ライフサイエンスコーパス: apoptotic pathway

1 efore oxidizing the lipid and initiating the apoptotic pathway.

2 to occur via activation of a p53-independent apoptotic pathway.

3 on neoplastic cells and induce the extrinsic apoptotic pathway.

4 and gradually terminated through a caspase-9 apoptotic pathway.

5 ressed all the effectors of the PTCH-induced apoptotic pathway.

6 rioles prevent activation of a p53-dependent apoptotic pathway.

7 2 induced cas8 gene at 24 hpf, suggesting an apoptotic pathway.

8 ability, through inhibition of the extrinsic apoptotic pathway.

9 cell death induced by the ligands follows an apoptotic pathway.

10 the BAX mRNA and concurrently activates the apoptotic pathway.

11 aspase 3, the final executor protease of the apoptotic pathway.

12 2 family proteins regulate the mitochondrial apoptotic pathway.

13 can find a way to impair the IRF-3-dependent apoptotic pathway.

14 nd activation of the intrinsic mitochondrial apoptotic pathway.

15 pase-8 activation, implicating the intrinsic apoptotic pathway.

16 ax-dependent committed step of the intrinsic apoptotic pathway.

17 small RNAs-mediated knockdown suppressed the apoptotic pathway.

18 PS), which is caused by mutations in the FAS apoptotic pathway.

19 verlapping, essential roles in the intrinsic apoptotic pathway.

20 ex, freeing Bim to trigger the mitochondrial apoptotic pathway.

21 P53) encodes p53, the central protein in the apoptotic pathway.

22 scavenger and a gatekeeper of the intrinsic apoptotic pathway.

23 rization and for activation of the intrinsic apoptotic pathway.

24 ockdown also triggered a caspase-independent apoptotic pathway.

25 that include the inhibition of the intrinsic apoptotic pathway.

26 regulates the p53-induced transcription and apoptotic pathway.

27 system and eventually activate the intrinsic apoptotic pathway.

28 plays an important role in inducing the Fas apoptotic pathway.

29 genes is the consequence of activation of an apoptotic pathway.

30 preceded the committed step of the intrinsic apoptotic pathway.

31 this initiator protease of the mitochondrial apoptotic pathway.

32 hat CurDD can induce HepG2 cell death via an apoptotic pathway.

33 onged mitotic arrest partially activates the apoptotic pathway.

34 of caspase 3 and PARP1, and execution of the apoptotic pathway.

35 hrome c release to augment the mitochondrial apoptotic pathway.

36 that it induces the intrinsic mitochondrial apoptotic pathway.

37 ostasis, resulting from mutations in the Fas apoptotic pathway.

38 al apoptosis via activation of the extrinsic apoptotic pathway.

39 aspase-3, -8, and Poly(ADP-ribose)polymerase apoptotic pathway.

40 aspase-8 independently of the death receptor apoptotic pathway.

41 ediated by the caspase-8-dependent extrinsic apoptotic pathway.

42 idative stress occurs early in the intrinsic apoptotic pathway.

43 decreased in mice lacking the Bid-dependent apoptotic pathway.

44 pathway but not the death receptor-mediated apoptotic pathway.

45 ative cell death by acting downstream on the apoptotic pathway.

46 on and abrogates p53-dependent activation of apoptotic pathway.

47 cinoma, resulting in the deregulation of the apoptotic pathway.

48 ranslocation revealed the involvement of the apoptotic pathway.

49 tes the apoptosis signal-regulating kinase-1 apoptotic pathway.

50 higher levels of apoptosis via the intrinsic apoptotic pathway.

51 ns implicate the initiation of the extrinsic apoptotic pathway.

52 s with phosphate activates the mitochondrial apoptotic pathway.

53 he resulting activation of the mitochondrial apoptotic pathway.

54 t of cancer therapies based on the extrinsic apoptotic pathway.

55 tosis of CLL cells through the mitochondrial apoptotic pathway.

56 duced apoptotic cell death via the intrinsic apoptotic pathway.

57 kemia cell death through a caspase-dependent apoptotic pathway.

58 ts which involves the PI3K/Akt signaling and apoptotic pathway.

59 is without affecting the caspase-independent apoptotic pathway.

60 considered the guardian of the mitochondrial apoptotic pathway.

61 es with cytokine triggering of the intrinsic apoptotic pathway.

62 nositol 3 kinase/Protein kinase B (PI3K/Akt) apoptotic pathway.

63 mycin, with each agent triggering a distinct apoptotic pathway.

64 which in turn triggers the induction of the apoptotic pathway.

65 urothelial cells by activating the intrinsic apoptotic pathway.

66 se to neural insults by activating a caspase apoptotic pathway.

67 ss, suppresses the p-eIF2alpha/ATF4/CHOP pro-apoptotic pathway.

68 aspase cascade, which mediates the intrinsic apoptotic pathway.

69 tivating the BAX/BAK-dependent mitochondrial apoptotic pathway.

70 Here, we focus on the BCL2 anti-apoptotic pathway.

71 point but independent of the downstream core apoptotic pathway.

72 ceptor superfamily involved in the extrinsic apoptotic pathway.

73 me c release and activation of the intrinsic apoptotic pathway.

74 unctional p53 nor activation of conventional apoptotic pathways.

75 l TMZ generates the more robust induction of apoptotic pathways.

76 pression of inflammatory genes and promoting apoptotic pathways.

77 IR often triggers the onset of p53-dependent apoptotic pathways.

78 ound not to be associated with activation of apoptotic pathways.

79 on and inflammatory responses, and increased apoptotic pathways.

80 uction of ROS, DNA double-strand breaks, and apoptotic pathways.

81 at nsPEF exposure triggers both necrotic and apoptotic pathways.

82 eventing the induction of caspase 2-mediated apoptotic pathways.

83 ting both caspase-dependent and -independent apoptotic pathways.

84 s cleaved by caspases upon the activation of apoptotic pathways.

85 ion of survival pathways and augmentation of apoptotic pathways.

86 onsequent activation of ER stress-associated apoptotic pathways.

87 could be inducing angiogenin for inhibiting apoptotic pathways.

88 NK is well known to have roles in activating apoptotic pathways.

89 is known about proteins counteracting these apoptotic pathways.

90 lls in vitro by activating caspase-dependent apoptotic pathways.

91 by direct interaction with highly conserved apoptotic pathways.

92 atins, possibly through the induction of pro-apoptotic pathways.

93 ssors, which largely utilize Bcl-2-dependent apoptotic pathways.

94 ssociated caspase-dependent and -independent apoptotic pathways.

95 related (p-PERK, p-eIF2alpha, ATF4 and CHOP) apoptotic pathways.

96 eins; Ca(2+) influx also initiates competing apoptotic pathways.

97 pha production, and activation of cell death/apoptotic pathways.

98 elial cells (ECs) via competing survival and apoptotic pathways.

99 initiate cell death through induction of pro-apoptotic pathways.

100 cing inflammasome activation and suppressing apoptotic pathways.

101 Caspases are key components of apoptotic pathways.

102 a PERK-eIF2alpha signalling axis and Fas-JNK apoptotic pathways.

103 g those involved in catabolic, anabolic, and apoptotic pathways.

104 s cell death, mediated by a newly discovered apoptotic pathway activated by virus infection.

105 Thus, our mechanistic data characterize an apoptotic pathway, activated by the selective synergy of

106 a critical role in the cellular response to apoptotic pathway activation in the embryo.

107 o explore the use of PET tracers that target apoptotic pathway activation or cell death.

108 ding death receptor up-regulation, extrinsic apoptotic pathway activation, and DNA damage induction.

109 The intrinsic mitochondrial apoptotic pathway acts through two core pro-apoptotic pr

110 L/HCQ co-delivery nanoparticles trigger anti-apoptotic pathway after repetitive intravenous administr

111 tinol induced the activation of an intrinsic apoptotic pathway along with increased surface expressio

112 ignificant enrichment in immune, growth, and apoptotic pathways among the methylation-regulated genes

113 e investigated the role of the mitochondrial apoptotic pathway and cell energy level during different

114 verexpression of Skp2 impaired the intrinsic apoptotic pathway and confers cisplatin resistance.

115 ption factor is upregulated to initiate this apoptotic pathway and directly activates puma transcript

116 ivation of caspase-3 and -9 of the intrinsic apoptotic pathway and enhances expression of antiapoptot

117 entify a novel Fos/FoxO1/Stat3-Bim intrinsic apoptotic pathway and establish the centrality of oxidat

118 associated with activation of the intrinsic apoptotic pathway and induction of late apoptosis/necros

119 To determine the associated apoptotic pathway and its role in renal interstitial fib

120 ondria is required to initiate the intrinsic apoptotic pathway and subsequent cell death, but how cer

121 Caspase-9 is involved in the intrinsic apoptotic pathway and suggested to play a role as a tumo

122 The intrinsic apoptotic pathway and the resultant mitochondrial outer

123 ve as essential gatekeepers of the intrinsic apoptotic pathway and, when activated, transform into po

124 ecrease in activation of ER stress-dependent apoptotic pathways and a preservation of beta-cell mass

125 ore, CF pig airways exhibited an increase in apoptotic pathways and a suppression of ciliary and flag

126 The IAPs are key regulators of the apoptotic pathways and are commonly overexpressed in man

127 s through mechanisms involving mitochondrial apoptotic pathways and by reducing reactive oxygen speci

128 membrane can connect extrinsic and intrinsic apoptotic pathways and can serve as sites of apoptosome

129 Mechanistically, alterations in apoptotic pathways and CDDP metabolism contributed to Ki

130 explants, oxygen deprivation (OD) activated apoptotic pathways and increased neuronal cell death in

131 This led to induction of the mitochondrial apoptotic pathways and increased ROS production.

132 mensacarcin activates caspase-3/7-dependent apoptotic pathways and induces cell death in melanoma ce

133 lls restored checkpoint function, suppressed apoptotic pathways and markedly increased clonogenic sur

134 .1 AHR, the dioxin receptor involved in anti-apoptotic pathways and melanoma progression; and 9q34.3

135 d the profound effects of signaling defects, apoptotic pathways and the ramifications of homeostatic

136 onstrate that EsxA interferes with host cell apoptotic pathways and, together with EsxB, mediates the

137 into the cytosol to engage in the intrinsic apoptotic pathway, and enters the nucleus where it imped

138 Fas is a critical mediator of the extrinsic apoptotic pathway, and its role in mediating lymphoproli

139 beta processing, activation of the extrinsic apoptotic pathway, and regulation of Hedgehog and Wnt li

140 activation of the p53- and caspase-dependent apoptotic pathway, and silencing of p53 decreased cell d

141 aspartic proteases) are induced early in the apoptotic pathway, and so we used their induction to mea

142 These proteins participate in the apoptotic pathway, and the interaction between them may

143 36 on MVECs activates a caspase-mediated pro-apoptotic pathway, and this effect is abrogated by histi

144 inflammatory neuronal loss is independent of apoptotic pathways, and is inhibited by blocking the PS/

145 caspase-3 cleavage to suggest activation of apoptotic pathways, and no increase in neutrophil gelati

146 asmic phosphatidylinositol-3-kinase/AKT anti-apoptotic pathway; and nuclear PTEN affects the cell cyc

147 Although caspase-dependent apoptotic pathways are activated after retinal detachmen

148 ial and endoplasmic reticulum stress-induced apoptotic pathways are activated by the combination of v

149 cal distortions, we have determined that pro-apoptotic pathways are activated by the formation of tri

150 ted, both Caspase-dependent and -independent apoptotic pathways are activated in the sensory ganglia

151 diseases where mitochondrial dysfunction and apoptotic pathways are involved.

152 ase, but treatments that specifically target apoptotic pathways are lacking.

153 ld be reduced in aging,and unique aspects of apoptotic pathways are potentially involved in the patho

154 Mutations that disable the intrinsic apoptotic pathways are sufficient to impart radiation re

155 rapid apoptosis uses the same mitochondrial apoptotic pathway as slow apoptosis.

156 ), the thyroid regulation pathway (DIO2) and apoptotic pathways as involved in genetic risk of large

157 al-regulating kinase 1 and activation of the apoptotic pathway, as evidenced by p38 MAPK and poly-ADP

158 Cytotoxicity was mediated by the intrinsic apoptotic pathway, as shown by an increase in Bcl2-like

159 accelerated by a cytokine-receptor mediated apoptotic pathway, as shown in a transgenic rat overexpr

160 they do not activate the caspase-independent apoptotic pathway associated with the apoptosis-inducing

161 protein interactions associated with the JNK apoptotic pathway, associations between lung development

162 death was a consequence of activation of the apoptotic pathway, because the cell death was rescued wi

163 cell death via inducing HSP70-mediated anti-apoptotic pathway but also promotes a robust EMT/CSC phe

164 phosphorylation to mediate the mitochondrial apoptotic pathway but not the death receptor-mediated ap

165 eover, BCDO2 prevented this induction of the apoptotic pathway by carotenoids.

166 nhibitor P22077 attenuates the p53-dependent apoptotic pathway by destabilizing Tip60.

167 TSA induced caspase-mediated apoptotic pathways; caspase induction was accompanied by

168 Mutational inactivation in cancer of key apoptotic pathway components, such as TP53/p53, undermin

169 th receptor-mediated extrinsic and intrinsic apoptotic pathways, confirmed in vivo for Ezh2-null IFN-

170 mitochondria and a critical component of the apoptotic pathway, contains a heme cofactor covalently a

171 Intrinsic and extrinsic apoptotic pathways converge to activate common downstrea

172 2+) stores, and is mediated by the intrinsic apoptotic pathway; down-regulation of AE2 in primary bil

173 ceptor (CSF-1R), which confers resistance to apoptotic pathways driven by tumor necrosis factor (TNF)

174 ns damaged in ALS activate the mitochondrial apoptotic pathway early in the disease process and that

175 The intrinsic apoptotic pathway engages caspases via members of the BC

176 iated in part by modulation of the intrinsic apoptotic pathway, exhibiting synergy with the BCL-2 inh

177 y mutations in genes affecting the extrinsic apoptotic pathway (FAS, FASL, CASP10).

178 antioxidant levels in cells to activate the apoptotic pathway for cell death.

179 The apoptotic pathway has been shown to be crucial in the de

180 While the p53 apoptotic pathway has clearly been associated with Abeta

181 insects, the most speciose animal group, the apoptotic pathway has only been fully characterized in D

182 activation of p53-dependent and -independent apoptotic pathways have been explored experimentally and

183 hereby inhibit the p-eIF2alpha/ATF4/CHOP pro-apoptotic pathway, identifying miR-30b-5p and miR-30c-5p

184 t the LVS delays activation of the intrinsic apoptotic pathway in a TolC-dependent manner, both durin

185 ith hallmarks of activation of the intrinsic apoptotic pathway in a tumor suppressor protein p53-depe

186 served domain identification to annotate the apoptotic pathway in A. pisum and found low caspase dive

187 ent of the canonical Egl-1/Ced-9/Ced-4/Ced-3 apoptotic pathway in Caenorhabditis elegans.

188 unappreciated role for DR4 and the extrinsic apoptotic pathway in cell fate choice following p53 acti

189 -induced activation of the IRE1alpha/JNK pro-apoptotic pathway in cytokine-exposed beta cells.

190 In this study, we describe an apoptotic pathway in human neutrophils that is triggered

191 plays a key role in regulating the intrinsic apoptotic pathway in intact cells.

192 ignificant functional role for the extrinsic apoptotic pathway in lethality.

193 planation for abrogation of the p53-mediated apoptotic pathway in melanoma, implicating novel approac

194 e potential of targeting the BCL-2-regulated apoptotic pathway in previously untreatable lymphoid mal

195 angiotensin (Ang) II activates the intrinsic apoptotic pathway in primary endothelial cells (ECs) via

196 that monoclonal FLCs activated the intrinsic apoptotic pathway in renal epithelial cells by activatio

197 order to operate an effective p53-dependent apoptotic pathway in response to genotoxic stress.

198 Here, we studied the apoptotic pathway in the aphid Acyrthosiphon pisum, an i

199 as well as Bcl-2 and survivin-mediated anti-apoptotic pathway in the infarcted myocardium.

200 Genetic ablation of the mitochondrial apoptotic pathway in these cells prolongs their survival

201 dings provide a rationale for targeting this apoptotic pathway in this disease.

202 ither drug alone in activating the intrinsic apoptotic pathway in transformed cells, as evidenced by

203 on, and induced both intrinsic and extrinsic apoptotic pathway in vitro with a dose-dependent manner.

204 en by pleiotropic effects on cell growth and apoptotic pathways in a context-specific manner.

205 shed light on a novel approach to reactivate apoptotic pathways in advanced PCa and support targeting

206 Molecular approaches to reengage the apoptotic pathways in cancer have been underway for over

207 al morphogenesis, in part by repressing core apoptotic pathways in cranial neural crest cells.

208 tes survival through acute downregulation of apoptotic pathways in effector T cells and by permanentl

209 oth the intrinsic and extrinsic drug-induced apoptotic pathways in MM cells.

210 t be mediated by inhibiting the p53 mediated apoptotic pathways in neurons through inhibition of Drp1

211 that may lead to the premature activation of apoptotic pathways in neurons, as well as current and pr

212 gh the activation of intrinsic and extrinsic apoptotic pathways in ovarian cancer but only the intrin

213 2 regulates proinflammatory cytokine-induced apoptotic pathways in pancreatic beta-cells by crosstalk

214 y which redox-sensitive molecules signal via apoptotic pathways in response to PD-relevant toxic stre

215 cell-delivered granulysin activate distinct apoptotic pathways in target cells.

216 pro-survival cascades and inhibition of pro-apoptotic pathways in the striatum and/or cortex, which

217 rial dysfunction and activation of intrinsic apoptotic pathways in these podocytes.

218 mozygous deletion of Sirt1 triggers cellular apoptotic pathways, increases cell death, diminishes aut

219 Analysis of the pro- and anti-apoptotic pathways indicated no significant changes in B

220 p38 MAPK and the p53-mediated mitochondrial apoptotic pathway induced by NS1 protein, which sheds li

221 A novel pro-apoptotic pathway initiated by the interaction between g

222 efective FAS-driven cell death and the Bcl-2 apoptotic pathway intersect in ALPS patients.

223 Herein we describe a novel apoptotic pathway involving alpha2-6 sialylation of the

224 B cells, show that a mitochondria-dependent apoptotic pathway involving p53 contributes to the high

225 We previously described an apoptotic pathway involving p53-->CDIP-->TNFalpha that w

226 lective inflammatory milieu within which the apoptotic pathway is a cardinal feature with potential t

227 The intrinsic (mitochondrial) apoptotic pathway is a conserved cell death program cruc

228 to examine the hypothesis that an intrinsic apoptotic pathway is activated by DMBA and that the ulti

229 Dysregulation of the "intrinsic" apoptotic pathway is associated with the development of

230 The extrinsic apoptotic pathway is initiated by cell surface death rec

231 A signature event during the cell intrinsic apoptotic pathway is mitochondrial outer membrane permea

232 sly reported findings that the developmental apoptotic pathway is not involved in photoreceptor cell

233 ons in TP53 occur infrequently, yet the TP53 apoptotic pathway is often abrogated.

234 c studies to determine whether the intrinsic apoptotic pathway is required for radiation to produce a

235 This cofilin-p53 pro-apoptotic pathway is subject to negative regulation by P

236 icating that this Myc-induced miRNA-mediated apoptotic pathway is suppressed in malignant cells, but

237 To avoid undesired cell death, this apoptotic pathway is tightly regulated by members of the

238 culum stress and activation of the intrinsic apoptotic pathway is widely believed to contribute to be

239 This switch in apoptotic pathways is regulated in a cell-autonomous man

240 lization (MOMP), a key step in the intrinsic apoptotic pathway, is incompletely understood.

241 dominantly via the mitochondrial (intrinsic) apoptotic pathway, is thought to be a major determinant

242 targeting of HER2 and the BCL-XL/BCL-2 anti-apoptotic pathway may increase responses to anti-HER2 th

243 mbine MEK inhibitors with agents that target apoptotic pathways may be a promising therapeutic approa

244 he concept that targeting metabolic and anti-apoptotic pathways may be an effective therapeutic strat

245 SMA, suggesting that specific inhibitors of apoptotic pathways may be beneficial for patients.

246 ata show that the inability of EBOV to block apoptotic pathways may open up new strategies toward the

247 on transport and that metabolic, rather than apoptotic, pathways mediate this dependence.

248 objective was to evaluate the expression of apoptotic pathway members in synovial sarcomas and inter

249 eneration on PDT in MDA-MB 231 cells and the apoptotic pathway of cell death was illustrated using di

250 ely deficient in components required for the apoptotic pathway of IRF-3.

251 epolarization are critically involved in the apoptotic pathway of the pre-diabetic heart.

252 While the mitochondrial apoptotic pathway plays a critical role during late embr

253 Blocking this apoptotic pathway prevents the removal of these poorly d

254 emical cytotoxic modality that activates the apoptotic pathway, reduced ABCG2 expression to increase

255 Activation of the intrinsic apoptotic pathway represents a major mechanism for breas

256 pies that induce cell death through multiple apoptotic pathways required inhibition of cIAP1, cIAP2,

257 Commitment to death via the mitochondrial apoptotic pathway requires activation of the mitochondri

258 Here, we show that this apoptotic pathway requires the inhibition of macroautoph

259 of the death receptor and the mitochondrial apoptotic pathways, respectively) promote tumorigenesis.

260 raft-like domains may lead to activation of apoptotic pathways, resulting in cell death.

261 programmed necrosis, how they intersect with apoptotic pathways, roles of necrosis in heart disease,

262 The suppression of these two anti-apoptotic pathways silences the typical routes by which

263 ally, B56epsilon regulates the p53-dependent apoptotic pathway solely through controlling the stabili

264 allowed spatial and temporal control of the apoptotic pathway specifically in mature, myelin basic p

265 dramatically inhibited the SubAB-stimulated apoptotic pathway: SubAB-induced Bax/Bak conformational

266 ests that direct activators of the intrinsic apoptotic pathway, such as BH3 mimetics, may be useful f

267 caspase-2, the cells exhibited hallmarks of apoptotic pathway, such as mitochondrial damage and tran

268 ng evidence and consideration of related non-apoptotic pathways suggest that ferroptosis could be an

269 rough alpha-MSH mediating suppression of the apoptotic pathway that is post-Caspase 3, but before DNA

270 This caspase has also been implicated in non-apoptotic pathways that regulate Fas-associated via deat

271 sted reduced activation of the mitochondrial apoptotic pathway, the death response to other stimuli s

272 By connecting the microRNA and apoptotic pathways, these findings imply an important ro

273 f cellular apoptosis by triggering intrinsic apoptotic pathway through depolarization of mitochondria

274 te the contribution of this newly discovered apoptotic pathway to the host's overall antiviral respon

275 s exposed to Ru(II) compounds die through an apoptotic pathway triggered by ROS production.

276 > Akt pathway, upregulation of the extrinsic apoptotic pathway- tumor necrosis factor alpha -> nuclea

277 s in GBM tumor cells despite deregulation of apoptotic pathways, underscoring its potential use as a

278 uced toxicity by mediating the mitochondrial apoptotic pathway via the induction and oligomerization

279 myc, Mycn and Mycl) target proliferative and apoptotic pathways vital for progression in cancer.

280 Ontology analysis of 88 genes related to apoptotic pathways was performed in gingival biopsies of

281 ersely, FAS expression and the FAS-mediating apoptotic pathway were up-regulated.

282 t analysis showed that the genes involved in apoptotic pathways were enriched in glaucomatous RGCs.

283 eased, the caspase-dependent and independent apoptotic pathways were mildly activated in the Irbp(-/-

284 y and induced multiple DNA damage repair and apoptotic pathways when compared with control siRNAs.

285 S2-VP10 cells results in cell death via the apoptotic pathway whereas inhibition of both autophagy a

286 ritic cell death through a caspase-dependent apoptotic pathway, whereas sera from nonsurviving patien

287 ti-tumor effects by activating the extrinsic apoptotic pathway which could overcome the cytoprotectiv

288 LigIIIalpha activated a caspase 1-dependent apoptotic pathway, which is known to be part of inflamma

289 o alterations of specific checkpoints in the apoptotic pathway, which may represent important molecul

290 iates retrograde activation of a somatic pro-apoptotic pathway, which, in turn, is required for dista

291 d cell death by reactivation of an extrinsic apoptotic pathway whose function is suppressed in the on

292 s-inducing ligand (TRAIL)-mediated extrinsic apoptotic pathway with the help of c-Jun N-terminal kina

293 1 activated both the extrinsic and intrinsic apoptotic pathways with activation of initiator caspases

294 erbating conjunctival apoptosis through dual apoptotic pathways with DS.

295 and initiating both extrinsic and intrinsic apoptotic pathways with reduced systemic toxicity compar

296 have documented activation of the extrinsic apoptotic pathway, with specific cleavage of caspase-8 a

297 duction of ROS by DDC consistently activated apoptotic pathways, with increased cell death in combina

298 miR-10b targeting, such metastasis-dependent apoptotic pathways would offer attractive targets for fu

299 nt an essential gateway to the mitochondrial apoptotic pathway, would protect against motor neuron de

300 on is attributable in part to suppression of apoptotic pathways, yet the mechanisms by which cancer c