ライフサイエンスコーパス: aortic sinus

1 ticularly abundant in the cardiac valves and aortic sinus.

2 t not established atherosclerotic lesions in aortic sinus.

3 analyzed to assess lipid accumulation in the aortic sinus.

4 te recruitment and lipid accumulation in the aortic sinus.

5 ural origin between the left and noncoronary aortic sinus.

6 observed by reduction in plaque necrosis in aortic sinus (35.8%) and in brachiocephalic artery (26%)

7 sense oligonucleotides led to a reduction in aortic sinus and en face lesion areas (47.2% or 58.8% de

8 sense oligonucleotides led to a reduction in aortic sinus and en face lesion areas (47.2% or 58.8% de

9 expression of these adhesion proteins in the aortic sinus and increased macrophage infiltration, comp

10 higher numbers of regulatory T cells both in aortic sinus and spleen with higher mRNA expression of C

11 n of atherosclerotic plaque size in both the aortic sinus and the thoracoabdominal aorta, and were le

12 Atherosclerosis was assessed in aortic sinuses and in en face preparation of whole aorta

13 ed by phase-contrast velocity mapping at the aortic sinuses and RVol(MR) as total left ventricular mi

14 not reliant on afferent feedback carried in aortic, sinus and vagus nerves.

15 -fold) larger atherosclerotic plaques in the aortic sinus area than the +/+ animals.

16 d significant atherosclerotic lesions in the aortic sinus as early as 4 to 5 weeks after birth.

17 In C57BL/6J mice, leukocyte entry into the aortic sinus, as assessed by en face preparations, was i

18 45 treatment markedly reduced plaque size in aortic sinuses, ascending aortas, and brachiocephalic ar

19 re advanced plaque in their aortic trees and aortic sinuses at 24, 36, and 48 weeks of age compared t

20 In contrast, D4F had no effect on the native aortic sinus atherosclerotic lesions (established lesion

21 ith GdCl(3) exhibited 50% reductions in both aortic sinus atherosclerotic lesions (P < 0.0097) and su

22 Significantly more of the aortic sinus circumference was covered by lesions in the

23 and atherosclerotic lesions in the aorta and aortic sinus compared with ApoE(-/-) mice orally challen

24 tty streak lesions in the proximal aorta and aortic sinus compared with female mice with intact ovari

25 e right ventricular outflow tract (RVOT) and aortic sinus cusp (ASC) during VT or PVCs.

26 total aorta en face and the cross-sectional aortic sinus, decreased macrophage number and apoptosis,

27 reduction in lesions in the whole aorta and aortic sinus despite high cholesterol and triglyceride l

28 The effects of introducing aortic sinus eddy vortices and variable systemic vascula

29 d (TgEST3ApoeKO) and examined lesions in the aortic sinus following 10 and 16 wk on a high-fat diet.

30 Intimal lesion area at the aortic sinus in controls was 0.69+/-0.06 mm(2).

31 However, the lesions in the aortic sinus in LDLR-/- P/E-/- mice were 40% smaller and

32 ed in whole aortae and cross sections of the aortic sinus in male and female mice fed a high-fat West

33 n the established atherosclerotic lesions in aortic sinus in the same mice.

34 nic gene expression in the arterial wall and aortic sinus induced by severe periodontitis.

35 on area (Western diet) and a 45% decrease in aortic sinus lesion area (normal chow) in the CD36-apo E

36 male mice for 8 weeks significantly reduced aortic sinus lesion area (P=0.0031) and en face whole ao

37 ice with anti-miR33 oligonucleotides reduced aortic sinus lesion area compared with controls, despite

38 reports, this was associated with increased aortic sinus lesion areas.

39 Importantly, the aortic sinus lesion formation was impaired in IRAK4KI/Ap

40 In contrast, C57BL/6 mice lacking p55 had aortic sinus lesion sizes 2.3-fold larger than C57BL/6 w

41 and inflamed atherosclerotic plaques in the aortic sinus, lesion development was profoundly reduced

42 ed extensive oil red O-staining fatty streak aortic sinus lesions (20,537+/-2,957 micron2), the size

43 female mice for 5 weeks caused regression of aortic sinus lesions (P=0.003).

44 Characterization of aortic sinus lesions by electron microscopy and immunohi

45 Immunohistochemistry showed that aortic sinus lesions from both strains contained macroph

46 , apoE(-/-) P(-/-) mice had 3.5-fold smaller aortic sinus lesions than apoE(-/-) P(+/+) mice.

47 chow developed larger, more macrophage-rich aortic sinus lesions than Prdx1(+/+)/apoE(-/-) mice, des

48 increase in atherosclerosis in the aorta and aortic sinus of Adamts13(-/-)/ApoE(-/-) mice compared wi

49 uced atherosclerotic lesion formation in the aortic sinus of both mouse models by approximately 20% a

50 kocytes and the accumulation of lipid in the aortic sinus of either wild-type mice (strain C57BL/6J)

51 ogenic diet, the fatty streaks formed in the aortic sinus of LDLR-/-vWf-/- mice of either sex were 40

52 cantly larger atherosclerotic plaques in the aortic sinus of the ApoE(-/-) mice compared with control

53 or left ventricular endocardium or from the aortic sinus of Valsalva (ASOV).

54 ing in the first five patients and performed aortic sinus of Valsalva mapping in all patients.

55 ents from either the left or the noncoronary aortic sinus of Valsalva.

56 Macrophage numbers in aortic sinuses of CD11d(-/-) mice were reduced without a

57 patients were successfully ablated from the aortic sinuses of Valsalva (95% CI 0% to 18%).

58 ricular contractions (PVCs) arising from the aortic sinuses of Valsalva (SOV) and great cardiac vein

59 had no effect on established lesions in the aortic sinuses or the rest of the aorta.

60 stage), the difference in lesion size in the aortic sinus persisted.

61 The aortic sinus plaque and aortic lesion size and lipid com

62 d with increased numbers of activated DCs in aortic sinus plaques and higher circulating levels of MC

63 Lipid and macrophage contents of the aortic sinus plaques were measured after oil-red O and M

64 rtic arch and the thoracic aorta than in the aortic sinus, reflecting the corresponding reductions in

65 atory cytokine production was reduced in the aortic sinus region of IRAK4KI/ApoE(-/-) mice compared w

66 educed the area of lipid accumulation in the aortic sinus, resulting in an approximate 66% decrease.

67 Aortic sinus sections were stained with Sudan IV for ass

68 ng and activity-tracing studies in the mouse aortic sinus showed that the Ahr pathway is active in mo

69 nti-cleaved-caspase 3 antibody) increased in aortic sinus slices measured as percentage of lesion by

70 - P/E-/- mice developed fatty streaks in the aortic sinus that were five times smaller than those in

71 In the aortic sinus, the lesions of the apoE(-/-) P(-/-) mice w

72 location of the arterial orifices within the aortic sinuses, the course of the proximal coronary arte

73 The development of atherosclerosis in the aortic sinus was also markedly altered in the double kno

74 e infected with MCMV, and lesion area in the aortic sinus was assessed using oil red O staining.

75 aining for scavenger receptor protein in the aortic sinus was more intense in lesions from the p55-nu

76 ed, including group 1: AAOLCA from the right aortic sinus with interarterial course, group 2: AAOLCA

77 erial course, group 2: AAOLCA from the right aortic sinus with intraseptal course, and group 3: AAOLC

78 mice are given a high fat diet, CC appear in aortic sinus within 1 week.