ライフサイエンスコーパス: apyrimidinic

1 d, such as a G4, to be displayed to apurinic/apyrimidinic 1 (APE1) and stalling on the fold to recrui

2 e damaged sites studied include apurinic and apyrimidinic a basic sites, thymine glycol and urea.

3 nohistochemistry while the number of apurnic/apyrimidinic abasic sites (AP sites) was also quantified

4 SV-1 DNA polymerase (UL30) exhibits apurinic/apyrimidinic and 5'-deoxyribose phosphate lyase activiti

5 e catalytic subunit (UL30) exhibits apurinic/apyrimidinic and 5'-deoxyribose phosphate lyase activiti

6 NA polymerase (Pol) (UL30) exhibits apurinic/apyrimidinic (AP) and 5'-deoxyribose phosphate (dRP) lya

7 example, it is capable of cleaving apurinic/apyrimidinic (AP) DNA via a beta-elimination reaction, a

8 aged or mismatched bases, producing apurinic/apyrimidinic (AP) DNA.

9 Apurinic/apyrimidinic (AP) endonuclease (APE) is a multifunctiona

10 The mammalian apurinic/apyrimidinic (AP) endonuclease (APE1) is a multifunction

11 Apurinic/apyrimidinic (AP) endonuclease (APE; EC 4.2.99.18) plays

12 Human apurinic/apyrimidinic (AP) endonuclease (hAPE) initiates the repa

13 Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) is a central par

14 The overexpression of human apurinic/apyrimidinic (AP) endonuclease 1 (APE1/Ref-1), a key enz

15 nd 8-oxoG DNA glycosylase 1 (OGG1), apurinic/apyrimidinic (AP) endonuclease 1, DNA polymerase beta, a

16 A base excision repair protein, Apurinic/apyrimidinic (AP) endonuclease 2 (APE2, APN2, or APEX2),

17 responsible for >/=95% of the total apurinic/apyrimidinic (AP) endonuclease activity in human cells.

18 Ape1 is the major apurinic/apyrimidinic (AP) endonuclease activity in mammalian cel

19 n was highly purified and exhibited apurinic/apyrimidinic (AP) endonuclease activity.

20 with uracil-DNA glycosylase (UDG), apurinic/apyrimidinic (AP) endonuclease and DNA ligase I, pol iot

21 Ape1 is the major human apurinic/apyrimidinic (AP) endonuclease and initiates repair of a

22 Apurinic/apyrimidinic (AP) endonuclease and polymerase gamma acti

23 Apurinic/apyrimidinic (AP) endonuclease Ape1 is a key enzyme in t

24 y reported domain homologous to the apurinic/apyrimidinic (AP) endonuclease family and shows nicking

25 IV is the archetype for a conserved apurinic/apyrimidinic (AP) endonuclease family that primes DNA re

26 so known as APE/Ref-1, is the major apurinic/apyrimidinic (AP) endonuclease in human cells.

27 Apn1 is the major apurinic/apyrimidinic (AP) endonuclease in yeast.

28 ve identified and characterised two apurinic/apyrimidinic (AP) endonuclease paralogues in the human p

29 ay employs a mitochondrial class II apurinic/apyrimidinic (AP) endonuclease to cleave the DNA backbon

30 adenine-DNA glycosylase activity by apurinic/apyrimidinic (AP) endonuclease using murine homolog of M

31 abasic site repair and between the apurinic/apyrimidinic (AP) endonuclease, Ape1, and the 8-oxoguani

32 recombinant CSB and the major human apurinic/apyrimidinic (AP) endonuclease, APE1, physically and fun

33 ns from the BER pathway, such as an apurinic-apyrimidinic (AP) endonuclease, as turnover-enhancing co

34 ort overexpression of the S. mutans apurinic/apyrimidinic (AP) endonuclease, Smx, in Escherichia coli

35 Apurinic/apyrimidinic (AP) endonuclease-deficient cells are sensi

36 ty that was restored by addition of apurinic/apyrimidinic (AP) endonuclease.

37 NEIL1, Nei, Fpg, Nth, and NTH1) and apurinic/apyrimidinic (AP) endonucleases (Apn1, APE1, and Nfo), t

38 diates, organisms are equipped with apurinic/apyrimidinic (AP) endonucleases and 3'-nucleases that in

39 In Saccharomyces cerevisiae, the apurinic/apyrimidinic (AP) endonucleases Apn1 and Apn2 act as alt

40 , uracil residues are eliminated by apurinic/apyrimidinic (AP) endonucleases in the nucleotide incisi

41 Here we report that the apurinic/apyrimidinic (AP) endonucleases--Escherichia coli Xth an

42 ycosylase (mtUDG) and mitochondrial apurinic/apyrimidinic (AP) endonucleases.

43 or lethal lesions is carried out by apurinic/apyrimidinic (AP) endonucleases.

44 id DNA that carries a site-specific apurinic/apyrimidinic (AP) lesion as template, we have found that

45 Duplex DNA containing an apurinic/apyrimidinic (AP) lesion undergoes cleavage significantl

46 mine glycol DNA glycosylase with an apurinic/apyrimidinic (AP) lyase activity encoded by the Escheric

47 Drosophila S3 also possesses an apurinic/apyrimidinic (AP) lyase activity in which the enzyme cat

48 been found to contain an associated apurinic/apyrimidinic (AP) lyase activity that cleaves phosphodie

49 t of glycosylases has an associated apurinic/apyrimidinic (AP) lyase activity that further processes

50 5' deoxyribosephosphate (5'dRP) and apurinic/apyrimidinic (AP) lyase activity, and showed this activi

51 possessing both DNA glycosylase and apurinic/apyrimidinic (AP) lyase activity.

52 y that is associated with its known apurinic/apyrimidinic (AP) lyase activity.

53 pathway, initiated by N-glycosylase apurinic/apyrimidinic (AP) lyase proteins.

54 se III (hNth1) is a DNA glycosylase/apurinic/apyrimidinic (AP) lyase that initiates base excision rep

55 initiated by the DNA N-glycosylase/apurinic/apyrimidinic (AP) lyase, human NTH1 (hNTH1), the homolog

56 1), the two major DNA N-glycosylase/apurinic/apyrimidinic (AP) lyases involved in the repair of oxida

57 cerevisiae N-glycosylase-associated apurinic/apyrimidinic (AP) lyases that recognize a wide variety o

58 lexes each containing two synthetic apurinic/apyrimidinic (AP) residues, positioned on opposite stran

59 ugar-phosphate bond 3' to an intact apurinic/apyrimidinic (AP) site (i.e. AP lyase activity).

60 or less frequently an A opposite an apurinic/apyrimidinic (AP) site but was unable to extend the DNA

61 Excision of an apurinic/apyrimidinic (AP) site by cutting the phosphate backbone

62 enome-wide mapping of occurrence of Apurinic/apyrimidinic (AP) site damage, binding of BER proteins,

63 e (APE1), an enzyme that cleaves an apurinic/apyrimidinic (AP) site from double stranded DNA.

64 bond cleavage creating an abasic or apurinic-apyrimidinic (AP) site in double-stranded DNA.

65 is pathway involves formation of an apurinic/apyrimidinic (AP) site in the DNA, which is further proc

66 step in BER is the processing of an apurinic/apyrimidinic (AP) site intermediate by an AP endonucleas

67 The apurinic/apyrimidinic (AP) site is a common lesion of DNA damage.

68 An apurinic/apyrimidinic (AP) site is one of the most abundant lesio

69 sert a dCMP opposite a DNA template apurinic/apyrimidinic (AP) site or a uracil residue.

70 o DNA repair lyase active sites for apurinic/apyrimidinic (AP) site processing, one within the N-term

71 otein for both O6-methylguanine and apurinic/apyrimidinic (AP) site repair as determined by biochemic

72 ed a substrate containing a reduced apurinic/apyrimidinic (AP) site resistant to beta-elimination and

73 DNA lesions arising in cells is an apurinic/apyrimidinic (AP) site resulting from base loss.

74 reated by the deaminase, forming an apurinic/apyrimidinic (AP) site that initiates the DNA repair pro

75 5hmC) when paired with a guanine, leaving an apyrimidinic (AP) site that is subsequently incised by t

76 al nucleotide capture, avoidance of apurinic/apyrimidinic (AP) site toxicity and coupling of damage-s

77 ost prevalent lesions in DNA is the apurinic/apyrimidinic (AP) site, which is derived from the cleava

78 The formation of apurinic/apyrimidinic (AP) site-derived crosslinks, at levels com

79 facilitates DNA repair by reducing apurinic/apyrimidinic (AP) sites after MNNG exposure and facilita

80 lian AP-endonuclease (APE1) repairs apurinic/apyrimidinic (AP) sites and strand breaks with 3' blocks

81 bose, resulting in the formation of apurinic/apyrimidinic (AP) sites and strand breaks.

82 Apurinic/apyrimidinic (AP) sites are alkali labile lesions that,

83 Apurinic/apyrimidinic (AP) sites are common DNA lesions that aris

84 Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotox

85 Apurinic/apyrimidinic (AP) sites are constantly formed in cellula

86 Apurinic/apyrimidinic (AP) sites are continuously generated in ge

87 Non-coding apurinic/apyrimidinic (AP) sites are generated at high frequency

88 Apurinic/apyrimidinic (AP) sites are one of the most frequent les

89 Apurinic/apyrimidinic (AP) sites are ubiquitous DNA lesions that

90 base effects DNA strand cleavage at apurinic/apyrimidinic (AP) sites arising via simple glycosylase a

91 Repair of apurinic/apyrimidinic (AP) sites by mammalian cell extracts was c

92 anded DNA treated with PAP contains apurinic/apyrimidinic (AP) sites due to the removal of adenine.

93 sphate (dRP) groups from 5'-incised apurinic/apyrimidinic (AP) sites during base excision repair.

94 or protein responsible for excising apurinic/apyrimidinic (AP) sites from DNA, cleaves 5' to natural

95 In growing cells, apurinic/apyrimidinic (AP) sites generated spontaneously or resul

96 endonuclease 1 (APE1) to cleave at apurinic/apyrimidinic (AP) sites in a collection of tandem DNA re

97 Non-coding apurinic/apyrimidinic (AP) sites in DNA are continually created i

98 major role in initiating repair of apurinic/apyrimidinic (AP) sites in DNA by catalyzing hydrolytic

99 Mammalian cells repair apurinic/apyrimidinic (AP) sites in DNA by two distinct pathways:

100 Non-coding apurinic/apyrimidinic (AP) sites in DNA form spontaneously and as

101 human Ape1 protein is to incise at apurinic/apyrimidinic (AP) sites in DNA via site-specific endonuc

102 oval of endogenous base lesions and apurinic/apyrimidinic (AP) sites in DNA.

103 etect traces of aldehyde-containing apurinic/apyrimidinic (AP) sites in nucleic acids has been develo

104 the PARP inhibitor is dependent on apurinic/apyrimidinic (AP) sites in the DNA and the presence of P

105 Repair of apurinic/apyrimidinic (AP) sites is initiated by AP endonucleases

106 Apurinic/apyrimidinic (AP) sites occur frequently in DNA as a res

107 terase on DNA containing 3'-incised apurinic/apyrimidinic (AP) sites to remove the product trans -4-h

108 ribose-5-phosphate at an incised 5' apurinic/apyrimidinic (AP) sites via a beta-elimination reaction.

109 t, deoxyinosine, and the numbers of apurinic/apyrimidinic (AP) sites were identical in DNA isolated f

110 age, including base loss (abasic or apurinic/apyrimidinic (AP) sites).

111 Apurinic/apyrimidinic (AP) sites, or abasic sites, which are a co

112 Apurinic/apyrimidinic (AP) sites, the most frequently formed DNA

113 S damage to DNA is the formation of apurinic/apyrimidinic (AP) sites, which without removal are known

114 ase excision repair of premutagenic apurinic/apyrimidinic (AP) sites.

115 ease IV (endo IV), which recognizes apurinic/apyrimidinic (AP) sites.

116 and minor grooves of DNA containing apurinic/apyrimidinic (AP) sites.

117 as phosphoglycolates and abasic or apurinic/apyrimidinic (AP) sites.

118 ey produce [e.g., 8-oxo-guanine and apurinic/apyrimidinic (AP) sites] have been linked to the pathoge

119 , is a DNA glycosylase with abasic (apurinic/apyrimidinic (AP)) lyase activity and specifically cleav

120 ble strand breaks (DSB) and abasic (apurinic/apyrimidinic (AP)) sites in DNA.

121 stos induces the DNA repair enzyme, apurinic/apyrimidinic (AP)-endonuclease, in isolated mesothelial

122 Abasic [apurinic/apyrimidinic (AP)] sites are common, noncoding DNA lesio

123 We investigated whether apurinic/apyrimidinic (AP/abasic) sites were more frequent in reg

124 Abasic (apurinic/apyrimidinic; AP) sites are generated in vivo through sp

125 However, apyrimidinic/apurinic (AP) endonuclease-deficient cells

126 tivities of uracil DNA glycosylase (UDG) and apyrimidinic/apurinic endonuclease (APE) digest G:U mism

127 hat uses human uracil DNA glycosylase (UDG), apyrimidinic/apurinic endonuclease (APE), and DNA polyme

128 activity that removes the faulty base and an apyrimidinic/apurinic lyase activity that introduces a s

129 ormation, and stimulates its glycosylase and apyrimidinic/apurinic lyase enzymatic activities.

130 The solution state structures of the apyrimidinic DNA duplex, with D6 indicating an abasic si

131 ts was evaluated using a preincised apurinic/apyrimidinic DNA.

132 ROCKI interacted with APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1) to form a ribonucl

133 Apurinic/apyrimidinic endonuclease (AP endo) is a key enzyme in o

134 Apurinic/apyrimidinic endonuclease (AP endo) is a key enzyme in t

135 e endonucleolytic activity of human apurinic/apyrimidinic endonuclease (AP endo) is a major factor in

136 Apurinic/apyrimidinic endonuclease (AP endo) is believed to play

137 state enzymatic binding kinetics of apurinic/apyrimidinic endonuclease (AP endo).

138 Apurinic/apyrimidinic endonuclease (APE) efficiently nicks DNA at

139 ied 12 property-based motifs in the apurinic/apyrimidinic endonuclease (APE) family of DNA-repair enz

140 The human DNA repair protein apurinic/apyrimidinic endonuclease (APE) is a dual-function prote

141 esulting abasic sites are nicked by apurinic/apyrimidinic endonuclease (APE).

142 racil DNA glycosylases-2 (UNG2) and apurinic/apyrimidinic endonuclease (APE).

143 We showed that human apurinic/apyrimidinic endonuclease (APE-1) has exonuclease activi

144 ll lines accumulated high levels of apurinic/apyrimidinic endonuclease (APE-1/Ref-1, redox effector-1

145 singly, this enzyme was found to be apurinic/apyrimidinic endonuclease (APE1) (), a well characterize

146 Human apurinic/apyrimidinic endonuclease (APE1) is an essential enzyme

147 It is known that apurinic/apyrimidinic endonuclease (APE1) plays a crucial role in

148 Human DNA apurinic/apyrimidinic endonuclease (APE1) plays a key role in the

149 Human apurinic/apyrimidinic endonuclease (Ape1) plays an important role

150 hMYH is associated in vivo with apurinic/apyrimidinic endonuclease (APE1), proliferating cell nuc

151 8-oxoguanine glycosylase (OGG1) and apurinic/apyrimidinic endonuclease (APE1), respectively.

152 shock protein 70 (HSP70) with human apurinic/apyrimidinic endonuclease (HAP1) was demonstrated by coi

153 hMYH and apurinic/apyrimidinic endonuclease (hAPE1) co-migrate with the pr

154 air enzyme, Redox effector factor-1/apurinic/apyrimidinic endonuclease (Ref-1/Ape), facilitates DNA b

155 opting a G-quadruplex fold in which apurinic/apyrimidinic endonuclease 1 (APE1) binds, but inefficien

156 The apurinic/apyrimidinic endonuclease 1 (APE1) functions are altered

157 Although it is presumed that the apurinic/apyrimidinic endonuclease 1 (APE1) generates DNA strand

158 both processes, a central role for apurinic/apyrimidinic endonuclease 1 (APE1) has been demonstrated

159 Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional

160 Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base

161 Human apurinic/apyrimidinic endonuclease 1 (APE1) is an important enzym

162 Apurinic/apyrimidinic endonuclease 1 (APE1) is the main abasic en

163 Apurinic/apyrimidinic endonuclease 1 (APE1) plays a central role

164 We have also found that apurinic/apyrimidinic endonuclease 1 (APE1) stimulates long patch

165 This presents AP to apurinic/apyrimidinic endonuclease 1 (APE1) that poorly cleaves t

166 we determined the ability of human apurinic/apyrimidinic endonuclease 1 (APE1) to cleave at apurinic

167 We found that the nuclear apurinic/apyrimidinic endonuclease 1 (APE1), a core enzyme in bas

168 Apurinic/apyrimidinic endonuclease 1 (APE1), a member of the diva

169 P-BER), including DNA glycosylases, apurinic/apyrimidinic endonuclease 1 (APE1), DNA polymerase beta

170 ntial base excision repair protein, apurinic/apyrimidinic endonuclease 1 (APE1), plays an important r

171 d by DNA polymerase beta (Polbeta), apurinic/apyrimidinic endonuclease 1 (APE1), poly(ADP-ribose) pol

172 hosphate dehydrogenase (GAPDH) with apurinic/apyrimidinic endonuclease 1 (Ape1), the major oxidized D

173 ical undamaged bases and stimulated apurinic/apyrimidinic endonuclease 1 (APE1)-mediated DNA incision

174 by uracil DNA glycosylase (UDG) and apurinic/apyrimidinic endonuclease 1 (APE1).

175 mmalian base excision repair (BER), apurinic/apyrimidinic endonuclease 1 (APE1).

176 sential base-excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1)/redox effector factor

177 lases and the downstream processing apurinic/apyrimidinic endonuclease 1 (APE1)] can be tested simult

178 ession of critical DNA repair genes apurinic/apyrimidinic endonuclease 1 (Apex1) and DNA polymerase b

179 Apurinic/apyrimidinic endonuclease 1 (APEX1) participates in the

180 ins, we demonstrate here a role for apurinic/apyrimidinic endonuclease 1 in pri-miRNA processing and

181 t findings point to a novel role of apurinic/apyrimidinic endonuclease 1 in RNA metabolism.

182 r mechanisms underlying the role of apurinic/apyrimidinic endonuclease 1 in these processes are still

183 cosidic bonds on RNA and that human apurinic/apyrimidinic endonuclease 1 incises RNA abasic sites in

184 Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme invol

185 show that endonuclease activity of apurinic/apyrimidinic endonuclease 1 is required for the processi

186 We also show that apurinic/apyrimidinic endonuclease 1 participates in RNA-interact

187 rmediate, the DNA is channeled from apurinic/apyrimidinic endonuclease 1 to DNA polymerase beta and t

188 acterization of the interactomes of apurinic/apyrimidinic endonuclease 1 with RNA and other proteins,

189 Apurinic/apyrimidinic endonuclease 1, a key enzyme in repairing a

190 e reactive geometry observed in the apurinic/apyrimidinic endonuclease 1, explaining the dephosphoryl

191 selected DNA glycosylases and human apurinic/apyrimidinic endonuclease 1.

192 The apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE

193 tiate radiotherapy, we investigated apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1)

194 or the base excision repair enzyme, apurinic/apyrimidinic endonuclease 2 (APE2) protein develop relat

195 The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participates in 3'

196 E2, a nuclease related to APE1, the apurinic/apyrimidinic endonuclease acting in base excision repair

197 ly of DNA repair enzymes, including apurinic/apyrimidinic endonuclease activity and repair activities

198 d with an increase in mitochondrial apurinic/apyrimidinic endonuclease activity in both H2O2- and O2-

199 uced 6.8-fold, and no difference in apurinic/apyrimidinic endonuclease activity is observed.

200 p53 did not influence mitochondrial apurinic/apyrimidinic endonuclease activity measured by incision

201 sic residues, which result from the apurinic/apyrimidinic endonuclease activity of Ape1.

202 n by a mechanism independent of its apurinic/apyrimidinic endonuclease activity.

203 la ribosomal protein P0 contains an apurinic/apyrimidinic endonuclease activity.

204 e transcription regulator FoxD3 and apurinic/apyrimidinic endonuclease and the presence of chromosome

205 The major mammalian apurinic/apyrimidinic endonuclease Ape1 is a multifunctional prot

206 the base excision repair-associated apurinic/apyrimidinic endonuclease APE1, independent of the BRCA2

207 NA damage is initiated by the major apurinic/apyrimidinic endonuclease Ape1, which specifically recog

208 smatch repair enzyme MUTYH, and the apurinic-apyrimidinic endonuclease APEX2.

209 asic site; this site was incised by apurinic/apyrimidinic endonuclease creating a nick with 3'-hydrox

210 r ung and mutY glycosylase and xthA apurinic/apyrimidinic endonuclease genes in H. pylori, mutants of

211 age and the additional depletion of apurinic/apyrimidinic endonuclease I (APE1) confers hypersensitiv

212 dehydrogenase and DNA repair enzyme apurinic/apyrimidinic endonuclease I protect smooth muscle cells

213 ition to its primary activity as an apurinic/apyrimidinic endonuclease in BER, Ape1 also possesses 3'

214 Apurinic/apyrimidinic endonuclease is a key enzyme in the process

215 Inhibition of apurinic/apyrimidinic endonuclease may therefore be a reasonable

216 nd U/G mispairs in double-stranded DNA; (ii) apyrimidinic endonuclease that cleaves double-stranded D

217 wo endonuclease III homologs and an apurinic/apyrimidinic endonuclease) that might account for this a

218 cil DNA glycosylase (UL2), cellular apurinic/apyrimidinic endonuclease, and DNA ligase IIIalpha-XRCC1

219 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically, with incr

220 d from yeast deficient in the major apurinic/apyrimidinic endonuclease, Apnl.

221 a ribosomal protein that is also an apurinic/apyrimidinic endonuclease, binds to YA in ovary and embr

222 e excision repair proteins, such as apurinic/apyrimidinic endonuclease, DNA polymerase beta, and liga

223 an enzymes: uracil-DNA glycosylase, apurinic/apyrimidinic endonuclease, DNA polymerase beta, flap end

224 DNA glycosylase, strand scission by apurinic/apyrimidinic endonuclease, DNA resynthesis and ligation.

225 tions of uracil-DNA glycosylase and apurinic/apyrimidinic endonuclease, human pol gamma was able to f

226 ssed at high levels relative to the apurinic/apyrimidinic endonuclease, increases spontaneous mutatio

227 Apurinic/apyrimidinic endonuclease-1 (APE-1) regulates transcript

228 Human apurinic/apyrimidinic endonuclease-1 (APE-1), a key enzyme involv

229 Apurinic/apyrimidinic endonuclease-1 (APE-1)/redox factor-1 (Ref-

230 und that recombinant purified human apurinic/apyrimidinic endonuclease-1 (APE1) and APE1 from human c

231 Apurinic/apyrimidinic endonuclease-1 (APE1) is a multifunctional

232 Apurinic/apyrimidinic endonuclease-1 (APE1) is an essential enzym

233 Aberrant expression of apurinic-apyrimidinic endonuclease-1 (APEX1) has been reported in

234 Apurinic/apyrimidinic endonuclease-1/redox effector factor-1 (APE

235 tly reported that the expression of apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE-1/Ref-1)

236 extraribosomal functions, including apurnic-apyrimidinic endonuclease-like activity suggested to be

237 ealed that it comprises a standalone apurnic-apyrimidinic endonuclease-like domain.

238 I, poly(ADP-ribose) polymerase, and apurinic/apyrimidinic endonuclease.

239 uclease-1, DNA polymerase beta, and apurinic/apyrimidinic endonuclease.

240 o one encoding ribosomal protein P0/apurinic/apyrimidinic endonuclease.

241 Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) (h

242 Apurinic/apyrimidinic endonuclease/redox factor-1 (Ape1/Ref-1) is

243 The dual-function protein apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/ref-1) is

244 The apurinic/apyrimidinic endonucleases (APE) contain several highly

245 IV belongs to a class of important apurinic/apyrimidinic endonucleases involved in DNA repair.

246 that is related in sequence to the apurinic-apyrimidinic endonucleases that participate in DNA repai

247 abasic sites, which are excised by apurinic/apyrimidinic endonucleases, eventually generating double

248 I, FAPY DNA glycosylase, both known apurinic/apyrimidinic endonucleases, or DNA deoxyribophosphodiest

249 ediates by the specific activity of apurinic/apyrimidinic endonucleases.

250 L1 retrotransposon and also to the apurinic/apyrimidinic endonucleases.

251 The apyrimidinic gap was not penetrated by water until the a

252 , an enzyme required for processing apurinic/apyrimidinic (known as abasic) sites, is also involved i

253 stimulated both the glycosylase and apurinic/apyrimidinic lyase activities of OGG1.

254 oli has adenine DNA glycosylase and apurinic/apyrimidinic lyase activities on A/G- and A/7,8-dihydro-

255 enzyme that has DNA glycosylase and apurinic/apyrimidinic lyase activities.

256 However, MutY(Dr) exhibits limited apurinic/apyrimidinic lyase activity and can form only weak coval

257 s a single strand break through its apurinic/apyrimidinic lyase activity to initiate base excision re

258 so suggest a role for Glu161 in the apurinic/apyrimidinic lyase chemistry.

259 with adenine that the abasic site (apurinic/apyrimidinic) lyase activity is alternatively regulated

260 DNA N-glycosylase/AP (apurinic/apyrimidinic) lyase enzymes of the endonuclease III fami

261 hermore, mtTGendo has an associated apurinic/apyrimidinic-lyase activity.

262 over, in vitro assays revealed that apurinic/apyrimidinic nuclease 1 provides nearly maximum stimulat

263 Thus, under our assay conditions, apurinic/apyrimidinic nuclease 1-mediated stimulation or other me

264 Abasic (apurinic/apyrimidinic or AP) sites are a frequent type of DNA dam

265 ichia coli exonuclease III (Exo III) removes apyrimidinic or apurinic (AP) sites and 3'-phosphate ter

266 The unrepaired apurinic/apyrimidinic site (AP site) in mitochondrial DNA (mtDNA)

267 e1 recruits pol beta to the incised apurinic/apyrimidinic site and stimulates 5'-dRP excision by pol

268 ent enzyme-DNA intermediate complex with the apyrimidinic site created by the glycosylase; and (iii)

269 abasic site is further processed by apurinic/apyrimidinic site endonuclease 1 (APE1) to create a sing

270 the T4 pyrimidine dimer glycosylase/apurinic/apyrimidinic site lyase (T4-pdg) has been exploited, nam

271 in, T4 pyrimidine dimer glycosylase/apurinic/apyrimidinic site lyase.

272 ances resection by BLM-DNA2, and an apurinic/apyrimidinic site stimulates resection by BLM-DNA2 and D

273 mes more tightly toward its product apurinic/apyrimidinic site than the substrate, whereas full-lengt

274 er bond 5 ' to a baseless sugar (apurinic or apyrimidinic site).

275 anodeoxyguanosine adduct and (2) an apurinic/apyrimidinic site, and the initiation of repair was exam

276 ackbone in DNA on the 5' side of an apurinic/apyrimidinic site, was monitored by FCCS using a double-

277 ity of a DNA fragment containing an apurinic/apyrimidinic site.

278 and then nicks the nascent abasic (apurinic/apyrimidinic) site by beta-elimination.

279 nliganded or bound to an abasic (apurinic or apyrimidinic) site, until now there was no structure of

280 trong binding by Dug to the reaction product apyrimidinic-site (AP) DNA.

281 Ung H187D binding to thymine-, uracil-, and apyrimidinic-site-containing DNA was (dT20) = (dT19-U) >

282 MPG binding affinity toward Hx and apurinic/apyrimidinic sites and thus is essential for the Hx clea

283 rate single-strand breaks (SSBs) at apurinic/apyrimidinic sites do not form DSBs immediately after me

284 pe1 protein initiates the repair of apurinic/apyrimidinic sites during mammalian base excision repair

285 nzyme that initiates the removal of apurinic/apyrimidinic sites from DNA, excises 3' replication-bloc

286 We further demonstrate that most apurinic/apyrimidinic sites in highly transcribed DNA are derived

287 re we show that the accumulation of apurinic/apyrimidinic sites is greatly enhanced in highly transcr

288 tY with GO mispaired with T, G, and apurinic/apyrimidinic sites may be involved in the regulation of

289 ates of religation for substrates containing apyrimidinic sites or deaminated cytosines.

290 ase of the dRP residue from incised apurinic/apyrimidinic sites to produce a substrate for DNA ligase

291 eaved and religated a DNA substrate in which apyrimidinic sites were simultaneously incorporated at e

292 ability to be covalently trapped to apurinic/apyrimidinic sites within duplex DNA under reducing cond

293 mage, as determined by the level of apurinic/apyrimidinic sites, also decreased significantly followi

294 of oxidative DNA adducts, mutagenic apurinic/apyrimidinic sites, and expression of base excision DNA

295 which fail to seal SSBs induced at apurinic/apyrimidinic sites, exhibit strongly elevated levels of

296 roduct-inhibited by both uracil and apurinic/apyrimidinic sites.

297 y prevent processing of 8-oxo-G and apurinic/apyrimidinic sites.

298 Abasic (apurinic/apyrimidinic) sites are among the most abundant DNA lesi

299 tive in base excision repair of AP (apurinic/apyrimidinic) sites in DNA.

300 tion mutant, the 5'-incision at AP (apurinic/apyrimidinic) sites is not detectable, supporting the no