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1 ethylation reaction that yields dimethylated arsenical.
2 ty to a number of toxic compounds, including arsenicals.
3 nicals producing methylated and dimethylated arsenicals.
4 ) bond in MAs(III) and in trivalent aromatic arsenicals.
5 (V)], monomethyl- [MMA], and dimethyl- [DMA] arsenicals.
6 trations and proportions of maternal urinary arsenicals.
7 nce to environmental methylated and aromatic arsenicals.
8 nd in trivalent roxarsone and other aromatic arsenicals.
9  than comparable simple inorganic or organic arsenicals.
10 harmacological uses of inorganic and organic arsenicals.
11 anic arsenate but not methylated pentavalent arsenicals.
12 , dependent on diamidines and melaminophenyl arsenicals.
13 c, contribution to the biological effects of arsenicals.
14 exposed to inorganic or methylated trivalent arsenicals.
15 inding complex in cells exposed to trivalent arsenicals.
16 in as a model protein, the trivalent organic arsenical 1 was found to demonstrate enhanced specificit
17                                              Arsenicals active in Hh pathway antagonism include arsen
18      To examine the role of PML in mediating arsenical activity, we also tested these agents using mu
19 jugative R-factor R773 confers resistance to arsenical and antimonial compounds in Escherichia coli,
20 e Escherichia coli plasmid R773 that confers arsenical and antimonial resistance is negatively regula
21                                              Arsenicals and antimonials are first line drugs for the
22                      Leishmania resistant to arsenicals and antimonials extrude arsenite.
23 id-encoded, ATP-dependent extrusion pump for arsenicals and antimonials in Escherichia coli, is allos
24 e arsRDABC operon that confers resistance to arsenicals and antimonials in Escherichia coli.
25 B pump that is responsible for resistance to arsenicals and antimonials in Escherichia coli.
26 ars) operons confer high level resistance to arsenicals and antimonials, while the chromosomally enco
27 n pump that is responsible for resistance to arsenicals and antimonials.
28 trategy for the design of more selective bis-arsenicals and better-optimized protein targets, with a
29 represent the two main classes of drugs, the arsenicals and diamidines, historically used to treat th
30 on protein increases cellular sensitivity to arsenicals and other metalloids and can modulate intrace
31 sformation of inorganic arsenic into organic arsenicals and vice versa.
32 oxicity relative to a small molecule organic arsenical, and an unfunctionalized polymer control.
33                                              Arsenicals are both environmental carcinogens as well as
34                                              Arsenicals are painful, inflammatory and blistering caus
35                               The effects of arsenicals are usually attributed to their ability to bi
36                          Chronic exposure to arsenicals at various life stages and across a range of
37                                              Arsenicals, at 10 microM, strongly disrupt the oxidative
38               Yet the mechanism by which bis-arsenicals become fluorescent upon binding a Cys4 motif
39 , and pre-steady-state methods, we show that arsenicals bind tightly to low micromolar concentrations
40 ilic inorganic anion, hexafluoroarsenate, an arsenical biocide found recently in wastewater.
41                     We found that methylated arsenicals, but not arsenobetaine, are proatherogenic an
42 detoxifies trivalent methylated and aromatic arsenicals by oxidation to pentavalent species.
43 miological studies have shown that inorganic arsenicals cause skin cancers and hyperkeratoses in huma
44 istance to, the diamidine and melaminophenyl arsenical classes of drugs that form the backbone of the
45 gene were also found to be more sensitive to arsenical compounds compared with p-null cell lines.
46 important causal role in the genotoxicity of arsenical compounds in mammalian cells.
47                                     Dyes and arsenical compounds that displayed selectivity against t
48 inhibition of the innate immune response for arsenical compounds that have been used as therapeutics
49         S. putrefaciens thiolated methylated arsenicals, converting MAs(V) into the more toxic metabo
50 no-glutathione) is a promising novel organic arsenical currently undergoing clinical studies in vario
51                 The toxicological effects of arsenicals depend on their oxidation state, chemical com
52 e biomethylated to form a variety of organic arsenicals differing in toxicity and environmental mobil
53 hylated arsenicals (MMAs), and %dimethylated arsenicals (DMAs).
54                                 Cessation of arsenical drug use could reduce exposure and the burden
55 development of new more potent and selective arsenical drugs against solid tumors.
56 ed sensitive assays that use the fluorescein arsenical dye FlAsH (fluorescein arsenical hairpin binde
57                                    These bis-arsenical dyes can become fluorescent when bound to a pr
58 lytic subunit of the Ars pump that catalyzes arsenical extrusion in Escherichia coli, thus providing
59 at can be site-specifically labeled with bis-arsenical fluorophore.
60 opy-driven affinity of trivalent (in)organic arsenicals for closely spaced dithiols has been exploite
61 operon catalyze extrusion of antimonials and arsenicals from cells.
62 stance to both diamidines and melaminophenyl arsenicals from the field, including crossresistance to
63  Using a panel of intramolecular fluorescein arsenical hairpin (FlAsH) bioluminescence resonance ener
64 er (FRET) approach using a small fluorescein arsenical hairpin (FlAsH) targeted to a short tetracyste
65 a GST construct that binds fluorescein-based arsenical hairpin binder (FlAsH) results in significantl
66 the CaM was labeled with a fluorescein-based arsenical hairpin binder (FlAsH) that enables our unambi
67 fluorescein arsenical dye FlAsH (fluorescein arsenical hairpin binder) to detect soluble oligomers an
68 sed YFP to a FRET acceptor, ReAsH (resorufin arsenical hairpin binder), targeted to each alpha1S intr
69  this limitation, we develop the Fluorescein Arsenical Hairpin Binder- (FlAsH-) based FRET in vivo ap
70 ns, to permit detection with the fluorescein arsenical hairpin binding (FlAsH) dye Lumio green.
71 tagged with tetracysteine-FlAsH (fluorescein arsenical hairpin) (acceptor) expressed in HEK293 cells.
72 id (CA) is labeled with a FlAsH (fluorescein arsenical hairpin) reagent.
73  (BRET)-based and conformational fluorescein arsenical hairpin-BRET sensors coupled with high-resolut
74  including isothiocyanates, bisbenzylidenes, arsenicals, heavy metals, and vicinal dithiols, showed h
75 all tetracysteine motifs and the fluorescein arsenical helix binder (FlAsH-PALM).
76     The donor fluorophore FlAsH (Fluorescein Arsenical Helix binder) was attached to a CCPGCC motif i
77 geting of this pathway with darinaparsin, an arsenical in clinical trials, reduced fibrosis through r
78 re used to differentiate iAs from less toxic arsenicals in food matrices.
79     The kinetics of production of methylated arsenicals in reaction mixtures containing enzyme, AdoMe
80                      The presence of organic arsenicals in tadpole tissues suggests they have the abi
81 ed by the relative distribution (%) of these arsenicals in urine.
82                          We report here that arsenicals, in contrast, antagonize the Hh pathway by ta
83 y additionally structurally distinct warfare arsenicals including diphenylchlorarsine (DPCA), dipheny
84 senical methylarsenate (MAs(V)) and aromatic arsenicals including roxarsone (4-hydroxy-3-nitrobenzene
85                           We discovered that arsenicals, including arsenic trioxide and sodium arseni
86                                   Methylated arsenicals, including highly toxic species, such as meth
87                       Exposures to trivalent arsenicals induce phosphorylation of extracellular signa
88 ecapitulates the known human pathogenesis of arsenicals-induced cutaneous inflammation and blistering
89 xide (PAO), a strong oxidant and a prototype arsenical is tested for its suitability to defining mole
90                     Melarsoprol, a trivalent arsenical, is the only drug that can be used to cure bot
91 sized and characterized the reactivity of an arsenical-maleimide (As-Mal) that can be efficiently con
92                 Thus, these studies identify arsenicals-manifested signaling pathways similar to thos
93  to defining molecular mechanisms underlying arsenicals-mediated tissue injury.
94 have investigated the effects of the organic arsenical, melarsoprol (a drug used for treatment of try
95 nic arsenic trioxide (As2O3) and the organic arsenical, melarsoprol, were recently shown to inhibit g
96  was methylated to the less toxic methylated arsenicals methylarsenate (MAs(V)), dimethylarsenate (DM
97 rsenite (iAsIII) or the methylated trivalent arsenicals methylarsine oxide (MAsIIIO), or iododimethyl
98 tabolites, measured as %iAs, %monomethylated arsenicals (MMAs), and %dimethylated arsenicals (DMAs).
99 position after inorganic arsenic, methylated arsenical, or arsenobetaine exposure in drinking water.
100 mbrane-permeating, vicinal cysteine-bridging arsenical phenylarsine oxide.
101 insecticide approximately 150 years ago: The arsenical poison Paris Green was green in color but defi
102 istent with a scheme in which monomethylated arsenical produced from arsenite is the substrate for a
103 r of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenic
104                                              Arsenicals provided protection against NLRP1-dependent a
105 , monomethylarsenous acid (MMA), and an aryl arsenical (PSAO)) have been tested with three reduced se
106         ArsA is the catalytic subunit of the arsenical pump, coupling ATP hydrolysis to the efflux of
107            A recent study takes advantage of arsenical reagent-based methodologies to monitor in vivo
108 , is one of the five proteins encoded by the arsenical resistance (ars) operon of plasmid R773 in cel
109                          The plasmid-encoded arsenical resistance (ars) operon of plasmid R773 produc
110                                          The arsenical resistance (ars) operon of the conjugative R-f
111                              Plasmid-encoded arsenical resistance (ars) operons confer high level res
112                                              Arsenical resistance (ars) operons produce resistance to
113 or that regulates expression of the arsRDABC arsenical resistance operon of plasmid R773 in Escherich
114 re this topology, as will ACR2, a eukaryotic arsenical resistance protein.
115 xpression of the ACR2 and ACR3 genes confers arsenical resistance.
116 nic and antimony are related metalloids, and arsenical resistant Leishmania strains are frequently cr
117 bially reduced to MAs(III), and the aromatic arsenical roxarsone (3-nitro-4-hydroxybenzenearsonic aci
118                                              Arsenicals (roxarsone and nitarsone) used in poultry pro
119  and increasing dietary diversity may reduce arsenical skin lesion risk in Bangladesh.
120 ng, socioeconomic status, betel nut use, and arsenical skin lesions status.
121 ic toxicity, potentially influencing risk of arsenical skin lesions.
122  text] from 400 Bangladeshi individuals with arsenical skin lesions.
123 methyl-arsenical species (MMAs) and dimethyl-arsenical species (DMAs), facilitating urinary excretion
124 rganic As (InAs) is methylated to monomethyl-arsenical species (MMAs) and dimethyl-arsenical species
125                                    Trivalent arsenicals such as arsenite (As(III)) and methylarsenite
126 rr promoter region was impaired by trivalent arsenicals such as arsenite and phenylarsine oxide.
127                             Skin exposure to arsenicals such as lewisite and phenylarsine oxide leads
128 nsively utilized as herbicides, and aromatic arsenicals such as roxarsone (Rox) are used as growth pr
129         It cleaved the C-As bond in aromatic arsenicals such as the trivalent forms of the antimicrob
130        Phenylarsine oxide (PAO), a trivalent arsenical that interacts with vicinal dithiols, is most
131 nzenearsonic acid) is a pentavalent aromatic arsenical that is used as antimicrobial growth promoter
132 ism by which cells distinguish between these arsenicals through one-step metabolism to differentially
133 mp, coupling ATP hydrolysis to the efflux of arsenicals through the ArsB membrane protein.
134 ing that PAO could be used as a prototype of arsenicals to define the molecular pathogenesis of chemi
135                                          The arsenical trimethyl arsine oxide accounted for the major
136 antly associated with the sum of the urinary arsenicals (U-tAs).
137 ATPase as a consequence of binding trivalent arsenicals under a variety of conditions.
138  in which it is found (e.g., toxic inorganic arsenicals vs nontoxic arsenobetaine), and two analytica
139                        In vitro, the organic arsenical was more effective than either arsenite or ant
140 e, known to play a role in detoxification of arsenicals, was diminished by 50% in p-expressing yeast.
141                                 * Methylated arsenicals were not found in the three plant species exp
142                                  Volatilized arsenicals were trapped, and the predominant species wer
143 ut did not affect resistance to a lipophilic arsenical, whereas recombinant AQP2 reversed MPXR in cel
144 lective toward trivalent methyl and aromatic arsenicals, with essentially no response to inorganic ar

 
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