotic resistance.

25 P prophylaxis in an era and area of frequent antibiotic resistance.

26 under antibiotic stress and led to increased antibiotic resistance.

27 ave sex with men (MSM) with raising rates of antibiotic resistance.

28 biotics, which are costly and risk spread of antibiotic resistance.

29 Antibiotic overuse drives antibiotic resistance.

30 nd a potential beneficial strategy to combat antibiotic resistance.

31 s worldwide with an increasing occurrence of antibiotic resistance.

32 e mutations pleiotropically confer increased antibiotic resistance.

33 ll as adverse public health outcomes such as antibiotic resistance.

34 d interrupt intraspecies HGT and exchange of antibiotic resistance.

35 need to address the growing threat posed by antibiotic resistance.

36 ioides difficile diarrhea) and contribute to antibiotic resistance.

37 nsider the crucial contribution of porins in antibiotic resistance.

38 e revisions and efforts to reduce increasing antibiotic resistance.

39 ier, which plays a key role in virulence and antibiotic resistance.

40 urther our understanding of pathogenesis and antibiotic resistance.

41 s essential for outer membrane formation and antibiotic resistance.

42 iotic consumption and other risk factors for antibiotic resistance.

43 Antibiotics can induce mutations that cause antibiotic resistance.

44 re needed to address the emergence of global antibiotic resistance.

45 tic therapies and for impeding the spread of antibiotic resistance.

46 eed in the current environment of increasing antibiotic resistance.

47 n of specific inhibitors useful in reversing antibiotic resistance.

48 d antimicrobial materials and help to combat antibiotic resistance.

49 ced by traditional antimicrobials, including antibiotic resistance.

50 colonization and subsequent transmission of antibiotic resistance.

51 ulates many virulence genes and is linked to antibiotic resistance.

52 an minimize the fitness cost associated with antibiotic resistance.

53 ical and health-related impacts by spreading antibiotic resistance.

54 acterial mechanisms to fight the increase of antibiotic resistance.

55 ibacterial therapies in this era of emerging antibiotic resistance.

56 hages can drive evolutionary trade-offs with antibiotic resistance.

57 aspects of the bacterial physiology, besides antibiotic resistance.

58 er mechanisms to explain the epidemiology of antibiotic resistance.

59 tibiotic use and reduce the global threat of antibiotic resistance.

60 s to determine their potential for spreading antibiotic resistance.

61 reat due to rapidly increasing incidence and antibiotic resistance.

62 with previously identified risk factors for antibiotic resistance.

63 of key human interest, such as virulence or antibiotic resistance.

64 om human pathogens implicated in transfer of antibiotic resistance.

65 g PG turnover, cell elongation/division, and antibiotic resistance.

66 Antibiotic use is a key driver of antibiotic resistance.

67 xicillin to overcome beta-lactamase-mediated antibiotic resistance.

68 and, simultaneously, help the fight against antibiotic resistance.

69 genetic perturbations leading to increasing antibiotic resistance.

70 e combining all three algorithms, to predict antibiotic resistance.

71 strategies might minimize clinical spread of antibiotic resistance.

72 To better combat bacterial antibiotic resistance, a growing global health threat, i

73 The spread of antibiotic resistance, a major threat to human health, i

74 namics, serotype diversity, and frequency of antibiotic resistance (ABR) and accessory genes.

75 m of E. coli linking aggregation directly to antibiotic resistance acts as a sensor for the innate (u

76 D-deficient P. aeruginosa displayed enhanced antibiotic resistance against tetracycline through incre

77 Both genera displayed low levels of antibiotic resistance and antibiotic resistance gene car

78 vely studied for understanding mechanisms of antibiotic resistance and bacterial defense against host

79 acterial infections associated with acquired antibiotic resistance and biofilms.

80 The rise of antibiotic resistance and declining discovery of new ant

81 an extensive repertoire of genes involved in antibiotic resistance and detoxification, including tran

82 nt and pathogen characteristics in detecting antibiotic resistance and diagnostic escape variants in

83 is important for predicting future rates of antibiotic resistance and for designing antibiotic stewa

84 recalcitrant to traditional therapies due to antibiotic resistance and formation of robust biofilms.

85 ed the contributions of AdeABC and AdeIJK in antibiotic resistance and growth physiology of the two M

86 encoding genes, including some essential for antibiotic resistance and host colonization.

87 ergy label associates with a higher risk for antibiotic resistance and increased health care use.

88 uding patient epidemiologic risk factors for antibiotic resistance and markers of lineage.

89 l challenge contributing to rising levels of antibiotic resistance and mortality.

90 burden is linked to the pathogen's intrinsic antibiotic resistance and protected intracellular locali

91 ritical for surface adhesion, pathogenicity, antibiotic resistance and survival.

92 associated with a high burden of disease and antibiotic resistance and the development of genotype-ba

93 fundamental insights into the development of antibiotic resistance and the resistance mechanisms unde

94 iate antibiotic use is crucial for combating antibiotic resistance and unnecessary adverse drug react

95 Antibiotic resistance and viral diseases are rising arou

96 ad bacterial differentiation program driving antibiotic resistance and virulence in many pathogens.

97 y promote Y. pestis survival in human serum, antibiotic resistance, and cell envelope integrity.

98 facilitates genetic transformation, spreads antibiotic resistance, and contributes to virulence.

99 Given concerns such as contact dermatitis, antibiotic resistance, and healthcare costs in conjuncti

100 t is also of great concern due to increasing antibiotic resistance, and is a priority organism for th

101 ux pumps, including the MexAB-OprM pump, for antibiotic resistance, and it also produces hydrogen sul

102 c has been limited by lengthy drug regimens, antibiotic resistance, and lack of a robustly efficaciou

103 s DNA origami as a tool in the fight against antibiotic resistance, and our results demonstrate the s

104 imarily focused on national surveillance for antibiotic resistance, and patterns of local transmissio

105 r elucidate a link between oxidative stress, antibiotic resistance, and sulfur metabolism.

106 However, this increases the risk of antibiotic resistance (AR) dissemination via irrigation.

107 ewater is a common pathway for the spread of antibiotic resistance (AR) genes and bacteria into the e

108 t microbiome harbors a 'silent reservoir' of antibiotic resistance (AR) genes that is thought to cont

109 as mcr positive) and 12 mcr-positive CDC-FDA Antibiotic Resistance (AR) Isolate Bank isolates for whi

110 High levels of antibiotic resistance are consistent with frequent antib

111 The molecular underpinnings of antibiotic resistance are increasingly understood, but l

112 However, genes that confer antibiotic resistance are not only associated with patho

113 minance shaping genetic cargo in MGEs, using antibiotic resistance as a model system.

114 n more detail using phenotypic virulence and antibiotic resistance assays and whole-genome sequencing

115 biomedical microdevices for drug discovery, antibiotic resistance assessment, and medical diagnostic

116 f compounds to address mechanisms underlying antibiotic resistance at both bacterial-cell and communi

117 bone but are able to drive up frequencies of antibiotic resistance because fitness burden of the bla(

118 bacteria with the highest risk of acquiring antibiotic resistance, being the most relevant hosts of

119 were associated with smaller differences in antibiotic resistance between those populations.

120 hat phages may be useful for the reversal of antibiotic resistance, but such applications will need t

121 a community increases the risk of acquiring antibiotic resistance by individuals living in that comm

122 al pathogens with a high capacity to develop antibiotic resistance by mutations.

123 Emergence and spread of antibiotic resistance calls for development of non-chemi

124 Genes that confer antibiotic resistance can rapidly be disseminated from o

125 aracterization of microbiomes, pathogens and antibiotic resistance cassettes in a tertiary-care hospi

126 It is predicted that the antibiotic resistance crisis will result in an annual de

127 iscovery pipeline in response to the growing antibiotic resistance crisis.

128 ional annotation including the Comprehensive Antibiotic Resistance Database to determine airway resis

129 s ramifications for predicting the future of antibiotic resistance, designing antibiotic resistance s

130 lass A serine beta-lactamases (SBLs) are key antibiotic resistance determinants in Gram-negative bact

131 nal repression critical for uncovering novel antibiotic resistance determinants.

132 oad range of ciprofloxacin concentrations on antibiotic resistance development in Escherichia coli.

133 BRs) can significantly reduce the release of antibiotic resistance elements to the environment.

134 tal gene transfer (HGT) facilitates spead of antibiotic resistance elements.

135 nsplastomic clones is based on selection for antibiotic resistance encoded in the first open reading

136 Moreover, we detected signals of antibiotic-resistance evolution occurring within species

137 actions with resident microbiota can inhibit antibiotic-resistance evolution of individual species.

138 The increasing rise of antibiotic resistance expressed by gonococci highlights

139 an approach that could reduce the spread of antibiotic resistance for important hospital pathogens.

140 SOS response accelerates the development of antibiotic resistance from these survivors.

141 effect of human migration on gut microbiome antibiotic resistance gene (ARG) carriage.

142 gut microbiome beta-diversity and increased antibiotic resistance gene alpha-diversity and prevalenc

143 ayed low levels of antibiotic resistance and antibiotic resistance gene carriage.

144 The antibiotic resistance gene may encode spectinomycin or k

145 in the Escherichia coli TEM-1 beta-lactamase antibiotic resistance gene using growth competition expe

146 nd gram-positive (GP) bacterial DNA, and the antibiotic-resistance gene bla(TEM) with femtomolar sens

147 Antibiotic resistance genes (ARGs) can spread among path

148 The environmental spread of antibiotics and antibiotic resistance genes (ARGs) from the land applica

149 rase chain reaction (PCR) identified several antibiotic resistance genes (ARGs) in our isolates.

150 sources, clinical relevance, and mobility of antibiotic resistance genes (ARGs) in watersheds.

151 In total, 1206 antibiotic resistance genes (ARGs) of 52 different categ

152 he identification of principal reservoirs of antibiotic resistance genes (ARGs) plus an understanding

153 hat constitute the gut microbiota can harbor antibiotic resistance genes (ARGs), including those enco

154 ronment conducive for horizontal exchange of antibiotic resistance genes (ARGs), thereby facilitating

155 e release of intracellular and extracellular antibiotic resistance genes (iARGs and eARGs) from an An

156 niques, despite being the primary vectors of antibiotic resistance genes across many key pathogens.

157 ad-host-range plasmids enables the spread of antibiotic resistance genes among human enteric pathogen

158 livestock production, but the prevalence of antibiotic resistance genes among the species of bacteri

159 een implicated in enrichment and exchange of antibiotic resistance genes and bacteria.

160 ulon, a quorum-sensing circuitry, to acquire antibiotic resistance genes and initiate its attack on t

161 her excavate potential relationships between antibiotic resistance genes and their phenotypic traits.

162 r treatment efficiently removes the hosts of antibiotic resistance genes and, consequently, the harbo

163 Carbapenemases and other types of antibiotic resistance genes are carried almost exclusive

164 De novo identification of the antibiotic resistance genes bla(NDM-5), bla(NDM-7), bla(

165 d distinct ecological niches of microbes and antibiotic resistance genes characterized by biofilm-for

166 eline (PRAP) for the rapid identification of antibiotic resistance genes from various formats of whol

167 e results reveal the diverse trajectories of antibiotic resistance genes in clinical settings, summar

168 r the replication of small plasmids carrying antibiotic resistance genes in Gram-positive bacteria.

169 s by demonstrating the detection of multiple antibiotic resistance genes in parallel.

170 aplasmids (>420 kb) carrying large arrays of antibiotic resistance genes located in discrete, complex

171 ion of numerous genetically encoded markers, antibiotic resistance genes or enzymes, such as Cre reco

172 rine poses a low potential for the spread of antibiotic resistance genes to bacteria once it is relea

173 th specific DNA sequences or knock out their antibiotic resistance genes using CRISPR technology.

174 is exacerbated by the horizontal transfer of antibiotic resistance genes via conjugative plasmids.

175 umannii isolates revealed that six groups of antibiotic resistance genes were carried by all seven ph

176 Notably, antibiotic resistance genes were found in similar geneti

177 xture within skin sites and dissemination of antibiotic resistance genes within-individual.

178 qPCR methods were utilized to identify FIB, antibiotic resistance genes, and human enteric viruses i

179 that deleterious genetic variants, including antibiotic resistance genes, can establish in population

180 cken were MDR, with the presence of multiple antibiotic resistance genes, including 3 (40.11%) and 4

181 Concerning the distribution of the antibiotic resistance genes, the examined strains harbor

182 am up-regulates expression of blaZ and pbp2a antibiotic resistance genes, we suggest further consider

183 even emerging microbial contaminants such as antibiotic resistance genes, which leads to better prote

184 , numerous virulence factors and no relevant antibiotic resistance genes.

185 tance genes and, consequently, the harboured antibiotic resistance genes.

186 ic resistance via inducing the expression of antibiotic resistance genes.

187 robiota, pathogen abundance, and carriage of antibiotic resistance genes.Methods: 16S rRNA sequencing

188 phoA, hly, eaeA, sta, and lt) as well as the antibiotic-resistance genes (bla(TEM), bla(KPC), and bla

189 e genes (oprL, exoS, phzM, and toxA) and the antibiotic-resistance genes (bla(TEM), tetA, and bla(CTX

190 ance traits, PCR-detection of virulence, and antibiotic-resistance genes of E. coli isolated from sec

191 TX-M), bla(TEM), and tetA genes are the main antibiotic-resistance genes that induce resistance patte

192 Several antibiotic-resistance genes were observed.

193 ulating the expression of the blaZ and pbp2a antibiotic-resistance genes, encoding PC1 and PBP2a, res

194 pecific introns into the coding sequences of antibiotic-resistance genes.

195 Antibiotic resistance has become an increasingly serious

196 The rise of antibiotic resistance has necessitated a search for new

197 The emergence of antibiotic resistance has raised serious concerns within

198 For infectious diseases, the steady rise of antibiotic resistance has resulted in super pathogens th

199 bactericidal antibiotic treatments, such as antibiotic resistance, heteroresistance or tolerance.

200 nic parallel evolution occur particularly in antibiotic resistance, immune evasion and epithelial adh

201 ible for a single adjuvant to reverse innate antibiotic resistance in all pathogenic GNB of the ESKAP

202 Antibiotic resistance in bacteria is typically conferred

203 ibiotic use and the population prevalence of antibiotic resistance in bacteria, but little is known a

204 l production has caused rapid development of antibiotic resistance in bacteria, which poses a serious

205 nii genome and are reported to contribute to antibiotic resistance in clinical isolates.

206 Antibiotic resistance in clinically important bacteria c

207 um of topA mutants enhances the emergence of antibiotic resistance in comparison to mismatch-repair (

208 r study, we did not observe any emergence of antibiotic resistance in digestive and nasal microbiolog

209 quently in TEM-1 than deleterious effects on antibiotic resistance in environments with low concentra

210 ptide (PAS8-b-PDM12) that reverses intrinsic antibiotic resistance in GNB by two distinct mechanisms

211 ors that disable the most prevalent cause of antibiotic resistance in Gram-negative bacteria, i.e., t

212 a sustained increase in macrolide and other antibiotic resistance in gut and respiratory bacteria.

213 MGE insertions likely contribute to antibiotic resistance in laboratory experiments and clin

214 The rise of antibiotic resistance in many bacterial pathogens has be

215 rtality worldwide, exacerbated by increasing antibiotic resistance in many bacterial species.

216 ons occurs with a corresponding reduction in antibiotic resistance in many cases.

217 This implies that selection for antibiotic resistance in multiple mutational steps is re

218 Antibiotic resistance in multiple strains of P. aerugino

219 ylase (PPHD) in the control of virulence and antibiotic resistance in P. aeruginosa We found that a P

220 environmental oxygen levels to virulence and antibiotic resistance in P. aeruginosa.

221 The widespread emergence of antibiotic resistance in pathogens necessitates the deve

222 hange in antibiotic use in one population on antibiotic resistance in that population could be reduce

223 onors, our focal E. coli strain only evolved antibiotic resistance in the absence of the resident mic

224 by limiting the emergence and propagation of antibiotic resistance in the environment.

225 h act as inhibitors of mechanisms underlying antibiotic resistance in the treatment of severe drug-re

226 fection can strongly influence virulence and antibiotic resistance in this pathogen, although the oxy

227 The development of antibiotic resistance in this species is enabled by effl

228 ances, this is due to intrinsic and acquired antibiotic resistance, indicating that new therapeutic a

229 Because of its rapid acquisition of antibiotic resistance, infections caused by A. baumannii

230 arbored a large plasmid that carries a novel antibiotic resistance integron.

231 Antibiotic resistance is a global human health threat, c

232 Antibiotic resistance is a growing threat, especially in

233 Since antibiotic resistance is a major threat to global health

234 is an exclusive human pathogen whose growing antibiotic resistance is causing worldwide concern.

235 ological mechanisms. One potential driver of antibiotic resistance is exposure to sub-inhibitory conc

236 increasing rapidly in many countries, while antibiotic resistance is making treatment more difficult

237 Antibiotic resistance is mediated through several distin

238 Antibiotic resistance is one of the most challenging iss

239 Antibiotic resistance is rising and we urgently need to

240 In 2016, the CDC established the Antibiotic Resistance Laboratory Network (AR Lab Network

241 ; crAssphage, enterococci) and anthropogenic antibiotic resistance markers (AARMs; intI1, sul1) in th

242 The solution to emerging antibiotic resistance may involve combination therapies

243 ence-based characterization of virulence and antibiotic resistance may require testing of multiple de

244 Multiple drug (antibiotic) resistance (MDR) has become a major threat t

245 This study has identified an antibiotic resistance mechanism mediated by allosteric e

246 e association models confirmed known genetic antibiotic resistance mechanisms, such as blaKPC and car

247 f between phage resistance and either of the antibiotic resistance mechanisms.

248 es on two host factors involved in different antibiotic resistance mechanisms: 1) the efflux pump pro

249 hibitors are increasingly used to counteract antibiotic resistance mediated by beta-lactamase enzymes

250 Due to its role in antibiotic resistance, Mfd is also emerging as a prime t

251 a coli strains, and previous observations on antibiotic resistance mutations.

252 The crisis of antibiotic resistance necessitates creative and innovati

253 to the increasingly problematic emergence of antibiotic resistance, novel strategies for combating pa

254 of action and are involved in pathogenesis, antibiotic resistance, nutrient uptake, and nucleic acid

255 achine learning models to accurately predict antibiotic resistance of bacterial infections of hospita

256 ture of a phosphorylated target protein with antibiotic resistance of Escherichia coli cells.

257 ontributes significantly to the emergence of antibiotic resistance, often by upregulating expression

258 equences within a controlled vocabulary, the Antibiotic Resistance Ontology (ARO), designed by the CA

259 or the acquisition of new phenotypes such as antibiotic resistance or virulence traits.

260 er patient treatment, such as the buildup of antibiotic resistances or low drug selectivity and toxic

261 g subtypes associated with pathogenicity and antibiotic resistance patterns.

262 Since TolC and LPS contribute to antibiotic resistance, phage U136B should select for the

263 Prediction of antibiotic resistance phenotypes from whole genome seque

264 Antibiotic resistance poses an increasing threat to glob

265 Antibiotic resistance poses one of the greatest threats

266 short-term antibiotic exposures predict the antibiotic resistance profile of Ng measured by plate gr

267 Here we accurately predict the antibiotic resistance profiles of bacterial infections o

268 ferent countries, which exhibited dissimilar antibiotic resistance profiles.

269 morphological analysis, and heterogeneity in antibiotic-resistance profiles, make it an excellent alt

270 reatment technologies to effectively prevent antibiotic resistance proliferation associated with thes

271 For example, antibiotic resistance rates are higher in patients with

272 Antibiotic resistance rates of enterobacterales were > 2

273 pecies encode PecS, a member of the multiple antibiotic resistance regulator (MarR) family of transcr

274 ibiotic stewardship and population levels of antibiotic resistance remains unclear.

275 Genotype-based diagnostics for antibiotic resistance represent a promising alternative

276 s highlight the importance of characterizing antibiotic resistance reservoirs in hospitals and establ

277 The data included antibiotic resistance results of bacterial cultures from

278 rthermore, screening the FMT donor stool for antibiotic resistance revealed 21 populations that evade

279 Models of antibiotic resistance should account for culture source.

280 e future of antibiotic resistance, designing antibiotic resistance stewardship policy, and interpreti

281 ally relevant, and comprehensive targets for antibiotic resistance surveillance in watersheds.

282 Our data show that in addition to elevating antibiotic resistance through mexXY expression (and also

283 fflux pumps have been demonstrated to convey antibiotic resistance to a wide range of pathogens and a

284 First, we used dynamical models of antibiotic resistance to predict the effects of spillove

285 The continued emergence of antibiotic resistance, together with our increasing unde

286 s are limited due to the increasing rates of antibiotic resistance, underscoring the importance of id

287 E. coli but also prevented it from evolving antibiotic resistance upon exposure to a beta-lactam ant

288 tics tool, variant mapping and prediction of antibiotic resistance (VAMPr), to (1) derive gene orthol

289 NA likely traverses to promote the spread of antibiotic resistance via horizontal gene transfer by na

290 ced H(2) S and sulfane sulfur may facilitate antibiotic resistance via inducing the expression of ant

291 ic elements (MGEs) facilitates the spread of antibiotic resistance, virulence, and environmental pers

292 lobacter spp. likely play important roles in antibiotic resistance, virulence, and horizontal gene tr

293 on sites often cluster near genes related to antibiotic resistance, virulence, and pathogenicity.

294 Antibiotic resistance was largely found in Ecc lineage 1

295 romycin or placebo twice yearly for 4 years, antibiotic resistance was more common in the villages th

296 Of note, the effect of the PPHD knockout on antibiotic resistance was phenocopied in bacteria expose

297 The contribution of different alleles to antibiotic resistance was predicted by a random forest c

298 se with each administration or wane owing to antibiotic resistance was unknown.

299 nantibiotic pesticides on the development of antibiotic resistance, we conducted long-term exposure e

300 ve identified a novel mechanism of inducible antibiotic resistance whereby isolates that appear to be