ライフサイエンスコーパス: arachidonic acid

1 with exogenous unsaturated free fatty acid (arachidonic acid).

2 the oxygenation of endocannabinoids but not arachidonic acid.

3 sulted the most abundant, followed by omega6 arachidonic acid.

4 atty acids, including both linoleic acid and arachidonic acid.

5 immunity, cell signaling, proliferation and arachidonic acid.

6 circulating n-3 and n-6 fatty acids, except arachidonic acid.

7 ukotrienes, are lipid mediators derived from arachidonic acid.

8 Bs and PGF2alpha were modulated by exogenous arachidonic acid.

9 onses associated with aberrant metabolism of arachidonic acid.

10 yl linoleic but efficiently oxidized alkynyl arachidonic acid.

11 c acid were compared to that of linoleic and arachidonic acid.

12 nd ketone oxidation products of linoleic and arachidonic acid.

13 nsatory increase in phospholipids containing arachidonic acid.

14 quite similar to 9.5 x 10(5) M(-1) s(-1) for arachidonic acid.

15 dy, inhibition of platelet aggregation after arachidonic acid 1.5 mmol/L at 30 minutes, was significa

16 Subsequent addition of arachidonic acid (10 mum), a channel opener, increased t

17 that older NHFs have significantly increased arachidonic acid 12-lipoxygenase (ALOX12) expression and

18 lipoxygenation) was 17 kJ/mol lower than for arachidonic acid 12-lipoxygenation.

19 Glutathione peroxidase 4 (GPX4) and arachidonic acid 15-lipoxygenase (ALOX15) are antagonizi

20 n (MS1) also contained significant levels of arachidonic acid (20:4 omega-6) and the omega-3 fatty ac

21 n level of alpha-linolenic acid (18:3, ALA), arachidonic acid (20:4, AA), and docosahexanoic acid (22

22 plasma fasting glucose and the proportion of arachidonic acid (20:4n-6) in plasma phospholipids and c

23 s (PUFAs) docosahexaenoic acid (22:6n-3) and arachidonic acid (20:4n-6), which were first permitted b

24 centrations of 5-lipoxygenase metabolites of arachidonic acid, 5-hydroxyeicosatetraenoic acid, and le

25 enase-2 (COX-2) catalyzes the oxygenation of arachidonic acid (AA) and endocannabinoid substrates, pl

26 donoylglyerol (2-AG) in the brain generating arachidonic acid (AA) and glycerol.

27 Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid (AA) and its ester analog, 2-arachidono

28 Arachidonic acid (AA) and prostaglandin D2 (PGD2) as wel

29 Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid (AA) and the endocannabinoids 2-arachid

30 Plasma eicosapentaenoic acid (EPA) and arachidonic acid (AA) concentrations increase with age.T

31 sPLA2 IB enhanced podocyte arachidonic acid (AA) content in a dose-dependent manner

32 production of 5-lipoxygenase (5-LOX)-related arachidonic acid (AA) derivatives in the peritoneal flui

33 ducible PGE(2) synthesis, cPLA(2) hydrolyzes arachidonic acid (AA) from cellular phospholipids to be

34 thesis of PGE2 begins with the liberation of arachidonic acid (AA) from membrane phospholipids by cyt

35 deling the phospholipid membrane, release of arachidonic acid (AA) from the membrane, and production

36 correlated with a reduction of its precursor arachidonic acid (AA) in free form.

37 oPC) content and circulating and erythrocyte arachidonic acid (AA) in mice with sickle cell disease (

38 responsible for Ca(2+)-activated release of arachidonic acid (AA) in mitochondria from non-failing h

39 Arachidonic acid (AA) increases the association of PM-re

40 ted DHA levels and revealed dysregulation of arachidonic acid (AA) levels as well ( approximately 32%

41 OX) is a promising strategy to intervene the arachidonic acid (AA) metabolite network and control inf

42 e effect of LMW HA on cPLA2alpha activation, arachidonic acid (AA) release, and subsequent eicosanoid

43 hospholipid-remodeling enzyme that transfers arachidonic acid (AA) to lysophosphatidylinositol to pro

44 also called cyclooxygenases (COXs), convert arachidonic acid (AA) to PGH2.

45 ic acid (DPA), and oleic acid, but decreased arachidonic acid (AA) versus controls.

46 Coincubation with arachidonic acid (AA) was conducted to determine the sit

47 5% CI 0.85-0.94) were inversely related, and arachidonic acid (AA) was not significantly associated,

48 c acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (AA) were quantified using RP-HPLC with

49 echanistic study of Mp1p-LBD2 suggested that arachidonic acid (AA), a precursor of paracrine signalin

50 cid precursor, including linoleic acid (LA), arachidonic acid (AA), docosahexaenoic acid (DHA), or ei

51 asil (Ocimum basilicum L.) leaves induced by arachidonic acid (AA), jasmonic acid (JA) and beta-amino

52 tuce caused by different chemical elicitors: arachidonic acid (AA), jasmonic acid (JA), and abscisic

53 PMN chemoattractant hepoxilin A3 (HXA3) from arachidonic acid (AA), promotes acute pulmonary inflamma

54 he omega-6 polyunsaturated fatty acid (PUFA) arachidonic acid (AA), which entails risk for developing

55 ytosolic phospholipase A2 (cPLA2), releasing arachidonic acid (AA), which is oxidized to proinflammat

56 ast cell (MC) activation causes synthesis of arachidonic acid (AA)-derived eicosanoids (leukotriene [

57 could be triggered by addition of exogenous arachidonic acid (AA).

58 of a novel antitumoral mechanism of the PUFA arachidonic acid (AA).

59 hydrolyzes membrane phospholipids to release arachidonic acid (AA).

60 fied this chemo-protective lipid mediator as arachidonic acid (AA).

61 Arachidonic acid (AA, 20:4) is an omega-6 polyunsaturate

62 ts, without the need to also include omega-6 arachidonic acid (AA; 20:4n-6).

63 2; 95% CI: 0.39, 0.70; P-trend < 0.001), and arachidonic acid (AA; HR: 0.62; 95% CI: 0.46, 0.85; P-tr

64 lenic acid) and n-6 PUFAs (linoleic acid and arachidonic acid [AA]) in blood samples at age 8 years w

65 et cell membranes with EPA, thereby reducing arachidonic acid abundance, would positively impact beta

66 In both, different metabolites of arachidonic acid act as mediators.

67 entration-response curves were generated for arachidonic acid, ADP, collagen, epinephrine, Thrombin r

68 measured platelet aggregation in response to arachidonic acid, ADP, collagen, or epinephrine by optic

69 ion-1 study measured platelet aggregation to arachidonic acid, ADP, protease-activated receptor (PAR)

70 thways initially involve the release of free arachidonic acid after activation of the CB2 receptor an

71 regation, p = 0.02) but not with collagen or arachidonic acid agonists.

72 rect incubation with gamma-linolenic acid or arachidonic acid also attenuated collagen deposits and L

73 Elicitation with 0.01 uM arachidonic acid also caused improvement of potential an

74 ownstream PUFAs like gamma-linolenic acid or arachidonic acid alter the transforming growth factor-be

75 be influenced/mediated by concentrations of arachidonic acid, an n-6 polyunsaturated fat.

76 alyses of lipid mediators revealed increased arachidonic acid and 12-lipoxygenase metabolites.

77 enic actions of various compounds, including arachidonic acid and a combination of linoleic acid and

78 Oncogenic PIK3CA results in an increase in arachidonic acid and a concomitant overproduction of eic

79 ediators derived from omega-3 fatty acids or arachidonic acid and by relevant proteins and signalling

80 h total or cause-specific mortality (eg, for arachidonic acid and CHD death, the extreme-quintile haz

81 tion attenuated the fMLP-mediated release of arachidonic acid and CysLT formation by eosinophils.

82 ions for changes in plasma concentrations of arachidonic acid and DHA in phospholipids and TLs and of

83 Arachidonic acid and docosahexaenoic acid, two final pro

84 biomarkers linoleic acid and its metabolite arachidonic acid and incident type 2 diabetes.

85 were increased while serine, asparagine and arachidonic acid and its derivatives were decreased in r

86 resulted in a rapid and dramatic decrease in arachidonic acid and its eicosanoid metabolites.

87 Surprisingly, release of arachidonic acid and LDH from cPLA2alpha-deficient fibro

88 cid beta-oxidation, phospholipid catabolism, arachidonic acid and linoleic acid metabolism, sphingoli

89 ining phospholipid substrates releasing free arachidonic acid and lysophospholipids and giving rise t

90 Channel activation by arachidonic acid and mechanical stretch involves convers

91 (LT) C4, LTD4, and LTE4, are metabolites of arachidonic acid and mediate inflammatory responses.

92 To investigate this, we locally applied arachidonic acid and skin-permeable peroxide by micropip

93 suppressive activity involved the uptake of arachidonic acid and the synthesis of prostaglandin E(2)

94 BP5 both promotes the hydrolysis of AEA into arachidonic acid and thus reduces brain endocannabinoid

95 osphoinositides, to form the proinflammatory arachidonic acid and, in parallel, the glycerophosphoino

96 ir hydrolysis products (oxygenated linoleic, arachidonic acids and monolysocardiolipins), is activate

97 ays (affinity comparable to pioglitazone and arachidonic acid), and in vitro murine adipocyte differe

98 (adenosine diphosphate 5 and 20 mumol/l and arachidonic acid), and vasodilator-stimulated phosphopro

99 (omega-3) FAs, 4) high linoleic acid and low arachidonic acid, and 5) high trans FAs.

100 LA), gamma-linolenic acid (GLA), dihomo-GLA, arachidonic acid, and adrenic acid were expressed as per

101 he FADS cluster on chromosome 11 with LA and arachidonic acid, and further observed novel genome-wide

102 enzymes release free fatty acids, including arachidonic acid, and generate lysophospholipids from ph

103 esponsible for the epoxidation of endogenous arachidonic acid, and is involved in the metabolism of e

104 (epoxI) given at 24 h selectively inhibited arachidonic acid- and linoleic acid-derived CYP450-epoxy

105 mega-alkynyl linoleic acid and omega-alkynyl arachidonic acid appear to be metabolically competent su

106 ith circulating and tissue concentrations of arachidonic acid (ARA) and dihomo-y-linolenic acid (DGLA

107 Arachidonic acid (ARA) is metabolized by cyclooxygenase

108 the key targets mediating the action of PUFA arachidonic acid (ARA) on meiotic maturation and demonst

109 Dietary LA can then be converted to arachidonic acid (ARA) utilizing three enzymatic steps.

110 we have made alphaS multimers in vitro using arachidonic acid (ARA), one of the most abundant fatty a

111 e of FADS1-rs174556 had lower proportions of arachidonic acid (ARA; 20:4n-6).

112 peroxide and the polyunsaturated fatty acid arachidonic acid are among the earliest known mediators

113 r the rapid production of F-series PGs using arachidonic acid as the substrate and worm lysate as sou

114 cosapentaenoic acid (EPA)/d together with an arachidonic acid-balanced diet compared with a control d

115 Levels of arachidonic acid biomarker were not significantly associ

116 The associations between linoleic acid and arachidonic acid biomarkers and the risk of type 2 diabe

117 and had data available for linoleic acid and arachidonic acid biomarkers at baseline.

118 assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabete

119 yses the biosynthesis of prostaglandins from arachidonic acid but also the biosynthesis of prostaglan

120 creased 2-AG and its major lipid metabolite (arachidonic acid), but increases of a 2-AG diacylglycero

121 d minor effects in the presence of exogenous arachidonic acid, but led to prominent reductions in 5LO

122 s ago, a third pathway for the metabolism of arachidonic acid by cytochrome P450 enzymes emerged.

123 ized phospholipids is through the release of arachidonic acid by cytosolic phospholipase A(2)alpha (c

124 f eicosanoid generation is the liberation of arachidonic acid by phospholipase A2, and the cytosolic

125 opic lipid mediator that is synthesized from arachidonic acid by the sequential actions of cyclooxyge

126 osynthesis involves sequential metabolism of arachidonic acid by two cell types expressing a combined

127 jor 15-lipoxygenase 1 (15-LO1) metabolite of arachidonic acid, by stimulating zona occludens (ZO)-2 t

128 Inhibition of multiple enzymes of the arachidonic acid cascade leads to synergistic anti-infla

129 ts of lung epithelial cellular breakdown and arachidonic acid cascade metabolites were associated wit

130 her than PGI2 production in either following arachidonic acid challenge.

131 icosapentaenoic acid, docosapentaenoic acid, arachidonic acid, CLA:9c11t and gamma linolenic acid.

132 ith platelet reactivity following stimuli to arachidonic acid, collagen, adenosine diphosphate, and t

133 loss of single platelets in blood exposed to arachidonic acid, collagen, U46619 or protease activated

134 owed us to explore ADP- and non-ADP-induced (arachidonic acid-, collagen-, thrombin receptor-activati

135 metabolites derived from docosahexaenoic and arachidonic acids comes from the introduction of the pol

136 ater inhibition of platelet aggregation with arachidonic acid compared with aspirin.

137 After adjustment for arachidonic acid concentrations, the association between

138 hibits a marked preference for hydrolysis of arachidonic acid containing phospholipid substrates rele

139 osolic phospholipase A2 (cPLA2alpha) targets arachidonic acid-containing phospholipids but the role o

140 ements in linoleic acid, linolenic acid, and arachidonic acid (control>ASYMAD>AD) and increases in do

141 ensor imaging showed that wound peroxide and arachidonic acid converged on half-millimetre-long lipid

142 ) pathway, as evident by increased levels of arachidonic acid, COX-2 expression, and PGE(2) synthesis

143 In addition to arachidonic acid, COX-2 oxidizes the endocannabinoid 2-a

144 enerate 20-hydroxyeicosatetraenoic acid from arachidonic acid, decreasing endothelial barrier functio

145 tty-acids (EpFAs), cytochrome P450 dependent arachidonic acid derivatives, have been suggested to hav

146 phospholipase A2 and generating vasodilatory arachidonic acid derivatives.

147 olvins, protectins, and maresins, as well as arachidonic acid-derived (n-6) lipoxins, which promote r

148 Arachidonic acid-derived epoxyeicosatrienoic acids could

149 Arachidonic acid-derived HETEs were significantly associ

150 efficient than DHA in reducing production of arachidonic acid-derived lipids, and both n-3PUFA lowere

151 comprise a family of mediators that include arachidonic acid-derived lipoxins, omega-3 fatty acid ei

152 The balance of arachidonic acid-derived mediators in leukocytes is thou

153 FA-derived oxylipins and moderately decrease arachidonic acid-derived oxylipins.

154 t is currently understood of the role of the arachidonic acid-derived prostaglandins, lipoxins, and t

155 ent increased concentrations of linoleic and arachidonic-acid-derived oxidized TRPV1 agonists in spin

156 ls of stearic acid/palmitic acid (SA/PA) and arachidonic acid/dihomo-gamma-linolenic acid (AA/DGLA) r

157 ipheral blood using established criteria for arachidonic acid, eicosapentaenoic acid, and docosahexae

158 l techniques, we show that both linoleic and arachidonic acid elicit FABP5's translocation by permitt

159 yunsaturated fatty acids (PUFAs) such as AA (arachidonic acid), EPA (eicosapentaenoic acid) and DyLA

160 Arachidonic acid epoxides generated by cytochrome P450 (

161 ed by phospholipase A(2)-mediated release of arachidonic acid, followed by its enzymatic oxidation re

162 Although the K(m) of arachidonic acid for acetylated COX-2 was ~3-fold lower

163 ce of an optimal DHA balance with respect to arachidonic acid for different aspects of neurodevelopme

164 solic phospholipase A2alpha, which mobilizes arachidonic acid for PG synthesis, preferentially transl

165 Light provoked the release of arachidonic acid from membrane phospholipids and product

166 e cytosolic phospholipase A2, which releases arachidonic acid from membrane phospholipids, and later

167 ivates the iPLA2gamma-mediated hydrolysis of arachidonic acid from phosphatidylcholine, thereby integ

168 ormation to LTA4 5-LOX is thought to receive arachidonic acid from the nuclear membrane-embedded 5-LO

169 ontained, in addition, docosahexaenoic acid, arachidonic acid (important for brain and eye developmen

170 proinflammatory lipid mediators formed from arachidonic acid in a 2-step reaction catalyzed by 5-lip

171 hains of three amino acids, allow binding of arachidonic acid in a catalytically competent conformati

172 ss (1) decreased 2-arachidonoyl glycerol and arachidonic acid in the cerebellar interpositus nucleus

173 cosatetraenoic acids (HETE) and 15-HETE from arachidonic acid in the testes were significantly elevat

174 idonic acid may limit the utility of alkynyl arachidonic acid in the tracking of cyclooxygenase-based

175 icosapentaenoic acid + docosahexaenoic acid, arachidonic acid) in hepatic total lipids were lower in

176 strated that 12-LOX-generated metabolites of arachidonic acid increase sharply during organogenesis s

177 Whereas treatment of control HEEs with arachidonic acid increased expression of inflammatory cy

178 ecreased and levels of the ALOX12 substrate, arachidonic acid, increased.

179 ndrial variant 3 catalyzed the metabolism of arachidonic acid into 8,9-, 11,12-, and 14,15-epoxyeicos

180 man hearts, cPLA2zeta metabolically channels arachidonic acid into EETs, whereas in failing hearts, i

181 sing fibroblasts that constitutively process arachidonic acid into highly labile prostaglandin E(2) (

182 rected by exocytosis and allows shuttling of arachidonic acid into platelets.

183 he nuclear envelope support a model in which arachidonic acid is generated by cPLA(2) in apposition t

184 r the prevention of type 2 diabetes and that arachidonic acid is not harmful.

185 When using 2-acyl LPI, where arachidonic acid is the predominant fatty acid, LC-MS an

186 d 2-arachidonoyl-glycerol, which derive from arachidonic acid, is influenced by dietary fatty acids (

187 active PLAAT inhibitor scaffold that reduced arachidonic acid levels in PLAAT3-overexpressing U2OS ce

188 onic morphine administration, an increase in arachidonic acid levels through the mu-opioid receptors

189 Cytochrome P450 pathway oxylipins from arachidonic acid, linoleic acid, alpha-linolenic acid an

190 lipase A2 (iPLA2beta) causes accumulation of arachidonic acid, lysophospholipids, and eicosanoids tha

191 This deviation from the metabolic profile of arachidonic acid may limit the utility of alkynyl arachi

192 including platelet reactivity in response to arachidonic acid (mean difference: 10.9 U; 95% CI: 1.9 t

193 nd epithelial cell mRNA expression levels of arachidonic acid metabolic enzymes.

194 o utilize an unbiased approach investigating arachidonic acid metabolic pathways in AERD.

195 to Toll-like and TNF receptor activation and arachidonic acid metabolism (P < .001) and in TAC2 for t

196 processes of glycerophospholipid metabolism, arachidonic acid metabolism and phospholipid biosynthesi

197 reveal how selenium-dependent modulation of arachidonic acid metabolism can be directed to trigger a

198 the alteration in cholesterol metabolism and arachidonic acid metabolism differ with tissue origin, s

199 ging induces generation of LOOHs produced by arachidonic acid metabolism in the cPLA(2) pathway contr

200 A dysregulation in arachidonic acid metabolism is thought to contribute to

201 We and others have recently shown that arachidonic acid metabolism pathways, specifically the c

202 -ETE, may contribute to the dysregulation of arachidonic acid metabolism via the 15-LO pathway and to

203 12-Lipoxygenase (12-LOX) is a key enzyme in arachidonic acid metabolism, and alongside its major pro

204 oxygenase (COX) and lipoxygenase branches of arachidonic acid metabolism, and then the rate constants

205 ays in pan-cancer are fatty acid metabolism, arachidonic acid metabolism, cholesterol metabolism and

206 e for activated PI3K signaling in regulating arachidonic acid metabolism, uncovering a targetable met

207 iene-C4 synthase (LTC4S) generates LTC4 from arachidonic acid metabolism.

208 ory mediators, in part, by the modulation of arachidonic acid metabolism.

209 nesis, fatty acid synthesis, and retinol and arachidonic acid metabolism.

210 ry condition, which is driven by an aberrant arachidonic acid metabolism.

211 within these loci are enriched for lipid and arachidonic acid metabolism.

212 potent vasoconstrictive and proinflammatory arachidonic acid metabolite.

213 oleic acid metabolites (OLAMs) and oxidative arachidonic acid metabolites (OAAMs) is the action of ox

214 Several arachidonic acid metabolites and enzyme transcripts invo

215 Macrophages are major producers of arachidonic acid metabolites and subject to metabolic re

216 Arachidonic acid metabolites are implicated in the patho

217 and proinflammatory signals associated with arachidonic acid metabolites differentially gate TRPV4 i

218 ished cellular production of 15-lipoxygenase arachidonic acid metabolites in IL-4-stimulated macropha

219 The role of arachidonic acid metabolites in NSAID-induced hypersensi

220 Although arachidonic acid metabolites, cysteinyl leukotrienes (cy

221 ed levels of acylcarnitines, proinflammatory arachidonic acid metabolites, cytokines, and chemokines

222 lex network mediators, such as nitric oxide, arachidonic acid metabolites, cytokines, and reactive ox

223 ent studies of soluble mediators, especially arachidonic acid metabolites, have defined their proinfl

224 uble mediators of inflammation, particularly arachidonic acid metabolites, in inflammatory bowel dise

225 ic oxide, other reactive oxygen species, and arachidonic acid metabolites.

226 channels, and the production and release of arachidonic acid metabolites.

227 d lipidomic approach was used to profile the arachidonic acid metabolome of amniotic fluid.

228 products of PLA2 (lysophosphatidic acid and arachidonic acid) mimicked treatment with gossypol.

229 P2X7 receptor can induce PLA2 activation and arachidonic acid mobilization.

230 atically in 1993, when anandamide, an NAE of arachidonic acid (N-arachidonylethanolamine), was shown

231 solution structure of 8R-LOX in complex with arachidonic acid obtained under anaerobic conditions.

232 en the somatic and germ cells is mediated by arachidonic acid (omega-6) and eicosapentaenoic acid (om

233 arachidonoylserotonin was similar to that of arachidonic acid, one of the previously identified fatty

234 1 progression was rescued by the addition of arachidonic acid or prostaglandin E2 (PGE2), indicating

235 nts and found that, when normalized to their arachidonic acid oxygenase activities, the lipoxin synth

236 e carriage associated with lower whole-blood arachidonic acid (P </= 0.002), and minor alleles of rs1

237 8), oleic acid (p < 0.0001, p = 0.0003), and arachidonic acid (p = 0.0001, p = 0.001).

238 se involved in NAR to all NSAIDs belonged to arachidonic acid pathway and HLA antigen processing path

239 Genes involved in NAR to aspirin belonged to arachidonic acid pathway, membrane-spanning 4A gene fami

240 shifts the balance toward resolution in the arachidonic acid pathway.

241 Studies done to assess the role of arachidonic acid pathways of the host in Kaposi's sarcom

242 rkers of inflammatory lipid metabolism, free arachidonic acid, phospholipases (PLA2G10), and prostagl

243 isoform of PLA2 that mediates the release of arachidonic acid, plays a role in the pathogenesis of sp

244 CYP4Z1-dependent metabolism of arachidonic acid preferentially generates 14,15-epoxyeic

245 ALOX12 catalyzes the addition of oxygen to arachidonic acid, producing 12-hydroperoxyeicosatetraeno

246 icosanoid concentrations correlated with the arachidonic acid proportion in plasma and with hsCRP (r

247 As in wounds, arachidonic acid rapidly attracted leukocytes through du

248 ated CRAC channels and the store-independent arachidonic acid-regulated ARC channels.

249 LDH release temporally correlated with arachidonic acid release but did not involve cytosolic p

250 regulator, also prevented MPTP formation and arachidonic acid release induced by A23187 and H2O2.

251 l-sn-glycerol and CsA blocked cell death and arachidonic acid release not by preventing mitochondrial

252 by a direct effect on mitochondria, LDH and arachidonic acid release were blocked by CsA and 1-oleoy

253 tacyclin-mediated dilations to serotonin and arachidonic acid, respectively.

254 Metabolism of arachidonic acid results in bioactive lipid mediators be

255 chromosome 16 with LA, GLA, dihomo-GLA, and arachidonic acid (rs16966952; P=1.2x10(-15), 5.0x10(-11)

256 ome 6 with adrenic acid after adjustment for arachidonic acid (rs3134950; P=2.1x10(-10); AGPAT1).

257 me catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized

258 nimal (except for dairy) products, including arachidonic acid (standardized beta: 0.25; 95% CI: 0.15,

259 ) channel 1 (TREK1), TREK2, and Twik-related arachidonic-acid stimulated K(+) channel (TRAAK) form th

260 ith a preferential release of membrane-bound arachidonic acid, stimulating the lipoxygenase (LOX) and

261 0 inhibits catalysis by preventing access of arachidonic acid substrate in the COX-1 isoenzyme.

262 n by gamma-ketoaldehyde isomers derived from arachidonic acid, termed isolevuglandins (IsoLGs), is em

263 erate distinct products from their substrate arachidonic acid: the human enzyme, a 15-S-hydroperoxy p

264 ) and converting 2-arachidonoylglycerol into arachidonic acid, thus providing ligands for nuclear rec

265 rome P450 (CYP) 4A and 4F enzymes metabolize arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-

266 t also allows oxygenation and cyclization of arachidonic acid to a 15 R-PG endoperoxide.

267 th enzymes transform phospholipid-esterified arachidonic acid to a 15-S-product.

268 zes rate-limiting steps in the conversion of arachidonic acid to a variety of lipid signaling molecul

269 ketoconazole, terfenadine, terfenadone, and arachidonic acid to CYP2J2 confirmed the role of those r

270 tional properties including bioactivation of arachidonic acid to epoxyeicosatrienoic acids, which, in

271 ts and catalyzes the oxygenation of cellular arachidonic acid to form proinflammatory intermediates.

272 genase and 12-lipoxygenase, which metabolize arachidonic acid to generate bioactive inflammatory eico

273 ) plays a critical role in the metabolism of arachidonic acid to leukotriene A4, the precursor to the

274 lin family), and in their ability to convert arachidonic acid to lipoxins, predominantly Lipoxin A4.

275 so called cyclooxygenase-2 (COX-2), converts arachidonic acid to PGH2 PGHS-2 is a conformational hete

276 one of the CYP epoxygenases that metabolize arachidonic acid to produce epoxyeicosatrienoic acids an

277 atory drugs interfere with the metabolism of arachidonic acid to proinflammatory prostaglandins and l

278 ion of a 20-carbon omega-6 fatty acid called arachidonic acid to prostaglandin endoperoxide H(2) (PGH

279 prostaglandin biosynthesis-the conversion of arachidonic acid to prostaglandin endoperoxide H(2) Both

280 (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin G2.

281 to a decrease in the rate of conversion from arachidonic acid to prostaglandin H2 in the PR pathway.

282 talyze the initial step in the metabolism of arachidonic acid to prostaglandins.

283 cyclooxygenase1 (Cox1), an enzyme processing arachidonic acid to synthesize thromboxane A2 (TxA2).

284 alase-lipoxygenase fusion protein transforms arachidonic acid to the allene oxide 8R,9-epoxy-5,9,11,1

285 ds, including epoxyeicosatrienoic acids from arachidonic acid to the corresponding proinflammatory di

286 ndocannabinoid levels, and directly shuttles arachidonic acid to the nucleus where it delivers it to

287 drugs, and endogenous substrates, including arachidonic acid, to physiologically active epoxyeicosat

288 metabolites, suggesting a metabolic shift of arachidonic acid under inhibition of the CYP2C pathway.

289 TP-gated channels, and that Ca(2+) generates arachidonic acid via phospholipase D2 and diacylglycerol

290 Tertile 2 of n-6 and arachidonic acid was associated with fracture risk in wo

291 mega-alkynyl linoleic acid and omega-alkynyl arachidonic acid were compared to that of linoleic and a

292 lenic acid, dihomo-gamma-linolenic acid, and arachidonic acid were not significantly associated with

293 mega-alkynyl linoleic acid and omega-alkynyl arachidonic acid were reacted with lipoxygenase enzymes

294 arly ratios of docosahexaenoic acid (DHA) to arachidonic acid, were lower in the hippocampi and corti

295 Prostaglandin E2 (PGE2) is derived from arachidonic acid, whereas PGE3 is derived from eicosapen

296 e-centered pentapeptide isoconformational to arachidonic acid, which exhibited appreciable selectivit

297 d receptor-independent mechanism mimicked by arachidonic acid, which has no activity on cannabinoid r

298 e synoviocytes, it suppressed the release of arachidonic acid with an IC50 value of 0.6 muM.

299 lenic acid, dihomo-gamma-linolenic acid, and arachidonic acid, with total and cause-specific mortalit

300 Peroxide promoted chemotaxis to arachidonic acid without being chemotactic on its own.