ライフサイエンスコーパス: apigenin

1 racterize two CD38 inhibitors: quercetin and apigenin.

2 an BACE-1, better than the parent flavonoid, apigenin.

3 in part, the photochemopreventive effects of apigenin.

4 ee-living NGR234 cultured in the presence of apigenin.

5 on, along with an increase in sub-G1 peak by apigenin.

6 vities of both enzymes could be inhibited by apigenin.

7 lumichrome and abscisic acid, and traces of apigenin.

8 of bioactive compounds such as catechin and apigenin.

9 of UVB (300-1,000 J/m(2)), then treated with apigenin (0-50 micromol/L), and harvested to assess apop

10 he sunflower honey, while a larger amount of apigenin (0.97 mg/kg) was determined in the buckwheat ho

11 Notably, Apigenin 4'-O-Rhamnoside and Apigenin-4'-Alpha-L-Rhamnos

12 Apigenin (4', 5, 7,-trihydroxyflavone), a common dietary

13 Notably, Apigenin 4'-O-Rhamnoside and Apigenin-4'-Alpha-L-Rhamnoside demonstrated higher poten

14 protein E7 (PDB ID 2EWL), while Apigenin and Apigenin 5-O-Beta-D-Glucopyranoside exhibited significan

15 s, taxifolin hexoside, quercetin dihexoside, apigenin-6,8-dipentoside, and isofraxidin hexoside.

16 s apigenin-6-C-galactoside-8-C-arabinoside & apigenin-6-C-arabinoside-8-C-galactoside, and 9,12,13-tr

17 ed to be L-tryptophan, Wessely-Moser isomers apigenin-6-C-galactoside-8-C-arabinoside & apigenin-6-C-

18 Apigenin 7-O-apiosylglucoside in celery leaves was resis

19 Apigenin 7-O-apiosylglucoside was converted to apigenin

20 idase-rich ingredients, but was converted to apigenin 7-O-glucoside at pH 2.7 when processed at 100 d

21 Apigenin 7-O-glucoside in chamomile extract was readily

22 Apigenin 7-O-glucoside showed little conversion or degra

23 igenin 7-O-apiosylglucoside was converted to apigenin 7-O-glucoside when heated at pH 3 and 100 degre

24 ganin, mussaenoside, luteolin 7-O-glucoside, apigenin 7-O-glucuronide and tricin 7-O-diglucuronide ha

25 affeoylquinic acid, 5-O-caffeoylquinic acid, apigenin 7-O-glucuronide in primary heads as well 1,5-di

26 uranetin 7-O-neohesperidoside (poncirin) and apigenin 7-O-neohesperidoside (rhoifolin).

27 idoside, 5.1 +/- 0.1mg/100g), and rhoifolin (apigenin 7-O-neohesperidoside, 2.0 +/- 0.1mg/100g).

28 ic acid) and flavonoids (apigenin, luteolin, apigenin-7-apioglucoside, and apigenin-7-O-glucoside) in

29 nd quercetin glucuronide, and (iii) parsley: apigenin-7-apiosylglucoside (apiin) and isorhamnetin-3-O

30 the melon peels by 33.45mg/100g, followed by apigenin-7-glycoside (29.34mg/100g).

31 in and less naringenin-7-O-B-d-glucoside and apigenin-7-O-B-d-glucoside than wild-type Nipponbare.

32 Apigenin-7-O-beta-d-glucuronide, caffeic and carnosic ac

33 The flavonoids luteolin-7-O-glucoside, apigenin-7-O-glucoside (cosmosiin), luteolin 3'-O-beta-d

34 hin, eriocitrin, rutin, apigenin, quercetin, apigenin-7-O-glucoside and kaempferol) were quantified u

35 nin, luteolin, apigenin-7-apioglucoside, and apigenin-7-O-glucoside) increased after cooking.

36 ty was attributed to luteolin-7-O-glucoside, apigenin-7-O-glucoside, caffeicacid, myrecitin and phlor

37 We have tentatively identified apigenin-7-O-glucoside, luteolin-3-O-glucuronide, malony

38 c compounds were identified in artichoke FB (apigenin-7-O-glucoside, syringic acid, catechin gallate,

39 caffeoylquinic acid (21.83 mg/g extract) and apigenin-7-O-glucuronide (10.6 mg/g extract) were the mo

40 The flavonoids apigenin-7-O-glycoside (1955.55 ng/mg) and luteolin-7-O-

41 7-O-neohesperidoside, 28.5 +/- 0.7 mg/100g), apigenin 8-C-neohesperidoside (16.9 +/- 0.1mg/100g), pon

42 cetin 6-C-neohesperidoside (isomargaritene), apigenin 8-C-neohesperidoside, and O-glycosides, such as

43 buting to antioxidant activity were DGPP and apigenin 8-C-neohesperidoside, which could be extracted

44 tamin B6), cyanocobalamin (vitamin B12), and apigenin (a plant flavonoid).

45 Apigenin, a common dietary flavonoid abundantly present

46 Consistent with this, we showed that apigenin, a dietary flavonoid that has been shown to inh

47 Apigenin, a flavonoid abundantly found in fruits and veg

48 identification of human cellular targets of apigenin, a flavonoid abundantly present in fruits and v

49 We investigated the effects of apigenin, a naturally occurring plant flavone, on prosta

50 nocytes, and this induction was inhibited by apigenin, a nonmutagenic bioflavonoid that has been show

51 ibitor U0126 had no effect and the flavonoid apigenin, a nonspecific inhibitor of ERK1/2 and COX-2, a

52 Apigenin, a selective CK2 inhibitor, diminishes interpha

53 e show that treatment of WEHI 231 cells with apigenin, a selective inhibitor of the protein kinase CK

54 etin, myricetin and gossypetin, and flavones apigenin, acacetin, luteolin, orientin and tricin, are s

55 , gallic acid, p-cumaric acid, sinapinic and apigenin acids were detected in Gemlik olive fruit.

56 Finally, apigenin administration to obese mice increases NAD(+) l

57 n chamomile extract was readily converted to apigenin aglycone after combination with almond, flax se

58 Apigenin also down-regulated STAT3 target genes MMP-2, M

59 state cancer cells with 10 and 20 micromol/L apigenin also increased protein levels of E-cadherin by

60 Apigenin also inhibits the increase in promoter activity

61 , a MEK inhibitor, and greatly attenuated by apigenin, an inhibitor of the Ras --> Raf --> MEK --> ER

62 and PLD2 enzymatic activity inhibitors (30nM apigenin and 300nM 5-fluoro-2-indolyl des-chlorohalopemi

63 he HPV45 oncoprotein E7 (PDB ID 2EWL), while Apigenin and Apigenin 5-O-Beta-D-Glucopyranoside exhibit

64 nd the structurally related natural flavones apigenin and chrysin break TRAIL resistance in HTLV-1-as

65 Hence, only hydroxyl flavones, such as apigenin and chrysin, and flavonols, such as galangin, k

66 ide, tryptophan, 6-C-glucosyl-8-C-arabinosyl-apigenin and diferulic acids.

67 ncreases non-specific endonuclease activity, apigenin and epicatechin increase the excision of damage

68 UHPLC-PDA methodology allow to identify that apigenin and epigallocatechin gallate are the most abund

69 ffeoylquinic acid, hydroxyphenylacetic acid, apigenin and genistein, could be considered as potential

70 specificity for flavones such as chrysin and apigenin and is responsible for biosynthesis of baicalei

71 In addition, exposure of apigenin and kaempferol to cultured hepatocytes, mimicki

72 of quercetin (3) and those of isorhamnetin, apigenin and luteolin (1).

73 in, kaempferol, and myricetin) and flavones (apigenin and luteolin) was assessed from food-frequency

74 ease of hydroxytyrosol, oleuropein aglycone, apigenin and phenolic acid metabolites in the first hour

75 Apigenin and quercetagetin demonstrated most significant

76 e that among the major flavonoids of citrus, apigenin and quercetagetin have potent anti-cancer activ

77 suggest that the change in Bax/Bcl2 ratio by apigenin and quercetagetin seems to be due to their abil

78 48h confirmed the induction of apoptosis by apigenin and quercetagetin.

79 cording to their major flavonoid (quercetin, apigenin and rutin) and phenolic (chlorogenic, caffeic a

80 fragmentation is reduced in the presence of apigenin and slightly increased by sakuranetin.

81 Results from these studies showed that apigenin and tt-farnesol may enhance the cariostatic eff

82 -genistein) and eight flavones (glycosylated apigenins and methyl-luteolins) were characterized as th

83 d with phenolic acids, flavone (luteolin and apigenin) and flavonol (quercetin) derivatives, which we

84 including myricetin, quercetin, kaempferol, apigenin, and carotenoids such as beta-carotene, alpha-c

85 Furthermore, we show that wogonin, apigenin, and chrysin also enhance TRAIL-mediated apopto

86 ounds such as 3-(3-hydroxyphenyl)propionate, apigenin, and naringenin, were more abundant in the dry

87 In concert with these results, apigenin, and not baicalein, blocked the localization of

88 esveratrol (a major polyphenol in red wine), apigenin, and S17834 (a synthetic polyphenol), increased

89 ct was rich in isoorientins, isovitexin, and apigenin, and showed the highest inhibiting effect, bein

90 cetoxypinoresinol, syringaresinol, luteolin, apigenin, and the hydrolysis products of oleuropein expr

91 Idf mutant produces highly reduced levels of apigenin- and tricin-related flavonoids, resulting in a

92 ease anti-tumor efficacy of the isoflavonoid apigenin (APG) in human malignant neuroblastoma SK-N-DZ

93 Apigenin (Api) and tt-farnesol (Far) are two naturally o

94 Apigenin (Api), a natural compound with notable anti-inf

95 demonstrated that the therapeutic effects of apigenin are pleiotropic, resulting in decreased oxidati

96 Ara h 8 binds the isoflavones quercetin and apigenin as well as resveratrol avidly.

97 tor, the flavonoid 4',5,7-trihydroxyflavone (apigenin), as well as RNA silencing, we found that the i

98 and derivatives and flavonoids (luteolin and apigenin), as well as tocopherols were quantified.

99 Instead we show that apigenin, as part of a non-canonical pathway, regulates

100 Three compounds, apigenin, baicalein, and quercetin, decreased Gli1 mRNA

101 cancer treatment and prevention abilities of apigenin, baicalein, curcumin, epigallocatechin 3-gallat

102 In the second protocol, administration of apigenin began 2 wk after tumor inoculation and continue

103 Apigenin binds to the C-terminal glycine-rich domain of

104 The selective CK2 inhibitor apigenin blocks proliferation of Wnt-1-transfected cells

105 reveal a novel anti-metastasis mechanism of apigenin but also support the notion that STAT3 is an at

106 ily hydroxylate position 6 of 7-O-methylated apigenin but not apigenin itself.

107 ene expression in an autoinductive loop, and apigenin, but not baicalein, treatment was associated wi

108 Oral intake of apigenin by gavage at doses of 20 and 50 microg/mouse/d,

109 Apigenin C-glycosides and phenylpropanoids acids were id

110 llowed the tentative identification of seven apigenin-C-glycosides, three methoxyluteolin-C-glycoside

111 hin-O-dihexoside, kaempferol-O-hexoside, and apigenin-C-hexoside-pentoside.

112 ), ferulic acid (6), grasshopper ketone (7), apigenin, cabraleone, chrysoeriol, 1beta,4beta-dihydroxy

113 luteolin 3'-O-beta-d-glucuronide, luteolin, apigenin, cirsimaritin, isokaempferide, penduletin, xant

114 r research aimed to cost-effectively enhance apigenin content in Chrysanthemum indicum L. extract usi

115 tion of 3 mL of soybean extract, yielding an apigenin content of 3.380 +/- 0.031 mg/g - a remarkable

116 As a glycoside derivative of apigenin, cosmosiin is characterized by low toxicity, hi

117 els and that treatment of cell cultures with apigenin decreases global acetylation as well as the ace

118 psis cauline and senescing leaves accumulate apigenin, demonstrating that Arabidopsis plants have an

119 Additional studies show that the apigenin-dependent suppression of differentiation is ass

120 infusion were 5-O-caffeoylquinic acid and an apigenin derivative.

121 sing energy-binding interactions between all Apigenin derivatives and the targeted proteins.

122 h the advanced in-silico analyses of several Apigenin derivatives to explore human papillomavirus-ass

123 olymerase theta, indicating the potential of Apigenin derivatives to inhibit this enzyme (PDB ID 8E23

124 PLC-MS technique indicated that luteolin and apigenin derivatives were the dominant flavonoids, while

125 oxidation most effectively, probably due to apigenin derivatives.

126 White teff mostly contained apigenin-derived flavones (86-92%), whereas luteolin der

127 c pathway, was identified as schaftoside, an apigenin di-C-glycoside.

128 Using EMSA, we found that apigenin does not alter NF-kappaB-DNA binding activity i

129 cted to have anti-fibrotic activity; indeed, apigenin dose-dependently reduced collagen I in the huma

130 The absence of the catechol group on apigenin drastically decreased arginase inhibition.

131 oncentration-dependent neutrophil apoptosis (apigenin, EC=12.2 muM; luteolin, EC=14.6 muM; and wogoni

132 Our results indicate that apigenin effectively suppressed prostate carcinogenesis

133 Further study indicated that apigenin effectively suppressed STAT3 phosphorylation, d

134 cosides), chrysoeriol (O-/C-glycosides), and apigenin (exclusively C-glycosides).

135 ents were investigated for the extraction of apigenin, followed by soybean treatment to increase agly

136 P.o. administration of apigenin further resulted in increased levels of E-cadhe

137 ic and vanillic acids, and flavonoids, i.e., apigenin, genistein, hesperetin, kaempferol, luteolin, r

138 Among them, apigenin-glucuronide, lucenin-2 and lithospermic acid we

139 In vitro, T21 cells cultured with apigenin had significantly reduced oxidative stress and

140 hese studies provide proof of principle that apigenin has multiple therapeutic targets in preclinical

141 However, the anti-metastasis mechanism of apigenin has not been fully elucidated.

142 Taken together, these findings suggest that apigenin has strong potential for development as an agen

143 )), while minor compounds were caffeic acid, apigenin, hesperetin and naringenin.

144 ents plot indicated that lupinalbin D and F, apigenin hexoside, kaempferol hexoside, albine, and hydo

145 Here, we tested the safety and efficacy of apigenin, identified with this approach, in both human a

146 ession of STAT3 or Twist1 partially reversed apigenin-impaired cell migration and invasion.

147 Here the apoptotic pathways induced by apigenin in combination with etoposide or cyclophosphami

148 These findings reveal a novel role of apigenin in inhibiting HIF-1 and VEGF expression that is

149 Furthermore, the theoretical solubility of apigenin in the supercritical fluid system was obtained

150 rosmarinic) acids and flavones (luteolin and apigenin) in extracts from both sources.

151 rosmarinic acids) and flavones (luteolin and apigenin) in the polar extracts, with rosmarinic acid be

152 Apparent absorption of quercetin and apigenin increased (p < 0.05) 3.3x and 1.5x, respectivel

153 The results also demonstrate that apigenin-induced suppression of MUC1-C expression is ass

154 Apigenin inhibited expression of HIF-1alpha and VEGF via

155 In addition, apigenin inhibited the hyperphosphorylation of the pRb p

156 Apigenin inhibited tube formation in vitro by endothelia

157 We found that apigenin inhibited VEGF expression at the transcriptiona

158 Here we demonstrate that apigenin inhibits expression of vascular endothelial gro

159 In addition, our studies indicate that apigenin inhibits in vivo LPS-induced TNF and the mortal

160 Here, we report for the first time that apigenin inhibits the growth of androgen-responsive huma

161 In this study, we demonstrate that apigenin inhibits the production of proinflammatory cyto

162 NF-kappaB reporter constructs indicated that apigenin inhibits the transcriptional activity of NF-kap

163 We show that apigenin inhibits this response.

164 us study suggested that one pathway by which apigenin inhibits UV-induced and basal COX-2 expression

165 Apigenin intake by these mice also resulted in simultane

166 tro and in vivo growth inhibitory effects of apigenin involve modulation of IGF-axis signaling in pro

167 The dietary flavonoid apigenin is a bioactive compound that possesses low toxi

168 Apigenin is a dietary polyphenol found abundantly in fru

169 Apigenin is a nontoxic dietary flavonoid that has been s

170 Apigenin is a plant-derived flavanoid that has significa

171 atory cytokine production persists even when apigenin is administered after LPS stimulation.

172 ol, 3,4-DHPEA-EDA, oleuropein, luteolin, and apigenin; it was more effective for F2AG than F1AG.

173 osition 6 of 7-O-methylated apigenin but not apigenin itself.

174 the reaction of MGO with trans-resveratrol, apigenin, kaempferol and fisetin were (2.7 +/- 0.2) x 10

175 between four polyphenols (trans-resveratrol, apigenin, kaempferol and fisetin) and methylglyoxal (MGO

176 During the fermentation gallic acid, apigenin, kaempferol, curcumin, vanillin, caffeic acid,

177 Treatment of MCF7 cells with apigenin leads to a dose-dependent arrest at the G(2)/M

178 vanillic acid, p-cumaric acid, luteolin, and apigenin levels were greater in early harvested samples

179 tates, which correlated with elevated plasma apigenin levels.

180 3 correlated with increasing serum and tumor apigenin levels.

181 appaB inhibitor IkappaBalpha was observed in apigenin LPS-stimulated human monocytes.

182 es of flavonoids include the flavones (e.g., apigenin, luteolin), flavonols (e.g., quercetin, myricet

183 Apigenin, luteolin, and chrysoeriol were most stable at

184 e we investigate the ability of the flavones apigenin, luteolin, and wogonin to induce neutrophil apo

185 by flow cytometry following incubation with apigenin, luteolin, and wogonin.

186 id and hydroxycinnamic acid) and flavonoids (apigenin, luteolin, apigenin-7-apioglucoside, and apigen

187 eotide reversed these effects and attenuated apigenin-mediated inhibition of IRS-1 phosphorylation co

188 ermore, both RNAi-mediated TAF1 ablation and apigenin-mediated inhibition of the kinase activity of T

189 uR levels by small interfering RNA inhibited apigenin-mediated stabilization of COX-2 mRNA.

190 rs (greater activity than reference compound apigenin), most of which were unrelated in chemical stru

191 ffects of combined cereal 3-deoxyflavonoids (apigenin, naringenin) and pulse flavonols (quercetin), a

192 ested for their activity on SIRT6, including apigenin, naringenin, luteolin, and kaempferol.

193 identified, secoiridoid, secoxyloganin, and apigenin-O-hexuronoside in higher concentrations.

194 Kaempferol, quercetin and apigenin-O/C-glycosides, fatty acyl amides and carotenoi

195 ted the in vivo growth inhibitory effects of apigenin on androgen-sensitive human prostate carcinoma

196 phorylation conferring inhibitory effects of apigenin on IGF-signaling.

197 which is exemplified here by the effects of apigenin on the alternative splicing activity of hnRNPA2

198 mRNA stability, and the inhibitory effect of apigenin on UVB-induced luciferase reporter gene activit

199 Blocking CK2 activity in LNCaP cells with apigenin or 5,6-dichlorobenzimidazole riboside led to a

200 treatment of cells with MEK/ERK inhibitors (apigenin or PD98059) eliminated TH expression and the as

201 of CK2alpha via the pharmacologic inhibitor apigenin or upon transfection of a CK2 kinase-inactive s

202 tance (100 and 180 degrees C, respectively); apigenin presented the highest thermal protection.

203 ional regulation, another mechanism by which apigenin prevents COX-2 expression is through mediating

204 t antimicrobial and anticancer properties of Apigenin, prompting the selection of its potential deriv

205 l characterization of AHR targeting PROTACS (Apigenin-Protac) designed to degrade and inhibit the AHR

206 and flavonoid (catechin, eriocitrin, rutin, apigenin, quercetin, apigenin-7-O-glucoside and kaempfer

207 Both natural extracts and apigenin-quercetin combinations synergistically (3-40 fo

208 sent study, we examine the mechanism whereby apigenin regulates normal human keratinocyte differentia

209 Apigenin, resveratrol, and piceatannol all induced Nrf2

210 levels of Nrf2, and this can be modulated by apigenin, resveratrol, and piceatannol.

211 rcritical CO2 (USC-CO2) extraction to obtain apigenin-rich extracts from Scutellaria barbata D.

212 ing reduced TIAR showed marked resistance to apigenin's ability to inhibit UVB-induced COX-2 expressi

213 identify C1QTNF2 as a potential mediator of apigenin's anti-fibrotic activity.

214 To identify proteins mediating apigenin's effect, we next overlapped a 122-gene signatu

215 Apigenin significantly improved several developmental mi

216 r-55 phosphorylation by a dietary flavonoid, apigenin, specifically blocks the CRM1-p53 association,

217 ellocathecin-3-gallate, is also inhibited by apigenin, suggesting that the two chemopreventive agents

218 In the present study, we showed that apigenin suppressed murine melanoma B16F10 cell lung met

219 dings suggest a molecular mechanism by which apigenin suppresses inflammation and modulates the immun

220 Apigenin suppresses the 12-O-tetradeconylphorbol-13-acet

221 The 160 identified high-confidence candidate apigenin targets are significantly enriched in three mai

222 green procedure yielded 20.1% and 31.6% more apigenin than conventional SC-CO2 extraction and HRE, re

223 ot blocked by the casein kinase II inhibitor apigenin, the protein kinase C inhibitor GF109203X, or e

224 The ability of apigenin to enhance UVB-induced apoptosis may explain, i

225 domain led to a reduction in the ability of apigenin to enhance UVB-induced apoptosis.

226 We investigated the ability of quercetin and apigenin to modulate platelet activation and aggregation

227 f the bioflavonoid 4',5,7-trihydroxyflavone (apigenin) to mouse skin effectively reduces the incidenc

228 Apigenin-treated mice had significantly diminished weigh

229 Here, we found that apigenin treatment also increased COX-2 mRNA stability,

230 Apigenin treatment also resulted in down-modulation of t

231 Apigenin treatment also resulted in induction of apoptos

232 as a chemopreventive compound indicates that apigenin treatment alters the molecular events initiated

233 Apigenin treatment enhanced UVB-induced apoptosis >2-fol

234 ogenous COX-2 mRNA in 308 keratinocytes, and apigenin treatment increased their localization to cell

235 that enhancement of UVB-induced apoptosis by apigenin treatment involves both the intrinsic and extri

236 In vivo, apigenin treatment mixed with chow was administered pren

237 Further, apigenin treatment of LNCaP cells resulted in G1 arrest

238 f human keratinocytes to study the effect of apigenin treatment on UVB-induced apoptosis: HaCaT human

239 ted by UVB exposure; however, the effects of apigenin treatment on UVB-irradiated keratinocytes are n

240 The cell growth inhibition achieved by apigenin treatment resulted in a significant decrease in

241 In cell culture studies, apigenin treatment resulted in cell growth inhibition an

242 When keratinocytes were exposed to UVB, apigenin treatment stimulated changes in Bax localizatio

243 efects or pup deaths resulting from prenatal apigenin treatment.

244 ntin, orientin, vitexin, swertisin, diosmin, apigenin, tricin and diosmetin) was carried out by LCMS.

245 Continuous intake of apigenin up to 50 weeks by TRAMP mice significantly impr

246 In the first protocol, apigenin was administered for 2 wk before inoculation of

247 Apigenin was administered to mice by gavage at doses of

248 The flavonoid apigenin was among 9 top-ranked compounds predicted to h

249 Using this approach, the flavone apigenin was identified as an inhibitor of MUC1-CD dimer

250 The tumor inhibitory effect of apigenin was more pronounced in the first protocol of ex

251 PS-stimulated mouse macrophages treated with apigenin was overcome by the over-expression of IKKbeta.

252 Among flavonoids, genistein and apigenin were able to effectively displace resveratrol f

253 roxyflavones, scutellarein, scutellarin, and apigenin, were quantified from leaves, stems, and roots.

254 Apigenin when combined with etoposide or cyclophosphamid

255 e effective than the analogues quercetin and apigenin when tested at a concentration fully consistent

256 o help elucidate the mechanisms of action of apigenin when used in combination with etoposide or cycl

257 ing proteins that are known to interact with apigenin, which identified C1QTNF2, encoding for Complem