ライフサイエンスコーパス: apical

1 ier integrity, so that directional (basal or apical) 5HT secretion was measurable.

2 owed that mIBG transport in the basal (B)-to-apical (A) direction is much greater than in the A-to-B

3 e, aldosterone's effect on pendrin total and apical abundance and subcellular distribution.

4 eveloping epithelial cells construct a dense apical actin cortex to carry out their barrier and excha

5 localized to the apical membrane and affects apical actin placement and RAB-8-mediated vesicular tran

6 and is required to slow down the turnover of apical actin.

7 from the basolateral membrane surface to the apical airway surface.

8 osphate monomers with N incorporated in both apical and as bridging sites in phosphate dimers.

9 uency tuning differ dramatically between the apical and basal (i.e., the low- and high-frequency) reg

10 gments, along with proximal segments on both apical and basal dendrites, and spine density was increa

11 Clonal analysis reveals that the apical and basal RBG are derived from distinct lineages

12 e volume was greater in primary dendrites of apical and basal segments, along with proximal segments

13 NHBE cells secrete EVs to the apical and basal side.

14 rigin of stochastic nuclear movement between apical and basal surfaces of neuroepithelia during inter

15 y, we found that SGs are equally distributed apical and basal to the CG membrane, so that the apical

16 stry, and confocal microscopy, we found that apical and basolateral dendrites are coordinately sculpt

17 sEV pools to mediate communication via their apical and basolateral domains and suggest that defectiv

18 evaluated under conditions of static fluid, apical and basolateral flow, and flow plus repetitive st

19 e altered primary cultures responded to both apical and basolateral PAR-2 stimulation.

20 dition of ST under flow conditions increased apical and basolateral secretion of cGMP relative to the

21 However, differences in apical and basolateral sEV composition and numbers were

22 his device enabled independent access to the apical and basolateral surfaces of the cholangiocyte cha

23 cells execute distinct signaling agendas via apical and basolateral surfaces to communicate with diff

24 iple epithelial tissues and localizes to the apical and junctional actin cortex in intestinal and kid

25 ing the appropriate membrane (i.e., basal or apical) and corresponding method when measuring receptor

26 hored to adherens junctions scales with cell apical area to limit larger cell elongation under mechan

27 play decreased cortical tension and expanded apical area.

28 Maintaining the correct ratio of apical, basal, and lateral membrane domains is important

29 The roles of Scrib and Lgl1 in apical-basal cell polarity have been studied extensively

30 At the morula stage, outer cells acquire an apical-basal cell polarity, with expression of atypical

31 results in loss of F-actin and expansion of apical-basal domains, which comes at the expense of late

32 s are located more basally, forming a robust apical-basal pattern.

33 tial for the stem cell specification and the apical-basal patterning of the SAMs.

34 ear how cells disperse from clusters lacking apical-basal polarity, a hallmark of advanced epithelial

35 ell death and/or cell proliferation, loss of apical-basal polarity, and appearance of epithelial-to-m

36 gnaling and AMOT function are interlinked in apical-basal polarized cells.

37 We show that the main apical/basal functional differences can be accounted for

38 nditioned medium from vaccinated cattle upon apical-basolateral migration of BCG was examined by quan

39 The complexity of apical, but not basal dendrites was significantly lower

40 ly required for the development of spines on apical, but not basal, secondary dendrites.

41 py (U-ExM) to localize the Toxoplasma gondii Apical Cap protein 9 (AC9) and its partner AC10, identif

42 al for ERK7 localization and function at the apical cap.

43 sine-1-phosphate (S1P)-dependent entosis and apical cell extrusion.

44 ryos display epidermal hyperplasia, but also apical cell extrusions, during which extruding outer ker

45 cells generates polarity such that the outer apical cells are trophectoderm (TE) precursors and the i

46 rentially regulated during development, with apical cells being more strongly dependent on experience

47 (-/-) mice, but to a much lesser extent than apical cells.

48 -on-cell migration: outer cells migrate with apical, centripetally polarised leading edge protrusions

49 s express basolateral secretin receptors and apical CFTR and pendrin.

50 Apical ciliated cells were the target for both viruses,

51 The surface area of apical coil IHCs (9-12 kHz cochlear region) decreases by

52 in the ability of IECs to partially tolerate apical commensals while remaining fully responsive to in

53 cated in the biogenesis and stability of the apical complex and, in turn, these discoveries have shed

54 Like AC9, ERK7 is required for apical complex biogenesis.

55 yle, little is known about the regulation of apical complex biogenesis.

56 ccidian subgroup of Apicomplexa possesses an apical complex harboring a conoid, made of unique tubuli

57 A conspicuous feature of the apical complex in many apicomplexans is the conoid, a ho

58 In Toxoplasma gondii, the apical complex is a central site of convergence for calc

59 While the apical complex is essential to the parasitic lifestyle,

60 The apical complex is integrally associated with both the pa

61 se a specialized cilium structure called the apical complex to organize their secretory organelles an

62 lexa has been defined by the presence of the apical complex, a structure composed of secretory organe

63 NF-kappaB modulates apical components of metabolic processes including metab

64 s morphogenetic event, including anisotropic apical constriction and coordinated cell movements.

65 is process involves a tissue-wide pattern of apical constriction controlled by Sonic hedgehog (Shh) s

66 yos expressing activated Smoothened, display apical constriction defects in lateral cells.

67 reveal a morphogenetic program of patterned apical constriction governed by Shh signaling that gener

68 gh processes such as convergent extension or apical constriction(1,2).

69 retina leads to increased cortical tension, apical constriction, and Yki-mediated hyperplasia, spect

70 morphogenetic events common to most animals: apical constriction, convergent extension and collective

71 ral cells are taller and undergo synchronous apical constriction, driving neural fold elevation.

72 ibits mesoderm invagination, which relies on apical constriction, mitotic entry in an artificially co

73 nt cells, causing impaired nucleokinesis and apical constriction.

74 ue shape through signal interference between apical contractility and mitosis.

75 we demonstrated that mitotic entry reverses apical contractility by interfering with medioapical Rho

76 al cell divisions with ectopic activation of apical contractility.

77 The apical cortex assembles in response to three-dimensional

78 on and negates its function to stabilize the apical cortex.

79 mediate planar polarization of the hair cell apical cytoskeleton, including the kinocilium and the V-

80 t, using dual whole-cell recordings from the apical dendrite and soma of layer 5 (L5) pyramidal neuro

81 Furthermore, apical dendrite inputs have larger receptive fields and

82 the modulation of dendritic excitability by apical dendrite length and show that the operational rep

83 ic Ca(2+) spikes as prominently found in the apical dendrite of S1 (somatosensory cortex) pyramidal n

84 DA spikes or trains of EPSPs from the distal apical dendrite to the soma in pyramidal neurons in the

85 s coordination, leading to retraction of the apical dendrite without altering basolateral dendrite dy

86 atory cells, preferentially targeting distal apical dendrites and apical dendritic tufts of pyramidal

87 for the control of pyramidal cells at their apical dendrites and support differential computational

88 in secondary branches and distal segments on apical dendrites following sleep deprivation.

89 drite inputs, suggesting a dominant role for apical dendrites in integrating feedback in visual infor

90 We investigated the synaptic innervation of apical dendrites of cortical pyramidal cells in a region

91 se is specific to L2/3 neurons and absent on apical dendrites of L5 neurons, and is dependent on expr

92 NDNF+ cells also inhibit the apical dendrites of L5 pyramidal tract (PT) cells to sup

93 odel with five crucial ionic currents in the apical dendrites reproduces all features of these neuron

94 most spine populations on basal and proximal apical dendrites, as well as firing rates and ocular dom

95 preferentially innervated either L2 or L3/5 apical dendrites, but not both.

96 are preferentially established on basal vs. apical dendrites.

97 hrough dendodendritic inputs on their distal apical dendrites.

98 ces in the extension and complexity of their apical dendrites.

99 mislocalization and development of multiple apical dendrites.

100 uced excitability is correlated with shorter apical dendrites.

101 elayed-rectifier K(+) conductances, while an apical-dendrites/trunk compartment included persistent N

102 er, EV treatment was associated with greater apical dendritic branching complexity, spine density, an

103 cope to image the Ca(2+) dynamics within the apical dendritic compartments of large mitral cell ensem

104 ve abnormally elevated calcium transients in apical dendritic spines.

105 tially targeting distal apical dendrites and apical dendritic tufts of pyramidal neurons in layer I,

106 d, epithelial cells round up and move in the apical direction before dividing, likely in response to

107 soft tissue architecture characterized by an apical discrepancy of the mucosal margin respective to i

108 in developing pollen grains and later to the apical domain in growing pollen tube tips characterized

109 lying mechanism of how ANKS4B targets to the apical domain of enterocytes to drive brush border assem

110 iciency leads to membrane herniations in the apical domain of epithelial cells, indicative of cortex

111 and Crumbs components synergistically to the apical domain, thus establishing apical epithelial polar

112 eral mobility, allowing the emergence of the apical domain.

113 Apical domains of epithelial cells often undergo dramati

114 n localizes at the polarisome and the hyphal apical dome (HAD) where it acts as a GTPase-activating p

115 The apical dose was 100 to 120 Gy aiming to deliver >=250 Gy

116 DMPA group exhibited a significantly thinner apical ectocervical epithelial layer and a higher propor

117 Vitamin K apical efflux was significantly decreased in presence of

118 one levels were in a zone within 1 mm of the apical end of the internal screw at T1 and remained in t

119 quently located in a zone within 1 mm of the apical end of the internal screw.

120 expressed in schizonts, be localized at the apical end of the merozoite, and preferentially bind ret

121 rve terminals extend towards the hair cell's apical end to re-establish contact with them.

122 nserved protein (EXC-9/CRIP1) that regulates apical endosomal trafficking.

123 echanisms governing its development into the apical epithelial cap (AEC), a signaling structure neces

124 ally to the apical domain, thus establishing apical epithelial polarity and adherens junctions.

125 isms allowing the generation of two opposing apical epithelial surfaces within the centre of an initi

126 ation cascade, associated with impaired ROMK apical expression in the distal part of the renal tubule

127 iderm layer abnormalities, including ectopic apical expression of adherens junction markers, similar

128 se tubes are molded and protected in part by apical extracellular matrices (aECMs) that line their lu

129 By examining the apical extracellular matrix (aECM), we also uncovered a

130 ode transmembrane proteases that remodel the apical extracellular matrix to promote wing morphogenesi

131 comparable calcium propagation also promotes apical extrusion of apoptotic cells.

132 l cells and zebrafish embryos, that prior to apical extrusion of RasV12-transformed cells, calcium wa

133 Furthermore, calcium wave facilitates apical extrusion, at least partly, by inducing actin rea

134 Epithelia can eliminate apoptotic cells by apical extrusion.

135 cross cells could compromise individual cell apical geometry and thereby organ function.

136 olateral membrane currents in low-frequency (apical) hair cells, such as I(K,n) (carried by KCNQ4 cha

137 ted lateral expansion of stems and decreased apical height growth and leaf size.

138 th of the root and hypocotyl, an exaggerated apical hook, and a thickening of the hypocotyl.

139 IL-13 stimulation, that ANO1 is the primary apical IL-13-induced Cl(-) transport mechanism within th

140 vitro human model that simulates the initial apical infection of alveolar epithelium with SARS-CoV-2

141 by undergoing a process of apical migration, apical insertion, and expansion [8].

142 either orientation is sufficient to promote apical insertion.

143 genitors, drives differentiation of RGs into apical intermediate progenitors, a more restricted proge

144 bosomal events in spindle, inflammation- and apical junction-related proteins in squamous, and extrac

145 ndotube, which is attached to the C. elegans apical junction.

146 colitis by maintaining the integrity of the apical junctional complex and its associated actin regul

147 ere supporting cells develop E-cadherin-rich apical junctions reinforced by robust F-actin bands, and

148 mone detection by receptors expressed in the apical layer of the VNO such as vomeronasal type 1 recep

149 eroids from MYO5B(P663L) piglets had reduced apical levels and diffuse subapical levels of sodium hyd

150 apping of the C terminus of protein A to the apical lobe, which correlates well with the predicted st

151 We show that ESCRT function is required for apical localization and mobility of retromer positive ca

152 These findings demonstrate that the apical localization of cone nuclei in the ONL is require

153 lated NCC levels decreased, and cleavage and apical localization of gamma-ENaC increased in nephrotic

154 Increased cleavage and apical localization of gamma-ENaC persisted at day 5 in

155 utagenesis experiment, we observe particular apical loop U bases, likely recognized by DGCR8, are imp

156 nked sialic acid and mediated by the exposed apical loops of the major capsid protein VP1, a broad ra

157 RNA hairpins displaying partly complementary apical loops.

158 nificant differences between basal, mid-, or apical LVs levels in LVdP/dtmax and SDAT.

159 g partner of EXC-9, is also localized to the apical membrane and affects apical actin placement and R

160 ication plays distinct and specific roles in apical membrane biogenesis.

161 ated by a recovery of chloride secretion and apical membrane conductance.

162 mice that anchoring of the centrosome to the apical membrane controls the mechanical properties of co

163 aired apical trafficking via Rab11, and thus apical membrane growth.

164 ynthesized membrane proteins from the TGN to apical membrane in live zebrafish.

165 tubules, distal convoluted tubules, and the apical membrane of collecting duct A-type intercalated c

166 tl) and Dachsous (HyDs) that localize at the apical membrane of ectodermal epithelial cells and are p

167 tial for the stability of myelin, and at the apical membrane of epithelial cells, where it has a crit

168 st-Golgi trafficking of different classes of apical membrane proteins.

169 in-based adhesion complexes to remodel their apical membrane protrusions into organized functional ar

170 reduced pendrin's relative abundance in the apical membrane region and pendrin abundance per cell wh

171 Our work reveals a new role for apical membrane remodeling in converting a multicellular

172 th receptors was significantly faster in the apical membrane than in the basal membrane, suggesting d

173 dergo a polarized form of cytokinesis at the apical membrane that is not well understood.

174 rt and further define the classical model of apical membrane traffic at the tip of elongating pollen

175 haracterize functions of these structures in apical membrane traffic.

176 rupts the anchorage of the centrosome to the apical membrane, resulting in the disorganization of mic

177 tubules and stretching and stiffening of the apical membrane.

178 lops distal appendages that anchor it to the apical membrane.

179 amined by quantifying recovered BCG from the apical, membrane and basolateral fractions over time.

180 n cultured MDCK cells, CRB2S associates with apical membranes and decreases cell cohesion.

181 ed HLCs with clearly defined basolateral and apical membranes separated by tight junctions.

182 from MYO5B(P663L) piglets maintained CFTR on apical membranes, like tissues from control pigs.

183 The mitotic activity of root apical meristem (RAM) is critical to primary root growth

184 The AP2 genes maintain shoot apical meristem (SAM) activity in part by keeping WUSCHE

185 ing how the distinct cell types of the shoot apical meristem (SAM) withstand ultraviolet radiation (U

186 since dark-grown seedlings have reduced root apical meristem activity, as observed in the clasp-1 nul

187 e rate of leaf initiation, an enlarged shoot apical meristem and an increase in the number of juvenil

188 these constructs on the lengths of the root apical meristem and cortical cells in the elongation zon

189 sence in lateral root primordia and the root apical meristem negatively regulates root system archite

190 nt of a FAC promoting flowering at the shoot apical meristem, downstream of OsFD1.

191 cells in leaves, root vasculature, and shoot apical meristem, implicating it in both local and system

192 opulation originally detached from the shoot apical meristem.

193 Along the vertical axis of plant shoot apical meristems (SAMs), stem cells are located at the t

194 pulations of pluripotent stem cells in shoot apical meristems (SAMs), which continuously produce new

195 ell division activity in both shoot and root apical meristems observed in fbl17 loss-of-function muta

196 US) defines the shoot stem cell niche in the apical meristems of many angiosperm species; we show tha

197 ations, folded plasma membrane, and multiple apical microvilli in the taste pore.

198 ronment using a densely packed collection of apical microvilli known as the brush border.

199 sess a large round or oval nucleus, a single apical microvillus extending through the taste pore, and

200 with an indented nucleus, possess a single, apical microvillus extending through the taste pore, and

201 pected alterations to cytokinesis, including apical midbody migration in polarizing epithelial cells

202 leton (LINC complexes) are essential for the apical migration of cone nuclei during development.

203 recession defect (GRD) may be defined as an apical migration of the gingival margin respective to th

204 rom a basal layer by undergoing a process of apical migration, apical insertion, and expansion [8].

205 nd hold broad implications for understanding apical morphogenesis in diverse epithelial systems.

206 ospectively obtained paired left ventricular apical myocardial tissue from nonfailing donor hearts as

207 basolateral HCO(3) (-) uptake to neutralize apical NH(4) (+) uptake during MAc; (2) inhibits HCO(3)

208 ve specimen, including both locoregional and apical node status, in contrast to the American Joint Co

209 Successful apical nuclear migration is critical for planar-orientat

210 Hz, SFOAE amplification extended two octaves apical of CF, which highlights that different vibratory

211 We created distal lung organoids with apical-out polarity to present ACE2 on the exposed exter

212 ght ventricular (RV) pacing, particularly RV apical pacing, can have deleterious effects on cardiac f

213 yssynchronous ventricular activation with RV apical pacing.

214 e aimed to reprogram stem cells from a tooth apical papilla (SCAP) of a patient with OFCD, termed SCA

215 marrow (BMSC), dental pulp (DPSC) and dental apical papilla (SCAP) to engineer pericyte-supported vas

216 Likewise, raising pH or apical perfusion did not improve clearance of mucus stra

217 where the cause of extraction was persistent apical periodontitis (35.7%), but this increase didn't r

218 usion protein formed a steep gradient at the apical plasma membranes of growing tip cells.

219 ot SHR, C-21 induced AT(2)R translocation to apical plasma membranes of renal proximal tubule cells,

220 ins and recycled membrane lipids to the same apical PM domain, and (2) FM4-64-labeled lipids, but not

221 invasive parasites and is associated to the apical polar ring (APR).

222 The crumbs (crb) apical polarity genes are essential for the development

223 placode through a negative regulation by the apical polarity protein Crumbs that is anisotropically l

224 Adherens junction remodeling regulated by apical polarity proteins constitutes a major driving for

225 stin(+) radial glia (dmNes+RG) down-regulate apical polarity proteins, including Crumbs2 (CRB2) and d

226 aPKC, an apical polarity regulator, maintains the robustness of p

227 , where they stabilize the cortex to promote apical polarization and YAP-dependent expression of CDX2

228 x and describe its essential role in guiding apical polarization and zonula adherens formation in epi

229 of microbiome-infected root canals at their apical portion.

230 s within a minute, via the vessel-associated apical processes.

231 n regulators that control the recruitment of apical proteins on the membrane, whereas RhoA regulates

232 Apical protrusion formation of nascent HCs and planar po

233 Emx2 facilitates Rock and Roll by delaying apical protrusion of its nascent HCs but it does not det

234 eurovascular bundle and more enriched in the apical region.

235 ls were the target for both viruses, but RSV apical release was significantly more efficient than HMP

236 the apical surface, but efficient spread and apical release were seen for respiratory syncytial virus

237 n in disease-remodeled epithelia may enhance apical responses and increase sensitivity to inhaled pro

238 roteins Roughest and Kirre, which coordinate apical retinal cell patterning at an earlier stage, accu

239 mechanosensory bristles undergo PCP-directed apical rotation, inducing twisting that results in a hel

240 , age, sex, and the presence of preoperative apical scarring and environmental allergies in a multiva

241 Preoperative apical scarring led to worsening haze (P = .0001), more

242 The size of the lumen is dependent on apical secretion of chloride ions, most notably by the C

243 ing protein for FgRab8 which is required for apical secretion-mediated growth and pathogenicity.

244 Apical secretions from infected cells contained increase

245 al and basal to the CG membrane, so that the apical SGs are not prevented from contacting PR axons by

246 ained activity is detrimental for the mature apical shape.

247 were not treated showed a significantly more apical shift of the gingival margin (almost two-fold).

248 A similar pattern toward apical shift of the gingival margin was noticed for the

249 NCs also trafficked to lysosomes from the apical side and, additionally, from the basolateral side

250 of AMOT reduces SMAD signaling only from the apical side of polarized cells, while basolateral BMP-SM

251 is highly polarized and present only at the apical side of polarized cells.

252 dependent on endocytosis and specific to the apical side of polarized epithelial and endothelial cell

253 switch in PIN1-HA polarity from the basal to apical side of root epidermal cells.

254 the spatial localization of the EGFR to the apical side of the FCs at early stages depended on the T

255 newly formed viral particles egress from the apical side of the lung epithelium, we compared the effe

256 asolateral side was more vulnerable than the apical side to treatment with either agent, suggesting a

257 vesicles of 350-600 nm in diameter at their apical side, continuously internalizing their surroundin

258 -optimal coverage (i.e. missing basal and/or apical slices), however most of them were limited to the

259 and 0.004 +/- 0.035 in the basal, mid-, and apical slices, respectively (mean +/- standard deviation

260 ticularly to resolve errors at the basal and apical slices.

261 , blocking intestinal bile acid uptake by an apical sodium-bile acid transporter (ASBT) inhibitor dec

262 The ileal apical sodium-dependent bile acid transporter (ASBT) is

263 Apical sodium-dependent bile acid transporter (ASBT), an

264 that the human airway epithelium responds to apical stimulation by A. fumigatus to promote the transe

265 wed an exacerbated immune response following apical stimulation.

266 ogenetic forces, we found that the number of apical stress fibers (aSFs) anchored to adherens junctio

267 n disrupts cytokinesis and causes defects in apical structures, even if inactivated post-mitotically.

268 echanisms targeting membrane proteins to the apical surface are still poorly understood.

269 suggested crowding from cell division at the apical surface drives basalward motion.

270 gesting that ClpA can rotate around the ClpP apical surface during processive steps of translocation

271 old) reduction in HSV-1 released through the apical surface into the extracellular environment.

272 accumulation of V-ATPase proton pumps at the apical surface of A-ICs in KO mice compared to controls.

273 t in the endothelial glycocalyx covering the apical surface of endothelial cells.

274 The immune defense is initiated at the apical surface of epithelial cells where the N-terminal

275 immunoglobulins from the basolateral to the apical surface of epithelial cells.

276 stereociliary bundles that project from the apical surface of hair cells within the cochlea.

277 e is positioned away from the nucleus at the apical surface of the ventricular zone of the cerebral c

278 t, suggesting a protective adaptation of the apical surface that is normally exposed to bile.

279 al cells build arrays of microvilli on their apical surface to increase membrane scaffolding capacity

280 Golgi-dependent transport of virus from the apical surface to the extracellular medium was significa

281 y precipitation from basal culture medium or apical surface wash were characterized by nanoparticle t

282 es establish efficient infection through the apical surface, but efficient spread and apical release

283 with the basolateral surface compared to the apical surface.

284 Aurora B has a role in the formation of the apical surface.

285 erin-like protein expressed primarily on the apical surfaces of ciliated airway epithelial cells.

286 Different matrix factors assemble on the apical surfaces of each vulva cell type, with clear dist

287 at are arranged in maze-like patterns on the apical surfaces of zebrafish skin cells.

288 midbrain neuroepithelium are flat with large apical surfaces, whereas lateral cells are taller and un

289 ce to cell membrane, causing an expansion of apical surfaces.

290 incidence of RPI in sites with a history of apical surgeries.

291 Implants placed in sites with previous apical surgery are not at an increased risk of implant f

292 ts that were placed in sites with a previous apical surgery had a cumulative survival rate of 92%.

293 estine and identified mutants with defective apical targeting of membrane proteins.

294 ted to the brush border using a noncanonical apical targeting sequence that maps to a previously unan

295 pe of stem cell typically extending from the apical to the basal side of the developing cortex.

296 al bone thickness <1 mm at the level of 4 mm apical to the CEJ (odds ratio 2.733, 95% confidence inte

297 the bottom of the sinus floor (SF) up to the apical top of the biopsy.

298 hesis of hydroxylated sphingolipids impaired apical trafficking via Rab11, and thus apical membrane g

299 d position encoding in simultaneously imaged apical tuft dendrites and their respective cell bodies i

300 ating that olfactory communication involving apical VNO receptors like V1R is important for the outco