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1 moiety reacts with the ortho position of the aromatic ring.
2 aring different pattern substitutions in the aromatic ring.
3 and fully recovered with residues bearing an aromatic ring.
4 loff effect of a radical association with an aromatic ring.
5 aals contact areas with the edge of opposing aromatic ring.
6 isatin bearing fluorine substituents on the aromatic ring.
7 ring only in methyl substitution of a single aromatic ring.
8 and electron-withdrawing substituents on the aromatic ring.
9 droxylated TBPH with a hydroxyl group on the aromatic ring.
10 ad formed via addition of an OH group to the aromatic ring.
11 aring different pattern substitutions in the aromatic ring.
12 er amines whose charge is insulated from the aromatic ring.
13 ric effects arising from substituents on the aromatic ring.
14 the triene tail of the natural product by an aromatic ring.
15 cis-resveratrol that generates a new central aromatic ring.
16 irality center nearby the amino group or the aromatic ring.
17 r weight (LMW-PAH) (liver > muscle) with 2-3 aromatic ring.
18 ed by the electronic nature of the migrating aromatic ring.
19 by electron-withdrawing substituents on the aromatic ring.
20 eraction with the pai-system of the adjacent aromatic ring.
21 ne subpocket of the AcCoA binding site by an aromatic ring.
22 ignificantly contribute to alkylation at the aromatic ring.
23 yl, and alkoxy substituents on either of the aromatic rings.
24 gD, number of rotatable bonds, and number of aromatic rings.
25 ic behavior were observed for the lipophilic aromatic rings.
26 the basis of Cl distribution between the two aromatic rings.
27 ydrophobic interactions between crotonyl and aromatic rings.
28 ng aromatics resulted in the opening of some aromatic rings.
29 l substituents at different positions on the aromatic rings.
30 und to be hydrogen-bonded with electron-rich aromatic rings.
31 of truncated analogues that have only three aromatic rings.
32 pi-stacked neutral arenes, let alone charged aromatic rings.
33 ticity, and small alternation in the central aromatic rings.
34 linker and two identical nitrogen-containing aromatic rings.
35 from the six chemical groups attached to the aromatic rings.
36 s containing amine and methoxy groups on the aromatic rings.
37 o replace the hydrogen atoms attached to the aromatic rings.
38 related to the hydroxyl groups in the three aromatic rings.
39 ion of additional methyl substituents on the aromatic rings.
40 arly 2.5 nm long cyclophane consisting of 12 aromatic rings.
41 nsertion of a nitro group in one of the four aromatic rings.
42 ially affects the electrostatic potential of aromatic rings.
43 tes to catalyze the O2-dependent cleavage of aromatic rings.
44 re valuable bioisosteres of para-substituted aromatic rings.
45 acid functions, each of these groups on the aromatic rings.
46 to their recent discovery as bioisosteres of aromatic rings.
47 ade reaction, creating new central pyran and aromatic rings.
48 tral compounds containing one, two, or three aromatic rings.
49 tegies for the electrophilic substitution of aromatic rings.
51 n which the zirconium center is bonded to an aromatic ring, a benzylic group, or an alkyl group that
52 the number of acetylenic linkages connecting aromatic rings, a new family of atomically thin graph-n-
53 an efficient atom-economic route to build an aromatic ring-a step ubiquitously important in organic s
54 led four possible pathways for attacking the aromatic ring: (a) electrophilic (2e(-)) attack by a bis
55 that contain flanking meta/para-substituted aromatic rings adjacent to the central anilinium ion.
57 to the cross-resonance of carbonyl with the aromatic ring, alkene-alkyne cycloaddition is more favor
58 m granted by the C-C bond connecting the two aromatic rings allowing the molecule to choose the degre
59 substitution into the ortho positions of the aromatic rings allows for the rings to become coplanar;
60 ed derivatives with intact drug moieties (an aromatic ring and a beta-ethanolamine moiety) were furth
61 a central aromatic ring o-substituted by an aromatic ring and a moiety bearing an O or S atom attach
62 rect oxidative C-N bond formation between an aromatic ring and a pendent free-NH2 moiety, features a
65 derivatives containing an electron deficient aromatic ring and capable of adopting flat conformations
66 gnificant preference for the centroid of the aromatic ring and distances near the sum of the van der
68 this complex, a larger distance between the aromatic ring and nitronium ion precludes the possibilit
70 features key to antiviral activity: a bulky aromatic ring and the 1,5-substitution pattern on the tr
73 nzylic fluorination of substrates containing aromatic rings and electron-withdrawing groups positione
77 ridinyl ring of 2 could be replaced by other aromatic rings and the pyrrolidinyl ring is not required
78 f the structure-activity relationship of the aromatic rings and their substituents, the alkyl chain l
79 ribac, a member of the PYBs, possesses three aromatic rings and these adopt a twisted "S"-shaped conf
80 f alkynes connected, on one side, to various aromatic rings and to chiral amino ester appendages on t
81 inker rigidification via the introduction of aromatic rings and/or a decrease in the overall lipophil
82 oning during migration, and demethylation of aromatic rings) and equilibrium processes (such as trans
83 investigated the effect substituents on the aromatic ring, and the cyclobutanol moiety, have on the
84 ultiple alkyl chains, branched alkyl chains, aromatic rings, and nonaromatic rings were evaluated.
85 romatic hydrocarbons (PAHs) with one to five aromatic rings, and the metal ions Cd(II), Cr(III), Pb(I
86 -4,5-diaryl imidazolines that project unique aromatic rings, and these were evaluated for MDM2-p53 in
88 tives depending on which substituents on the aromatic ring are conjugated with the butadiene fragment
93 pi, donor-pi, halogen-pi, and carbon-pi) and aromatic ring-aromatic ring (pi-pi) interactions, within
95 sm does not lead to cyclization of the third aromatic ring as expected but rather undergoes ethynyl s
97 ating and electron-withdrawing groups on the aromatic ring at both propargyl and alkyne positions.
98 n, antiattack of the electron cloud from the aromatic ring at the activated triple bond, and cyclizat
100 least two methoxy groups distributed in the aromatic rings, at least one of which had to be located
102 Using an electrostatic model of the modified aromatic ring based on quantum chemistry, the calculatio
103 aerosol yield and chemical composition on an aromatic ring basis are developed and utilized to explor
104 Potentially, this approach can convert any aromatic ring bearing a -CH(2) Br or a -CHO group into a
106 rtant for stable aromatic interactions among aromatic rings, but studies in the context of a protein'
107 ctions require substantial activation of the aromatic ring by electron-withdrawing substituents, such
108 one-directed regioselective monoarylation of aromatic rings by C-H bond activation is developed.
109 t formed as a result of the oxidation of PES aromatic rings by substitution of hydrogen by hydroxyl r
110 ith the disappearance of the band related to aromatic rings, by Gaussian fitting, and modifications i
111 ized (1) pi-pi* and (3) pi-pi* states of the aromatic ring can be bridged by intramolecular CT states
112 how the third dimension above and underneath aromatic rings can be exploited to precisely control ele
113 report herein the first example of a Mobius aromatic ring capped by a cavity, consisting of a Mobius
114 rly demonstrates the greater significance of aromatic ring carbons compared with alkyl carbon substit
115 ntacts, and hydrogen bonds and specific atom-aromatic ring (cation-pi, donor-pi, halogen-pi, and carb
116 ormalization of yield and composition to the aromatic ring clearly demonstrates the greater significa
118 s between a series of monosaccharides and an aromatic ring close to the glycosylation site in an N-gl
119 of the C horizontal lineC double bonds of an aromatic ring completes a pseudo-square-planar coordinat
121 ens show a common scaffold consisting of two aromatic rings connected by a linear or a cyclic spacer.
122 In the latter case, the attack at the less aromatic ring corresponds to a higher barrier because a
123 modified according to a strategy of reducing aromatic ring count and introducing a greater degree of
125 ing products are now accessible in which the aromatic rings coupled to the azobenzene bear functional
126 field effect on an aromatic molecule is the aromatic ring current, which can be thought of as an ind
127 These contracted porphyrinoids also exhibit aromatic ring currents, and the internal CH resonances s
128 forded cationic species with slightly larger aromatic ring currents, and under strongly acidic condit
130 ic acids: the first in the 4-position of the aromatic rings (DBS-CO2H), the second having glycine con
131 isoalloxazine ring system with a fourth non-aromatic ring, derived from sequential linkage between a
132 ntaining biomass, it secretes SACTE_2871, an aromatic ring dioxygenase domain fused to a family 5/12
133 ndicate that the electrophilic attack on the aromatic ring does not involve formation of a Cu(III)2(O
134 of heteroatom-based substituents (X) on the aromatic ring does not readily occur, and the robustness
135 primarily the result of hydroxylation of the aromatic ring, double bond of the methyldehydroalanine (
136 strategies enable studies of sub-nanosecond aromatic-ring dynamics using solution NMR relaxation met
137 Ester arms-positioned above the planes of aromatic rings-enable it to distinguish between nearly i
138 rophilic attack of the ferryl species on the aromatic ring, five channels were considered: attacks on
142 ic precursors to the molecular weight of the aromatic ring [Formula: see text], where i is the aromat
143 ponential decay, with the nitro-group on the aromatic ring found to control the formation and loss of
144 in the inner transmembrane domain swings the aromatic rings from downstream Phes in the cavity of the
146 anism has long been viewed as a key route to aromatic ring growth of polycyclic aromatic hydrocarbons
148 onship revealed that the substituents on the aromatic rings had a considerable effect on the overall
153 ir widespread use to forge bonds between two aromatic rings has enabled every branch of chemical scie
154 which the alkene component is embedded in an aromatic ring, has only been reported in a few (four) in
156 s containing electron-donating groups at the aromatic ring have been prepared and characterized, toge
157 razaacenes with as many as 85 linearly fused aromatic rings have been synthesised with thermal stabil
158 five physicochemical descriptors: number of aromatic rings, heavy atoms, MWHBN (a descriptor compris
160 ized molecular orbital first appearing on an aromatic ring (i.e., the highest occupied molecular orbi
161 he chemoselective cleavage of a six-membered aromatic ring in biphenylene is reported using an alumin
164 stabilizing cation-pai interactions with the aromatic ring in N (6)-Phe-cAMP or N (6)-Bn-cAMP or a st
165 n addition, the effect of electronics on the aromatic ring in N-phenyl substrates was studied computa
166 ther than pi-pi stacking interactions of the aromatic ring in p-methylbenzyl-D-galactonoamidine were
167 ong-range ordered structures, which hold the aromatic ring in place and parallel to the surface, are
168 h exchange between rotamer states of a large aromatic ring in the middle of the network shifts the co
170 eductions of substrates bearing at least two aromatic rings in excellent yields, at room temperature,
172 id sequences attached to the upper and lower aromatic rings in order to promote hydrogen bond formati
176 otably, we show that the introduction of the aromatic rings in the major groove does not significantl
180 As the electron-donating capacity at the aromatic ring increases, the overpotential is drasticall
181 comparison of the rate constant for various aromatic rings indicates that electron-donating substitu
183 is series, whereas the reincorporation of an aromatic ring into the pendant enhanced MOR-potency.
186 n decalin indicate that addition of H to the aromatic ring is involved in the rate-limiting step.
187 opt a conformation in which the plane of the aromatic ring is perpendicular to the benzylic C-H bond.
188 n edge-on interaction between sulfur and the aromatic ring is quite favorable, and also confirm that
190 ed on the alkoxyl substituent present on the aromatic ring led to the identification of improved liga
192 ith other hindered structures containing two aromatic rings linked by a short tether, diarylamines ma
193 actions that enhance the coplanarity between aromatic rings maximizing the electronic effects exerted
194 to the aqueous interface or, if occluded by aromatic rings, may cause a transmembrane helix to exit
195 proper distance between positive charge and aromatic ring (Me13) or with homologs having the chirali
197 nsertion is not possible, so addition to the aromatic ring occurs, followed by ring expansion to gene
198 ribe how subtle modifications of the central aromatic ring of a series of phenylbutyrate-based antago
199 on the interaction of the thiol S-H with the aromatic ring of an adjacent molecule, with a through-sp
201 hrome P450 (P450)-catalyzed oxidation of the aromatic ring of estradiol can result in 2- or 4-hydroxy
202 m Fe(II) dioxygenase capable of cleaving the aromatic ring of p-hydroquinone and its substituted vari
203 ormation through this pathway can retain the aromatic ring of parent aromatics, shedding light on the
205 thdrawing or electron-donating groups at the aromatic ring of the 2-aminoaryl aldehyde derivatives us
207 epends on the pi-pi interactions between the aromatic ring of the C-2 protecting group with the exocy
208 hydroxyl substituent must be present at the aromatic ring of the l-carbidopa analogues and show that
209 e is the formation of a diazonium ion on the aromatic ring of the MOF, and the potential reduction of
211 of the transition states, we found that the aromatic ring of the phenyl aliphatic amines may form ca
214 evealed the hydrophobic interactions between aromatic rings of curcumin and the cavity of beta-cyclod
216 trong interactions between the five-membered aromatic rings of FeCp(2) and the six-membered aromatic
217 T unfolds HA via pi-pi interactions with the aromatic rings of HA without significant perturbation on
219 luding hydrophobic pai-pai interactions with aromatic rings of side chains and hydrophilic interactio
220 CH(2) group in the substrate and one of the aromatic rings of the biaryl section of the chiral auxil
221 phobic thioether side chain is packed by the aromatic rings of Tyr(312) and Trp(273), as well as the
222 t, which is due to favorable stacking of the aromatic rings of Y169 and F175, and a stable hydrogen b
224 ectrophile would remove an electron from the aromatic ring or react in a Friedel-Crafts-type manner,
225 ious compounds, when attached directly to an aromatic ring or to other functions like alkyls, ethers/
226 chemical moieties, for example, CH(2)-units, aromatic rings or hydroxyl groups, contribute differentl
227 turated) chains, saturated and aromatic/anti-aromatic rings, organic, inorganic or metallic in nature
229 eous formation of mono- and polyhydroxylated aromatic rings (PHA) and chromophoric mono- and polyhydr
230 d cross coupling, de novo construction of an aromatic ring, point-to-axial chirality transfer or an a
231 tion process demonstrates that the amount of aromatic rings present is a more significant driver of a
232 ntal composition is explored relative to the aromatic ring rather than on a classical mole basis.
233 nding of acidic hydrogens with electron-rich aromatic rings rather than adjacent carbonyl groups.
236 ry of the -S-R group to coplanarity with the aromatic ring resulted in a dramatic decrease in the com
237 binding affinities, incorporation of larger aromatic rings resulted in a significant size-related in
238 eaction is unaffected by substituents on the aromatic ring (rho approximately 0), suggesting general
239 nucleic acid functional groups (heterocyclic aromatic ring, ring methyl, carbonyl and phosphate O, am
241 at its conservation has been enjoined by the aromatic ring's contributions to native stability and se
243 reater electron density at the center of the aromatic ring showed a greater potential for cation-pi i
244 lic groups as additional substituents in the aromatic ring slightly reduced the inhibitory effect.
245 i interactions in systems with electron-rich aromatic rings slow exchange of the alcoholic proton, th
246 and, afterward, hydrophobic interactions and aromatic ring stacking stabilize the positioning of meta
249 Besides COBE, two other substrates with aromatic ring structures were also used in this biphasic
250 umber, number of oxygen atoms, and number of aromatic ring structures, lead to over fit models, and a
251 st report demonstrating that halogenation of aromatic rings substantially enhance inhibitory capaciti
253 teric and electronic effects promoted by the aromatic ring substituents also play an important role i
256 products originating from OH-addition to the aromatic ring such as o-hydroxybenzylalcohol and o-dihyd
257 mponent of the electric dipole moment in the aromatic ring, suggesting that an attractive electronic
258 onic 5-HT in the membrane interface with the aromatic ring system pointing inward and a prevailing re
260 les to an electron transfer (eT) between the aromatic ring systems of the cofactors and further trigg
262 action is accelerated by substituents in the aromatic ring that increase the basicity of the aromatic
263 ne moiety of the macrocyclic ring affords an aromatic ring that must undergo further intramolecular r
264 n >/= 0) when the HOMO is not located on the aromatic ring); the number of compounds tested (N) was 1
265 When protecting groups do not contain an aromatic ring, the sterochemical outcome is dictated by
266 oped for the functionalization of pre-formed aromatic rings, the direct construction of an aromatic c
267 photoprecursors, halogen-substituted in the aromatic ring, their intramolecular [4 + 4] or [4 + 2] c
268 bles incorporation of deuterium atoms on the aromatic ring, thereby ensuring retention of the isotope
269 oryl radical, reduction of the electron-poor aromatic ring to a radical anion, coupling of the radica
270 ich could potentially be replaced by a fused aromatic ring to enhance the rigidity and conjugation of
273 ene boranes (NHC-boranes) with electron-poor aromatic rings under photoredox conditions provide dearo
275 alogs of warfarin with additional lipophilic aromatic rings, up to 100-fold greater potency, and long
278 l can be fine-tuned with substituents on its aromatic ring via through-bond effects, the role of thro
280 n of individual PAHs containing five or more aromatic rings was found to be strongly correlated to th
281 ylene) (OPE)-type molecules possessing three aromatic rings was investigated both experimentally and
282 he rotation of the 5-benzoyl group and the 4-aromatic ring were measured by dynamic NMR and rationali
284 (4) methoxy substituents attached on the six aromatic rings were separated by HPLC using chiral stati
285 s required in a particular distance from the aromatic ring, whereas the hydroxyl group in the para-po
286 tramolecular addition of the alkoxide to the aromatic ring wherein charge on the aromatic system is s
287 s a wide variety of functional groups on the aromatic ring (whether electron donating or electron wit
288 ted by electron donating substituents on the aromatic ring, which stabilize the hole character that i
289 The latter activates the substrate on the aromatic ring, while compound II picks up the ipso-hydro
290 otonated by (n)BuLi at the 5-position of the aromatic ring, while the 5-alkyl isomers are completely
291 "iron laws" of EAS is that an electron-rich aromatic ring will react more rapidly than an electron-p
292 assumed that activation of a C-H bond of an aromatic ring with Pd(II) occurs, directed by the primar
293 2 featuring ortho/ortho'-substituents on the aromatic ring with various ortho-, meta-, and para-subst
295 C(sp(2))-C(sp(2)) bond formation between two aromatic rings with concomitant de novo atroposelective
300 ss II BCRs catalyze electron transfer to the aromatic ring, yielding a cyclic 1,5-dienoyl-CoA via two