ライフサイエンスコーパス: articular cartilage

1 II collagen, the major structural protein of articular cartilage.

2 ng, result in progressive damage and loss of articular cartilage.

3 hythm and caused progressive degeneration of articular cartilage.

4 g new insights into the impact of hypoxia in articular cartilage.

5 le in maintaining the health and function of articular cartilage.

6 e equilibrium electro-chemical properties of articular cartilage.

7 ular matrix concentration in neonatal bovine articular cartilage.

8 r targeting the surface or interior zones of articular cartilage.

9 ere co-localized in chondrocytes of degraded articular cartilage.

10 chondral bone attenuated the degeneration of articular cartilage.

11 nsgenic mice markedly activated autophagy in articular cartilage.

12 1) histone methyltransferase is expressed in articular cartilage.

13 fibroblast growth factor 2 (FGF-2) from the articular cartilage.

14 ase and involves progressive degeneration of articular cartilage.

15 nti-catabolic and anti-inflammatory in human articular cartilage.

16 MMP-13, which are constitutively present in articular cartilage.

17 effect on morphologic characteristics of the articular cartilage.

18 on of sclerostin has an impact on knee joint articular cartilage.

19 of these were significantly regulated in the articular cartilage.

20 PA) is necessary for the cryopreservation of articular cartilage.

21 ator in the development of osteoarthritis in articular cartilage.

22 1L in chondrogenic differentiation and adult articular cartilage.

23 e 2-dimensional and 3-dimensional changes of articular cartilage.

24 uce profound morphologic changes in immature articular cartilage.

25 ular chondrocytes in the mid-region of mouse articular cartilage.

26 to determine the viscoelastic properties of articular cartilage.

27 concept of ACVs as physiologic structures in articular cartilage.

28 are extracellular organelles found in normal articular cartilage.

29 roblast growth factor (FGF)/Erk signaling in articular cartilage.

30 zed by proteoglycan loss and fibrillation of articular cartilage.

31 t, thickness, and volume of the femoral head articular cartilage.

32 E3 ubiquitin ligases abundantly expressed in articular cartilage.

33 differentiation of MF-activated SSCs toward articular cartilage.

34 ty for assessment of pathological changes in articular cartilage.

35 nitor cells (CPC) derived from human OA knee articular cartilage.

36 n upregulation of Runx2-Adamts5 signaling in articular cartilage.

37 icin (Prg4), the major boundary lubricant of articular cartilage.

38 is often associated with the degeneration of articular cartilage.

39 nd contribute to the growth and reshaping of articular cartilage.

40 nd organized cartilage resembling the native articular cartilage.

41 ntrast agent (CA4+) is described for imaging articular cartilage.

42 ches for application of miRNAs to regenerate articular cartilage.

43 NFkappaB and LCN2 in the pathophysiology of articular cartilage.

44 ing and the sGAG and collagen content of the articular cartilage.

45 in irreversible, progressive destruction of articular cartilage(1).

46 joints causes profound loss of volume in the articular cartilage, a clinical observation first descri

47 erved early degenerative changes of condylar articular cartilage, abnormal development of the articul

48 Articular cartilage (AC) and intervertebral discs are ca

49 tifactorial disease that is characterized by articular cartilage (AC) degradation.

50 This study investigated articular cartilage (AC) homeostasis and different signa

51 therapies to manage osteoarthritis (OA) and articular cartilage (AC) injuries.

52 Articular cartilage (AC) lacks the ability to self-repai

53 Injury to the surface of intact articular cartilage activates Src-like kinases as well a

54 development of synthetic composite gel-based articular cartilage analog suggests new avenues to explo

55 ctures include a skeletal element lined with articular cartilage and a synovial cavity, and we demons

56 ition as it progresses to destruction of the articular cartilage and ankylosis of the joints.

57 ure of osteoarthritis is the gradual loss of articular cartilage and bone deformation, resulting in t

58 Expression of sclerostin was determined in articular cartilage and bone tissue obtained from mice,

59 characterised by progressive destruction of articular cartilage and chondrocyte cell death.

60 Articular cartilage and cultured chondrocytes from Sulf(

61 int disease that involves the destruction of articular cartilage and eventually leads to disability.

62 gen tension in the region destined to become articular cartilage and higher oxygen tension in transie

63 sing the mechanical properties of engineered articular cartilage and identifying potentially importan

64 and LC3 was analyzed in normal and OA human articular cartilage and in knee joints of mice with agin

65 with enhanced EGF receptor signaling in the articular cartilage and in the abnormally formed osteoph

66 ding chondrocytes in the superficial zone of articular cartilage and in the meniscus, as well as syno

67 oint motion via adsorption to the surface of articular cartilage and its lubricating properties in so

68 ubricin) is secreted by cells that reside in articular cartilage and line the synovial joint.

69 duced joint pathology, including thinning of articular cartilage and loss of proteoglycans in the car

70 nosis is key to preventing compromise to the articular cartilage and maximizing opportunity to perfor

71 collagen network and proteoglycan content in articular cartilage and meniscal matrix.

72 Injuries to articular cartilage and menisci can lead to cartilage de

73 ence was found in morphological thickness of articular cartilage and menisci in early osteoarthritis

74 T1 and T2 relaxation time values of articular cartilage and menisci were significantly highe

75 nologies that are being developed for use in articular cartilage and meniscus repair and regeneration

76 collagen is the most prominent component of articular cartilage and other cartilage-like tissues suc

77 lay unique aggressive behavior, invading the articular cartilage and promoting inflammation.

78 genes that maintain the homeostasis of adult articular cartilage and regenerate its lesions, we initi

79 potential in amelioration of degeneration of articular cartilage and subchondral bone microarchitectu

80 erestingly, IL-3 reduces the degeneration of articular cartilage and subchondral bone microarchitectu

81 Changes in articular cartilage and subchondral bone were analyzed b

82 e both beneficial and detrimental effects on articular cartilage and subchondral bone, and may subseq

83 OA) is a progressive degenerative disease of articular cartilage and surrounding tissues, and is asso

84 We found that SnCs accumulated in the articular cartilage and synovium after ACLT, and selecti

85 r findings suggest that Gdf5 upregulation in articular cartilage and synovium is a generic response t

86 pression of miRNA 146a was analyzed in human articular cartilage and synovium, as well as in dorsal r

87 study demonstrates the presence of D-COMP in articular cartilage and the systemic circulation, and to

88 degeneration of joints, involving mainly the articular cartilage and the underlying bone, and severel

89 Current literature suggests that articular cartilage and transient cartilage originate fr

90 ochondral defects contain damage to both the articular cartilage and underlying subchon- dral bone, w

91 ollagens in bones, as well as prominently in articular cartilages and tumors characterized by high MM

92 Aggrecan is a major matrix component of articular cartilage, and its degradation is a crucial ev

93 he Tak1 mutant mice showed defects in skull, articular cartilage, and mesenchymal stromal cells.

94 ent a new type of contrast agent for imaging articular cartilage, and the results demonstrate the imp

95 artilage did not differ from those of native articular cartilage, and were significantly greater than

96 dent of joint loading forces responsible for articular cartilage anisotropy.

97 ating skeletal bone mass, but its effects in articular cartilage are not known.

98 r microcomputed tomography (muCT) imaging of articular cartilage are reported.

99 e exhibited hyperplasia in the glenoid fossa articular cartilage, articular disc, and synovial membra

100 ted tissues was compared with that in native articular cartilage as a means of assessing the progress

101 Here, by using self-assembled articular cartilage as a model to examine the effects of

102 III collagen, which is synthesized in mature articular cartilage, as a covalent modifier that may add

103 n seconds of injury to the surface of intact articular cartilage, as did activation of MAPKs and IKK.

104 r the correct development and homeostasis of articular cartilage, as evidenced by the fact that aberr

105 crystals are universally present in hyaline articular cartilage, as well as the meniscus of the knee

106 ties of the superficial zone of young bovine articular cartilage at deformation amplitudes, delta, of

107 uciate ligament (ACL) remnants compared with articular cartilage at the cellular and tissue level.

108 nlike the well-defined zonal organization of articular cartilage attributed to postnatal biomechanica

109 xpression level of ADAM12 protein in the KBD articular cartilage (average positive chondrocyte rate =

110 rate = 47.59 +/- 7.79%) compared to healthy articular cartilage (average positive chondrocyte rate =

111 escribe physiological benchmarks for healthy articular cartilage behavior during walking and provide

112 e hyaline cartilage, which expressed typical articular cartilage biomarkers, including established in

113 sion to show that chondrocytes isolated from articular cartilage biopsies of patients and subjected t

114 Osteoarthritis is characterized by articular cartilage breakdown, and emerging evidence sug

115 res and CC/TAC (calcified cartilage to total articular cartilage), but increased SBP (subchondral bon

116 ave been proposed for replacement of damaged articular cartilage, but they suffer from a complete lac

117 esponsible for the remarkable lubrication of articular cartilage; but alone, these molecules cannot e

118 e Prg4 expression in the superficial zone of articular cartilage by engaging the same signaling pathw

119 identified Fgf18 as a molecule that protects articular cartilage by gene expression profiling, and th

120 hyaluronan, anchored at the outer surface of articular cartilage by lubricin molecules, complexes wit

121 ycans (PG) provide compressive resistance to articular cartilage by means of their fixed charge densi

122 lays an essential role in the maintenance of articular cartilage by preventing articular chondrocytes

123 arthritis and its hallmark is degradation of articular cartilage by proteolytic enzymes leading to lo

124 DT imaging of articular cartilage can enable physicians to detect and

125 ific mouse tryptase plays prominent roles in articular cartilage catabolism.

126 Impact loading of articular cartilage causes extensive chondrocyte death.

127 evated ratio of calcified cartilage to total articular cartilage (CC/TAC), and synovial hyperplasia w

128 croRNA expression profiling in healthy human articular cartilage cells (chondrocytes), we identified

129 t, similar to transient cartilage, embryonic articular cartilage cells also originate from the prolif

130 Primary articular cartilage chondrocytes from Smad3(fl/fl) mice

131 Fgf18 was strongly expressed in the articular cartilage chondrocytes of adult rats.

132 ignificantly greater agent uptake of CA4+ in articular cartilage compared to that of similar anionic

133 Growth plate and articular cartilage constitute a single anatomical entit

134 rocyte catabolism, not death, contributes to articular cartilage damage following injury.

135 tion of lentiviral Wnt7a strongly attenuated articular cartilage damage induced by destabilization of

136 The articular cartilage damage present in the knee joints of

137 , in spite of the protection from structural articular cartilage damage, the postnatal growth plates

138 he progeny of these cells reconstitute adult articular cartilage de novo, entirely substituting fetal

139 y, mice underwent knee surgery to produce an articular cartilage defect and received chlorodeoxyuridi

140 The development of morphologic articular cartilage defects (Whole-Organ MR Imaging Scor

141 termine the incidence with which morphologic articular cartilage defects develop over 48 months in ca

142 ethods for clinical diagnosis and staging of articular cartilage degeneration are important to the ev

143 ate ligament (ACL) and their relationship to articular cartilage degeneration are not well characteri

144 e the potential to therapeutically attenuate articular cartilage degeneration as part of OA.

145 ecific reduction of Smad3 caused progressive articular cartilage degeneration due to imbalanced carti

146 uated hedgehog-induced or surgically induced articular cartilage degeneration in mouse models of OA.

147 ith losartan both delayed the progression of articular cartilage degeneration induced by DMM compared

148 Reduction of DDR-2 expression attenuates the articular cartilage degeneration of knee joints induced

149 Initiation or acceleration of articular cartilage degeneration was not observed by the

150 l joints were characterized for evidences of articular cartilage degeneration.

151 s Runx2-inducible gene expression to prevent articular cartilage degeneration.

152 gery in Cre-negative control mice, including articular cartilage degradation and subchondral sclerosi

153 ufficient extracellular matrix synthesis and articular cartilage degradation, mediated by several pro

154 on is mild and normalizing with age, but the articular cartilage degrades with age and bones develop

155 As a result, this study suggests articular cartilage derived-CPSC can be used as a novel

156 r chondrocytes and synoviocytes, stimulating articular cartilage destruction.

157 ession to direct interzone progeny fates and articular cartilage development and disease.

158 ere investigated for their ability to affect articular cartilage development in a scaffoldless, 3-dim

159 We conclude that Phd2 is a key regulator of articular cartilage development that acts by inhibiting

160 Biomechanics plays a pivotal role in articular cartilage development, pathophysiology, and re

161 ve and shear properties of TGFbeta3-mediated articular cartilage did not differ from those of native

162 y a progressive and irreversible loss of the articular cartilage, due in main part to the cleavage of

163 lycan from the extracellular matrix of their articular cartilage during inflammatory arthritis than w

164 n collagenase responsible for degradation of articular cartilage during osteoarthritis and therefore

165 particularly in the middle and deep zones of articular cartilage, during CPA loading.

166 Articular cartilage enables weight bearing and near fric

167 We demonstrate that PPARgamma-deficient articular cartilage exhibits elevated expression of the

168 growth factor stimulation of immature bovine articular cartilage explants in serum-free culture mediu

169 Bovine full-depth articular cartilage explants were loaded to 2.5 MPa (phy

170 To simulate osteoarthritis in vitro, human articular cartilage explants were placed in culture and

171 as to investigate if chondrocytes from human articular cartilage express gap junction proteins called

172 e was little histological evidence of mature articular cartilage formation in all animals.

173 We characterized undamaged and damaged articular cartilage from 22 participants having hip repl

174 Normal human articular cartilage from a range of donors was obtained

175 to reduced type II collagen mRNA expression, articular cartilage from Col2-Cre;Smad3(fl/fl) mice was

176 Lipid peroxidation in articular cartilage from OA patients and from lesion-fre

177 lage was assessed in vitro by immunostaining articular cartilage from RA and OA patients and from nor

178 Finally, mouse articular cartilage from Sirt1(-/-) presented increased

179 Conditions of the articular cartilage from the knee joints of the double-h

180 Articular cartilage from young, old and OA knees was use

181 ture, ultrastructure and function of hyaline articular cartilage (HAC) and subchondral bone (SCB), an

182 years it has become increasingly clear that articular cartilage harbours a viable pool of progenitor

183 Articular cartilage has little regenerative capacity.

184 de insight into the regulatory mechanisms of articular cartilage homeostasis and maintenance by morph

185 role of miR-146a in the regulation of human articular cartilage homeostasis and pain-related factors

186 more relevant in examining their effects on articular cartilage homeostasis and the development of o

187 Characterization of articular cartilage homeostasis and the mechanism of sup

188 hACs and the importance of NGF signaling in articular cartilage homeostasis.

189 ed with abnormally expressed pathways in KBD articular cartilage, identified by microarray study of K

190 f Prg4 in the superficial zone of knee joint articular cartilage in a COX-2-dependent fashion, which

191 wing chondrocyte progenitors, which form the articular cartilage in juvenile mice.

192 growth and differentiation of transient and articular cartilage in juxtaposed domains.

193 drocyte differentiation, and degeneration of articular cartilage in osteoarthritis (OA).

194 omogeneities in the mechanical properties of articular cartilage in situ.

195 chronic disease characterized by the loss of articular cartilage in synovial joints through a process

196 arthritis, characterized by the breakdown of articular cartilage in synovial joints, has long been vi

197 d extensive synovial hypertrophy and loss of articular cartilage in the knees.

198 as a frictional behaviour resembling that of articular cartilage in the major joints.

199 isease involving the mechanical breakdown of articular cartilage in the presence of altered joint mec

200 hat the chondrocytic primary cilium forms in articular cartilage in the presence or the absence of lo

201 e of COX-2 in regulating MMP-1 expression in articular cartilage in vivo was demonstrated using COX-2

202 findings show that RRV infection damages the articular cartilage, including a loss of proteoglycans w

203 th KBD, but also abnormally expressed in KBD articular cartilage, including REACTOME_INTRINSIC_PATHWA

204 Mechanical loading on articular cartilage induces various mechanical stresses

205 nic joint pain resulting from degradation of articular cartilage, inflammation of the synovial lining

206 Articular cartilage injury can result in chondrocyte los

207 The native extracellular matrix (ECM) of articular cartilage is a 3D structure composed of protei

208 Articular cartilage is a highly efficacious water-based

209 Articular cartilage is a load-bearing tissue found in an

210 Mammalian articular cartilage is an avascular tissue with poor cap

211 The superficial zone (SZ) of articular cartilage is critical in maintaining tissue fu

212 Articular cartilage is exposed to a gradient of oxygen l

213 The articular cartilage is exquisitely sensitive to mechanic

214 The articular cartilage is known to be highly mechanosensiti

215 nes, we propose that the collagen network in articular cartilage is near a percolation threshold that

216 Among mammalian soft tissues, articular cartilage is particularly interesting because

217 but the exact targets of NGF action on human articular cartilage is unknown.

218 fering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage

219 analyzed for boundary lubrication of normal articular cartilage (kinetic friction coefficient [mu(ki

220 nic disease characterized by degeneration of articular cartilage leading to pain and physical disabil

221 Histologic changes seen in OA, including articular cartilage lesions and osteophytes, were presen

222 and control contralateral joints, including articular cartilage lesions, osteophyte formation, and p

223 ry to immature knee joints most often causes articular cartilage lesions, this study was undertaken t

224 In human articular cartilage, LfcinB antagonizes interleukin-1 be

225 tants failed to upregulate expression of the articular cartilage marker gene Prg4.

226 The age-related loss of HMGB2 in articular cartilage may represent a mechanism responsibl

227 abnormalities or morphologic defects in the articular cartilage (mean age, 54 years +/- 5; 51% women

228 issected tissues of the joint, including the articular cartilage, meniscus, and epiphysis.

229 fication of extracellular matrix proteins in articular cartilages, meniscus, intervertebral disc, rib

230 The insufficient healing capacity of articular cartilage necessitates mechanically functional

231 Chondrocytes were isolated from articular cartilage obtained during talonavicular joint

232 olated chondrocytes from the surface zone of articular cartilage of bovine stifle joints were culture

233 s of articular chondrocytes were seen in the articular cartilage of ESET-null animals.

234 ditionally overexpressing DDR2 in the mature articular cartilage of mouse knee joints requires activa

235 creased levels of hypertrophy markers in the articular cartilage of the cKO mice.

236 e tibia and femur, and in the epiphyseal and articular cartilage of these bones.

237 used towards the repair of focal defects in articular cartilage or broadly towards widespread biomed

238 However, structural changes of articular cartilage or menisci cannot be directly evalua

239 ntitative ultrasound grading of knee femoral articular cartilage, osteophytes and meniscal extrusion,

240 r-sized, anatomically shaped pieces of human articular cartilage over 5 wk of culture.

241 tion of the Phd2 gene in chondrocytes on the articular cartilage phenotype in mice.

242 Gdf5 expression was upregulated in articular cartilage post-DMM, and was increased in human

243 Mechanical overloading of articular cartilage producing hydrostatic stress, tensil

244 In this study we propose articular cartilage progenitor/stem cells (CPSC) as a va

245 at acts by inhibiting the differentiation of articular cartilage progenitors via modulating HIF-1alph

246 Articular cartilage quality was assessed by quantitative

247 lesion scores in ankle-joint, knee-joint and articular cartilage, reduced pain perception.

248 Our findings indicate that articular cartilage regeneration in mice is heritable, t

249 Cell and tissue engineering approaches for articular cartilage regeneration increasingly focus on m

250 nstructs from MSCs for future transplantable articular cartilage regeneration therapies.

251 ls have emerged as a favourable approach for articular cartilage regeneration.

252 sources of endogenous cells that regenerate articular cartilage remain elusive.

253 n of sclerostin with Scl-Ab has no impact on articular cartilage remodeling in rats with posttraumati

254 Articular cartilage repair remains a significant and gro

255 attractive therapeutic solution for targeted articular cartilage repair, allowing for a controlled an

256 tion, suggesting their potential utility for articular cartilage repair.

257 mensions on the nanoscale for application to articular cartilage repair.

258 Aging-associated changes in articular cartilage represent a main risk factor for ost

259 s, which falls within the range reported for articular cartilage, requires the stiffness-sensitive in

260 The spatial organization of the articular cartilage results from a band of Nog-expressin

261 and histologic sections of growth plate and articular cartilage revealed no significant abnormalitie

262 tes taken from paired intact versus degraded articular cartilage samples across 38 patients undergoin

263 bilization of the medial meniscus (DMM), and articular cartilage samples were microdissected and subj

264 access to active TGF-beta: the synovium and articular cartilage secrete latent TGF-beta into the SF

265 Articular cartilage specimens from 8 subjects were colle

266 scence imaging were combined to characterize articular cartilage, subchondral bone, vascularization,

267 y investigated mechano-regulation of miRs in articular cartilage subjected to 'physiological' and 'no

268 Physiologically, articular cartilage sustains millions of cycles of mecha

269 rent organization of the superficial zone of articular cartilage that normally exerts an anti-frictio

270 ded that focus on the tissues outside of the articular cartilage that play a role in osteoarthritis.

271 ciated with chondrocyte hypertrophy in adult articular cartilage, the lack of which protects from car

272 Unlike appendicular articular cartilage, the TMJ has two distinct functions

273 In both age groups, articular cartilage thickness decreased, and subchondral

274 We found that articular cartilage tissue sections from y/y mice of up

275 tilage strands as building units to bioprint articular cartilage tissue.

276 lasticity of the composites approach that of articular cartilage tissue.

277 at underscores the need to subject the mouse articular cartilage to a destabilizing challenge in orde

278 Exposure of articular cartilage to excessive mechanical loading is d

279 is a novel adipokine that negatively impacts articular cartilage, triggering catabolic and inflammato

280 It reduces the coefficient of friction of articular cartilage under boundary mode conditions (0.08

281 Stick-slip friction was observed in articular cartilage under certain loading and sliding co

282 ignaling and allows them to differentiate as articular cartilage under the influence of Wnt signaling

283 The degeneration of articular cartilage underscores the clinical pathology o

284 Articular cartilage vesicles (ACVs) are extracellular or

285 te-derived extracellular organelles known as articular cartilage vesicles (ACVs) participate in non-c

286 ion channel transduces mechanical loading of articular cartilage via the generation of intracellular

287 running show higher reductions of knee joint articular cartilage volume after 75 minutes of running.

288 uantitative assessment of parameters such as articular cartilage volume and surface area.

289 We quantified knee joint articular cartilage volumes before and after the run usi

290 ional overexpression of DDR2 in mature mouse articular cartilage was controlled via the cartilage oli

291 In the OA and OPOA groups, articular cartilage was degenerated and Osteoarthritis R

292 Articular cartilage was harvested from the paws and knee

293 Articular cartilage was obtained from the knees of 4 nor

294 Articular cartilage was predicted to be one of the first

295 MATERIAL/METHODS: Labral pathology and articular cartilage were prospectively evaluated with MR

296 Chondrocytes from normal human articular cartilage were treated with glucosamine (0.1-

297 expressed during chondrogenesis and in adult articular cartilage, where it can regulate TGFbeta signa

298 The articular cartilage, which lines the joints of the limb

299 imaging in comparison with the incidence in articular cartilage without signal abnormalities at base

300 ecreted from both the synovium and all three articular cartilage zones (superficial, middle, and deep