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1  group specified by the LIM-homeodomain gene apterous.
2 o those produced by mutant clones of Chip or apterous.
3 ised of Chip and the LIM-homeodomain protein Apterous.
4  in those dFMRFa neurons that do not express Apterous.
5 cription factor, an orthologue of Drosophila Apterous.
6 , E75A mRNA levels are reduced in ovaries of apterous(4) mutant adults defective in JH secretion.
7 he phenotype seen when mutant clones lacking Apterous, a LIM homeodomain protein known to be essentia
8 of the Drosophila FMRFa neuropeptide gene by Apterous, a LIM homeodomain transcription factor.
9 oof-of-principle experiments, we manipulated apterous, a regulator of wing development.
10 modimer is the functional unit through which Apterous acts during neuronal differentiation.
11  expression, and acts potently together with apterous and BMP signaling to trigger Fmrf expression ec
12 utants and of embryos doubly mutant for both apterous and Chip.
13 e developing Drosophila optic lobe, eyeless, apterous and distal-less, three genes that encode transc
14 ts in neurotransmitter production that mimic apterous and islet mutants.
15 orsal expression of the transcription factor Apterous and it has been hypothesized that apterous (ap)
16 g development, Delta is under the control of apterous and might be the Notch ligand in this process.
17               This signal acts together with apterous and squeeze to activate FMRFamide expression.
18 ing development (such as Wingless signal and apterous), and has nubbin enhancer activity.
19 n the club required bric-a-brac, aristaless, apterous, and pdm.
20 nd the tarsal PD genes, bric-a-brac 2 (bab), apterous (ap) and BarH1 (Bar).
21         The LIM homeodomain (LIM-HD) protein Apterous (Ap) and its cofactor DLDB/CHIP control dorso-
22            The LIM-HOM transcription factors apterous (ap) and Lim1 (also known as dlim1), and the ho
23 osed to exist across the DV axis, along with apterous (ap) as a dorsal selector gene [5], mediating c
24 ling is necessary and sufficient to activate apterous (ap) expression, thereby segregating the wing d
25                               The Drosophila apterous (ap) gene encodes a protein of the LIM-homeodom
26 osophila wing is regulated downstream of the apterous (ap) gene, which encodes a transcription factor
27  (EGFR) signaling, which heritably activates apterous (ap) in D compartment cells and maintains Iroqu
28 n the pretarsus, Bar (B) in ta IV and V, and apterous (ap) in ta IV.
29  the LIM domains of the LIM-HD family member Apterous (Ap) in wing and nervous system development.
30 ctor for the Drosophila LIM-HD family member Apterous (Ap) in wing development.
31                    We show that the Lhx gene apterous (ap) is also required for PD leg development, a
32                            The selector gene apterous (ap) is expressed in dorsal cells of the wing d
33 db/Chip function cause the same phenotype as apterous (ap) lack of function; i.e. dorsal to ventral t
34 w instance of transvection at the Drosophila apterous (ap) locus.
35 r Apterous and it has been hypothesized that apterous (ap) maintains compartmentalization by directly
36                                              Apterous (Ap), the best studied LIM-homeodomain transcri
37 IM homeodomain (LIM-HD) transcription factor Apterous (Ap), which is known to regulate various develo
38  of neurons express the LIM-homeodomain gene apterous (ap).
39 g this enhancer element, we demonstrate that Apterous (Ap, a selector protein), and the Notch and Win
40                                   dFMRFa and Apterous are expressed in partially overlapping subsets
41                                 Using a Chip/Apterous chimeric molecule lacking domains normally requ
42                                              Apterous contributes to the initiation of dFMRFa express
43                                              Apterous contributes to the maintenance of dFMRFa expres
44 includes direct mechanisms, although ectopic Apterous does not induce ectopic dFMRFa.
45        We show that a small complement of 28 apterous-expressing cells (Ap-let neurons) in the ventra
46   Chip is also required cell-autonomously by Apterous-expressing neurons for proper axon guidance, an
47 ment for egghead early in the development of apterous-expressing ventral nerve cord neurons to rescue
48 ng that these interactions are important for Apterous function in vivo.
49                  Expression of SOCS36E under apterous-GAL4 control resulted in outstretched wings.
50     In addition, we found that the Tribolium apterous genes are not only essential for exoskeletaliza
51 rotein interacts with the LIM domains in the Apterous homeodomain protein, and Chip interacts genetic
52                                              Apterous is not required for Tv neuron survival or morph
53 are a common neurotransmitter phenotype, the Apterous LIM homeoprotein helps define neurotransmitter
54 g requires the localized accumulation of the Apterous LIM/homeodomain protein (Ap) in dorsal cells.
55 artially winged (brachypterous) or wingless (apterous) lineages, and some entire orders are secondari
56 and that a tetrameric complex comprising two Apterous molecules bridged by a Chip homodimer is the fu
57 lex and rescued the axon guidance defects of apterous mutants, of Chip mutants and of embryos doubly
58            Furthermore, neurotransmission in apterous neurons is required to elicit the SP response.
59                        egghead expression in apterous neurons rescues neuronal targeting and the resp
60                                              Apterous regulation of dFMRFa expression includes direct
61            The LIM-homeodomain family member Apterous requires the LIM-binding protein Chip to execut
62 protein, and Chip interacts genetically with apterous, showing that these interactions are important
63                                              apterous specifies dorsal cell fate and directs outgrowt
64  this "code," by combined BMP activation and apterous/squeeze misexpression, triggers ectopic FMRFami
65   Our results suggest that Lhx2 is closer to apterous than Lmx-1, yet, in vertebrates, Lhx2 does not
66 rt of the dorsal compartment by induction of apterous, the dorsal selector gene, and consequently als
67  and for the activation of the homeobox gene apterous, the Zinc-finger gene rotund and the bHLH-PAS g
68 ivity of the dorsal specific nuclear protein Apterous, which regulates the expression of the Notch li
69 ng tissue (e.g., scalloped, Beadex, cut, and apterous-Xasta), Lyra wing discs do not exhibit increase