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1 te is required to develop a more efficacious antibody.
2 tralizing virus when expressed as monoclonal antibodies.
3 , for assessing the stability of therapeutic antibodies.
4 clusters closely associated with SARS-CoV-2 antibodies.
5 ctionalization with specific anti-PARK7/DJ-1 antibodies.
6 uring viral growth in the presence of single antibodies.
7 by a fast rise in serum IgG and neutralizing antibodies.
8 o difference in the presence of neutralizing antibodies.
9 e overcome using PD-L1 or PD-1 immunotherapy antibodies.
10 f Brazil and exhibit nonpathogenic anti-DSG1 antibodies.
11 s of secreted proteins such as cytokines and antibodies.
12 with cell-surface receptors and neutralising antibodies.
13 mline sequences, to HIV broadly neutralizing antibodies.
14 viously emerged as a target for neutralizing antibodies.
15 es in the presence of specific IgG biomarker antibodies.
16 on in mouse for brain parenchyma penetrating antibodies.
17 nitial screen for all therapeutic monoclonal antibodies.
18 oV-2 antibodies, compared with those without antibodies (93.4% versus 78.7%, p < 0.001), whereas tast
19 sign is complicated by concern that elicited antibodies (Abs) may cross-react with other flaviviruses
20 coincident with the development of antidrug antibodies (ADAs) against each of the DART molecules.
22 r-protocol set developed clade C Env binding antibodies after the second vaccination, with higher tot
23 The patient was found to have anti-retinal antibodies against carbonic anhydrase II and enolase pro
24 e feasibility of isolating recombinant phage-antibodies against gluten from a non-immunized library o
25 While the therapeutic benefit of monoclonal antibodies against infectious disease agents may be deba
27 r than 10% of the US adult population formed antibodies against SARS-CoV-2, and fewer than 10% of tho
28 ted two fully human, neutralizing monoclonal antibodies against severe acute respiratory syndrome cor
29 by identification of immunoglobulin G (IgG) antibodies against T. gondii embryogenesis-related prote
30 after a delay of around 4 months, protecting antibodies against the short L1 appeared, enabling the v
31 n recognized by a broadly neutralizing human antibody against a broad range of H3N2 with high potency
34 2 of 10 (20%) relapses in patients with MOG antibodies and 12 of 13 (92.5%) with AQP4 antibodies (p
37 e, orthogonal and adaptable to different IgG antibodies and can be employed to achieve the targeted s
38 hese studies identify promising prophylactic antibodies and define protective epitopes that can be us
40 ignificantly reduced both class I and II HLA antibodies and increased the likelihood of identifying a
42 e semen significantly reduces the potency of antibodies and microbicides that target glycans on the e
44 analyses of antibodies, including bispecific antibodies and potential mispaired side products, in cel
45 evelopment and selection of humanized animal antibodies and provide actionable information for use in
46 A antigens synergize with HLA donor-specific antibodies and significantly increase the odds of reject
47 protein (Env) is the target of neutralizing antibodies and the template for vaccine immunogen design
48 layed significantly decreased donor-specific antibodies and, on prolonged treatment, modulated reject
49 on between a trans-cyclooctene (TCO)-bearing antibody and a tetrazine (Tz)-based radioligand via the
50 ccination than after the fourth, with higher antibody and cellular response rates at month 18 than at
53 lycan profile of a biotherapeutic monoclonal antibody and was able to achieve sensitive glycan identi
55 were reactive by the Abbott IgG, Roche total antibody, and Abbott IgM assays, respectively, with samp
56 p = 0.001 for sacituzumab govitecan vs naked antibody, and sacituzumab govitecan vs control-ADC, resp
58 loyed to assess anti-human leukocyte antigen antibodies (Anti-HLA Ab) for donor-recipient matching an
59 ions, tumor cell doubling time, administered antibody, antibody specific-activity, and antigen-site d
61 urrently still only one therapeutic anti-IgE antibody approved for the treatment of allergic conditio
66 r findings reinforce the power of monoclonal antibodies as tools to interrogate structure-function re
67 to the poor sensitivity of immunofluorescent-antibody assays (IFAs), a reliable serodiagnostic test f
74 -IL-12/23 remained significant and anti-IL-6 antibodies became a trend after controlling for physical
75 Cox proportional hazard model, HLA class II antibodies before transplantation were associated with i
79 cess, careful structural analysis beyond the antibody binding site is required to develop a more effi
82 infection by a class of broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus
83 vident in the sera of the MS cohort, and the antibodies bound a heterogeneous set of molecules, inclu
84 ural changes for parent and affinity-matured antibodies bound to ARG2, with a large reorientation of
88 lement-dependent cytotoxicity panel reactive antibody [CDC PRA+], C1q+) heart transplant candidates w
91 spike protein receptor binding domain total antibody chemiluminescence assay (100% sensitivity, 99.8
93 hly variable, differing in their format, the antibody class detected, the targeted antigen, and the a
94 ically relevant impact of IVIg on monoclonal antibody clearance and indirectly hint at an IVIg mechan
95 re prevalent in participants with SARS-CoV-2 antibodies, compared with those without antibodies (93.4
97 t arm (10 mg/kg, providing therapeutic-level antibody concentrations), immediately followed by approx
102 highly sensitized (calculated panel reactive antibody [cPRA] class I and/or II >99%, complement-depen
103 d with samples of anti-SARS-CoV-2 monoclonal antibody CR3022 (0.1 mug/ml, 1.0 mug/ml, 10 mug/ml).
105 multiple myeloma (MM) include the anti-CD38 antibody daratumumab, which, in addition to its inherent
107 r is a reliable approach to simplify complex antibody data and an ideal endpoint for desensitization
111 PPD-specific isotype/subclass, PPD-specific antibody-dependent phagocytosis, cellular cytotoxicity,
112 o providing guidance for vaccine design, the antibodies described here are promising candidates for C
113 Early diagnosis of an infection based on antibody detection might lead to less invasive, early in
114 Env trimer immunization elicits neutralizing antibody development and production of antibodies facili
115 s)IgA, esIgE, esIgD, esIgG(1) , and esIgG(4) antibodies directed at 58 (15-mer) overlapping peptides,
120 spiking in known amounts of HCPs to purified antibody drug substance with low levels of HCPs, we demo
121 the selective cleavage of a tetrazine-linked antibody-drug conjugate by trans-cyclooctenes, affording
122 n both the heavy and light chains of a model antibody-drug conjugate, and calculation of the overall
123 Complex biotherapeutic modalities, such as antibody-drug conjugates (ADC), present significant chal
129 onset, immunoglobulin (Ig) M, IgA, and total antibody ELISAs increased in sensitivity to >80% between
132 , were down-regulated as cellular demand for antibody expression increased in CHO cells during the pr
133 izing antibody development and production of antibodies facilitating uptake of immunogens by antigen-
135 engineering of anti-influenza IgG monoclonal antibodies for selective binding to the activating Fcgam
137 evels only in dAP7 cells and synergized with antibody for RNA clearance and improved cell survival.
139 In this study, we isolated a single-chain antibody from an Indian dromedary camel (ICab) immunized
140 ed from the immunized camel and purified the antibody from Escherichia coli after refolding it from i
146 o infect individuals with naturally acquired antibodies highly blocking the binding of PvDBP to the D
147 munized with recombinant LJM17 produced IgG1 antibodies (human IgG4 homolog) that strongly cross-reac
149 hermal unfolding of a recombinant monoclonal antibody IgG1 (mAb) was measured with differential scann
150 emplar, whereby CTLA4 activity is blocked by antibodies in cancer immunotherapy and augmented by the
153 tially injected intravenously with unlabeled antibody in a peripheral vessel in the right arm (10 mg/
154 rom Staphylococcus aureus We identified this antibody in a yeast display screen built from mononuclea
155 e concentration between HCPs and therapeutic antibody in solution, which precludes the effective iden
156 plus pembrolizumab (an anti-PD-1 monoclonal antibody) in previously treated patients with HER2-posit
157 platform affords high-throughput analyses of antibodies, including bispecific antibodies and potentia
158 The EBBINGHAUS (Evaluating PCSK9 Binding Antibody Influence on Cognitive Health in High Cardiovas
159 ximately 40 MBq of one of the (89)Zr-labeled antibodies injected intravenously in a peripheral vessel
161 ertheless, the development of biotherapeutic antibodies is complex, expensive, and time-consuming, an
163 hmatic sputum and targeting Siglec-8 with an antibody is a plausible strategy to decrease sputum eosi
165 ongly correlate with the total anti-PLA(2)R1 antibody level (Spearman's rho, 0.95, 0.64, and 0.40; P<
166 antibody responses correlated strongly with antibody levels measured by ELISA (R(2)=0.67 by Marburg
167 d ELISA showed that domain-specific PLA(2)R1 antibody levels targeting CysR, CTLD1, and CTLD7 strongl
168 d subjects, and a wide range of serum/plasma antibody levels was delineated in infected subjects.
171 the high targeting specificity of monoclonal antibodies (mAb) with the potency of small molecule ther
172 Here, we developed an anti-AQP3 monoclonal antibody (mAb) that inhibited AQP3-facilitated H(2)O(2)
176 It correlated with tubulitis, arteritis, and antibody markers within concurrent histology (P < 0.001)
178 of protection against many viral pathogens, antibodies mediate additional immune functions that may
182 hanisms by which the early synergism between antibody-mediated toxin neutralization and tissue-specif
184 ped SARS-CoV-2-specific immunoglobulin (IgG) antibodies, neutralizing plasma, and memory B and memory
185 cross-protectivity, the diagnostic value of antibodies of different isotypes, and the use of antibod
187 roduce a method for a related task: given an antibody of interest and its inferred ancestral lineage,
188 shing steps that desorbs the capture antigen/antibody off the polystyrene plate, thereby producing in
189 mean titres of SARS-CoV-2 serum-neutralizing antibodies on day 43 were 0.7-fold (1-mug dose) to 3.5-f
191 ors in vitro after exposure to patients' CSF antibodies or SSM5, we used a functional assay based on
192 Targeting MARCO or IL37 receptor (IL37R) by antibody or CRISPR knockout of IL37 in lung cancer cell
196 ull cells treated with an ERBB3-neutralizing antibody partially downregulated mTOR pathway activation
197 ility of research findings, and inconsistent antibody performance leads to variability in Western blo
200 this enriched immunodominant spike-specific antibody profile in convalescents was confirmed in a lar
202 Passively acquired maternal GBS-specific antibodies protect newborns from early-onset disease, ye
203 ory syndrome coronavirus 2 (anti-SARS-CoV-2) antibodies provide one method for estimating infection r
208 f anti-PD-1 inhibitory and anti-OX40 agonist antibodies reduces the proportion of T-regulatory and ex
209 ble, the functional characterization of such antibodies represents a powerful tool for the developmen
210 " viruses significantly enhances the anti-NA antibody response compared to vaccination with unmodifie
212 and their vaccine efficacy (antigen-specific antibody responses and IFN-gamma production) and biodist
213 g rare B cells capable of broadly protective antibody responses are not hindered by promotion of term
214 induction of functionally active polyclonal antibody responses as measured in the standard membrane
219 w that mRNA-1273 induces potent neutralizing antibody responses to both wild-type (D614) and D614G mu
225 thionines throughout one of the most popular antibody scaffolds, trastuzumab, used for antibody engin
226 nting instrumentation and will be useful for antibody screening, custom assay development, biomarker
230 dentify features that distinguish one set of antibody sequences from antibody sequences in a referenc
232 RS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convale
233 We demonstrate that using cGMP-specific antibody, sGC or PDE activity and the effect of small mo
236 typically stimulate the production of potent antibodies specific for the pathogen through a Darwinian
237 r cell doubling time, administered antibody, antibody specific-activity, and antigen-site density mos
240 ic (CD14) but not CD4+ T cell-specific (CD3) antibodies, suggesting that M-tropic viruses had a macro
241 more, clinically approved PCSK9-neutralizing antibodies synergize with anti-PD1 therapy in suppressin
242 that nascent plasma cells adapt to increased antibody synthesis by activating the unfolded protein re
244 ls who were seronegative for anti-SARS-CoV-2 antibodies targeting spike (S) and nucleoprotein (N).
246 ynamics (PD) of the human anti-C5 monoclonal antibody tesidolumab (LFG316) in end-stage renal disease
247 bodies of different isotypes, and the use of antibody testing in identification of acutely ill patien
249 oduce high quantities of the glycan-specific antibodies that can be protective against infectious age
251 We find that this vaccine strain elicits antibodies that have reduced reactivity to a wild-type 3
252 platform for the detection of IgG anti-drug antibodies that may provide an initial screen for all th
253 combination of antigen- and epitope-specific antibodies that using 3- to 15-month or 2- to 3-year sam
254 ere, we stabilize immature Zika virus via an antibody that binds across the E and prM proteins, resul
255 AK002 (lirentelimab) is an anti-Siglec-8 antibody that depletes eosinophils and inhibits mast cel
256 that a patient with VZV CNS vasculopathy had antibody that neutralized interferon (IFN)-alpha, but no
258 are predominantly targeted and drugged with antibodies, they harbor pockets that are only accessible
259 ion and analyzed in relation to preinfection antibody titer (measured by inhibition enzyme-linked imm
260 not all recovered patients develop adequate antibody titers for donation and the relationship betwee
261 erpesvirus (KSHV) DNA in blood and increased antibody titres may indicate KSHV reactivation, while th
262 Seasonal IIV could not induce seroprotective antibodies to 2010.1 cluster A(H3N2)v viruses in young c
264 le of the microbiota in eliciting protective antibodies to a specific neonatal pathogen represents an
266 based assay for the detection of IgM and IgG antibodies to B. burgdorferi The BioPlex 2200 Lyme Total
269 ative antigen for vaccine development, since antibodies to NS1 do not bind to the virion, thereby eli
271 e, patterns of, and factors associated with, antibodies to RVF virus (RVFV) in livestock in an area h
273 eflectometry (AIR) platform for detection of antibodies to SARS-CoV-2, SARS-CoV-1, MERS, three circul
277 ) assays, we characterized IgG, IgM, and IgA antibodies to the spike receptor binding domain (RBD), S
278 undamental information relating sequences of antibodies to their unique properties as inhibitors.
279 antation, the presence of naturally-existing antibodies to TKO pig cells in OWMs complicates the tran
280 n experimental studies, we used a monoclonal antibody to urokinase plasminogen activator receptor (uP
281 munity [thyroid peroxidase and thyroglobulin antibodies (TPOAb and TgAb, respectively)] in serum usin
285 ) is essential in the induction of anti-RABV antibodies via the facilitation of germinal center forma
286 in combination with the broadly neutralizing antibody VRC01-N using a highly reproducible humanized m
289 ping showed that this collection of nineteen antibodies was about equally divided between those direc
290 oglobulin G (IgG) and immunoglobulin M (IgM) antibodies was undertaken under medical supervision.
292 ss-reacted with recombinant DSG1; these IgG1 antibodies were inhibited by LJM17, LJM11, and DSG1 in a
293 osted regimens, half-lives of gp120-specific antibodies were longer but peak magnitudes were lower in
296 rrently solely based on expensive monoclonal antibodies, which often inflict immune-related adverse e
298 onse without eliciting significant anti-ZIKV antibodies, while vaccination with Ad5-prM-E leads to th
299 ax, the RBD derivative elicited neutralizing antibodies with an endpoint geometric mean titer of ~415
300 mer peptide and found that it binds the scFv antibody with a K(D) (equilibrium dissociation constant)