ライフサイエンスコーパス: as observed in

1 n of the authors' experience on NITAG's role as observed in 2 particular local settings and applied t

2 ether, constraints in cage-orientation, such as observed in 4, produce unfavorable intercage steric i

3 In the long term, as observed in 6-mo-old offspring, the double insult, i.

4 patient may also provide a functional cure, as observed in a bone marrow transplant performed with h

5 vergence in lncRNAs and protein-coding RNAs, as observed in a broad variety of species.

6 s model fails to repair larger (>mm) defects as observed in a clinical setting.

7 The dominance of electrostatic parameters, as observed in a computational DFT study, is consistent

8 ceptibility to T-cell-mediated tissue injury as observed in a mouse model of intestinal graft-versus-

9 ction is independent of Drosha core domains, as observed in a second structure in the partially docke

10 throughout the Delta's multi-aquifer system as observed in a spatially exhaustive data set of arseni

11 nesis to probe the anesthetic-binding cavity as observed in a TASK-3 homology model.

12 d tumor progression, are still controversial as observed in a variety of cell types.

13 ol was conceptually necessary to explain TFR as observed in about half of the patients.

14 ly with these two proteins within filopodia, as observed in acceptor photobleaching FRET studies.

15 substitutions of guanines in a GpC context, as observed in aflatoxin-induced liver cancers.

16 exception, to the dominant fibril morphology as observed in AFM or SEM images.

17 be acute, as seen in stroke, or more chronic as observed in age-related diseases such as Parkinson's

18 Accordingly, diminished Hsp70 levels, as observed in aging or certain pathological conditions,

19 panied by a disruption of behavioral control as observed in aging or neuropsychiatric diseases such a

20 events is likely to make even rapid recovery as observed in Aldabra's lagoon too slow to prevent long

21 rong oscillatory regulation of spike timing, as observed in alert cortex processing complex natural s

22 2+) also made the CDR3 loop highly flexible, as observed in all-atom simulations.

23 ether with axonal and neuronal degeneration, as observed in ALS patients.

24 ith either male or female somatic phenotypes as observed in an XY father and XY daughter, respectivel

25 ion of key gene families such as DCL and AGO as observed in angiosperms occurred early in land plants

26 apitulate age-dependent vascular dysfunction as observed in animal models and in humans but with an a

27 d the incorporation of alternative monomers, as observed in Arabidopsis mutants with altered monolign

28 ECM) in the airway smooth muscle (ASM) layer as observed in asthma may influence ASM mechanical prope

29 ns of Gly-213 abolish allosteric regulation, as observed in AtCM2.

30 ithout evidence of solvent or dopant effects as observed in atmospheric pressure photoionization (APP

31 The expression of inflammatory genes, as observed in biopsies taken at the end of surgery, as

32 2) systolic twitch forces at a similar level as observed in bona fide postnatal myocardium; (3) a pos

33 shment of metastatic cells in distant organs as observed in bone.

34 the VLPs completely abrogated these dynamics as observed in both localization correlation analysis an

35 ey features of striatal population activity, as observed in brain slices.

36 hough they are lacking strong hydrogen bonds as observed in calixarenes, the two examples introduced

37 cellular pH lower than the intracellular pH, as observed in cancer cells(6).

38 As observed in cancer immunotherapy, MDSCs could be a no

39 rate inducible, low-level pathway activation as observed in cancer, we quantified 7566 unique phospho

40 the aforementioned pharmaceutical treatment as observed in cancerous stromal fibroblasts.

41 Pstpip2(cmo)mice provides similar protection as observed in caspase-1 and caspase-8-deficientPstpip2(

42 ng an explanation of transcriptional cycling as observed in cell populations, both on promoter chroma

43 As observed in cell systems, administration of adenosine

44 Reproducing fast fusion rates as observed in cells by reconstitution in vitro has been

45 king this interaction inhibits cell division as observed in cells lacking G2L1.

46 renders the spindle susceptible to breakage, as observed in cells with a variety of defects.

47 ic edema in conditions of low energy supply, as observed in cerebral ischemia.

48 IV-1 infection in this model depletes ILC3s, as observed in chronic HIV-1-infected patients.

49 ut also key to understand biopackaging, such as observed in circular DNA of viruses or genome folding

50 drug-induced changes of willingness to work, as observed in classical experiments with the D2-antagon

51 howed optimum emulsion and process stability as observed in CLSM images, droplet size data and in the

52 of Schwann cells did not exit the cell cycle as observed in control animals and the growth fraction i

53 nization during rest compared with the task, as observed in controls.

54 e for treating acute hyperinflammation, such as observed in coronavirus disease 2019 (COVID-19), high

55 As observed in cryo-electron micrographs, AVP-p treatmen

56 that GINS is a compact tetramer in solution as observed in crystal structures, but also forms a doub

57 properties can modulate pump activity, and, as observed in crystal structures, several lipids are bo

58 terification through decreasing PME activity as observed in CsF3H transgenic lines.

59 ifested as increased cytoplasmic vacuolation as observed in cultured fibroblasts.

60 urate LTD produced the same impairment in WT as observed in DKO mice.

61 toward trafficking vesicles and organelles, as observed in E46K-like cellular and murine models, as

62 atic fat accumulation in obese mouse models, as observed in earlier studies, and the beneficial effec

63 cytokinesis and finally to multinuclearity, as observed in EBV-associated HL.

64 to a difference in oxidation peak potential as observed in electrochemical measurements.

65 at regulate ordered mineralization in vitro, as observed in enamel rods.

66 model reproduces the VIII-X phase transition as observed in experiment.

67 and its value could be unphysically negative as observed in experiment.

68 ous approaches, such as ligand-binding sites as observed in experimental complex structures, or predi

69 o stabilize the T(0) state relative to R(0), as observed in experiments (El Hage et al., 2018).

70 pisodes with long-range spatial correlations as observed in experiments.

71 in solution and not just when bound to Get1, as observed in experiments.

72 cal beta(2)AR stimulation of crest membrane, as observed in failing cardiomyocytes.

73 induction of the adjacent mRNAs or lncRNAs, as observed in fbp1 These Atf1-binding sites exhibit low

74 t that severe respiratory chain dysfunction, as observed in few cells leading to a mosaic in aged tis

75 hose perimeter-area relationship is the same as observed in field data for the clustering of trees.

76 hat manifest as biological oscillators, such as observed in fireflies, heartbeats, and circadian rhyt

77 endothelium was almost completely abrogated, as observed in flow chamber adhesion assays and during e

78 lt of accumulation of chlorophyll precursors as observed in fluorescent (flu)-like mutants.

79 ation of the dienoyl-coenzyme A intermediate as observed in Geobacter metallireducens and Syntrophus

80 were enriched for light zone gene signatures as observed in germinal centers.

81 (H) 17, a neutrophilic inflammatory response as observed in global IL-4Ralpha-deficient mice after in

82 As observed in Gtpbp2(-/-) mice (Ishimura et al., 2016),

83 -EF5 in hypoxic cells in certain tumor types as observed in H460 in this study.

84 Conversely, as observed in HD knock-in ESCs (Q111 ESCs), mHtt enhanc

85 cts in MMR exist among MMR-proficient cells, as observed in healthy intestinal tissues from patients

86 duced IK1 density and gap junction coupling, as observed in heart failure, increase the probability o

87 signatures of a quantum critical point(3-5), as observed in heavy-fermion(6) and iron-based(7) superc

88 ugh an allosteric desymmetrization mechanism as observed in high-resolution crystal structures.

89 sh mutant that exhibits pancreas hypoplasia, as observed in HNF1B monogenic diabetes, we show that hn

90 to possess both MAT1-1-1 and MAT1-2-1 genes as observed in homothallic filamentous Ascomycetes.

91 nib molecules do not cluster in the same way as observed in HPMC-P, where ionic interactions are pres

92 ss whether coupled theta-gamma oscillations, as observed in human auditory cortex, could underpin the

93 activation on conventional outflow facility, as observed in human eyes.

94 enes commonly associated with liver cancers, as observed in human FL-HCC.

95 ted TME that closely resembles tumour growth as observed in human lesions and supports cell survival

96 decreased ceramide-1-phosphate (C1P) content as observed in human podocytes in vitro and in kidney co

97 TNF-like ligand 1A (TL1A), and TNF in TECs, as observed in human renal injury.

98 and to increase the Bifidobacterium amounts as observed in human-milk-fed infants.

99 ensitization and low food-antigen IgE titers as observed in humans with clinical food allergy.

100 e-dependent cytoplasmic inclusion pathology, as observed in humans with hnRNPA2B1-related myopathy.

101 Our findings indicate that, as observed in humans, tandem or partially tandem duplic

102 . report that VSG rapidly reduces bone mass, as observed in humans, via rapid demineralization and de

103 , but rather likely promoted lymphomagenesis as observed in humans.

104 (DLAL) Strategy uses acoustic gaze scanning, as observed in hunting bats.

105 rom muscular dystrophy to accelerated aging, as observed in Hutchinson-Gilford progeria and atypical

106 ected with OROV was not as rapid or complete as observed in Ifnar(-/-) mice, indicating that other tr

107 a Th9 subtype by increasing IL-9 production, as observed in in vitro studies, or rather favors Th17 d

108 L)-10, decreased epithelial CD1d expression--as observed in inflammatory bowel disease--may contribut

109 that can lead to excessive immune responses as observed in inflammatory bowel disease.

110 to prevent chronic intestinal inflammation, as observed in inflammatory bowel diseases (IBD).

111 for the development of chronic inflammation, as observed in inflammatory bowel diseases.

112 mediated inflammation and epithelial damage, as observed in inflammatory disorders of mucosal surface

113 The catalyst is remarkably active as observed in initiation experiments showing complete c

114 of fibroblast differentiation, and its loss as observed in IPF facilitates profibrotic phenotypic ch

115 ese two ubiquitins adopt a compact structure as observed in K48 di-ubiquitin.

116 gnificantly induced erythroid-related genes, as observed in K562 cells, suggesting that DZNep induces

117 n the brain contributes to neurodegeneration as observed in Lafora disease.

118 -/-) mice no longer decreases TG degradation as observed in LDs from wild-type mice, supporting the m

119 e nucleated from the same endosomal vacuole, as observed in living cells.

120 y cell infiltration and mucus hypersecretion as observed in lung sections, and mRNA expression of ICA

121 tonotopic maps oriented along the same axis as observed in macaque and owl monkey.

122 from shape selectivity in posterior regions, as observed in macaques, indicating a considerable disso

123 al assemblies in synchrony changed with time as observed in mammalian brains.

124 the night, SWS decreased and REM increased, as observed in mammals and songbirds.

125 dysfunction of even a portion of the raphe, as observed in many SIDS cases, can impair ability to au

126 or alterations in striatal dopamine turnover as observed in mental diseases (e.g., in schizophrenia).

127 correlated with patient survival, including as observed in MGMT-deficient GBM patients.

128 ion from ischemic stroke to a similar degree as observed in mice with CypD-deficient platelets.

129 on and depletion of the mitochondrial genome as observed in mitochondrial diseases.

130 introduction and infection of these species as observed in mixed backyard poultry during the early o

131 ntake during times of nutritional challenge (as observed in modern wild orangutans(5)).

132 ed support for a parcellation into two parts as observed in monkeys, but it also highlighted a much f

133 d antiviral IgG responses to the same extent as observed in mus(-/-) mice.

134 myocyte hyperplasia (increased cell number), as observed in Mybpc(t/t) mice.

135 As observed in myocytes, CaMKII shifted WT I(Na) availab

136 l CCS distributions to follow the same trend as observed in N(2), while CCS for the most compact ion

137 Alterations in mitochondrial function, as observed in neurodegenerative diseases, lead to disru

138 associated with the presence of metal ions, as observed in neurodegenerative diseases.

139 formation of amyloid-like protein aggregates as observed in neurodegenerative diseases.

140 tenuate muscle loss due to NMJ deterioration as observed in neuromuscular diseases and aging is ambig

141 thin trait space along the same common slope as observed in non-wetland plants, with lower leaf mass

142 by impairing the trafficking of cholesterol, as observed in NPC pathology.

143 During more excessive lipid accumulation, as observed in NS cells, promising commercial harvest as

144 ual, maladaptive and resistant to extinction as observed in obsessive compulsive disorders (OCD).

145 vity between different cellular states (such as observed in oncogenesis).

146 Isolated as observed in one sibling, CD137 deficiency resulted in

147 ) has a double-stranded beta-helix core fold as observed in other 2OG and iron-dependent oxygenase fa

148 mischarged serine and glycine to tRNA(Ala), as observed in other bacteria, and also transferred alan

149 gree of anionic substitution of its glycans, as observed in other marine invertebrates.

150 attachment of amorphous precursor particles as observed in other minerals and biominerals?

151 ays involved in mitochondrial bioenergetics, as observed in other neurodegenerative disorders, are si

152 As observed in other patient cohorts, renal artery steno

153 to move systematically through sleep states as observed in other species with consolidated sleep.

154 e, the increased persistence of algal blooms as observed in our mesocosm experiment.

155 nd developmental modules within paired fins, as observed in paired limbs.

156 damages caused by alpha-synuclein oligomers, as observed in Parkinson disease and several other neuro

157 so that prolongation of these beta episodes, as observed in Parkinson's disease, could produce delete

158 ignificant disruption of these blood vessels as observed in pathological conditions, including cancer

159 nslation of dipeptide repeat (DPR) proteins, as observed in patients with C9orf72-related disease.

160 on (i.e., the sensing of visceral feelings), as observed in patients with cardiodynamic deficits.

161 ngs but did reduce serum creatinine and BUN, as observed in patients with CKD.

162 with infection-induced inflammatory changes as observed in patients with disseminated intravascular

163 ciated with the aberrant FBW7/NOTCH2 pathway as observed in patients with HCS.

164 on absorption and chronic iron accumulation, as observed in patients with hemochromatosis.

165 as experimentally demonstrated in vitro and as observed in patients with HUS.

166 ese parameters, they remain highly variable, as observed in patients, impeding reliable one-dimension

167 hrenia-related changes in brain connectivity as observed in patients.

168 Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD

169 As observed in previous studies, we find that Treponema

170 ations--or below levels found in upper soils as observed in previous studies--with the presence of an

171 and a 4-, 5-, and 6-fold Al-O coordination, as observed in previous studies.

172 s found to vary between different countries, as observed in previous studies.

173 ic disparity tuning curves compared with V1, as observed in primate visual cortex.

174 hich are in agreement with domain boundaries as observed in protein 3D structure, and which model the

175 actions with non-polar and polar side chains as observed in protein structures and in molecular dynam

176 to the lack of regular secondary structures as observed in proteins.

177 and consequent neuroinflammatory processes, as observed in psychiatric disorders and neurodegenerati

178 luding cellular alternans at rates > 250 bpm as observed in rabbit myocytes, reentrant spiral waves a

179 ins) leading to formation of a compact dimer as observed in Ras crystal structures.

180 N neurons increases dendritic spine density, as observed in rats after long-term cocaine administrati

181 metallosilylene-like (LnM-Si-R) reactivity, as observed in reactions of nonenolizable ketones, enone

182 In particular, as observed in real fluids, different points of the wave

183 the gene is silent in the majority of cells as observed in recent experiments.

184 leading often to a shorter coalescence time, as observed in recent experiments.

185 xponent gamma ranging between 1.11 and 1.21, as observed in recent studies based on mobile phone data

186 l to lead to on-target off-tumor toxicities, as observed in recent trials.

187 h some elevation of risk, though not as much as observed in regular welders.

188 was correlated with the availability of LAE as observed in release kinetics.

189 tributes to inflammation-mediated bone loss, as observed in rheumatoid arthritis (RA) patients.

190 sorders with pancreatitis-causing treatments as observed in rodent acini.

191 As observed in rodents, Layer 4 is thin in the nostril s

192 ns reproduce the waves' main characteristics as observed in satellite imagery, and the results sugges

193 d to cerebellum-driven eye-movement deficits as observed in SCA patients.

194 othelial activation leading to vasoocclusion as observed in SCD.

195 Oxidative stress as observed in schizophrenia affects parvalbumin interne

196 amphetamine-induced positive-symptom change, as observed in schizophrenia.

197 phenocopied the retinal lamination phenotype as observed in sec13(sq198).

198 ease, exhibited similar defects in apoptosis as observed in serglycin(-/-) cells, indicating that the

199 e behavior at very short and long time lags, as observed in several experiments.

200 tions of poor protein homeostasis in muscles as observed in several myopathies and aging.

201 ic deficiency leads to cognitive malfunction as observed in several neurodevelopmental psychiatric di

202 were counteracted by EAAT and NCX blockers, as observed in SH-SY5Y and C6 cells.

203 sulted in a major ATP hydrolysis deficiency, as observed in situ by histochemistry and in primary smo

204 l populations outgrow the local vasculature, as observed in solid tumors.

205 city of the remote ion-binding site in H-Ras as observed in solution.

206 iate attractive intermolecular interactions, as observed in some BPTI crystal structures, without the

207 that nonsymmetric average avalanche shapes (as observed in some experiments) occur for certain combi

208 elimination of neurons and cortical thinning as observed in some forms of mental retardation and feta

209 t initiates amyloid-beta (Abeta) generation, as observed in sporadic AD.

210 tion could lead to different subtypes of CD, as observed in studies in cohorts of primarily European

211 likely bind in the palmitate binding cavity as observed in tablysin-15, since MpPR-1i binds palmitat

212 gamma-CD-IC-NF (2:1) preserved much more THY as observed in TGA and stability of THY/gamma-CD-IC (2:1

213 d to regression to the mean and time effects as observed in the 4 cohorts presented here.

214 substituted products (and in the same ratio) as observed in the acid-catalyzed reaction.

215 es not undergo 1,2-shift of the carbon atom, as observed in the acid-catalyzed reaction.

216 , rather than driving feedforward inhibition as observed in the adult.

217 cteristics of cascadeness and sequentiality, as observed in the budding and fission yeast cell- cycle

218 have reduced root apical meristem activity, as observed in the clasp-1 null mutant.

219 e near the exterior heme beta- or delta-edge as observed in the class of heme peroxidases.

220 e phenotypes for each of the categories and, as observed in the clinical data of PTSD patients, the s

221 odifying large volumes of continental crust, as observed in the continents today.

222 he Phe side chain of the so-called DFG motif as observed in the crystal structure of compound 7m.

223 does not bind in the TMD intrasubunit cavity as observed in the crystal structure of GLIC with bound

224 exhibit few contacts between the RRMs, such as observed in the crystal structure.

225 th the DPP core acceptor in another molecule as observed in the crystal structures.

226 ctated by the differences in the axial ends, as observed in the crystalline order of symmetry.

227 bis-THF moiety retained similar interactions as observed in the darunavir-protease complex regardless

228 , with both subtypes becoming less virulent, as observed in the data.

229 f presynaptic branches of the phrenic nerve, as observed in the diaphragm.

230 further validated in the TCGA data set, and, as observed in the discovery series, both models had a h

231 in vitro at a similar critical repeat number as observed in the diseases.

232 rom severe reduction of motor axon extension as observed in the dorsal forelimb to shortening of pres

233 t all myosin heavy chain protein degradation as observed in the electrophoresis.

234 same large-scale roughening characteristics as observed in the experiment.

235 is accompanied by a catastrophic force drop as observed in the experimental or simulated force (F)-d

236 unt for the reduction of the magnetic moment as observed in the experiments.

237 on of the ferromagnetic TBG near 3/4 filling as observed in the experiments.

238 lence and intensity of sporozoite infection, as observed in the field.

239 r PAP levels negatively affect plant growth, as observed in the fry1 papst2 mutant, which lacks the P

240 ies derived from blood memory B cells in RMs as observed in the HVTN 505 vaccine efficacy trial.

241 rence of millimetre-sized grains of pure ice as observed in the Imhotep debris falls is best explaine

242 Furthermore, as observed in the LCD1 patients, corneal epithelial wou

243 lergenic proteins with high cross-reactivity as observed in the lipid transfer protein (LTP) syndrome

244 er significantly fibrin multiscale structure as observed in the literature.

245 e beneficial clinical effects of eplerenone (as observed in the main study) were preserved for the EM

246 d cell lineage tracked over many generations as observed in the mother machine, (ii) population snaps

247 bolism genes, and mitochondrial dysfunction, as observed in the mouse model.

248 tom abstraction followed by radical rebound, as observed in the native C-H hydroxylation mechanism of

249 ng a continuation of processes in the future as observed in the past (a business-as-usual scenario).

250 similar brain DNA methylation abnormalities as observed in the paternal sperm.

251 Abnormal perineuronal nets, as observed in the postmortem patient brain, may thus un

252 me rather than a clockwise-rotated ribosome, as observed in the presence of EF4-GDP and P site tRNA.

253 formation, instead of forming an alpha-helix as observed in the previously solved structure of the GC

254 l three-dimensional network of Pa3 symmetry, as observed in the pyrite model structure, at variance w

255 was compared with histopathologic regression as observed in the resection specimen.

256 hypothermia and increased survival duration as observed in the septic model developed by the laborat

257 s of PTEN as PI3K signaling is not as robust as observed in the setting of loss of PTEN.

258 opted the same C3'-endo ribose conformations as observed in the structure of the unmodified RNA.

259 the resting state to the oscillatory regime, as observed in the subcellular model and experimentally.

260 donor nuclei demonstrate a mitotic advantage as observed in the traditional reprogramming with somati

261 ng to a potential reduction in transmission, as observed in the US experience with universal mass vac

262 not with an increase in T-regulatory cells, as observed in the vemurafenib-only run-in period.

263 ator-gated spike-timing-dependent plasticity as observed in the visual cortex and can be fit to data

264 rtunity for residual-disease guided therapy, as observed in these trials, is lost when patients under

265 esting that 10 days of antimicrobial therapy as observed in this cohort did not sterilize testing; ho

266 recognition responses and metabolic linkages as observed in this model system may influence carbon tr

267 The short-term variances as observed in this study might have been missed during

268 mical reactions on aquated aerosol surfaces, as observed in this study, are overlooked in most atmosp

269 e-bound phosphorus driven by cable bacteria, as observed in this study, contributes to the seasonalit

270 As observed in this study, the bioaccessibility of the P

271 As observed in this study, virions were inactivated with

272 short reaction times are easily exfoliated, as observed in this work using high-resolution transmiss

273 ditions of suboptimal NAIP/NLRC4 activation, as observed in THP-1 cells, possibly explaining the redu

274 cts, multipolar mitosis, and multinuclearity as observed in time-lapse microscopy.

275 Triassic where the same level of complexity as observed in today's marine ecosystems is reached with

276 fects on distant nonirradiated tumor lesions as observed in transplanted MC38 (colorectal cancer), B1

277 alculation-window duration on lifespan gain (as observed in trials) and on who gains most.

278 uenced the clinical impact of dexamethasone, as observed in tuberculous meningitis.

279 latent membrane protein 1 (LMP1) expression as observed in tumor cells of Epstein-Barr virus (EBV) -

280 lected by membrane disruption and cell death as observed in U937 and A549 cells.

281 sm of an IDP segment to its binding partner, as observed in unbiased molecular dynamics simulations.

282 (and to the same extent) in wild-type cells as observed in unchallenged HR(-) cells.

283 tion of partially unfolded states by Mg(2+), as observed in unfolding experiments, with this stabiliz

284 skeleton failed to increase FGF23 expression as observed in uremic KL(fl/fl) mice.

285 endent plasticity of intrinsic excitability, as observed in vitro, is an attractive candidate.

286 ar morphological changes in effector T cells as observed in vitro, suggesting that the above process

287 dynamics of extracellular lactate and oxygen as observed in vivo in rats.

288 As observed in vivo, Epac1 inhibition prevents hypoxia/r

289 cate that long term supplementation with DHA as observed in vivo, resulted in deceased Notch 1/Jagged

290 Importantly, as observed in vivo, the KC-MBON synapse is highly plast

291 egree of synchrony in 3D networks decreased, as observed in vivo.

292 xes, producing distinct tissue morphologies, as observed in vivo.

293 se variability decreased during stimulation, as observed in vivo.

294 tion in adipose stem cells and/or adipocytes as observed in vivo.

295 in GPR120-deficient mice to a similar degree as observed in wild-type mice, indicating that the effec

296 ants over the background of cigarette smoke, as observed in wild-type mice, was absent in Il17a(-/-)

297 cantly reduced hepcidin expression similarly as observed in wild-type mice.

298 sed dissemination, pathology, and mortality, as observed in (wild) birds infected during the 2016-201

299 As observed in yeast cells, the TATA-binding protein (TB

300 s not strong ERC between crossover proteins, as observed in yeasts.