ライフサイエンスコーパス: as little as

1 Importantly, as little as 0.0005% of ring stage parasites can be dete

2 s, and can be carried out in high yield with as little as 0.01 mole per cent catalyst with a moisture

3 endent manner, and a single mosquito bite or as little as 0.01 mug of SGE was effective at enhancing

4 rdi assay based on the Mo2 repeat can detect as little as 0.01 pg.

5 mbrane; Kir2.1 shows measureable activity in as little as 0.01% PIP(2), and open probability increase

6 trate that for Abeta(1-40), and Abeta(1-42), as little as 0.01mol equivalent of Zn(2+) (100nM) is suf

7 ion was seen after intracameral injection of as little as 0.02 and 0.08 EU in OVD and DPBS eyes, resp

8 s were carried out in less than a day, using as little as 0.02 milligrams of material per reaction.

9 MS-eLCR required as little as 0.04 pM of starting material and was sensit

10 1, 8a-e, 9, 12, and 13 can be mediated with as little as 0.05 mol % of Cu(TPMA)SO(4).5H(2)O in the p

11 ormations to be performed in the presence of as little as 0.05 mol %, which is the lowest catalyst lo

12 ine partial genomes of bacteria representing as little as 0.05%.

13 e, and click chemistry, we demonstrated that as little as 0.1 fg of lambda-DNA (close to copy number

14 They weigh as little as 0.1 g cm(-2) and have the ability to 'pop-b

15 umptive analysis of Si and phosphorus (P) in as little as 0.1 g dried and ground plant material using

16 s and stereoselectivities in the presence of as little as 0.1 mol % of a chemoselective peptidic cata

17 o efficiently reduce the catalyst loading to as little as 0.1 mol %, the lowest one described for thi

18 ecific and recognized oligosaccharides, from as little as 0.1 mug of material.

19 kb of long-range sequencing information with as little as 0.1 ng input material.

20 ute and was complete by 90 minutes-even with as little as 0.1 nM lacritin, and involved the donors ly

21 tuning the hydrogel and solution properties, as little as 0.1 U/muL protein kinase A could be detecte

22 The addition of as little as 0.1% polyphenols to bread significantly red

23 In some instances, as little as 0.15 mol % of the catalytically active alky

24 s are described in more detail and show that as little as 0.15 nmol of nitric oxide and 0.20 nmol of

25 ted that for the light-driven RWGS reaction, as little as 0.2 at.

26 me format, allows absolute quantification of as little as 0.2 fmol of miR-203.

27 ectively reduced to Hg(0) in the presence of as little as 0.2 mg/L reduced HA, whereas production of

28 prevented by intracellular acidification by as little as 0.2 pH units, induced by either lowered med

29 that differ in collisional cross section by as little as 0.2% before injecting them into a cryogenic

30 The addition of as little as 0.2% TFE increases aqueous spray stability

31 ingent conditions, and can be performed with as little as 0.25 mole per cent catalyst in less than si

32 ion in a highly enantioselective manner with as little as 0.25% mol catalyst loading.

33 100 amol of polymerase product, representing as little as 0.25% of a monolayer.

34 rage can allow 57% emissions reductions with as little as 0.3% renewable curtailment.

35 ear-future increases in local temperature of as little as 0.5 degrees C result in this protective mec

36 in the bone marrow was dose dependent, with as little as 0.5 Gy causing a significant long-term redu

37 hole-body general anesthesia; microinjection as little as 0.5 mm off-target did not.

38 As little as 0.5 mol % CuCl is sufficient to catalyze th

39 is readily promoted at room temperature with as little as 0.5 mol % of catalyst, and demonstrates hig

40 This method can detect as little as 0.5% bovine whey in ricotta cheese from the

41 ivity and in high yields using in most cases as little as 0.5-0.1 mol % Pd(OAc)(2) as the catalyst wi

42 ithin the gels, enabling precise analysis of as little as 0.6 femtomoles of DNA target.

43 This novel assay allowed detection of as little as 0.65 pg/ml GAD65.

44 The instrument requires as little as 0.75 mL of a solution to provide a full pro

45 rtual machines, we processed the samples for as little as $0.09 (USD) per sample.

46 The catalytic performance was measured using as little as 1 cycle of Pt ALD, which corresponded to a

47 at social interactions with adult tutors for as little as 1 d significantly enhanced vocal learning.

48 The entire protocol can be completed in as little as 1 d.

49 ve to thermal perturbations and temperatures as little as 1 degrees C above the average summer maxima

50 temperature and can perceive a difference of as little as 1 degrees C.

51 tation to process the full human genome when as little as 1 GB of RAM is made available.

52 entration-enhancing agent, which acts within as little as 1 h after administration to mammalian cells

53 ntimicrobial resistance gene profiles within as little as 1 h of sequencing.

54 case of spores, the exposure was detected in as little as 1 h without the use of antibodies or fluore

55 Consequently, over as little as 1 h, reference electrode frits with low flo

56 false-positive by administering the patient as little as 1 MBq/kg.

57 SIDRs were obtained, for all substances, in as little as 1 min.

58 we were able to isolate RNA produced during as little as 1 minute, allowing the detection of nascent

59 t and reliable method of DNA extraction from as little as 1 ml of early positive mycobacterial growth

60 sing this approach permitted reductions with as little as 1 mol % Sm.

61 tal groups with eight subjects each can take as little as 1 month if optimized for speed, or approxim

62 e profiling can be completed in one day with as little as 1 ng of purified RNA footprints.

63 requency mtDNA point mutations starting with as little as 1 ng of total DNA.

64 equences exactly and resolves differences of as little as 1 nucleotide.

65 10) M(-1) s(-1)) radicals, besting thiols by as little as 1 order and as much as 4 orders of magnitud

66 lts show that the anti-ZIKV-PSBs can capture as little as 1 PFU of ZIKV in 100 mul of saline, human p

67 timized linker amplification method requires as little as 1 pg of DNA and is the most precise and acc

68 me library generation can be accomplished in as little as 1 week, although 2-3 weeks would be a more

69 on in a recipient host can be carried out in as little as 1 week.

70 than 6 um, and the ink can be stabilized by as little as 1 wt% graphite.

71 As little as 1% impervious land cover surrounding a lake

72 s were assembled for bacteria that comprised as little as 1% of the community, as well as nine partia

73 e substantially if vaccine coverage drops by as little as 1%.

74 ighly efficient and is generally complete in as little as 1-2 h, giving the products in good to excel

75 g window from approximately 5 nucleotides to as little as 1-2 nucleotides.

76 n, gene modifications can be achieved within as little as 1-2 weeks, and modified clonal cell lines c

77 port that mice fed a high-fat diet (HFD) for as little as 1-3 days show increased differentiation of

78 esolution can distinguish peaks separated by as little as 1.1 mDa), and high mass accuracy enables as

79 because only 1 microl of liquid is required, as little as 1.2 fmol of trypsin can be detected by usin

80 efficiency) may be accurately computed from as little as 1.5-2.0 minutes of RS functional MR imaging

81 er that substoichiometric amounts of PrP(C), as little as 1/20, relative to Abeta will strongly inhib

82 te the detection of telomerse extracted from as little as 10 cells/muL and 100 cells/muL in buffer an

83 se in most of the vaccinated hamsters within as little as 10 days.

84 c and reproducible and able to detect MSV in as little as 10 fg/ul of purified genomic DNA obtained f

85 ynucleotide chain terminator sequencing from as little as 10 genome equivalents of template, dependin

86 nputs that are shifted in the sniff cycle by as little as 10 milliseconds, which is similar to the te

87 nel optical layout to acquire CPL spectra in as little as 10 milliseconds.

88 this MALDI-TOF MS method was accomplished in as little as 10 min from isolated colonies and 30 min fr

89 -FKBP, Fos-Jun, and neuroligin-PSD-95), with as little as 10 min of coumarin treatment.

90 e taken several days, can now be obtained in as little as 10 minutes, greatly facilitating candidate

91 ots, even when administration was delayed by as little as 10 minutes, while it concurrently prevented

92 In summary, elevating [Na(+)](o) by as little as 10 mM can significantly modulate mechanical

93 ad movements followed the visual stimulus in as little as 10 ms-a delay similar to the human vestibul

94 of a wide variety of NMR-active nuclei with as little as 10 muL of sample in a microcoil.

95 complex bisulfite sequencing libraries from as little as 10 ng of input DNA, and ample useful sequen

96 urther limited to 50% by RvD1 treatment with as little as 10 ng of RvD1 per mouse.

97 ifies thousands of m(6)A sites in cells from as little as 10 ng of total RNA and can detect m(6)A acc

98 This protocol uses as little as 10 ng of total RNA, allows multiplex sequen

99 enerated high-quality RNA-seq libraries from as little as 10 pg of mRNA ( approximately 1 ng of total

100 collected, differentiating among populations as little as 10 to 20 m in depth from one another.

101 rine pancreas development in humans and that as little as 10% NEUROG3 is sufficient for formation of

102 able signal for LAMP reaction amplified from as little as 10(-19) M virus gene.

103 upplied polyamines, but supplementation with as little as 10(-8) m spermidine restores their growth.

104 e an RT-QuIC assay for H-BSE that can detect as little as 10(-9) dilutions of brain tissue and neat c

105 nhancement; detection could be achieved with as little as 10(2) EID(50)/mL (50% egg infective dose pe

106 Our results indicate that as little as 10(5) WBC and 100 mul of blood collected fr

107 Using this technique, it is possible to see as little as 10-100 amol of polymerase product, represen

108 We demonstrate that cshRNAs coded from as little as 100 bps of total coding space can precisely

109 y syncytial and West Nile viral samples from as little as 100 copies of viral RNA.

110 luence specific neural mechanisms active for as little as 100 ms during the flow of human information

111 TE-polarised light with a pulse duration of as little as 100 mus.

112 ible sensor displacement on radiographs with as little as 100 N of axial compressive loading.

113 As little as 100 Pa causes a rapid (<10 s), sustained sh

114 As little as 100 V produces an increase in ion abundance

115 The reaction proceeds in high yield with as little as 1000 ppm catalyst loading, while 5 mol % ca

116 carboxyl-PEG layer, we could directly detect as little as 10fM of miRNA targets in 20microl of unproc

117 dendrite formation on cycled lithium anodes; as little as 11 wt % PP-IL in a PC-LiTFSI host produces

118 ution-phase and bead-bound streptavidin with as little as 12% (v/v) phenol, leaving the biotin tag ac

119 generations in the recombination assay with as little as 125 sorted prostate cells.

120 ted cells, that virtual odors that differ by as little as 13 ms are distinguishable by mice.

121 ) suggest this threshold could be reached in as little as 13 years.

122 amming to full pluripotency, despite sharing as little as 13% sequence identity with mouse Nanog.

123 was accomplished in a single chromatogram in as little as 14 min.

124 individual pure substance microparticles of as little as 14 mug in initial mass, in a matter of seco

125 RS features are observed for Rhodamine 6G in as little as 15 min of ion deposition.

126 e sample, with the sequencing process taking as little as 15-60 min.

127 LIP, and we have identified RBP targets from as little as 150 specific fly neurons.

128 t intermittent energy restriction periods of as little as 16 h can improve health indicators and coun

129 ents of 10 megabases or greater occurring in as little as 16% of the sample in exome sequencing data

130 c) was predominantly of contemporary origin (as little as 17% historic).

131 we have demonstrated repeatable detection of as little as 188 fg of protein.

132 2D SnTe films with a thickness of as little as 2 atomic layers (ALs) have recently been sh

133 polymerase chain reaction, and could detect as little as 2 copies of B. cinerea DNA.

134 fter surgery and these changes were observed as little as 2 days post-op.

135 drug resistance screening of TB specimens to as little as 2 days.

136 Warming by as little as 2 degrees C increased both the probability

137 From as little as 2 g of intact human adipose tissue, greater

138 This process takes as little as 2 min, and we determined its accuracy to be

139 ficiently processed to linear alcohols using as little as 2 mol % of 12 at ambient temperature, and t

140 he textiles, even for textiles that retained as little as 2 mug/g Ag after washing.

141 This color change is easily observed with as little as 2 nM of target, 100-fold lower than the tar

142 recording of powder diffraction patterns in as little as 2 s, meaning that thermally induced phase c

143 This protocol can be performed in as little as 2 weeks to complete more than 100 rounds of

144 purified DNA polymerase, the assay detected as little as 2 x 10(-11)U of enzyme ( approximately 50 m

145 Despite the noisiness of citation dynamics, as little as 2 years of postpublication data yield accur

146 tively detected unique haplotypes comprising as little as 2% of a polyclonal infection.

147 equence verification-can be completed within as little as 2-3 weeks, and cancer variant stratificatio

148 , validation, and HIV spreading infection in as little as 2-3 weeks.

149 ounds that increase frameshift efficiency by as little as 2-fold may be effective at suppressing HIV-

150 intolerant macroinvertebrate taxa occur when as little as 2.2% of contributing catchments are mined.

151 ase, reliable profiles can be generated with as little as 2.4x coverage.

152 r over 100 days after two immunizations with as little as 2.5 ng of antigen.

153 As little as 2.5 nM thrombin maximally increased CaMKIId

154 tive, detecting differences in HOS affecting as little as 2.5-5% of the molecular population, levels

155 ibed herein, we were successful in detecting as little as 2.94 fM of pathogen DNA, and using crude ex

156 gher, RICS data quality was sufficient using as little as 20 images, whereas the optimal number of fr

157 leated on collagenase-challenged dentin with as little as 20 min of 1:4 peptide incubation.

158 a 0.8-mm inner diameter, allow separation of as little as 20 mug of total cell lysates.

159 lumn which enables an accurate analysis from as little as 20 muL of plasma or 50 mg of tissue for typ

160 ted masks to focus the metal ions to an area as little as 20 mum in diameter.

161 he activity dropped dramatically for enzymes as little as 20 nm apart.

162 hed from control cells with incorporation of as little as 20 nM of the xenon MRI readout unit, crypto

163 DEEPER-Seq can create NGS libraries from as little as 20 pg DNA with PCR error correcting capabil

164 As little as 20% of the halogen inventory from Mt.

165 served in LQTS2 patients can be explained by as little as 20% variation in the levels of ionic conduc

166 fHbp DeltaNspA mutant strains were killed by as little as 20% wild-type infant rat serum.

167 in the western Williston Basin persisted for as little as 20,000 years after the impact.

168 Target proteins were depleted in as little as 20-30 min, and their expression could be re

169 ions between spin-up and spin-down states in as little as ~20 nanoseconds.

170 more peptides per protein and starting from as little as 200 mul of plasma.

171 a polyelectrolye multilayer coating carrying as little as 200 ng of bone morphogenetic protein-2 and

172 The proposed "ElectroPen" device can cost as little as 23 cents (US dollars) to manufacture, is po

173 pithelial cells (HMEC) was demonstrated from as little as 25 mug tryptic peptides from whole cell lys

174 -phosphorylating deoxyribozyme Dk2 to detect as little as 25 nM GTP even in the presence of 1 mM ATP,

175 infection of retrovirus particles containing as little as 25% of the restriction-sensitive CA protein

176 ooled CUT&Tag libraries can be sequenced for as little as $25 per sample.

177 roefficacy trials of equivalent vaccines was as little as 26%, and estimates of the relative risk of

178 fying 1 case of hearing loss due to cCMV was as little as $27460 by universal screening or $975 by ta

179 59989 dose-dependently reduced brain KYNA to as little as 28% of basal levels, and prevented amphetam

180 that cocaine potency is increased following as little as 3 days of IntA and further augmented follow

181 ine, but increasing core body temperature by as little as 3 degrees C causes coved-type ST elevations

182 ify KPC-producing Gram-negative pathogens in as little as 3 h after isolation of pure colonies and do

183 The tissue clearing takes as little as 3 h, and imaging can be completed in approx

184 Our developed assay can generate data in as little as 3 h, is optimized for 96-well plates, and a

185 h the DNA profiles held on a DNA Database in as little as 3 h.

186 ed in the growth inhibition of E. coli, with as little as 3 min of irradiation.

187 ce, an imaging technique used clinically, in as little as 3 months after the initiation of treatment,

188 henotype of progressive IDA that develops in as little as 3 months following disruption of intestinal

189 alysis of genes and other genomic factors in as little as 3 months, in the context of a whole organis

190 multiplexed detection of three analytes from as little as 3 muL.

191 can detect aneuploidy in samples containing as little as 3 pg of DNA.

192 ions for a wide range of microorganisms with as little as 3 weeks of dedicated labor and at a cost of

193 ion is observed in mutant plants, which have as little as 3% of wild-type CA activity, but surprising

194 eeks, and desired clones can be generated in as little as 3-4 weeks.

195 e to process thousands of DNA samples within as little as 3-4 weeks.

196 exceptionally rapid, with furrows forming in as little as 3.75 min.

197 ed dose- reduction, with vaccines containing as little as 3.75 or 7.5mug HA being immunogenic.

198 For a human sample, as little as 30 Gbp of additional sequencing data are ne

199 quantitative measures of growth kinetics in as little as 30 hrs under a wide variety of environmenta

200 we measure degradation-resistant glycogen in as little as 30 mg of skeletal muscle or a single hippoc

201 ts, which utilizes a colorimetric readout in as little as 30 min.

202 ng, while 5 mol % can provide high yields in as little as 30 min.

203 om readily available and affordable parts in as little as 30 min.

204 ibility of the bacteria can be determined in as little as 30 minutes compared with days required for

205 ng on the experiment, FDAA labeling can take as little as 30 s for a rapidly growing species such as

206 ocytosis and target cell permeabilization in as little as 30 seconds.

207 ng-standing rule-of-thumb that proteins with as little as 30% sequence identity adopt the same fold.

208 We show that we require as little as 30x coverage Illumina data and 15x PacBio d

209 ral-water interface in a flow environment in as little as 31-40 min.

210 s us to efficiently store assembly graphs in as little as 4 bits per k-mer, albeit inexactly.

211 nitude and facilitated iPS cell formation in as little as 4 days.

212 man Cohesin, CCC and Mediator complexes from as little as 4 micrograms of input lysate, representing

213 Feeding for as little as 4 weeks with a WD promoted mild dermatitis

214 ion of gene-modified mice can be achieved in as little as 4 weeks.

215 and clearly present with tones separated by as little as 4%, near the behavioral frequency differenc

216 y of 30% and 99%, respectively, separated in as little as 4-7 min.

217 ring in electric field vector orientation by as little as 4.4 degrees .

218 tants, one arm of homology can be reduced to as little as 40 bp while still promoting integration of

219 can classify the time series early by using as little as 40%-64% of the time series' length.

220 ving highly accurate classification by using as little as 40%-64% of the time series.

221 This means that as little as 45.5 pg of hCG can be detected by this meth

222 n gave rise to chimera-competent iPSCs after as little as 48 h of OKSM expression.

223 y forming units (CFUs) at 1 per 1000 CFUs in as little as 48 hrs.

224 llowing for sensitive, specific detection of as little as 5 amol (50 fM in 100 muL) of target DNA.

225 of the ridge axis from the volcanic front of as little as 5 km, seafloor morphology changes from shal

226 is capable of producing positive results in as little as 5 min.

227 rmed with near zero sample consumption using as little as 5 pL of sample and 240 yoctomoles ( approxi

228 Our data suggest that a cellular strain of as little as 5% affects the shape of transverse tubules,

229 ent of deuteration in the carbon source, and as little as 5% deuteration can be distinguished by anal

230 nt but can be fully rescued by incorporating as little as 5% of brain tubulin into the homogeneous al

231 ukocyte adhesion deficiency, mice expressing as little as 5% of kindlin-3 were viable and protected f

232 The second band could be observed with as little as 5% of the RTIL.

233 As little as 5% of the structural variant could be detec

234 bond, in aqueous buffer solutions containing as little as 5% organic cosolvent, resulting in exclusiv

235 sex, presynaptic autophagy can be induced in as little as 5-10 min and eliminates primarily the damag

236 figurations to impart as much as 45.3 mDa or as little as 5.8 mDa per tag between labeled peptides.

237 ent ion multiplet peaks separated in mass by as little as 5.8 mDa, enabling up to 4-plex quantificati

238 Moreover, minor HA variants present in as little as 5.9% of viruses within the source animal be

239 The fact that a dose as little as 50 bacteria is lethal to mice illustrates t

240 tocol for sequencing capped RNA 5' ends from as little as 50 ng total RNA.

241 pproximately 10(-10) and that can start from as little as 50 pg DNA.

242 Each immunostaining reaction requires as little as 50-100 microl of peripheral whole blood and

243 Using this approach, as little as 500 attomoles (10 pM) could be detected wit

244 uantifying ~10,000 ubiquitylation sites from as little as 500 mug peptide per sample from cells or ti

245 ully generate genome wide 5hmC patterns from as little as 500 ng of genomic DNA in less than 4 days.

246 hnique works robustly and reproducibly using as little as 500 ng of starting DNA, with results correl

247 Allerod warmth halved the mass of the CIS in as little as 500 years, causing 2.5 to 3.0 meters of sea

248 We found that as little as 53% of the combined CVD and congenital hear

249 ing effect in different TrpB homologues with as little as 57 % sequence identity.

250 assay detected norovirus in some samples in as little as 6 min, and the entire detection process can

251 lifera) can use stimulus onset asynchrony of as little as 6 ms to segregate learned odor components w

252 esign to identification of founders can take as little as 6 weeks, of which <10 d is actual hands-on

253 o quantify down to ~10(9) vesicles/mL, using as little as 60 muL of the sample.

254 sed to detect topoisomerase 1-DNA adducts in as little as 60 ng of DNA, corresponding to 10 000 human

255 atistical correlations from metabolites with as little as 60 nmol of material.

256 Furthermore, exposure to as little as 65% CO2 affected the motor capability of D.

257 The concentration process using HiSMRT takes as little as 7.5 min.

258 f chemical reactions are feasible in volumes as little as 71 nL.

259 Delaying therapy for as little as 8 hours postcecal ligation and puncture fai

260 anut allergy to be rapidly desensitized over as little as 8 weeks of peanut oral immunotherapy.

261 the meningococcal chromosome can occur with as little as 80 bp, and that minor sequence differences

262 n of auxin with protein half-life reduced to as little as 9 min and proceeding to completion with fir

263 ns from the same renewable penetrations with as little as 9% renewable curtailment.

264 nsitive, achieving quantitative detection of as little as 9.6 attograms of target DNA, and we show th

265 cZ phage, the fluorescent signal appeared in as little as 90 min.

266 vaccination, with 100% protection induced in as little as 96 h.

267 e PCR can detect amebic DNA corresponding to as little as a 0.1 trophozoite equivalent of any of thes

268 all intestinal loops and colonic loops after as little as a 1-h treatment with 50 mug/ml of CPE.

269 With as little as a 5 min duration of status epilepticus (SE)

270 This network can span from as little as a few centimeters (or less) in species like

271 can be reliably quantified, evidencing that as little as a few tens of copies of redox-labeled macro

272 With as little as a five minute exposure to 100% CO2, D. mela

273 mal label enrichment and can be performed on as little as a single biopsy, thereby overcoming critica

274 y related oligotypes, differing sometimes by as little as a single nucleotide, that showed dramatical

275 be very sensitive to retrieval results from as little as a single query.

276 Importantly, our findings indicate that as little as a two- to fourfold reduction in mTOR activi

277 ve contributions from the cytoskeleton, with as little as a ~5 nm increase in non-binding protein siz

278 conds, stable network templates emerge after as little as approximately 100 s of recording and persis

279 However, when artificially clustered into as little as dimer of dimers, the type-VI kinesin-14 (a

280 orm these measurements on samples containing as little as eight nanomoles of GB1.

281 Recharge in some humid locations varies by as little as five per cent (by coefficient of variation)

282 Biochemical studies have demonstrated that as little as four repeats have the ability to form a sta

283 vitational potential energy differences from as little as micrometers of vertical separation generate

284 presented by human tissue samples containing as little as nanograms of peptide material in 2 d.

285 photodetector can detect at light levels of as little as nW cm(-2) intensity with a responsivity of

286 sis, where 6-10mL of whole blood may contain as little as one bacterial colony forming unit (cfu).

287 The addition of as little as one CH2 group to the methyl adduct of the a

288 As little as one dye molecule per nanoparticle can effic

289 Maximal in-gel digestion was achieved in as little as one hour, depending on incubation temperatu

290 ner, thereby minimizing helix abrogations to as little as one to two turns.

291 The goal was to produce in as little as one week thousands of doses of an intervent

292 Cyp in vitro to capsid assemblies containing as little as one-fourth wild-type CA protein.

293 construction where mutational effects change as little as possible across adjacent genetic background

294 l bimodality occurred in both experiments in as little as six generations of divergent adaptation des

295 fast, leading to severe loss of activity in as little as ten minutes.

296 remove all but decadal-scale processes after as little as two centuries.

297 how that inaccuracies begin to accumulate in as little as two decades and can remove all but decadal-

298 f AKT in a concentration-dependent manner in as little as two hours.

299 e reactions are efficient, being complete in as little as two minutes, and can be applied to a broad

300 yase activity is also strongly suppressed by as little as two paired bases 5' of the abasic site.

301 However, shortening it by as little as two residues or making substitutions of >=1