ライフサイエンスコーパス: antimicrobial

1 tory, anti-HIV, antidiabetic, antitumor, and antimicrobial.

2 lones and to test the efficacy of additional antimicrobials.

3 these cases were treated with QT-prolonging antimicrobials.

4 hasis on early administration of appropriate antimicrobials.

5 subtypes displayed broad and potent in vitro antimicrobial activities comparable to the hospital gent

6 Antimicrobial activities were also promising, especially

7 back loop that exponentially amplifies their antimicrobial activities, causing antimicrobial synergy.

8 ially associated to their ripening-dependent antimicrobial activities, whereas said observables shall

9 nt, anti-proliferate, anti-inflammatory, and antimicrobial activities.

10 al peptides with potent immunomodulatory and antimicrobial activities.

11 primarily been developed for both its direct antimicrobial activity (e.g., toxin and viral neutraliza

12 LKL) and Leg2 (RIKTVTSFDLPALRWLKL) exhibited antimicrobial activity against 16 different bacteria, in

13 The essential oils exhibited strong antimicrobial activity against all test-microorganisms.

14 trix with an average size of 140 nm and with antimicrobial activity against both sensitive and resist

15 Plain TVO showed the highest antimicrobial activity against E. coli, S. aureus, and S

16 Anise extract nanoemulsion showed higher antimicrobial activity against most of the tested pathog

17 ysines have been earlier reported to possess antimicrobial activity against pathogenic bacteria, fung

18 de formed by ~ 25 lysine residues with known antimicrobial activity against several human microbial p

19 f stereochemical analogues and explore their antimicrobial activity for the first time.

20 The antimicrobial activity of AA/PA-MEs used as a washing so

21 Our aim was to evaluate the antimicrobial activity of EPL against four phytobacteria

22 utralization) and its ability to enhance the antimicrobial activity of the host immune response via e

23 ined all bacterial targets involved in their antimicrobial activity reporting, when described, their

24 The antimicrobial activity showed that CC extract is a poten

25 portance of these molecules stems from their antimicrobial activity towards relevant oral pathogens w

26 thiostrepton derivatives generally maintain antimicrobial activity, and importantly, eight of the de

27 an inactive model peptoid and its increased antimicrobial activity, we designed chlorinated and brom

28 agarised assay system, GO and MGO exhibited antimicrobial activity, with higher efficacy against Gra

29 tive pathogens, verine showed broad-spectrum antimicrobial activity.

30 s was reported to both increase and decrease antimicrobial activity.

31 ich synthesizes itaconate, a metabolite with antimicrobial activity.

32 -subtypes and impurities for ototoxicity and antimicrobial activity.

33 could partially explain the observed lack of antimicrobial activity.

34 ptide that displays both amyloid-forming and antimicrobial activity.

35 capacity, enzyme inhibitory experiments, and antimicrobial activity.

36 at play roles in chemical defence as well as antimicrobial activity.

37 not necessarily associated with a decreased antimicrobial activity.

38 tance but has little effect on S100A8/S100A9 antimicrobial activity.

39 Group antimicrobial administration is used to control disease

40 The Standardized Antimicrobial Administration Ratio (SAAR) is a risk-adju

41 approved regimen that includes an additional antimicrobial agent (ie, CRO 250 mg, intramuscular singl

42 Triclosan is a frequently detected and toxic antimicrobial agent present in many consumer and industr

43 Although antimicrobial agent-modified dental restoration systems

44 aditional understanding of honey function as antimicrobial agent.

45 nd biosynthesis of this clinically important antimicrobial agent.

46 ration (2.29 [1.22-4.29]), and not receiving antimicrobial agents at day 1 (3.56 [1.94-6.53]) were id

47 Two antimicrobial agents such as surfactin and Herbmedotcin

48 ts it as an attractive target for developing antimicrobial agents that interfere specifically with la

49 ling a controlled and slow release of active antimicrobial agents, such as essential oils (EO).

50 microbial consortia, rather than individual antimicrobial agents, underlie the observed reductions i

51 f bacteria embedded in a biofilm to existing antimicrobial agents.

52 on therapy to augment the effects of current antimicrobial agents.

53 peptide pathway and known to be involved in antimicrobial and anti-inflammatory activities, showed a

54 biological activities including antioxidant, antimicrobial and anti-inflammatory ones.

55 st of the groups considered, has the largest antimicrobial and electrochemical potential, when consid

56 IT, gammadeltaT, and iNKT cells) with potent antimicrobial and regulatory functions.

57 We reviewed use of specific antimicrobials and illness outcome among cases of plague

58 We also investigated the effect of pretest antimicrobials and interpretation of molecules of microb

59 Klebsiella pneumoniae resists penetration by antimicrobials and protects the bacteria from the innate

60 osed for this compound including anticancer, antimicrobial, anti-inflammation, and anti-diabetic acti

61 Finally, producing antimicrobial/antioxidant peptide from wastes by EDUF fi

62 therapeutic potential including antioxidant, antimicrobial, antityrosinase, anticancer, antihyperlipi

63 4); risk was higher in patients who received antimicrobials (aOR, 2.4; 1.7-3.4).

64 nally, this study demonstrated the promising antimicrobial application of VitC, in situ, in Indian so

65 recover it at a sufficient concentration for antimicrobial applications, a new sustainable technology

66 etic cells, then immunosuppressive drugs and antimicrobial approaches to infection control.

67 Numerous antimicrobials are considered effective for treating pla

68 floxacin and levofloxacin, 2 fluoroquinolone antimicrobials, are >=90% effective for the treatment of

69 l infections have led scientists to start an antimicrobial arms race.

70 gainst any of the bacteria strains tested at antimicrobial assays.

71 cell wall deconstruction, biofilm formation, antimicrobials biosynthesis, and metabolism of diverse n

72 interfering enzymes constitute new promising antimicrobial candidates.

73 sults may not influence initial intravitreal antimicrobial choice.

74 All antimicrobial classes identified in the review are class

75 nii, is effected through the proteobacterial antimicrobial compound efflux (PACE) family.

76 nvasive and multicompartment measurements of antimicrobial concentration-time profiles in humans(3).

77 bases for primary sources on the safety of 9 antimicrobials considered for plague during pregnancy (a

78 Secondary endpoints were antimicrobial consumption, in-hospital mortality, length

79 Median antimicrobial days of therapy (DOT) was shorter in both

80 ns, demonstrating the relevance of CD163 for antimicrobial defense as well.

81 ombin/fibrinogen axis is fundamental to host antimicrobial defense, offer a possible explanation for

82 nduced genes involved in Ag presentation and antimicrobial defense.

83 n have demonstrated a role for MAIT cells in antimicrobial defense.

84 il numbers in circulation, cell trafficking, antimicrobial defenses, and host well-being.

85 Cross-resistance profiles from each antimicrobial differed within and between taxa.

86 e ROK family and highlights a novel area for antimicrobial discovery to fight Gram-positive and S. au

87 infection sites hinders efforts to optimize antimicrobial dosing and shorten TB treatments(2).

88 esional drug PK, have major implications for antimicrobial drug development.

89 ibility of transfer, and 4) determination of antimicrobial drug production capability of the strain w

90 Emergence of antimicrobial drug-resistance amongst food-borne pathoge

91 Potential challenges to shorter antimicrobial duration in sepsis include inadequate sour

92 However, guidance regarding antimicrobial duration in sepsis is surprisingly limited

93 he purpose of this study was to evaluate the antimicrobial effect of ozonized physiological saline so

94 The strongest antimicrobial effect was obtained with MC films enriched

95 tment and unveil possible mechanisms for its antimicrobial effect, using a label-free proteomic appro

96 ies with antibiotics that would increase its antimicrobial efficacy and at the same time reduce the d

97 d concentration significantly influenced the antimicrobial efficacy of PA (p < 0.05).

98 In antimicrobial efficacy studies, human-equivalent doses o

99 The antimicrobials, either singly or in combination, can be

100 As such, conventional approaches for antimicrobial evaluation (genetic or chemical) rely on t

101 The antimicrobials examined were vancomycin, cefepime, piper

102 Estimated annualized savings on antimicrobial expenditures were $142 629.83.

103 ion, increased ID consultations, and reduced antimicrobial expenditures.

104 ae from 2011-2018 and collected demographic, antimicrobial exposure, and infection data.

105 wth, phagocytic attack and secretion of host antimicrobial factors.

106 We propose a revaluation of empirical antimicrobials for dysenteric diarrhea and endorse the u

107 cases of disease, we sought FDA approval of antimicrobials for treatment under the Animal Efficacy R

108 f corrosion-inducing microorganisms with the antimicrobial free nitrous acid, which is generated in s

109 I genes, and IFN-gamma-induced GTPases, with antimicrobial function.

110 ts has been shown to negatively impact their antimicrobial function.

111 ockout macrophages hyperinduce expression of antimicrobial genes like Nos2 and are significantly bett

112 e (AMR), and lack of new classes of licensed antimicrobials, have made alternative treatment options

113 thways for cotinine-associated genes include antimicrobial humoral response, regulation of humoral re

114 c HIV-1 infection is a significant insult to antimicrobial immune defenses.

115 interleukin (IL)-1beta is a key mediator of antimicrobial immunity as well as autoimmune inflammatio

116 peri-implant plaque biofilms and mechanical antimicrobial interventions were applied on the Ti-bound

117 ic alterations that predispose to inadequate antimicrobial levels.

118 EP of plague during pregnancy; the choice of antimicrobials may be influenced by these data as well a

119 Patients who had received prior antimicrobial medications (n = 603) had significantly hi

120 Potential strategies for designing antimicrobial microneedles and their targeted therapy ar

121 However, the magnitude of antimicrobial MR1-dependent activation remained as poten

122 satile carriers to host, protect and release antimicrobials, offering a strong tool to tackle antimic

123 ic regulation, resistance to antibiotics and antimicrobials, pathogenesis, and adhesion to the mucosa

124 DO1, SOCS3, and IL10), and a proinflammatory antimicrobial peptide (S100A7).

125 Biochemical studies suggested that the antimicrobial peptide apidaecin (Api) inhibits protein s

126 As a consequence, levels of antimicrobial peptide derived from epithelial cells are

127 n the JNK-pathway by the immune effector and antimicrobial peptide Drosomycin.

128 fected tongue but not to alterations in oral antimicrobial peptide expression.

129 show that human dNK cells highly express the antimicrobial peptide granulysin (GNLY) and selectively

130 Peptidase inhibitor 3 (PI3), a gene in the antimicrobial peptide pathway and known to be involved i

131 dysone positively regulates both molting and antimicrobial peptide production, so the inactivation of

132 let-derived protein 3alpha (REG3alpha) is an antimicrobial peptide secreted by intestinal Paneth cell

133 Nisin is an antimicrobial peptide with bacterial, fungicidal, viruci

134 ides (LDAQSAPLR, LKGYGGVSLPEW, and LKALPMH), antimicrobial peptides (AASDISLLDAQSAPLR, IIAEKTKIPAVF,

135 Antimicrobial peptides (AMPs) are essential components o

136 tides with the right properties, for example Antimicrobial peptides (AMPs), can disrupt this protecti

137 l diversity and stimulated to release stored antimicrobial peptides (AMPs).

138 s (e.g. involucrin, SERPINB7 and SERPINB13), antimicrobial peptides (e.g. B-defensins like DEFB4A, DE

139 pT, which confers resistance to host-derived antimicrobial peptides and bile, respectively.

140 f PCs and ISCs, which enhanced production of antimicrobial peptides and caused microbiome changes.

141 Furthermore, host defense antimicrobial peptides and small-molecule peptide mimeti

142 the expression of chemokines, cytokines, and antimicrobial peptides involved in pathogen clearance.

143 adoptive transfer of macrophages containing antimicrobial peptides linked to cathepsin B in the lyso

144 Antimicrobial peptides secreted from S. capitis E12 were

145 the expression of the Toll pathway-mediated antimicrobial peptides when the flies were challenged wi

146 er, bacterial thymidine kinase, antibiotics, antimicrobial peptides, bacterial antibodies, bacterioph

147 ding enzymes involved in the biosynthesis of antimicrobial peptides, camalexin, and 4-OH-ICN, as well

148 We identify six antimicrobial peptides, two plant immune regulators and

149 However, the lack of reliable data on antimicrobial pharmacokinetics (PK) at infection sites h

150 ospective evidence to support development of antimicrobial policy and appropriate stewardship interve

151 They acquire this antimicrobial potential during their maturation in the b

152 ucial enzymes related to metabolic syndrome, antimicrobial potential, and in vitro protein digestibil

153 roquinolone prescribing should also focus on antimicrobial prescribing at hospital discharge.

154 portant roles in both defending against host antimicrobial programs and in evading these programs alt

155 Our novel microcomposite cryogels exhibit antimicrobial properties and inhibit antibiotic-resistan

156 Materials with inherent antimicrobial properties offer the potential to reduce t

157 The lower content of ellagitannins with antimicrobial properties under drought reveals an adapti

158 Sphingosine, a metabolite of ceramide with antimicrobial properties, is not upregulated in response

159 fection produced non-cytotoxic amyloids with antimicrobial properties.

160 ounds with anti-inflammatory, antioxidant or antimicrobial properties.

161 tial and non-redundant role in governing the antimicrobial protein (AMP) response.

162 sed of DNA complexed with histones and toxic antimicrobial proteins that ensnare pathogens, but also

163 Case fatality rate by antimicrobial regimen was calculated.

164 sional COVID-19 relief bills are considering antimicrobial reimbursement reforms and antimicrobial su

165 We are experiencing an antimicrobial resistance (AMR) crisis, brought on by the

166 we have little insight into how this impacts antimicrobial resistance (AMR) gene dynamics.

167 Antimicrobial resistance (AMR) is a major challenge in t

168 Antimicrobial resistance (AMR) is a threat to global pub

169 Antimicrobial resistance (AMR) is an increasing threat t

170 The increase of antimicrobial resistance (AMR), and lack of new classes

171 ing data to identify genetic determinants of antimicrobial resistance (AMR), but they lack causal int

172 oles of Bacteroides species and describe the antimicrobial resistance biogeography along the intestin

173 Improved rapid diagnosis and antimicrobial resistance determination, such as by whole

174 d validated on qPCR for the detection of the antimicrobial resistance gene MCR-2.

175 This study aims to test the presence of antimicrobial resistance genes in milk metagenome, inves

176 effects on the gut resistome, a reservoir of antimicrobial resistance genes in the body, of twice-yea

177 gnostic techniques that detect pathogens and antimicrobial resistance genes within clinical samples p

178 ification of 20 Gram-positive bacteria, four antimicrobial resistance genes, and both Pan Candida and

179 communities and clinical samples with known antimicrobial resistance genes.

180 h analysis uncovered the presence of several antimicrobial resistance genes.

181 nrichment of potentially pathogenic taxa and antimicrobial resistance genes.

182 The rise in antimicrobial resistance has prompted the development of

183 nalysis of sequence variants associated with antimicrobial resistance identified the genetic backgrou

184 many publications have examined transferable antimicrobial resistance in bacteria isolated from marin

185 nstrate that wild-type AdeT1 does not confer antimicrobial resistance in E. coli, highlighting the im

186 Antimicrobial resistance in Mycoplasma genitalium (MG),

187 elopments in typhoid vaccines and increasing antimicrobial resistance in Salmonella Typhi that have s

188 Antimicrobial resistance is a serious threat to human he

189 Maintenance and persistence of antimicrobial resistance is likely to vary across differ

190 ics on vertical transmission of microbes and antimicrobial resistance is not well understood.

191 nce data on Typhi isolates in CDC's National Antimicrobial Resistance Monitoring System from 1999 thr

192 , was previously demonstrated to enhance the antimicrobial resistance of Escherichia coli.

193 modifications, such as those associated with antimicrobial resistance phenotypes, during Gram-negativ

194 Rising levels of antimicrobial resistance pose serious dangers to patient

195 s and undesirable genes, 3) determination of antimicrobial resistance properties and their possibilit

196 sed to expand the availability of gonococcal antimicrobial resistance testing for both clinical and s

197 microbials, offering a strong tool to tackle antimicrobial resistance, a serious global health proble

198 tors to effective therapy, the prevention of antimicrobial resistance, and newer designs for clinical

199 ptions for enteric as a result of increasing antimicrobial resistance, and therefore typhoid vaccinat

200 ndustry, which may contribute to the rise of antimicrobial resistance, carrying potential consequence

201 With the alarming rise of antimicrobial resistance, studies on bacteria-surface in

202 Isolates were characterized for antimicrobial resistance, virulence genes, and diversity

203 companied by the acquisition of mutations in antimicrobial resistance- and bacteriocin-encoding genes

204 identifying bacterial and fungal species and antimicrobial resistance.

205 quired infections and contribute to fighting antimicrobial resistance.

206 , is an important part of efforts to address antimicrobial resistance.

207 lity of the spectroscopic approach to detect antimicrobial resistance.

208 f this approach on global challenges such as antimicrobial resistance.

209 methods to detect pneumococcal serotypes and antimicrobial resistance.

210 eutic development to preempt efflux-mediated antimicrobial resistance.

211 and shared some of their latest findings on antimicrobial resistance.

212 raits is a viable solution to the problem of antimicrobial resistance.

213 y relevant determinants of pathogenicity and antimicrobial resistance.

214 In light of the global antimicrobial-resistance crisis, there is an urgent need

215 for Disease Control and Prevention (CDC) and antimicrobial-resistance data on Typhi isolates in CDC's

216 Antimicrobial resistant (AMR) microorganisms affect near

217 we aim to understand the evolution of novel antimicrobial resistant (AMR) S. sonnei variants after i

218 significant correlations between most of the antimicrobial resistant phenotypes and genotypes observe

219 for the emergence, spread and persistence of antimicrobial-resistant (AR) bacteria, but their relativ

220 Because gulls are mobile and can shed antimicrobial-resistant bacteria for extended periods, g

221 ited context, we examine the distribution of antimicrobial-resistant enteric bacteria from three ethn

222 e pediatric travelers were unvaccinated, and antimicrobial-resistant infections were common.

223 Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections in hosp

224 The rise of antimicrobial-resistant pathogens can be attributed to t

225 host larvae to molt, and probably a reduced antimicrobial response.

226 issue protection or regeneration, facilitate antimicrobial responses, and directly regulate adaptive

227 possible mechanisms of fibrin(ogen)-mediated antimicrobial responses.

228 Taken together, our study describes a new antimicrobial role for S. parasanguinis and highlights h

229 ervention, retinal detachment (RD) rate, and antimicrobial sensitivities.

230 Antimicrobials should be used for treatment and PEP of p

231 Honey has been valued as a powerful antimicrobial since ancient times.

232 imperative; however, suitable approaches to antimicrobial stewardship (AMS) in low-income settings a

233 We report the successful introduction of an antimicrobial stewardship approach in Malawi.

234 help target future surveillance efforts and antimicrobial stewardship policies.

235 microbiological diagnostics with and without antimicrobial stewardship program (ASP) intervention, an

236 Other rapid platforms coupled with antimicrobial stewardship program (ASP) real-time notifi

237 cillin allergy de-labeling into a new arm of antimicrobial stewardship programs (ASPs) has become an

238 vention (CDC) in 2015 as a tool for hospital antimicrobial stewardship programs (ASPs) to track and c

239 ections (URIs) is a high-priority target for antimicrobial stewardship that has not been described fo

240 ge or provocation," "cross-reactivity," and "antimicrobial stewardship".

241 reduce adverse healthcare outcomes, improve antimicrobial stewardship, and decrease healthcare costs

242 to exclude bacteraemia may be of benefit in antimicrobial stewardship.

243 ve UAT result are opportunities for improved antimicrobial stewardship.

244 the design of novel antibiotic compounds or antimicrobial strategies.

245 ring antimicrobial reimbursement reforms and antimicrobial subscription models, but it is unclear if

246 We investigated the impact of an antimicrobial surface coating on HAIs and environmental

247 Such a discrepancy between in vitro antimicrobial susceptibility and in vivo treatment outco

248 tiology of ocular and periocular infections, antimicrobial susceptibility profile and associated fact

249 Antimicrobial susceptibility test was performed accordin

250 As a result, AZI antimicrobial susceptibility testing (AST) cannot be int

251 k of a rapid pathogen identification (ID) or antimicrobial susceptibility testing (AST), resulting in

252 ntly, clinical FDA and European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoint

253 Culture, antimicrobial susceptibility testing, P1 subtyping, and

254 c device that was capable of executing rapid antimicrobial susceptibility tests with one, two, or eve

255 to be taken into consideration when in vitro antimicrobial susceptibility to cefiderocol is determine

256 Sp2 isolates were tested for antimicrobial susceptibility, Multilocus Sequence Typing

257 diagnosed and 5004 Typhi isolates tested for antimicrobial susceptibility.

258 fies their antimicrobial activities, causing antimicrobial synergy.

259 ted invariant T (MAIT) cells are innate-like antimicrobial T cells recognizing a breadth of important

260 E. coli, S. aureus, and S. typhi in in vitro antimicrobial tests, followed closely by AA/PA-MEs.

261 We identified 10 antimicrobials that would have qualified for an exclusiv

262 s of this serotype can acquire resistance to antimicrobials, the temporal dynamics of this acquisitio

263 clinical implementation of nanomaterials as antimicrobial therapeutics.

264 ial ureases, important molecular targets for antimicrobial therapies, was developed.

265 ated with increased completion of parenteral antimicrobial therapy (64.08% vs 46.15%; odds ratio [OR]

266 Duration of antimicrobial therapy depends on severity of clinical pr

267 Empiric antimicrobial therapy for healthcare-acquired infections

268 Discontinuation of inappropriate antimicrobial therapy is an important target for steward

269 Timely empiric antimicrobial therapy is associated with improved outcom

270 on; patients requiring outpatient parenteral antimicrobial therapy must seek treatment in high-risk s

271 Outpatient parenteral antimicrobial therapy with addiction treatment may be fe

272 1942-2018, 426 (80%) received high-efficacy antimicrobial therapy.

273 ulations that are not the intended target of antimicrobial therapy.

274 r procedures; this risk was not mitigated by antimicrobial therapy.

275 rtality rates, which increase with delays in antimicrobial therapy.

276 steroids are used as an adjuvant to standard antimicrobial therapy.

277 ted a systematic review of published data on antimicrobial treatment of plague reported in aggregate.

278 s with a focus on providing tailored patient antimicrobial treatment options.

279 positivity rates than patients without prior antimicrobial treatment-31% versus 22% (P < 0.0001)-with

280 onsidered a definite infection that required antimicrobial treatment.

281 nd is one of the most significant drivers of antimicrobial usage in dairy cattle.

282 on Ratio (SAAR) is a risk-adjusted metric of antimicrobial use (AU) developed by the Centers for Dise

283 However, quantitative antimicrobial use across a highly diversified aquacultur

284 results suggest that, in a setting with high antimicrobial use and a high prevalence of AMR commensal

285 have a crucial role in limiting unnecessary antimicrobial use and AMR.

286 Here, we estimate global trends in antimicrobial use in aquaculture in 2017 and 2030 to hel

287 Reports have documented antimicrobial use in the rapidly expanding aquaculture i

288 We estimate antimicrobial use intensity (mg kg(-1)) for six species

289 ffect logit models to evaluate the effect of antimicrobial use on blood culture positivity, adjusted

290 rveys, which identified 146 species-specific antimicrobial use rates.

291 Antimicrobial use was tracked using days of therapy (DOT

292 cin is responsive to short-term variation in antimicrobial use.

293 of animal health, productivity, welfare and antimicrobial use.

294 Colistin is a last-resort antimicrobial used for the treatment of human infections

295 The safety profile of antimicrobials used during pregnancy is one important co

296 ia telehealth, led to reduced broad-spectrum antimicrobial utilization, increased ID consultations, a

297 rticles which possess simultaneously active (antimicrobial, UV-protective and antioxidant) and smart

298 ed Salmonella, morphological changes to this antimicrobial varied substantially among the Salmonella

299 pic AMR testing, and resistance to empirical antimicrobials was associated with a significantly longe

300 s the issue of how long treatment with these antimicrobials would remain effective after fever onset.