ライフサイエンスコーパス: apolar

1 not be explained by the change in polar and apolar accessible surface areas.

2 alpha H58L replacement creates a completely apolar active site, which prevents electrostatic stabili

3 ing any polar functional groups) behave like apolar adsorbents and exhibit very interesting and unexp

4 al mechanism is not based on saponification, apolar adsorption or anion exchange, but most probably a

5 lar balances to measure interactions between apolar alkyl chains in 31 organic, fluorous and aqueous

6 central region between the dimers, where an apolar amino acid is located.

7 ectron micrographs reveal that filaments are apolar and made of stacked tetramers oriented with expos

8 Overall, mutation of apolar and polar amino acids to charged amino acids are

9 Water structuring around apolar and polar groups is an important factor in their

10 proteins albumin and lysozyme to LHA and to apolar and polar model surfaces.

11 molecular recognition of monosaccharides in apolar and polar protic solvents.

12 l contains an unusual alternating pattern of apolar and polar residue pairs that generate a rare righ

13 via two different routes in shape space--an apolar and polar route.

14 The apolar and polar routes may have evolved in order to fac

15 block, and random copolymers combining both apolar and polar vinylic repeat units.

16 ses in our scoring, particularly overweighed apolar and underweighted polar terms.

17 ydrophilic, whereas at pH 7.4 it is neutral, apolar, and hydrophobic.

18 Both polar and apolar aromatic compounds, including pyridine, benzene,

19 Small, apolar aromatic groups, such as phenyl rings, are common

20 eractions are the major driving force behind apolar association in solution.

21 ganization, namely bundled filaments, linked apolar asters, and a lattice of polar asters.

22 lity, the compressibility of water hydrating apolar atoms is somewhat larger than bulk water compress

23 s focused on separation of petrochemicals in apolar backgrounds, but the attention has moved now to t

24 amphiphilic peptides embedded near the polar/apolar bilayer interface.

25 d complex with octanal and NAD(+) reveals an apolar binding site primed for aliphatic aldehyde substr

26 eptide, mutations within thrombin's aryl and apolar binding site were explored.

27 referentially docked to the polar versus the apolar binding site were tested experimentally.

28 en BRCA1 and PALB2 is primarily mediated via apolar bonding between their respective coiled-coil doma

29 Though the interaction potential is strictly apolar, both, polar and nematic order may emerge and eve

30 We found that apolar bundles show a remarkable sensitivity to environm

31 From their difference in apolar buried surface area, hydrophobic interaction is p

32 that DosC is a globin-coupled sensor with an apolar but accessible heme pocket that binds oxygen with

33 mperature using the slightly polar CDCl3 and apolar C6D6 as solvents in 5 mM and 54 mM concentrations

34 The extent to which water is present within apolar cavities in proteins remains unclear.

35 In contrast to apolar cavities in rigid carbon structures, such as nano

36 99A/M102Q) but do not detectably bind to the apolar cavity (L99A).

37 al phases, we estimate that occupancy of the apolar cavity in IL-1beta by solvent is close or equal t

38 The database was first screened against the apolar cavity site created by the mutation Leu99Ala (L99

39 ate that water is not present in the central apolar cavity.

40 wo fully occupied water molecules within the apolar cavity.

41 meres that allocate polar cells to outer and apolar cells to inner positions initiate the first cell

42 mal hyphal growth and endocytosis defects in apolar cells.

43 and outer polarised cells become inner-like apolar cells.

44 to be dominant in driving the association of apolar chains in aqueous solution.

45 der Waals forces in the self-association of apolar chains.

46 In contrast, blocking the entrance to the apolar channel by increasing the size of Ala-55(E18) to

47 ze of the E7 gate and closing the end of the apolar channel in CerHb by site-directed mutagenesis.

48 gly polar channels are coupled to completely apolar channels, in which case auxin in the apolar part

49 Sec17(F21S,M22S), with diminished apolar character to its hydrophobic loop, fully supporte

50 ionic guests increases continuously with its apolar character, as shown by the significant change of

51 ee cysteine side chain does possess strongly apolar characteristics.

52 contributions of dispersion interactions in apolar cohesion were found to be strongly attenuated in

53 erature for the resolution of both polar and apolar complex mixtures components by NMR spin diffusion

54 re amphoteric in nature with the dispersive (apolar) component of surface energy dominating the speci

55 n-specific in polar compounds but less so in apolar compounds and a diffusive IE that is not position

56 e in water's heat capacity upon hydration of apolar compounds is one signature of the hydrophobic eff

57 ing the molecular interactions made by these apolar compounds with biological membranes or their effe

58 using HPLC-ESI-QTOF-MS analysis of polar and apolar compounds.

59 ctive site, the xylan backbone makes limited apolar contacts with the enzyme, and the hydroxyls are s

60 ce of interhelical salt bridges here exposes apolar core atoms to solvent.

61 use of this stabilizing contribution in the apolar core of the bilayer.

62 nteract in a complicated fashion through the apolar core of the folded antibody.

63 d they also form an integral part of a small apolar core.

64 Conventionally, the contribution of apolar desolvation to affinity is attributed to gain of

65 te in the E7 channel that can accommodate an apolar diatomic ligand and enhances ligand uptake partic

66 ) and PIN2-GFP displayed abnormal, partially apolar distribution.

67 The apolar domain consists of a hydrogenated chain, and a pa

68 The apolar domain consists of a perfluorohexyl main chain an

69 drophobicity while keeping the length of the apolar domain short.

70 ch explains why the denser packing of larger apolar domains of the guests does not necessarily lead t

71 ned to minimize autoxidation of the unstable apolar E7 mutants.

72 th 7alpha-OH groups of bile acids, and (iii) apolar EL1 residues map to hydrophobic ligand pharmacoph

73 ophobic transmembrane (TM) segments into the apolar environment of the lipid bilayer.

74 approximately 2125 cm(-1), indicative of an apolar environment, is observed for CNRs bound to H64A o

75 with burial of the tryptophan residues in an apolar environment.

76 els are often incompletely reduced in highly apolar environments.

77 2, WAVE2, and activation of CDC42 results in apolar F-actin localization, leading to defects in adhes

78 in which EPM expression was expressed in an apolar fashion on the surface of mammary epithelial cell

79 I present arguments here that ParM may be an apolar filament, in which the two helical strands are an

80 omplexes, which serve as building blocks for apolar filamentous structures that differ among cell typ

81 s, which in turn are able to polymerize into apolar filaments and higher-order structures.

82 Endocytosis was severely impaired in apolar fimA disruption cells.

83 dapted a UV photolabeling approach, using an apolar fluorescent probe, 4,4'-dianilino-1,1'-binaphthyl

84 condary structure and its ability to bind an apolar fluorophore.

85 nctionally critical approximately 20-residue apolar "fusion peptide" (HFP) that associates with targe

86 gesting that hydrophobic partitioning of the apolar gas from the aqueous phase into the relatively ap

87 tingly, treadmilling bundles with an initial apolar geometry eventually evolve to a whole gamut of ne

88 In this study an apolar glycolipid, presumably corresponding to dimycolyl

89 th a severe decrease in the level of a major apolar glycolipid.

90 higher affinity natural ligand, occupying an apolar groove between its alpha(1) and alpha(2) domain h

91 ce shows that the enthalpy of dehydration of apolar groups at the HMG-D/DNA interface is not fully co

92 The transfer free energy of apolar groups from water to TMAO consists of favorable e

93 es around polar and apolar groups: polar and apolar groups have a deficit or excess, respectively, of

94 The differential solubility of polar and apolar groups in water is important for the self-assembl

95 The interaction between TMAO and apolar groups is slightly favorable.

96 folded state results in hydration of exposed apolar groups of the interface and the disruption of hel

97 by extensive van der Waals contacts between apolar groups, i.e. a more tightly packed interface form

98 butions for the interaction between urea and apolar groups.

99 ferent hydration structures around polar and apolar groups: polar and apolar groups have a deficit or

100 apolar pockets can be designed to recognize apolar guests in water, complementary strategies are req

101 Cry1Ab adsorption to relatively apolar HAs at I = 50 mM exhibited rapid initial rates, w

102 ccharomyces cerevisiae, four septins form an apolar hetero-octamer (Cdc11-Cdc12-Cdc3-Cdc10-Cdc10-Cdc3

103 tricted assembly into distinct categories of apolar heterohexamers and heterooctamers.

104 ntributed to Cry1Ab protein adsorption to an apolar humic acid (HA).

105 operative activation of protic, hydridic and apolar HX bonds across a Group 13 metal/activated beta-d

106 ith the most prominent effects shown for the apolar hydrocarbon solvents and 2-propanol.

107 er a minimalistic model interface between an apolar hydrophobic phase (n-decane) and an aqueous phase

108 the potential of mean force between ionic or apolar hydrophobic solutes in dilute aqueous solutions d

109 e significantly more stable compared with an apolar initial configuration.

110 egates polarized trophectoderm cells from an apolar inner cell mass (ICM).

111 port the concept of a pai-pai stacking as an apolar interaction between Y373 and W322 to be responsib

112 d might participate in sugar binding through apolar interactions.

113 this amphipathic structure matches the polar/apolar interface of the lipid bilayer very well.

114 ever, the presence of the Met residue in the apolar interface of the tetramer markedly alters its loc

115 e PE and PPE proteins mate along an extended apolar interface to form a four-alpha-helical bundle, wh

116 /L, the peptide primarily binds on the polar-apolar interface with its helical axis parallel to the b

117 rom simple starting materials at other polar-apolar interfaces; this could have numerous materials an

118 s the 4E10 epitope was immersed in the polar-apolar interfacial region of the lipid bilayer.

119 Strong loss-of-function mutants assemble apolar intersecting microtubule arrays, whereas weaker m

120 In the apolar L99A cavity, affinity for Ab dropped only slightl

121 arity, with higher Cry1Ab affinities to more apolar LHA regions due to the hydrophobic effect.

122 This site sequesters apolar ligands via a concave hydrophobic surface in SAA

123 uried sites: a hydrophobic cavity that binds apolar ligands, a slightly polar cavity that binds aryl

124 solvation energies improved ranking of known apolar ligands, and better distinguished them from more

125 igh-density lipoproteins (HDL); they have an apolar lipid core and polar surface composed of exchange

126 complexes containing a triacylglycerol-rich apolar lipid core and polar surface composed of phosphol

127 Mature spherical HDL contain the apolar lipid core and polar surface of proteins and phos

128 tion reflects HDL rupture and release of the apolar lipid core.

129 involves particle rupture and release of the apolar lipid core.

130 Apolar lipids are known to form lipid droplets or lipopr

131 rmation of larger particles and repacking of apolar lipids but no global protein unfolding.

132 of compact bones indicated a high content of apolar lipids, including triglycerides and cholesterol e

133 bserved in glycopeptidolipids, polar lipids, apolar lipids, or mycolic acids of the cell wall.

134 phosphatidylinositol mannosides, and highly apolar lipids, similar to the Minnikin model of 1982.

135 bmicrolitre aqueous droplets submerged in an apolar liquid containing lipid can be tightly connected

136 ctly requires Sec18 and Sec17, and the Sec17 apolar loop has functions beyond membrane anchoring.

137 ayer of the SNARE complex and its N-terminal apolar loop.

138 s-SNARE complexes, oligomerizes, and inserts apolar loops into the apposed membranes, locally disturb

139 ns (significant in transitions from polar to apolar media), accurate transmembrane dipole potential,

140 T by the addition or removal of water to the apolar medium.

141 to HOPS and a C-terminal SNARE domain but no apolar membrane anchor.

142 urfactant migration entails a net shift from apolar membrane spanning regions to more polar regions o

143 ckbone hydrogen bonds should be strong in an apolar membrane, potentially rigidifying helices.

144 colipids with polar moieties in an otherwise apolar milieu.

145 dissolved in DMSO-d6/GL (8:2, v/v) and of an apolar mixture made of beta-ionone, (+/-)-citronellal, (

146 lized by a favorable packing of the ligand's apolar moieties with the hCAII "hydrophobic wall".

147 rophobic pocket in HCAII that stabilizes the apolar moiety of sulfonamide inhibitors is replaced with

148 that has frequent dynamic interactions with apolar molecules; both hexane and a long-chain fatty aci

149 e this hypothesis, acidic, basic, polar, and apolar mutations were introduced at positions 94-98.

150 mechanism minimizes aqueous exposure of the apolar mycolates.

151 s are consistent with the model in which the apolar N-terminal and central regions of the peptides pe

152 on rate of HFPtr because of placement of the apolar N-terminal regions of all strands on the same sid

153 ith intermolecular hydrogen bonding of 15-16 apolar N-terminal residues and this hydrogen-bonding pat

154 The apolar nature of TMDs necessitates the use of membrane-m

155 s the initial breakage of the symmetry of an apolar neutrophil and is required for subsequent polariz

156 Cdc3, Cdc10, Cdc11, and Cdc12 form an apolar octameric rod with Cdc11 at each tip, which polym

157 d groups, whereas stimulatory compounds were apolar oils.

158 others are required for transitions via the apolar or polar route and not amoeboid or mesenchymal mo

159 ed transformations involve the activation of apolar or weakly polar sigma-bonds (E-H and E-E' bonds,

160 stigating the coordination and activation of apolar or weakly polar sigma-bonds at copper using chela

161 thacrylate) (PMMA) colloids, suspended in an apolar organic medium.

162 ferentially populates a helical structure in apolar organic solvent, while in pure water, the peptide

163 mply bubbling CO2 through their solutions in apolar organic solvents (CHCl3, benzene) and even in the

164 and 8 also adopted helical conformations in apolar organic solvents.

165 The apolar outer barrel surface with large sidechains is imm

166 me, emphasizing a prominent role for precise apolar packing in membrane protein folding, stabilizatio

167 apolar channels, in which case auxin in the apolar part is 'dragged along' by the polar part in a so

168 protein-binding site, comprising an unusual apolar patch on the surface together with surrounding ch

169 ) (PEO-b-PCL) block polymers modified at the apolar PCL terminus with thioctic acid and at the polar

170 hat was achieved choosing the immunodominant apolar peptide from alpha2-gliadin as a target for selec

171 The polar and apolar phases of the limonene/methanol/water 10/9/1 v/v

172 ABCB19 exhibits a predominantly apolar plasma membrane (PM) localization and stabilizes

173 t two specific locations within the spacious apolar pocket and an ordering effect of endogenous resid

174 Our results indicate that apolar pocket interactions are a common feature of tande

175 a beta-barrel structure with a predominately apolar pocket representing a potential binding site for

176 mic acid analogues interact with the dynamic apolar pocket that surrounds the C4 and C5 hydroxyl grou

177 ged hydrophobic channel that merges with the apolar pocket.

178 two different lipid-binding modes within the apolar pocket.

179 the hydrophobic channel that merges with the apolar pocket.

180 hanced hydrophobic effect upon binding to an apolar pocket.

181 ves as a gate for passage of ligand into the apolar pocket; and (iii) that this loop and the adjacent

182 Equivalent occupied apolar pockets are also seen in the tandem LIM domain st

183 cognized approach to this challenge in which apolar pockets can be designed to recognize apolar guest

184 of classical monopartite NLSs by generating apolar pockets for the P3 and the P5 lysine/arginine sid

185 e residues from Arp7A that occupy equivalent apolar pockets in both LIM domains as well as an interve

186 e for association than Asn residues near the apolar/polar interface.

187 pare nanoparticles that have a gold core, an apolar polyester layer for drug loading, a polar PEO cor

188 s, but can also function when anchored by an apolar polypeptide.

189 pocket that is capable of accommodating the apolar Pro(P+1) residue of the peptide.

190 s from the aqueous phase into the relatively apolar protein interior lowers the free energy barrier f

191 ntial contributions from charged, polar, and apolar protein-water interfaces.

192 ion of cofilin expression in MTLn3 cells (an apolar randomly moving amoeboid metastatic tumor cell) c

193 NaY and zeolite beta were used as polar and apolar reference adsorbents, respectively.

194 itionally, the N-terminal domain contains an apolar region comprising almost half its solvent accessi

195 ermediate between that of bulk water and the apolar region of micelle.

196 re was a good match between the width of the apolar region of the bilayer and the hydrophobic length

197 (HIV) fusion peptide (HFP) is the N-terminal apolar region of the HIV gp41 fusion protein and interac

198 se data show that Asn side chains within the apolar region of the transmembrane helix provide a signi

199 s affording a combination of hydrophobic and apolar regions on one hand and dipolar, protic, and posi

200 nment for membrane proteins and can serve as apolar reservoirs for lipid-derived second messengers or

201 Remarkably, a single mutation of an apolar residue at the bottom of an otherwise hydrophobic

202 Prior work showed that converting K84 to an apolar residue or converting V96 to an acidic residue im

203 often occupying the same face, whereas polar/apolar residue pairs tend to occupy opposite faces.

204 the HDAC4 tetramer lacks regularly arranged apolar residues and an extended hydrophobic core.

205 is postulated that propensities possessed by apolar residues are due in part to peptide-solvent inter

206 A central constriction of six apolar residues has been shown to form a seal, but also

207 rees C, consistent with favorable packing of apolar residues in the membrane.

208 essivity in which wedging of Leu78 and other apolar residues into the base pairs of the DNA restricts

209 The approximately 20 N-terminal apolar residues of gp41 are called the HIV fusion peptid

210 winding of the DNA is facilitated by several apolar residues, including Leu78, that wedge into the ba

211 ments used to determine the propensities for apolar residues, plus glycine, asparagine, and glutamine

212 three Pro moieties and a high percentage of apolar residues.

213 bstitutions in the guide strand of U for the apolar ribo-2,4-difluorotoluyl nucleotide (rF) as well a

214 ed on identifying novel substituents for the apolar S2 pocket of cathepsin L and was conducted entire

215 These filaments are assembled from apolar septin hetero-octamers.

216 or the hydrogen bonds, thus resulting in an "apolar" sheet.

217 d using this code and stabilized entirely by apolar side chains conform to the intended fold.

218 The hydrophobic interface is stabilized by apolar side chains from adjacent sheets, whereas the hyd

219 vely charged, positively charged, polar, and apolar side chains) into live cells.

220 Our measurements reveal parity for apolar side-chain contributions between soluble and memb

221 fect contributes little to the energetics of apolar side-chain packing in membranes.

222 roteins are alpha-helical with predominantly apolar side-chains packing in a hydrophobic interface.

223 ices in parallel and in register so that the apolar sides face each other, and the oppositely charged

224 ability of copper to promote the addition of apolar sigma-bonds to CC multiple bonds via a 2e redox s

225 ps by increasing contact within the aryl and apolar sites.

226 High levels of racemisation in more apolar, slowly racemising amino acids suggest that some

227 l electrostatic fields in the presence of an apolar solute.

228 dynamics simulation the solubility of small apolar solutes in a solvent whose particles interact via

229 ate (K(D) > or = 10(6) M(-1) per capsule) in apolar solution with the formation of linear self-assemb

230 ion with cyclohexanol and cyclohexene in the apolar solvent decalin has been studied using in situ (1

231 solvents, and by varying the composition of apolar solvent mixtures both the difference in refractiv

232 applied to a pure component suspension in an apolar solvent, a strong inhomogeneous electric field in

233 pam on the MIP columns was achieved using an apolar solvent, and the binding capacity of the polymer

234 n with either fluorine content or changes in apolar solvent-accessible surface area.

235 s and, similarly, correlates with changes in apolar solvent-accessible surface area.

236 d correlates well with calculated changes in apolar solvent-accessible surface area.

237 on of contributions from charged, polar, and apolar solvent-accessible surfaces.

238 orm with t-BuNCO and an inorganic base in an apolar solvent.

239 CO(2) rapidly reacts with chains 1n in apolar solvents and cross-links them with the formation

240 gh a concerted mechanism in gas phase and in apolar solvents but a stepwise mechanism in polar solven

241 phylloxanthobilin Z isomers photodimerize in apolar solvents by regio- and stereospecific thermorever

242 we show that using non-interacting anions in apolar solvents can maximize favorable interactions betw

243 to the O5 atom of alpha-D-hexopyranosides in apolar solvents is evidenced in (1)H NMR spectra.

244 The use of apolar solvents is particularly useful for assigning the

245 Studies in apolar solvents such as CD(2)Cl(2) and benzene-d(6) reve

246 pyrrolidinopyridine (PPY) are much larger in apolar solvents than in DMF.

247 The rods are stable in both aqueous and apolar solvents, and by varying the composition of apola

248 r (cis) around the carbonyl-nitrogen bond in apolar solvents, in contrast to other aliphatic secondar

249 This is in contrast to partitioning into apolar solvents, which exhibits the classic hydrophobic

250 hese isoprostanyl phospholipids aggregate in apolar solvents.

251 at about 530 nm with good quantum yields in apolar solvents.

252 nts and an inverted micelle-like assembly in apolar solvents.

253 cooperative formation of cyclic hexamers in apolar solvents.

254 tion that the two glycocalixarenes assume in apolar solvents.

255 derate to very good yields in both polar and apolar solvents.

256 d a charged separation, which is unlikely in apolar solvents.

257 ]2.L (coordinated L = Et2O: 2b, dman: 2c) in apolar solvents.

258 and mei-1(-) mutants assemble monopolar and apolar spindles, respectively.

259 iate their cytoskeleton polarization from an apolar state in circulation for their extravasation duri

260 -C) was identified, which has a crystalline, apolar structure and exhibited significant antioxidant a

261 ved in the presence of Ca(2+), suggests that apolar surface area buried in the Ca(2+)-bound state bec

262 The increased solvent exposure of apolar surface area in the Ca(2+)-free protein is consis

263 the proportionality between free energy and apolar surface area is discussed.

264 l affinity of a binding site in terms of its apolar surface area is proposed.

265 is inferred to result from the reduction of apolar surface area of the enzyme ensuing from a conform

266 c parameterization to estimate the polar and apolar surface area of the interface.

267 The exposure of substantial apolar surface area suggests the intriguing possibility

268 such denaturation decreased with increasing apolar surface area, all proteins exhibited high melting

269 t accompany DNA binding, derived from buried apolar surface area, coupled folding, and restriction of

270 a simple model including terms for polar and apolar surface area, surface complexity, and pocket dime

271 lated estimate indicates burial of polar and apolar surface areas in equal measure upon ligand bindin

272 used to generate cavities with increasingly apolar surface areas inside a dodecameric ferritin-like

273 served hydrophobic region forms an extensive apolar surface at a dimer interface on the opposite side

274 cause the correlation of entropy change with apolar surface burial is relatively weak, it cannot, on

275 is found between the binding free energy and apolar surface burial upon complex formation.

276 rgetics correlates better with the amount of apolar surface buried upon sugar stacking on top of the

277 inct from the Ca(2+)-bound protein, exposing apolar surface for interaction with ANS.

278 V, perhaps due to greater solvent-accessible apolar surface in the native form.

279 ng indicate no significant burial of protein apolar surface nor altered accessibility of Trp-121 upon

280 configure a docking site that complements an apolar surface of the CKA1 PTB domain.

281 tic difference, on average, in the burial of apolar surface or polar surface area, implying that van

282 gest that burial of about 1000--1600 A(2) of apolar surface takes place in the N fragment (probably a

283 his corresponds to 648 +/- 36 A(2) of buried apolar surface upon Nkx2.5(C56S) binding duplex B-DNA.

284 ATH is accompanied by diminished exposure of apolar surface, relative to Ca(2+)-free rat beta-PV, per

285 c lectins" which employ oligophenyl units as apolar surfaces.

286 r branching in the chemical structure of the apolar tails.

287 mann equation, with a surface-area-dependent apolar term and contributions from conformational change

288 ation combined with a surface area-dependent apolar term.

289 vided that the organic layer is sufficiently apolar, the resultant Meisenheimer adduct is considerabl

290 polarity: It is deactivated/switched-off in apolar toluene, while in polar benzonitrile it is activa

291 amino acids extending diagonally across the apolar top of Lox-1, a central hydrophobic tunnel that e

292 ed photoproduct, together implicate both the apolar tunnel and the static and dynamic properties of t

293 ork within the distal heme pocket and a long apolar tunnel linking the external solvent to the distal

294 ccessible side chain positions; and (iv) the apolar tunnel linking the heme site to the solvent biase

295 e distal heme pocket, (ii) from the adjacent apolar tunnel prior to conformational relaxation, and (i

296 onformational relaxation, and (iii) from the apolar tunnel subsequent to conformational relaxation.

297 utating these negatively charged residues to apolar uncharged residues completely blocks activity, ev

298 t; and (iii) that this loop and the adjacent apolar V59-W63 loop form a surface patch with two expose

299 NAP and/or synaptotagmin, which insert their apolar "wedge" domains into the bilayers, initiating the

300 cations, i.e. RHO-ZMOF, and (iii) two rather apolar zeolitic imidazolate framework (ZIF) materials wi