コーパス検索結果 (１語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 injection happens at a position far from the antigen binding site.
2 e Ig molecule at a location distant from the antigen binding site.
3 ns that are involved in the formation of the antigen binding site.
4 codes a potent CD4 T cell autoantigen in its antigen binding site.
5 tions located on surface loops distal to the antigen binding site.
6 within the VH CDR3 loop at the center of the antigen binding site.
7 did not affect the kinetic properties of the antigen binding site.
8 y repertoire is focused at the centre of the antigen binding site.
9 thymine bases in hydrophobic pockets on the antigen binding site.
10 might affect the structural integrity of the antigen binding site.
11 2, as it displays a highly similar variable antigen-binding site.
12 ain variable fragments with mutations in the antigen-binding site.
13 vy chain (CDR-H3), the center of the classic antigen-binding site.
14 the Ig variable-region genes that encode the antigen-binding site.
15 edominated, especially at amino acids in the antigen-binding site.
16 h the CDR loops disposed to form part of the antigen-binding site.
17 cules with variability on one or both of the antigen binding sites.
18 mains on Herceptin (HER), which included the antigen binding sites.
19 l-encoded regions were generally proximal to antigen binding sites.
20 against gp120 are tyrosine sulfated at their antigen binding sites.
21 that the nucleophiles are located within the antigen binding sites.
22 ementarity-determining regions (CDRs) of the antigen-binding sites.
23 xplains the high abundance of Tyr in natural antigen-binding sites.
24 ion of a dimeric Mr 50,000 molecule with two antigen-binding sites.
25 n for amino acid replacement at the putative antigen-binding sites.
26 ch have an RGD-related RYD sequence in their antigen-binding sites.
28 ied specific positions that clustered in the antigen binding site (28, 30-33, 35 in V(H) and 24, 49-5
30 ves is approximately 1.8 times the number of antigen-binding sites accessible for targeting by radiol
31 lementarity-determining region) loops at the antigen binding site adopt nearly identical conformation
32 d the electrostatic surface potential of the antigen binding site, allowing for an increase in positi
33 lectrostatic complementarity between the mAb antigen binding site and the p40 D1 domain epitope appea
34 nzyl-DTPA and its complexes bind both to the antigen binding site and to multiple charged sites on th
35 did not participate in the formation of the antigen binding site and were not at the interface of th
36 lance of reciprocal binding events among the antigen binding sites and distant points on the constant
37 his model, may also propagate beyond the TCR antigen-binding site and directly affect self-associatio
38 eletions are clustered at "hot-spots" in the antigen-binding site and frequently result in the creati
39 ontribute generally to the affinity of naive antigen-binding sites and is detrimental to specificity.
40 ng and the content of Tyr, Ser or Gly in the antigen-binding site, and in fact, the most specific ant
41 mous variation, concentrated in the putative antigen-binding sites, and little synonymous variation.
42 l heterogeneity and slow dynamics at protein antigen binding sites appears to be a conserved feature
45 antibodies from all strains, the distinctive antigen-binding sites associated with VHQ52 differ subst
46 rst step, the overall positive charge of the antigen binding site attracts the negatively charged DNA
47 ps and, also, nonconventional libraries with antigen-binding sites built from CDR3 and the former lig
48 to support both conventional libraries with antigen-binding sites built from the three CDR loops and
49 -based was due to a reduced set of effective antigen-binding sites caused by the non-covalent LIG-mAb
50 regions have been pursued to design a second antigen-binding site (chi-site) in a chimeric single-cha
51 tep involved generation of a library of m836 antigen binding sites combined with diverse human germli
56 -PTM antibodies, antigen clasping, where two antigen binding sites cooperatively sandwich a single an
59 ntigen-4) possessing an outer tumor-specific antigen-binding site engineered to shield the inner anti
60 er holding in place a peptide that masks the antigen binding site, exerted antitumor effects comparab
61 ate that at least three helically in-phase T-antigen binding sites exist in the GC box region located
62 dulated: antibody binding sites for antigen; antigen binding sites for antibody, and antibody Fc bind
63 d in most of the molecular features of their antigen-binding sites from antibodies that do not change
64 l antibodies were obtained from a library of antigen-binding sites generated by a binary code restric
66 letion analysis showed that only the large T-antigen binding site II (the core origin) was required b
67 ined through energy minimization, reveals an antigen binding site in the shape of a large canyon with
68 studies have revealed that the hearts of the antigen binding sites in both free anti-IL-1beta Fab and
69 triking similarities to the arrangement of T-antigen binding sites in the SV40 ori even though the re
70 Bispecific antibodies combine two different antigen-binding sites in a single molecule, enabling mor
71 ibodies (BsAbs), which combine two different antigen-binding sites into one molecule, are a promising
72 16 amino acid positions that are part of the antigen binding site is 0.389 whereas that for the 67 am
73 odies are devoid of the light chain, and the antigen binding site is comprised exclusively of the var
74 d antigens suggest that the formation of the antigen-binding site is generally a destabilizing proces
75 As expected, sequence variability of the antigen-binding site is overall diminished compared to k
76 hat the overabundance of tyrosine in natural antigen-binding sites is a consequence of the side chain
77 s, producing antibody-like molecules with an antigen binding site made up of 2 kappa variable domains
78 ophilic residues such as Trp adjacent to the antigen binding site may explain difficulties in eliciti
79 pleen necrosis virus (SNV), that display the antigen binding site of an antibody on the viral surface
82 ).We examined the effect of mutations in the antigen-binding site of a Kb-restricted TCR on T cell ac
83 CARs) on T cells is a means of combining the antigen-binding site of a monoclonal antibody with the a
84 bles site-specific conjugation away from the antigen-binding site of antibody fragments, with a contr
85 study, extensive mutational analysis of the antigen-binding site of Fab b12 was carried out to inves
86 binatorial mutagenesis was used to study the antigen-binding site of Fab2C4, a humanized monoclonal a
88 specific polymorphic amino acids lining the antigen-binding site of the DPbeta1*0201 allotypic prote
89 f a silanized glass capillary column and the antigen-binding sites of anti-Pac saturated with rhodami
91 atible with concurrent engagement of all ten antigen-binding sites of DH1017.IgM, a solution not avai
93 able, drug-like compounds able to target the antigen-binding sites of most or all patients in a stere
95 the introduction of sequence motifs into the antigen-binding sites of the B-cell receptor (BCR), to w
96 s and biophysical analyses revealed that two antigen-binding sites of these antibodies form a head-to
98 urfaces displaying 35 times as many variable antigen-binding sites per square centimeter as surfaces
99 sampling combinations of amino acids in the antigen-binding site predicted to mediate high antibody
100 ain (VH-B1a) to support diversity within its antigen-binding site relative to the conventional antige
101 established modular architecture wherein the antigen-binding site residing in the antigen-binding fra
102 The amino acid sequence composition at the antigen binding site shows conservation within the light
105 b are similar in terms of the regions of the antigen-binding site that can tolerate diversity without
107 nd light-chain variable domains and form the antigen-binding site, the relative orientation of the he
108 egion affects the secondary structure of the antigen binding site, thus accounting for variations in
109 taining, IgG-like tetravalent BsAb, with two antigen-binding sites to each of its target antigens, by
110 y that contains an optimized RGD loop in its antigen binding site, was used as the model ligand.
111 atients carried class II HLA molecules whose antigen-binding sites were characterized by a high level
112 igen-binding fragments (Fabs) with synthetic antigen-binding sites were isolated from phage-displayed
113 All four subclasses, carrying the identical antigen-binding site, were fully assembled in planta and
114 from cellular or serum proteins bound in the antigen-binding site, which copurify with the class II m
115 His L91 is now centered at the bottom of the antigen-binding site with the imidazole ring poised for
117 ected for CDR2 mutations that blocked 72% of antigen-binding sites with N-linked glycan, decreased af
118 complementarity-determining region 3 (CDR3) antigen-binding site, with particularly heavy counter-se
120 on, the unusual level of conservation in key antigen binding sites within the V(H) region suggests th
121 markedly increases the density of available antigen-binding sites, yielding a system that is highly