ライフサイエンスコーパス: antisense DNA

1 oplasm in cells incubated with 99mTc-labeled antisense DNA.

2 eased mRNA production by the presence of the antisense DNA.

3 m)Tc-antisense DNA with increasing dosage of antisense DNA.

4 lementary DNA elongation in cells exposed to antisense DNA, acting therefore as an intracellular PCR

5 As reported earlier, an antisense DNA against the mdr1 mRNA coding for P-glycopr

6 , inhibition of polysialic acid synthesis by antisense DNA approach induced differentiation in both h

7 cumulations, our results may be explained if antisense DNAs are targeting mdr1 mRNAs produced at high

8 thesis, a novel approach using 99mTc-labeled antisense DNA as a probe of total mRNA from cells previo

9 regulating transcription in cells exposed to antisense DNA as no increase in mRNA levels was detected

10 ulting in the release of the fluorophore and antisense DNA as well as the aggregation of AuNPs for in

11 One of the problems that hamper the use of antisense DNAs as effective drugs is the non-specific bi

12 omponents: (1) inhibition of pRNA by a short antisense DNA (asDNA) that can bind to the 3' end of the

13 s direct evidence for targeting neuroglia by antisense DNA-based SPION-gfap that enables in vivo MRI

14 riphosphate into RNA in cells exposed to the antisense DNA but not to the control DNA and, second, an

15 rget mRNA expression in cells exposed to the antisense DNA but not to the control DNA.

16 t preexposure of cells to targeted complexed antisense DNA can substantially block viral gene express

17 or its depletion by small interfering RNA or antisense DNA caused marked and sustained regression of

18 ctive in this study was to determine whether antisense DNA could be targeted to hepatocytes to preven

19 nd release Mipomersen, a clinically approved antisense DNA drug, in response to pH change.

20 e size, but not the relative position, of an antisense DNA fragment is important in mediating the ant

21 , 78 growth-retarded transformants harboring antisense DNA fragments were also identified.

22 The conjugation of fluorescently-labeled antisense DNA hairpin oligonucleotides to the surface of

23 nd the development of a second generation of antisense DNAs have occurred largely within the antisens

24 se DNA, an increased accumulation of (99m)Tc-antisense DNA in another RI alpha-positive tumor cell li

25 for the observed migration of 99mTc-labeled antisense DNA into the nucleus.

26 erived HT1080 cells were transfected with an antisense DNA ligase III expression vector and clones wi

27 cts prepared from human cells overexpressing antisense DNA ligase III mRNA possessed substantially le

28 constructs, comprised of spherically-arrayed antisense DNA (liposomal spherical nucleic acids [L-SNAs

29 Novel demethylating agents such as antisense DNA methyl transferase and small interference

30 Nucleic acid therapeutics such as antisense DNA, mRNA, small interfering RNA (siRNA) or mi

31 ever, the observed specific accumulations of antisense DNAs of about 10(6) per cell over 10 h could n

32 treatment with dehydroepiandrosterone or the antisense DNA oligomer of G6PD mRNA resulted in the inhi

33 Recently, digestion using RNaseH and antisense DNA oligomers tiling target rRNAs has emerged

34 n (125)I was located close to the end of the antisense DNA oligonucleotide, we observed breaks in RNA

35 hibitor, 5-aza-2-deoxy-cytidine, and 2 DNMT1 antisense DNA oligonucleotides inhibits the phosphorylat

36 Defining antisense DNAs on the basis of their effects on global g

37 RNA hairpin could be mimicked by pairing of antisense DNA or RNA oligonucleotides to the nascent tra

38 ss of endoglin expression mediated by either antisense DNA or siRNA results in a direct perturbation

39 pected cellular accumulations of about 10(5) antisense DNAs per cell over 24 h suggest stabilization

40 hybridized to a digoxigenin-labeled telomere antisense DNA probe.

41 By Southern blot hybridization of specific antisense DNA probes to segments of genomic DNA that enc

42 PC12/Tat cells, as the inhibition of Id1 by antisense DNA restored the serum-dependent growth of PC1

43 The solution structure of an antisense DNA.RNA hybrid duplex, d(CGCGTT-MMI-TTGCGC).r(

44 Sixty-two nucleotides of an ftsZ(Bbu) antisense DNA sequence under the control of a tetracycli

45 A method of phosphorothioate antisense DNA sequencing analysis using UV detection cou

46 The deoxyriboses in the antisense DNA strand exhibit a mixed behavior with almos

47 antibodies to a peptide translated from the antisense DNA strand of PR-3 (complementary PR-3, cPR-3)

48 ctly (p <0.0001) detect the origin (sense vs antisense DNA strands) of DNA methylation at splice site

49 The progress of antisense DNA therapy demands development of reliable an

50 Antisense DNA to a 24-base sequence identified as being

51 om cells previously saturated with unlabeled antisense DNA was used to estimate the transcription rat

52 The question considered here is whether antisense DNAs will also be important to future nuclear

53 Therefore, the expectation is that antisense DNAs will be important to future chemotherapy.

54 e increased cellular accumulation of (99m)Tc-antisense DNA with increasing dosage of antisense DNA.