ライフサイエンスコーパス: antigen specificity

1 beta epitope (in a prior nomenclature for e-antigen specificity).

2 aid in the design of antibodies with altered antigen specificity.

3 described, based on their TCR repertoire and antigen specificity.

4 n induce tumor-specific T cells with defined antigen specificity.

5 s to redirect T cell and natural killer cell antigen specificity.

6 ild-type IgG1 (IgG1/wt) or IgG2 of identical antigen specificity.

7 ditioned secondary recipients, demonstrating antigen specificity.

8 ved with IgG1/wt, IgG2, or IgG4 of identical antigen specificity.

9 fetal antigen, demonstrating their inherent antigen specificity.

10 for ERCC1-XPF were not rigorously tested for antigen specificity.

11 model antigens were preserved demonstrating antigen specificity.

12 tly regulated event and is governed by islet antigen specificity.

13 + regulatory T cells (T(reg)) independent of antigen specificity.

14 reased on memory CD8(+) T cells according to antigen specificity.

15 T cell antigen receptors (TCRs) that confer antigen specificity.

16 terminant of preferential infection based on antigen specificity.

17 ls without impairing phenotype, function, or antigen specificity.

18 emory CD4(+) T-cell subsets, irrespective of antigen specificity.

19 s and effector Th2 cells displaying the same antigen specificity.

20 lation likely requires in vivo generation of antigen specificity.

21 previously derived from IAC, without losing antigen specificity.

22 munoglobulin (Ig) gene usage, clonality, and antigen specificity.

23 entify and isolate NK T cells based on their antigen specificity.

24 gy to produce therapeutic T cells of defined antigen specificity.

25 in, and entered the CNS independent of their antigen specificity.

26 x T cell populations that differ in size and antigen specificity.

27 he heavy and the light chains contributed to antigen specificity.

28 f B cells and for determining their eventual antigen specificity.

29 y time to LAT condensation and alters T cell antigen specificity.

30 ed antitumor CD8(+) T-cell responses require antigen specificity.

31 ing regions (CDR1-CDR3), which contribute to antigen specificity.

32 toire consolidation directly correlated with antigen specificity.

33 tibody properties, such as immunogenicity or antigen specificity.

34 ceptor (TCR) sequence features provide about antigen specificity.

35 fort to tackle the problem of predicting TCR-antigen specificity.

36 ltimodal over unimodal approaches to capture antigen specificity.

37 long-term memory with a broad repertoire of antigen specificity.

38 rally unrelated hapten-BSA adducts confirmed antigen specificity.

39 therapeutics for autoimmunity is the lack of antigen specificity.

40 tumor progression regardless of CD8(+) TILs' antigen specificity.

41 beta chain libraries pre-enriched for target antigen specificity.

42 ss II molecules is as or more important than antigen specificity.

43 sely adjacent Treg cells regardless of their antigen specificity.

44 -specific antibodies is separable from their antigen specificity.

45 B cell helper quality differed depending on antigen specificity.

46 therapeutic functions while still retaining antigen specificity.

47 nd beta-chains contribute to determining TCR antigen specificity.

48 the infused T-cell population had restricted antigen specificity.

49 at allows proliferative responses, enforcing antigen specificity.

50 , thus providing greater scope for differing antigen specificities.

51 n enormous array of receptors with different antigen specificities.

52 madelta T cells rather than constrains their antigen specificities.

53 ment has little role in generating different antigen specificities.

54 e an almost infinitely diverse repertoire of antigen specificities.

55 autoimmune hepatitis, and they have diverse antigen specificities.

56 from different individuals, pathologies, and antigen specificities.

57 (V(H)3-30), despite an apparent diversity of antigen specificities.

58 he generation of pMHC-I molecules of desired antigen specificities.

59 d light-chain BCR sequences to their cognate antigen specificities.

60 fic TILs without previous knowledge of their antigen specificities.

61 ssion, rapid effector responses and 'public' antigen specificities.

62 of the VDJdb in the task of exploring T-cell antigen specificities.

63 te repertoires with extensive collections of antigen specificities.

64 fection of CD4 T cells of different pathogen/antigen specificities.

65 on of DSA (including two new human leukocyte antigen specificities) 2 months after initial bortezomib

66 currently under investigation to (1) confer antigen specificity, (2) enhance T cell effector functio

67 to chronic stimulation, regardless of their antigen specificities, a phenotype reversed by the expre

68 gA and FcgammaR-binding antibodies and among antigen specificities accurately predicted infection sta

69 A comprehensive analysis of TCR antigen specificity, affinity, crossreactivity, and CD8

70 These cells showed antigen specificity against HIV proteins.

71 Antigen specificity also factored into TLR7-induced dise

72 T cells that regulate CD4(+) and CD8(+) self-antigen specificities and autoimmune diabetes in NOD mic

73 Antigen specificities and functions differed between IgG

74 These two subsets differ in their principal antigen specificities and in the T-cell receptor signal

75 Notably, the tumor-antigen specificities and TCR repertoires of the circula

76 unresolved, especially with regard to their antigen specificities and the cellular and molecular pat

77 The antigen specificity and affinity of both receptors is de

78 f CAR T cell products for therapy, including antigen specificity and affinity, metabolic fitness, phe

79 gic memory that has 2 basic characteristics, antigen specificity and an amplified response upon subse

80 two-step staining approach is used to detect antigen specificity and antibody expression: in order to

81 innate immune system, are considered to lack antigen specificity and be devoid of immunological memor

82 ion and purification, the Mbs retained their antigen specificity and bound primary CD8(+) T cells fro

83 combinant IgG-DAF chimeric proteins retained antigen specificity and bound to dansylated Chinese hams

84 acent CD1 residues in a manner that explains antigen specificity and CD1 restriction.

85 Importantly, however, the antigen specificity and cellular origin of maternal T(re

86 h2G7 retained identical antigen specificity and comparable affinity as m2G7.

87 ovel TCR transgenic mice with a defined self-antigen specificity and conventional mouse models, we de

88 vided insight into the mechanisms underlying antigen specificity and cross-reactivity.

89 MHC) tetramer staining to directly correlate antigen specificity and cytolytic ability on a single-ce

90 ts priming of naive CD8+ T cells that retain antigen specificity and cytotoxic function for more than

91 ine staining was used to determine the viral antigen specificity and expression levels of various cyt

92 More surprisingly, immunocytokine antigen specificity and Fcgamma receptor interactions di

93 However, the antigen specificity and functional properties of these c

94 f human malignancies and, given their target antigen specificity and generally minimal toxicity, are

95 infiltrate into the CNS regardless of their antigen specificity and have the potential to be re-stim

96 erein, we discuss different forms of NK cell antigen specificity and how these responses may be tuned

97 re, we screened related LS-specific TCRs for antigen specificity and identified a peptide derived fro

98 e restored by transfer of Ig irrespective of antigen specificity and isotype.

99 tional techniques being developed to predict antigen specificity and mechanistic basis of TCR targeti

100 and characterization of B-CLL mAbs to study antigen specificity and of B-CLL DNA to investigate mole

101 Therapeutic activity required tumor antigen specificity and perforin expression by the adopt

102 ed probes and flow cytometry to evaluate the antigen specificity and phenotype of RSV F-specific B ce

103 Our study details the antigen specificity and phenotype of T-cell clones gener

104 HCV TCRs that differ in antigen specificity and polyfunctionality were examined.

105 Ls, thereby providing insight into MAIT cell antigen specificity and potency.

106 ell clones expressing cloned TCRs with known antigen specificity and relative affinities.

107 k for linking B cell clonal composition with antigen specificity and serum antibody responses.

108 ition of the signal on the array defined the antigen specificity and the antibody class was defined b

109 iew, the mechanism of action of Tregs, their antigen specificity and their frequency and function in

110 fficient to recruit CTLs regardless of their antigen specificity and to induce insulitis.

111 c anaphylaxis in vivo and to investigate the antigen specificity and underlying mechanisms of rapid d

112 However, antigen specificity and VLA-4 expression were required f

113 Expression of LIR-1 was dependent on CTL-antigen specificity and was associated with a differenti

114 Such auto- antigen specificity and/or cross-reactivity may dictate

115 CARs combine antigen-specificity and T cell activating properties in

116 between antibody features (IgG subclass and antigen specificity) and effector function activities (a

117 surface immunoglobulin (sIg), which provides antigen specificity, and a noncovalently associated sign

118 repertoires, classifying CDR3 repertoires by antigen specificity, and distinguishing general patholog

119 The quality, antigen specificity, and functions associated with antib

120 tility owing to their biocompatibility, high antigen specificity, and targeted immune stimulation.

121 Despite unorthodox binding, TCR signaling, antigen specificity, and the ability to use CD8 are main

122 of the T cell receptor (TCR), which confers antigen specificity, and the CD8 coreceptor, which stabi

123 populations, which have not taken account of antigen specificity, and understanding their properties

124 e diseases, self-reactive T cells with known antigen specificity appear to be particularly promising

125 Although the antigen specificities are presently unknown, similar cha

126 is system, clonal naive T cells with defined antigen specificity are generated by retrovirus-mediated

127 While their precise role and antigen specificity are unclear, T cell-derived cytokine

128 d version of E16 was generated that retained antigen specificity, avidity and neutralizing activity.

129 I binding, demonstrating the need for target antigen specificity both in vitro and in vivo.

130 NKT cells are of limited antigen specificity but possess the ability to be recrui

131 n does little to constrain gammadelta T cell antigen specificities, but instead determines their effe

132 lood-brain barrier (BBB) regardless of their antigen specificity, but studies have focused on CD4 T c

133 rs (3.9 +/- 1.3 %ID/g, P < 0.01), indicating antigen specificity by (89)Zr-alphaGPC3.

134 Fv and IgG mutant forms were then tested for antigen specificity by ELISA, for tissue specificity by

135 Redirecting T lymphocyte antigen specificity by gene transfer can provide large n

136 ocytes were quantified by flow cytometry and antigen specificity by in vitro cytokine production.

137 tes with adaptive immune features, including antigen specificity, clonal expansion and memory.

138 ed by infection have a distinct hierarchy of antigen specificity compared to the periphery.

139 We assessed the antigen specificity, cytokine signature, and mechanisms

140 dicate that BCR signal strength, rather than antigen specificity, determines mature B cell fate.

141 crosomal type 1 (LKM-1) showing a remarkable antigen-specificity directed against cytochrome P4502D6.

142 infiltrate dynamics and the requirement for antigen specificity during progression of autoimmune dia

143 olecular phenotypes, architectural contexts, antigen specificities, effector mechanisms and regulator

144 urprisingly, T cell populations differing in antigen specificity expand, contract, and enter the T ce

145 tailored generation of T cells of unlimited antigen specificity for improving the effectiveness of a

146 of the TCR-repertoire underpins the distinct antigen specificity for iNKT cells in peripheral tissues

147 eering of novel T-cell receptors that impart antigen specificity for virally infected or malignant ce

148 very different clinical features relative to antigen specificity; for example, most patients with Weg

149 In contrast, T cells with other antigen specificities from these patients, or autoreacti

150 The recent work on the antigen specificity, generation and mode of action of T

151 e of immunosuppressive medications that lack antigen specificity, have many adverse side effects, and

152 and antibody expression: in order to detect antigen specificity, hybridoma cells are incubated with

153 onstraint of fitting a diverse repertoire of antigen specificities in a limited total population of l

154 ription profiles together with their cognate antigen specificities in a single experiment.

155 cells (LT-HSCs) alters the representation of antigen specificities in the peripheral B-cell repertoir

156 The consistency of CD2, CD3, CD11a, and CD45 antigen specificities in thymoglobulin was determined us

157 t parasites and venoms and are the source of antigen specificity in allergic patients, yet the develo

158 coordination and the generation of a common antigen specificity in CBD.

159 A characterization of the antigen specificity in DO11.10 TCR transgenic mice demon

160 ifferent patterns of accumulation based upon antigen specificity in the at-risk cases.

161 these cells lack polyreactivity yet manifest antigen specificity in the context of lipids, shaping MP

162 gether, our data highlight the importance of antigen specificity in the functional dynamics of the T-

163 -related TCR, and therefore sharing the same antigen specificity, invariably shared the same NKG2A co

164 As antigen specificity is a hallmark of an adaptive immune

165 Antigen specificity is critical in immune response and r

166 It is currently thought that islet antigen specificity is not a requirement for islet entry

167 Although critical to T cell function, antigen specificity is often omitted in high-throughput

168 logous peripheral CD8(+) T lymphocytes whose antigen specificity is redirected by transduction with l

169 munity, Lennon et al. demonstrate that islet-antigen specificity is required for accumulation in the

170 The match of T-cell effector function with antigen specificity is thus determined by the type of ba

171 Accurate prediction of antibody-antigen specificity is vital for understanding immune re

172 Antigen-specificity is a hallmark of adaptive T cell-med

173 inflammatory property of IgG, independent of antigen specificity, is described.

174 Antigen specificity, isotype profile, Fc-gamma receptor

175 y-purified antibodies were also examined for antigen specificity, isotype, and crossreactivity.

176 ation and cytokine production independent of antigen specificity, its therapeutic effect is abrogated

177 Antigen specificity mapping and functional activity meas

178 However, the degree of antigen specificity mediated by alloreactive T cells, an

179 the post-translational acquisition of novel antigen specificities might play an important role in th

180 ale proteome array to systematically profile antigen specificities of antibody responses to C. tracho

181 current knowledge on the cellular states and antigen specificities of antitumour T cells and examine

182 This review focuses on antigen specificities of autoantibodies in lupus anticoa

183 emory T cells, the developmental origins and antigen specificities of CD8-MP cells remain incompletel

184 Here, we examined the antigen specificities of HCC-infiltrating T cells and th

185 the CDR3 regions were found to determine the antigen specificities of T10- and T22-reactive gammadelt

186 roteome and used them to determine the major antigen specificities of the human humoral immune respon

187 activity and potentially harmful unpredicted antigen specificities of the resultant TCRs.

188 ic response after adoptive transfer, but the antigen specificities of the T cells transferred have no

189 cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes

190 Bispecific antibodies (bsAbs) combine the antigen specificities of two distinct Abs and demonstrat

191 In summary, we have combined the antigen specificities of two highly efficacious anti-H5N

192 We investigated the antigen specificity of a human gammadelta-TCR previously

193 We also found that the antigen specificity of a single T-cell clone can be dege

194 ation is needed to identify the mechanism of antigen specificity of adverse reactions to foods in FPI

195 To help understand the frequency and antigen specificity of AMAs in an asymptomatic populatio

196 cells), these entities combine the exquisite antigen specificity of antibodies with the polyfunctiona

197 We examined the timing and HIV-1 antigen specificity of antiviral CD8(+) T cells during A

198 polyclonal and virus-specific processes, the antigen specificity of B cells in lymphoid tissues of mo

199 emic associated with the origin, target, and antigen specificity of both endogenous and induced regul

200 These results indicate antigen specificity of both immune induction and the rec

201 ase inhibitor (SLPI), and to investigate the antigen specificity of both NE and PR3 ANCA in patients

202 However, very little is known about the antigen specificity of CD4(+) Treg cells.

203 The antigen specificity of CD8(+) T cells infiltrating islet

204 olipin binding, raising the possibility that antigen specificity of certain antibodies may exclusivel

205 The TCR diversity and antigen specificity of CMV-specific T cells remained rem

206 ted that costimulatory molecule B7 modulates antigen specificity of CTLs, and provides a missing link

207 regulatory T cells alone can account for the antigen specificity of dominant transplantation toleranc

208 The antigen specificity of each construct was for the hapten

209 esults challenge current paradigms about the antigen specificity of GvHD effector mechanisms and conf

210 Antigen specificity of IFN-gamma release was demonstrate

211 However, the antigen specificity of IgA and IgG for the microbiota an

212 Testing of the SIV antigen specificity of IgG from SIV-infected macaques re

213 ime (MST), and alloimmune responses, and the antigen specificity of induced tolerance were studied.

214 Furthermore, these studies revealed that the antigen specificity of influenza virus-reactive CD4 and

215 if and how the tissue environment shapes the antigen specificity of iNKT cells remains unknown.

216 ant role for negative selection in mediating antigen specificity of mature T cells and a molecular me

217 tometry profiling of CD8+ T-cell subsets and antigen specificity of reconstituting CD4+ and CD8+ T ce

218 To investigate the antigen specificity of regulatory T cells capable of pre

219 Antigen specificity of RTL raises the question as to whe

220 om KRASMUT have been described, but the fine antigen specificity of T cell responses directed against

221 However, data on lymphocyte dynamics and the antigen specificity of T cells in Ebola survivors are sc

222 ively link intratumoural phenotypes with the antigen specificity of T cells provided by T cell recept

223 y complex is the key interaction involved in antigen specificity of T cells.

224 ity complex (MHC) multimers which mirror the antigen specificity of T-cell receptor recognition.

225 cient killing of bacteria, regardless of the antigen specificity of the antibody.

226 o, but the extent of this activation and the antigen specificity of the CD8(+) T cells remain uncerta

227 a, implying a common mechanism, the issue of antigen specificity of the cells involved has not yet be

228 enzymes may enable pathogens to subvert the antigen specificity of the humoral immune response to fa

229 for extracellular bacteria, we assessed the antigen specificity of the induction and recall of this

230 Because of the antigen specificity of the inhibition, these results col

231 s more compelling if concordance between the antigen specificity of the leukocyte antibodies in the d

232 which does not depend upon knowledge of the antigen specificity of the original T cell clone trigger

233 with other dietary proteins, which suggests antigen specificity of the secretion of dietary protein

234 ut it provides limited information about the antigen specificity of the sequenced BCRs.

235 Antigen specificity of the suppressive nanovesicles was

236 However, the antigen specificity of the T-cell response to C. neoform

237 udy, we used two approaches to determine the antigen specificity of the T-cell response to C. neoform

238 lls but not resting T cells, irrespective of antigen specificity of the target T cells.

239 antibody types (4.6-6.0), demonstrating the antigen specificity of the tumor targeting.

240 lesions (CIMDL), but the pathogenic role and antigen specificity of these antibodies are unknown.

241 sitive target cells further demonstrated the antigen specificity of these CTLs.

242 comprehensive understanding of the roles and antigen specificity of these endogenous T cells at the i

243 ten contain B cells and plasma cells but the antigen specificity of these intratumoral B cells is not

244 rotection following CNS injury; however, the antigen specificity of these T cells and how they mediat

245 Using LIBRA-seq, we mapped the antigen specificity of thousands of B cells from two HIV

246 Here we examined the antigen specificity of tissue-infiltrating CD4(+) T cell

247 Characterization of antigen specificity of tumor-infiltrating lymphocytes (T

248 at virtually every CDR can contribute to the antigen-specificity of a T cell.

249 e unresolved issue of antigen-dependency and antigen-specificity of autoimmune disease suppression by

250 Here, to identify the origin and antigen-specificity of intestinal Treg cells, we perform

251 We characterized the antigen-specificity of L363 toward several different gly

252 regulation which is thought to maintain the antigen-specificity of T cell apoptosis.

253 We investigated the antigen-specificity of T cells isolated from patients wi

254 the isotype and IgG subclasses, but not the antigen specificity, of the local antibody response.

255 Helper T cells confer antigen specificity on eosinophil cytotoxicity, but not

256 The role of antigen specificity on neonatal tT(reg) cell selection i

257 drug without measurable impairment of their antigen specificity or cytotoxic activity.

258 and warn that care must be taken when using antigen-specificity or surface IgG as an indicator of B

259 Despite their antigen specificity, pea-T10 cells of patients with PA w

260 ave a large antibody repertoire with diverse antigen specificities, poised to react to invading patho

261 forms other state-of-the-art methods for TCR-antigen specificity prediction.

262 Tregs), their anergic phenotype, and diverse antigen specificity present major challenges to harnessi

263 responses of CTL populations that differ in antigen specificity range in magnitude from large, domin

264 let membrane preparations, others have known antigen specificities, reacting with defined islet cell

265 ology; however, their exact contribution and antigen specificities remain unclear.

266 How this diversity captures antigen specificity remains incompletely understood.

267 ng the ontogeny of the divergent IgG and IgA antigen specificity repertoires and their effects on ant

268 However, CARs have a fixed antigen specificity such that only one tumor-associated

269 mber injection of antigen, as shown by their antigen specificity, surface expression of CD8, and capa

270 ces of adaptive immunity, which is built for antigen specificity, tend to produce organ-specific auto

271 ur data indicated that despite their similar antigen specificity, the functional NKT cell subsets wer

272 , and despite the lack of information on TCR antigen specificity, the sharing of top abundant clones

273 uencing approach (linking B cell receptor to antigen specificity through sequencing (LIBRA-seq)) enab

274 resent LIBRA-seq (linking B cell receptor to antigen specificity through sequencing), a technology fo

275 diversity of immune functions by coupling of antigen specificity through the Fab domain to signal tra

276 ith ARLA living in Europe, we aimed to infer antigen specificity through unbiased analysis of TCR rep

277 e we define the minimal requirements for TCR antigen specificity, through an analysis of TCR sequence

278 formation is currently available about their antigen specificity, tissue distribution, and biological

279 Assigning antigen specificity to T cell receptor (TCR) sequences i

280 sary for the induction of ACAID and conveyed antigen specificity to the suppressor T cells.

281 ed that CD4(+) T cell clones in mice exhibit antigen specificity towards self-peptides of myelin and

282 y their functional heterogeneity, breadth in antigen specificity, transient appearance in circulation

283 suspected CJD group were further studied for antigen specificity using cell-based assays.

284 Their antigen specificity was assessed by cytofluorimetry usin

285 Antigen specificity was assessed by measurement of proli

286 Antigen specificity was confirmed in lines from six diab

287 rent regions of the TCR play in affinity and antigen specificity, we have studied the TCR from T cell

288 r bulk CXCR5(+) CD4(+) T cells nor other HIV antigen specificities were associated with gp120-specifi

289 tibodies, 20-1 and NZA6, with very different antigen specificities were found to be highly homologous

290 Antigen specificities were very similar, with a slightly

291 reg and their immunosuppressive function and antigen specificity were assessed using flow cytometry,

292 hat cytotoxic CD8+ T cells with relevant EBV antigen specificity were detectable in the blood of the

293 O1, O4, A2B5, and HNK-1), each with distinct antigen specificities, were evaluated and found to promo

294 cells from CHB patients, regardless of their antigen specificity, were impaired in their ability to p

295 contain antibodies with numerous and diverse antigen specificities, whereas sera from conidium-expose

296 press either VLRAs or VLRCs of yet undefined antigen specificity, whereas the VLRB antibodies secrete

297 CD8(+) T regs display antigen-specificity, which is most exquisitely manifeste

298 ional plasticity enabling the integration of antigen specificity with environmentally responsive immu

299 s, including surface markers, cytokines, and antigen specificity with modified peptide-MHC tetramers.

300 Memory T cells exhibit tremendous antigen specificity within the immune system and accumul