ライフサイエンスコーパス: apex

1 ated by engineered ascorbic acid peroxidase (APEX).

2 , whereas the LOC innervation peaks near the apex.

3 cochlea, and outer hair cells mainly in the apex.

4 against an epitope at or close to the trimer apex.

5 MADS-Box gene APETALA1(AP1)/MC at the shoot apex.

6 stimulus that moves from leaves to the shoot apex.

7 ndomly and often project toward the cochlear apex.

8 sensitivity than did subjects with a central apex.

9 m-like glioblastoma stem cells (GSCs) at the apex.

10 ng SFT in the leaves and AP1/MC at the shoot apex.

11 unogens that elicit antibodies to the trimer apex.

12 trate both exocytosis and endocytosis at the apex.

13 time" of the electron gas temperature at the apex.

14 ed by V1V2 loops that interact at the trimer apex.

15 hallus shape given growth suppression at the apex.

16 s from the level of the prostate base to the apex.

17 kills epidermal and niche cells in the shoot apex.

18 rriers by slowing down plasmons at the taper apex.

19 ilization of the distal region of the trimer apex.

20 mixing with cold seawater at the tufa-column-apex.

21 es PIN3, promoting auxin accumulation in the apex.

22 was a complete triangle reaching the orbital apex.

23 t base and the pattern reversed at the crypt apex.

24 resulting from an intricate heat flow at the apex.

25 s driven by lateral inhibitions at the shoot apex.

26 that was wrapped around the left ventricular apex.

27 h coordinated movements of the entire trimer apex.

28 cardiomyocytes of the left ventricular (LV) apex.

29 the antero-posterior dimension from base to apex.

30 0.95, with greatest variance at the base and apex.

31 l corneal apex than for those with a central apex.

32 ical infection that forms around the implant apex.

33 f the cochlea, this correlation fails at the apex.

34 ue, decreasing in concentration from base to apex.

35 -specific lncRNA-mediated regulation in root apexes.

36 over a 24-week treatment period (the phase 3 APeX-2 trial).

37 eroxidase (HRP), and ascorbate peroxidase 2 (APEX-2) proximity labelling, alongside light and electro

38 ablations in 79% of patients, mostly in the apex (72%) and inferior/inferolateral (74%).

39 res that would be somehow limited by the tip apex, a statement well accepted for the past 2 decades.

40 es in the myocardium from the LV base to its apex; after this period, it is uniformly expressed throu

41 tricular myocyte K(V) current density in the apex and also in the subpopulation of septal myocytes th

42 crotubule plus ends extend toward the cell's apex and base with a region of antiparallel microtubule

43 e of that in Tmc1 wild-type mice, similar at apex and base, and lacking the tonotopic size gradient s

44 ea varies substantially between the cochlear apex and base.

45 gin hierarchy in which stem cells sit at the apex and differentiated cell types are least susceptible

46 from xylem, allowing the toxic ion to reach apex and flowers.

47 re assessed for PAPVR or TAPVR, PDA, cardiac apex and heart chambers, interatrial or interventricular

48 ns reduce electrostatic repulsion at the Env apex and increase PG16 recognition of Env sequences from

49 ior (D(apexant)) and posterior (D(apexpost)) apex and minimum thickness points (D(mctant), D(mctpost)

50 nces arise when the relative position of tip apex and molecule changes by a fraction of the molecule

51 neal backscatter between 0 and 2 mm from the apex and relative increase in central corneal thickness

52 the severe alterations observed in the shoot apex and reproductive organs under salinity conditions.

53 in I(Kslow,2) (conducted by K(V)2.1) in both apex and septum.

54 escribed a bnAb lineage targeting the Env V2 apex and the Ab-Env co-evolution that led to development

55 nces between the epicardial border of the LV apex and the midpoint of a line connecting the origins o

56 ecutive radii centered to anterior/posterior apex and thinnest point were evaluated.

57 (mAbs) indicated major contacts with the V2 apex, and 3D electron microscopy reconstructions of Fab-

58 th pacing from the atrium, right ventricular apex, and an left ventricular branch of the coronary sin

59 hlear mechanical compression in the cochlear apex, and likely resides in the receptor cells.

60 Overall, 3mut can stabilize the Env trimer apex, and the resultant apex-stabilized Env trimers can

61 s: (i) identification of the HIV envelope V2 apex as a new in vivo protective epitope, (ii) a novel c

62 of both mechanical and neural tuning at the apex, as well as the spatial variation of mechanical tun

63 close-proximity interactions between the RC-APEX baits and their respective prey.

64 The RC-APEX baits produced almost entirely distinct interactome

65 as fused to four different RC components (RC-APEX baits) and 55 unique high-confidence prey were iden

66 recombination events, an alternative mode of apex binding has been sought.

67 lineage thus identifies a solution for V1V2-apex binding that provides a more conventional B cell pa

68 he surface of expressing cells using tagged, apex-binding Fab PG16 and determined the structure of th

69 y while improving the presentation of trimer apex bNAb epitopes.

70 tion of immunization strategies to induce V2 apex bnAb responses.

71 oscopy, we solved the atomic structure of an apex bnAb, PGT145, in complex with Env.

72 accination approaches capable of inducing V2-apex bnAbs against HIV-1.

73 V2-apex bNAbs are derived from rare precursors with long an

74 The evolution of apex bnAbs from one donor (CAP256) has been studied in d

75 ant elite neutralizers are susceptible to V2-apex bnAbs.

76 Apex broadly neutralizing HIV antibodies (bnAbs) recogni

77 normal response to extracellular ATP at the apex but show a strongly dampened [Ca(2+)](cyt) response

78 ent and emergent leaf primordia at the shoot apex, but not in the vegetative meristem or stem.

79 lates rhythmic organ production at the shoot apex, but the spatio-temporal dynamics of auxin gradient

80 AK6 reduces cell production in the aak6 root apex, but this is partially compensated for by longer ma

81 tion of F-actin unleashes SVs focused at the apex by myosin-5 to microtubule-dependent motors, we est

82 c thin section of the approximately 3,465 Ma Apex chert of northwestern Western Australia, prepared f

83 ontains loops with variable regions at their apexes conferring capsid surface topologies different fr

84 tip' events (Hot phenotype) in the root hair apex, consistent with the role of this endoglucanase in

85 On average, a damaged apex cost each ramet 5015 seeds.

86 ward a finite-time singularity or blow-up of apex curvature that is cut off once the pinnacle tip rea

87 ratio statistical variable selection and the apex detection algorithms in order to perform prioritiza

88 The link between delayed shoot apex development and the induction of cold tolerance was

89 which begins at birth and follows a base to apex developmental gradient.

90 from the outpatient department (OPD) of the apex diabetic healthcare hospital of the country under t

91 Here, we isolated a lineage of Env apex-directed neutralizing antibodies, N90-VRC38.01-11,

92 hyB, positioning plastids at the information apex directing adaptive responses.

93 in the opposite direction of the keratoconus apex (direction (ax) CB).

94 Considering left ventricular base-to-apex distribution, MF was 31.9%, 43%, and 46.2% at basal

95 ) and high-dose (HD) groups (</= or > median apex dose 84.35 Gy).

96 ndent biotinylation in live tissue using the APEX enzyme to interrogate the RC interactome.

97 eneration procedure was developed from shoot apex explants and used to downregulate expression of 3 m

98 brane receptor potential fluctuations in the apex for precise phase-locking to sound signals.

99 compositions confirm the biogenicity of the Apex fossils and validate their morphology-based taxonom

100 in (KI) an engineered ascorbate peroxidase (APEX) gene to the endogenous locus of lysosome-associate

101 Subjects with a peripheral corneal apex had stronger correlations with visual acuity and co

102 APEX has been used to capture entire organelle proteomes

103 vant to vaccine design involving its dynamic apex.IMPORTANCE The Env trimer is the only viral protein

104 ded based on their terminal reach toward the apex: important: >75% (n = 1,698); and less important: <

105 ace was <1 mm at a distance of 3 mm from the apex in both types of roots.

106 laced the anterior mitral leaflet toward the apex in most young patients, was significantly associate

107 mote organogenesis at the reproductive shoot apex in parallel with MP via histone-deacetylation media

108 ne transfer of TBX18 to the left ventricular apex in the CAVB rats resulted in ectopic ventricular be

109 n the trimer while apparently leaving the V2 apex intact.

110 orm a triangle of tissue back to the orbital apex, intraconal spread apparently being prevented by th

111 ependent activation of autophagy in the root apex is a consequence of local Pi sensing and the associ

112 tations in the V3 loop (N301D) and in the V2 apex (K171E) partially restored viral fitness without af

113 taxa are lower than those of bulk samples of Apex kerogen (-27 per thousand), those of SIMS-measured

114 fair comparisons among different batches of APEX labeling and different APEX probes.

115 om distant failure rates were 96% and 95% in apex LD and HD groups at 5 years and 77% and 95% at 10 y

116 Apex LD and HD groups did not differ for time to death o

117 isual acuity outcomes did not differ between apex LD and HD groups.

118 dom from local failure rates were 90% in the apex LD group vs 89% in the HD group at 5 and 10 years (

119 nd optic neuropathy rates were higher in the apex LD than HD group.

120 Eyes were divided into apex low-dose (LD) and high-dose (HD) groups (</= or > m

121 lamina-associated domain are larger for loop apexes mapping closest to nuclear speckles, suggesting t

122 seq, with the spatial proteome determined by APEX-mass spectrometry (APEX-MS), obtained precisely in

123 ering has yet to be articulated in a base-to-apex mathematical model.

124 osin contractility in the middle of the cell apex (medioapical) can change cell shape (e.g., apical c

125 This necessary apex-membrane contact (or alignment) is not immediately

126 RBC deformation aids in the establishment of apex-membrane contact through partial parasite wrapping

127 comparative evaluation between this KI-LAMP1-APEX method and our two overexpression LAMP1-APEX probes

128 ration sequencing, autozygosity mapping, and apex microarray, were tried to reach a diagnosis; all pa

129 At the apex, microscale fluid dynamics and nanoscale channel dy

130 ing 49% of a 208-strain panel, revealed a V2 apex mode of recognition like that of human broadly neut

131 oteome determined by APEX-mass spectrometry (APEX-MS), obtained precisely in parallel, provides new i

132 Leaf thickness near the apex, near the base, and half-way between the two points

133 risk of autotoxicity, as necrosis killed the apex of 37% of the ungalled ramets.

134 These AML LSCs were shown to reside at the apex of a cellular hierarchy that initiates and maintain

135 ed the default network, is positioned at the apex of a gradient of sequential networks that radiate o

136 0 bipotent liver progenitors residing at the apex of a hepatoblast hierarchy.

137 erein light is confined and amplified at the apex of a nanoscale plasmonic probe, meets these criteri

138 le, Ni(cyclopentadienyl)(2), adsorbed at the apex of a scanning probe tip, to sense exchange interact

139 Therefore SVs arrive at the apex of A. nidulans by anterograde transport involving c

140 ch glioblastoma stem cells (GSCs) are at the apex of an entropic hierarchy and impart devastating the

141 rked upon in decades past, it could mark the apex of antibiotic drug development for years to come.

142 WERING LOCUS C (FLC) is reduced in the shoot apex of atu2af65b, due to both increased intron retentio

143 Post-translational modifications are at the apex of cellular communication and eventually regulate e

144 of unusually high expression located at the apex of chromosome loops protruding from the nuclear per

145 ly, SNS produced APD(80) prolongation in the apex of control but not DBH-Sap hearts.

146 ucted by placing a tri(hydroxy) group at the apex of dendritic oligo-fluorenes is observed.

147 to the ATM and ATR kinases which are at the apex of DNA damage signaling pathways.

148 diverge markedly in cells at the center and apex of hyphae during Arabidopsis thaliana colonization

149 asculature of developing nodules, and at the apex of mature nodules.

150 A dense glycan shield at the apex of pre-fusion hMPV F suggests that antibodies again

151 ersity in the structures of the loops at the apex of the C2 domain implicated in membrane recognition

152 Acoustic energy propagates toward the apex of the cochlea through vibrations of the organ of C

153 ification is greater in the base than in the apex of the cochlea.

154 ath, revealed that many sensory cells at the apex of the cochlear spiral were missing.

155 nce of a marginal dentition ankylosed to the apex of the dentary, maxilla, and premaxilla; the presen

156 zed gastro-esophageal junction (GEJ) and the apex of the diaphragmatic hiatus after maximal thoracic

157 t302, Leu320, and Pro329, that stabilize the apex of the Env trimer in a prefusion-closed conformatio

158 ntially affects antigenic structure near the apex of the Env trimer.

159 a DQVD caspase cleavage site exposed on the apex of the HAZV nucleocapsid protein arm domain that is

160 uns with RAP set above the head (P1), at the apex of the head (P2), or at heart level (P3) with foot-

161 med with the RAP above the head (P1), at the apex of the head (P2), or at heart level (P3), with foot

162 ls are minimally differentiated cells at the apex of the hierarchical system of memory T lymphocytes.

163 tibodies that recognize the V2 region at the apex of the HIV envelope trimer are among the most commo

164 Neutralizing antibodies that target the V1V2 apex of the HIV-1 envelope (Env) trimer feature unusuall

165 ed tomography showed a hypodense area in the apex of the left ventricle in a 57-year-old man with a h

166 longitudinal direction from the base to the apex of the left ventricle, there was a trend of decreas

167 -J gp85 on chNHE1 is probably located on the apex of the molecule; the receptor-binding mode might be

168 ow the highest concentrations (%wt) near the apex of the ovipositor, where other structural modificat

169 wo potential ferredoxin-binding sites at the apex of the peripheral arm.

170 cifically recognizes antigenic site O at the apex of the pre-F protein trimer.

171 gs from V1 and laterolateral area LL (at the apex of the putative ventral-like hierarchy) of male adu

172 e that forms at the subunit interface at the apex of the receptor.

173 Quaternary epitopes at the apex of the spike are recognized by some of the most pot

174 ent bnAbs target a quaternary epitope at the apex of the surface HIV envelope (Env) trimer.

175 , bind asymmetrically as a single Fab to the apex of the symmetric Env trimer using a protruding CDRH

176 nfined phase is first seen to form along the apex of the wedge and then grows out of the pocket openi

177 They show that tumor cells at the apex of this hierarchy reside in particular tumor zones

178 The E1 enzyme functions at the apex of this pathway and plays a critical role in activa

179 Plasma bnAbs targeting V2-apex on the env are predominant in infant elite and broa

180 e of cylinders and immediately downstream of apexes on corrugated surfaces, in stark contrast to wher

181 of pulse trains on single electrodes at the apex or middle of long electrode arrays.

182 either tightly packed at the membrane-distal apex or rotated into a receptor-accessible conformation.

183 hollow Au24 nanoparticle either through the apex or side entry, while shuttling a metal atom out of

184 rsors of bNAbs that target either the trimer apex or the CD4-binding site.

185 Live-cell proximity labeling using APEX peroxidase followed by anti-biotin enrichment and m

186 Being at the food chain apex, polar bears (Ursus maritimus) are highly contamina

187 n-1 with myosin-5 and can move away from the apex powered by dynein.

188 Collectively, our results indicate that high apex predator abundance might not always have negative e

189 lta(15) N was highest where coyotes were the apex predator and lowest where coyotes co-occurred with

190 for disentangling ecological consequences of apex predator declines.

191 We contend that trophic cascades induced by apex predator extirpation may be an overlooked driver of

192 gs), an otherwise allopatric kelp-associated apex predator in False Bay.

193 Daspletosaurus was an important apex predator in the late Campanian dinosaur faunas of L

194 ionships, as the coyote varied from being an apex predator to a subordinate, mesopredator across samp

195 vides evidence linking the suppression of an apex predator to the historic encroachment of shrubs.

196 ogy from migratory birds and ungulates to an apex predator, further demonstrating the potential effec

197 on traits at different flows of a freshwater apex predator, Ganges River dolphin (GRD, Platanista gan

198 demographic and ecological data for a marine apex predator, the broadnose sevengill shark Notorynchus

199 ach toxicological thresholds in at least one apex predator.

200 y exposing them to predation risk from avian apex predators (cormorants, Phalacrocorax carbo).

201 Late Cretaceous) have been characterized as apex predators [2-5], whereas members of the distantly r

202 e mesopredators need to simultaneously avoid apex predators and acquire prey.

203 Several species of apex predators clustered in the weak selection category.

204 Given the NCEs of apex predators demonstrated here, however, unbiased asse

205 Theory predicts that when apex predators disappear, large herbivores become less f

206 pture (CR) modeling techniques used to study apex predators has also limited robust temporal and cros

207 Humans have supplanted large carnivores as apex predators in many systems, and similarly pervasive

208 Birds of prey (raptors) are dominant apex predators in terrestrial communities, with hawks (A

209 Apex predators initiate trophic cascades which can influ

210 Extirpation of apex predators is linked inextricably to pastoralism, bu

211 Apex predators may alter their behavior where subsidies

212 Shifts in densities of apex predators may indirectly affect fundamental ecosyst

213 than their iconic representation as gigantic apex predators of Mesozoic marine ecosystems suggests.

214 studies, most focused on top-down effects of apex predators on mesopredator population dynamics, wher

215 Apex predators such as large carnivores can have cascadi

216 Sharks, particularly apex predators such as the white shark, are believed to

217 alligators (Alligator mississippiensis) are apex predators that have received minimal attention with

218 s are struggling to relearn how to live with apex predators that kill livestock, compete for game spe

219 Polar bears (Ursus maritimus) are apex predators that primarily consume benthic and pelagi

220 forests, a 50% reduction in the densities of apex predators was associated with a 50% reduction in de

221 ies reversed this effect-in part because the apex predators were trophic omnivores.

222 We hypothesized that altering abundances of apex predators would have stronger effects on soil commu

223 undances of the largest arthropod predators (apex predators) in field mesocosms replicated in the lea

224 As long-lived apex predators, predatory birds represent a sentinel spe

225 l and morphological features essential to be apex predators.

226 es the sequential rise and decline of marine apex predators.

227 portant factor driving the dynamics of these apex predators.

228 among species ranging from mesocarnivores to apex predators.

229 Despite global declines of apex predatory sharks, evidence for ecosystem consequenc

230 The Sargassum apex presents characteristics of a self-organising syste

231 APEX method and our two overexpression LAMP1-APEX probes, achieving complementary coverage of both kn

232 erent batches of APEX labeling and different APEX probes.

233 que, termed the absolute protein expression (APEX) proteomics tool.

234 25 plaque brachytherapy (67.5-81 Gy at tumor apex) provides safe and effective tumor control for juxt

235 re most effective when SOSIP trimers with an apex-proximate neutralizing epitope are displayed.

236 mporal disassembly sequence using multi-bait APEX proximity proteomics.

237 well-established injury model of ventricular apex resection, autophagy plays a critical role during c

238 embryonic day (E) 9.5-10.5, and those in the apex (responding to low-frequency sounds) born late arou

239 e demonstrate that, using a single protocol, APEX-RIP can isolate RNAs from a variety of subcellular

240 Since APEX-RIP is simple, versatile, and does not require spec

241 Here, we develop such a method, termed APEX-RIP, which combines peroxidase-catalyzed, spatially

242 logical and human well-being implications of apex scavenger decline, including carrion removal and di

243 Many apex scavenger species, including nearly all obligate sc

244 Our understanding of how apex scavengers regulate populations of mesoscavengers,

245 increase in carrion in the face of declining apex scavengers.

246 tive release of these species by the loss of apex scavengers.

247 central point of the cornea and keratoconus apex; second, as the perpendicular axis) to read the ele

248 We show that APEX-seq can resolve the localization of RNAs within the

249 APEX-seq in nine distinct subcellular locales produced a

250 APEX-seq should be widely applicable to many systems, en

251 We introduce APEX-seq, a method for RNA sequencing based on direct pr

252 veloped an RNA proximity labeling technique, APEX-seq, which uses the ascorbate peroxidase APEX2 to p

253 ng the spatial transcriptome, as revealed by APEX-seq, with the spatial proteome determined by APEX-m

254 ace can be represented by a centroid or peak apex, similar to the data-reduced histogram spectra used

255 forests, the same reduction in densities of apex soil predators did not alter the rate of litter dec

256 the adult heart has few sox10+ cells in the apex, sox10 and other neural crest regulatory network ge

257 oisoning, pushing the populations of several apex species to the edge of extinction.

258 The current increases arose from an apex-specific increase in slow transient outward current

259 Antibodies that bind at the trimer apex stabilize a "closed" conformation characteristic of

260 of these trimers confirmed prefusion-closed apexes stabilized by hydrophobic patches contributed by

261 we show that subsequent boosting with a 3mut-apex-stabilized consensus C-Env trimer, modified to have

262 ilize the Env trimer apex, and the resultant apex-stabilized Env trimers can be used to expand the ne

263 oon to morning were Delta corneal thickness (apex) +/- standard deviation (SD) 41.45 +/- 34.1 mum (P

264 s's Alzheimer's Prevention through Exercise (APEX) Study.

265 described for another donor who developed V2-apex targeting bnAbs.

266 The SIMS data for the two highest delta(13)C Apex taxa are consistent with those of extant phototroph

267 Using proximity-based APEX technology and topological dissection, we show that

268 onger for subjects with a peripheral corneal apex than for those with a central apex.

269 of expression with Fzd3 being higher in the apex than in the base.

270 ecognition of gl-bNAb epitopes at the trimer apex that extensively involve V2 residues.

271 trate-parallel contractile actin belt at the apex that governs anaphase cell flattening.

272 lpropyl dendrons with chiral groups at their apex that produces single-handed chiral supramolecular s

273 centrated endocytosis just behind the hyphal apex (the "endocytic collar"); and small, rapidly moving

274 a uniform shape and functioning from base to apex, the development of 3D MRI has provided opportuniti

275 y locally relaxing cortical tension at their apex, thereby allowing extrinsic pulling forces from nei

276 unique transcripts were identified in shoot apex tissue between fast- and slow-developing RILs, 13 o

277 AEs while perfusing guinea pig cochleas from apex to base with salicylate or KCl solutions that reduc

278 As solution flowed from apex to base, SFOAE reductions generally occurred later

279 regulate the actin cytoskeleton at the tube apex to drive tip growth.

280 coefficients at the base, midventricle, and apex to further analyze the contour quality.

281 This positions iNKT cells at an apex to support or inhibit B cell responses in inflammat

282 omplexan parasites have to adhere with their apex to the RBC membrane.

283 the point of perception in the leaves at the apex to the roots.

284 we applied engineered ascorbate peroxidase (APEX) to map the proteome at EMCs in live HEK293 cells.

285 Inner hair cells are transduced in an apex-to-base gradient, with transduction reaching 96% in

286 random orientation, they need to align their apex toward the membrane in order to start the invasion

287 The apex transmodal network comprises frontopolar and rostra

288 opulation was assessed in this retrospective APEX trial substudy (Acute Medically Ill Venous Thromboe

289 ion of the stray field surrounding the probe apex using electron holography convincingly demonstrates

290 nt viruses acquired unique changes in the V2 apex, V3, V4, and CD4-binding regions of the HIV-1 envel

291 In the shoot apex, VRN2 differentially modulates flowering time depen

292 The incidence of an isthmus 3 mm from the apex was 89.3% and 100% in the MB roots of the maxillary

293 APEX was fused to four different RC components (RC-APEX

294 APEX was targeted to the outer mitochondrial membrane, a

295 pression atlas of the vegetative maize shoot apex, we show here that distinct sets of genes govern th

296 Using this technique, termed "GPCR-APEX," we track activation and internalization of the an

297 responding prostate shapes were noted at the apex when comparing the Cl- and PCa+ prostates.

298 e pre-mRNA splicing of FLC and ABI5 in shoot apex, whereby AtU2AF65b is involved in ABA-mediated flow

299 kely to create a critical site at the pillar apex, which delivers significant in-plane strains and ma

300 le-cell transcriptomic analyses of the shoot apex yield insight into the processes of stem-cell funct