ライフサイエンスコーパス: aspartic acid

1 nce of acidic amino acids (i.e. glutamic and aspartic acids).

2 it makes an intramolecular salt bridge to an aspartic acid.

3 ugation of one of the alkyl side chains with aspartic acid.

4 phan triad and proton transfer from a nearby aspartic acid.

5 served element of the I-Ak binding motif, an aspartic acid.

6 ecycle except when serine 312 was mutated to aspartic acid.

7 lpiece or their mutation to glutamic acid or aspartic acid.

8 d initiates the conversion of isoAsp back to aspartic acid.

9 ,2-oxazol-4-yl) propanoic acid or N-methyl-d-aspartic acid.

10 a water molecule coordinated by a catalytic aspartic acid.

11 Arg-Gly triplet is recognized by a conserved aspartic acid.

12 gamma-iodo NHBoc-amino ester, derived from L-aspartic acid.

13 icular N-glycosylated asparagine residues to aspartic acid.

14 h alanine, present in higher plants, or with aspartic acid.

15 ally catalytic residues, including essential aspartic acids.

16 le crystals containing glycine (0-7 mol%) or aspartic acid (0-4 mol%), we elucidate the origin of the

17 In both cases, we identify aspartic acid 137 as the caspase cleavage site and demon

18 Cleavage of JunB at aspartic acid 137 separates the N-terminal transactivati

19 mus), with the latter being reprotonated by aspartic acid 156 (t(1/2) = 2 ms).

20 d to identify a region of ~350A(2) involving aspartic acids 186, 228, and 246 in Gbetagamma where we

21 ion of a fibril-specific salt bridge between aspartic acid 23 and lysine 28.

22 he N276 glycan, loop D, and V5, but not with aspartic acid 368, similarly to HJ16 and 179NC75.

23 ich is demonstrated to then be protonated by aspartic acid 396 to the neutral radical within 3.5 mus.

24 vibration of two non-natural amino acids, L-aspartic acid 4-methyl ester and L-glutamic acid 5-methy

25 vitro phosphorylation that histidine 245 and aspartic acid 536 are conserved sites of phosphorylation

26 The spike aspartic acid-614 to glycine (D614G) substitution is pre

27 Glycine, glutamic and aspartic acids accounted for 40% of total amino acids.

28 cial model peptides containing protein-bound aspartic acid, alanine and methionine, respectively, at

29 o acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isol

30 t-poly(ethylene glycol)-S-S-arginine-glycine-aspartic acid (Alg-g-RGD).

31 Enhanced levels of indole-3-aspartic acid (an indicator of high indole-3-acetic acid

32 that contributed to flavour (glutamic acid, aspartic acid and alanine) were present and the most abu

33 o catalyze the hydrolysis of asparagine into aspartic acid and ammonia has been recently put into que

34 he first time that a glycopeptide containing aspartic acid and an O-sulfated glycan was synthesized.

35 , are conserved, but the salt bridge between aspartic acid and arginine is lost.

36 (ASPH), which has been found to hydroxylate aspartic acid and asparagine residues on epidermal growt

37 d proteins specifically at the C-terminus of aspartic acid and at the N-terminus of cysteine.

38 lysine, leucine, alanine, arginine, glycine, aspartic acid and glutamic acid residues represented the

39 equired for Aly1-mediated trafficking of the aspartic acid and glutamic acid transporter Dip5 to the

40 88 to lysine) and Nav1.6 (asparagine 1768 to aspartic acid and leucine 1331 to valine) by obtaining w

41 , followed by N-[4'-hydroxy-(E)-cinnamoyl]-l-aspartic acid and N-[3',4'-dihydroxy-(E)-cinnamoyl]-3-hy

42 c acid is a nitrogen acceptor while alanine, aspartic acid and proline are nitrogen donors in cancero

43 ticed in the case of glutamic acid, alanine, aspartic acid and proline between cancer and healthy cel

44 y available and inexpensive materials (i.e., aspartic acid and purine heterocycles).

45 The major phosphoprotein in dentin is the aspartic acid and serine-rich protein called dentin phos

46 ven by competing effects of acidic residues (aspartic acid and sialic acid) on ion-pair formation and

47 linear relationship between the d/l ratio of aspartic acid and the age of the specimens.

48 jugate reactions targeting lysine, glutamine/aspartic acid, and cysteine residues.

49 netic code four amino acids-valine, alanine, aspartic acid, and glycine-were coded by GNC codons (N =

50 describe a method to characterize the human aspartic acid- and glutamic acid-ADP-ribosylated proteom

51 ving copper-catalyzed allylation of serine-, aspartic acid-, and glutamic acid-derived organozinc rea

52 ere prepared by coating protected chiral D/L aspartic acid appended polyfluorene in the pores.

53 how that when gas-phase mixtures of D- and L-aspartic acid are exposed to an achiral Cu(111) surface,

54 ng seawater saturation state and increasing [aspartic acid], as occurs in some corals at high pCO(2),

55 y on the PHR domain, that replacement of the aspartic acid Asp-396 with cysteine prevents proton tran

56 Acidic amino acids, aspartic acid (Asp) and glutamic acid (Glu) can enhance

57 unctionalization of peptides that employs an aspartic acid (Asp) as a native directing motif, which d

58 ations including methionine (Met) oxidation, aspartic acid (Asp) isomerization, and asparagine (Asn)

59 t bridge between (4S)-aminoproline (Amp) and aspartic acid (Asp) that directs the composition and reg

60 We study a model system consisting of l-aspartic acid (Asp) which when added to the precipitatio

61 hosphomimetic mutant EWSR1/FLI1-T79D (Thr to aspartic acid (Asp)) retained the high activity as wild-

62 Aspartic acid (Asp), wool, parchment, and rabbit skin gl

63 transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown t

64 Specifically, a conserved aspartic acid (Asp53) of the LytR response regulator was

65 ophan, l-cysteine, methionine, cycloleucine, aspartic acid, asparagine, tyrosine, and glutamic acid).

66 nd that concentrations of total amino acids, aspartic acid/asparagine (Asx), glutamic acid/glutamine

67 However, aspartic acid at amino acid position 9 in HLA-B (B(pos-9

68 ction from PBC, and its sequence includes an aspartic acid at beta57.

69 The formation of an external aldimine with aspartic acid at pH 9 also produces the ketoenamine form

70 in the substitution of an asparagine for an aspartic acid at position 10 of ACT1 (ACT1-D10N) is asso

71 hown to bind Mamu-KIR3DL01 allotypes with an aspartic acid at position 233.

72 en ablated by deletion of a highly conserved aspartic acid at position 385, which, for HIV-1, plays a

73 gnition motif (RRM) of CSTF2 that changes an aspartic acid at position 50 to alanine (p.D50A), result

74 3 of ERalpha, resulting in a substitution of aspartic acid at position 538 to glycine (D538G), was id

75 The mutation substituting the aspartic acid at position 838 (equivalent to the human a

76 The replacement of tyrosine by aspartic acid at position M210 in the photosynthetic rea

77 raction of cathepsin Z with arginine-glycine-aspartic acid-binding integrins, specifically alphavbeta

78 RGD (arginine-glycine-aspartic acid) blocking peptides induced CNTF expression

79 vels of amino acid racemization not only for aspartic acid, but also for phenylalanine and tyrosine,

80 Adding NLS, replacing aspartic acid by glutamic acid residues, or changing the

81 The phosphomimetic aspartic acid can restore activity at the two serine sit

82 )) tagged with the tripeptide arginyl-glycyl-aspartic acid cell adhesion motif RGD, which can be used

83 [X = U, C, A or G]), alanine (coded by GCX), aspartic acid (coded by GAY [Y = U or C]), glutamic acid

84 at the pH, saturation state and approximate aspartic acid concentrations inferred to occur at the co

85 fragments with all four serines replaced by aspartic acids confirmed that the motif did adopt a more

86 io- and chemoselectively N-oxidized using an aspartic acid containing peptide catalyst to afford stab

87 vels of asymmetric induction are provided by aspartic-acid-containing peptides as the aspartyl side c

88 n Dd2, whereas the phosphomimetic amino acid aspartic acid could fully and glutamic acid could partia

89 oxylacylcarnitine metabolites and asparagine/aspartic acid could serve as biomarkers associated with

90 ionally-constrained, cyclic arginine-glycine-aspartic acid (cRGD) to enable highly selective binding

91 unctionalized with a cyclic arginine-glycine-aspartic acid (cRGD) tripeptide for targeting integrin a

92 of alanine, alpha-ketoglutarate, asparagine, aspartic acid, cystathionine, total cysteine, glutamic a

93 from other herpesviruses revealed conserved aspartic acid (D) and glutamic acid (E) residues.

94 pocket with conserved glutamic acid (E) and aspartic acid (D) residues.

95 Mice with various alanine (A) or aspartic acid (D) substitutions of the three main phosph

96 of transgenic mice carrying the mutation of aspartic acid (D) to alanine (A) at amino acid 20 (IL-37

97 dditionally, ICl of the mutant containing an aspartic acid (D) to asparagine (N) substitution at posi

98 acting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail 2) is a transcriptional modu

99 D-aas such as D-Asp (aspartic acid), D-Glu (glutamic acid), combined D-[Asp/G

100 k)](2) = glutamic acid-[cyclo(arginyl-glycyl-aspartic acid-D-phenylalanine-lysine)], both in several

101 suggests that ATP-binding shifts the pKa of aspartic acid D396, the putative proton donor to FAD.(-)

102 48), Ser(226), and Ser(227) were replaced by aspartic acid (designated as D-Tg) or alanines (designat

103 A phosphorylation or serine replacement with aspartic acids did not affect persistence length (0.43 +

104 The most potent congeners were a l-aspartic acid diisoamyl ester phenoxy prodrug and a l-ph

105 Proteins composed exclusively of arginine-aspartic acid dipeptide repeats undergo length-dependent

106 Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1), a dN

107 In contrast, mutations to aspartic acid drastically destabilize the protein and re

108 observe changes in the protonation state of aspartic acid during folding that have not been captured

109 iable gene segments encoding a glutamic acid-aspartic acid (ED) motif for K169 recognition.

110 N-acetyl-l-aspartate (NAA) to acetate and l-aspartic acid, elevates brain NAA and causes "spongiform

111 Amylopectin, agarose, and aspartic acid exhibited similar critical ice saturations

112 The dynamics of the aspartic acid follow the dynamics of the intermediate ph

113 d by the PPi dissociation from two catalytic aspartic acids, followed by a comparatively slow jump-fr

114 Substituting aspartic acid for hydrophobic interface residues dramati

115 The D/L ratio of aspartic acid for these specimens ranged from 2.4% to ~1

116 traction of the C3 proton by the active site aspartic acid, forming Neu5Ac2en.

117 Free glutamic acid and free aspartic acid found in the PPI hydrolysate likely increa

118 pitope could be engaged, despite the lack of aspartic acid/glutamic acid encoded in the mouse reperto

119 earing Vlambda rearrangements that expressed aspartic acid/glutamic acid in CDR L2.

120 han in vegetable protein (alanine, arginine, aspartic acid, glycine, histidine, lysine, methionine, a

121 (glutamine-histidine-arginine-glutamic acid-aspartic acid-glycine-serine), as a therapeutic candidat

122 a peptide-bound residue (like asparagine and aspartic acid) has not been demonstrated.

123 the DHHC (letters represent the amino acids aspartic acid, histidine, histidine, and cysteine in the

124 ddition to the already known indole-3-acetyl-aspartic acid (IA-Asp) and indole-3-acetyl-glutamic acid

125 in the conjugated forms indole-3-acetic acid aspartic acid (IAA-Asp) and indole-3-acetic acid glutami

126 fy the presence of D-serine, D-alanine, or D-aspartic acid in eight biologically relevant peptides.

127 chondrial import, whereas the presence of an aspartic acid in over 95% of all avian influenza viruses

128 cond transgenic model was generated in which aspartic acid in position 163 was substituted for aspara

129 The pK(a) value of aspartic acid in the catalytic triad of serine proteases

130 ans, as well as metabolites such as N-acetyl-aspartic acid in the developing nervous system and N-ace

131 pled to protein folding; the apparent pKa of aspartic acid in the folded protein is 6.4.

132 The conversion of homoserine to aspartic acid in the glycopeptide was successfully accom

133 A motif of histidine, proline, and aspartic acid in the J domain of DNAJB6a was required fo

134 One compound with an aspartic acid in the P2 position (compound 16) displayed

135 tides, one challenge is the incorporation of aspartic acid in the peptide backbone and acid sensitive

136 D1416 in the IHD motif (isoleucine-histidine-aspartic acid) in the NBARC domain cause effector-indepe

137 beta-catenin, where serine 45 is mutated to aspartic acid, in mice resulted in improved liver regene

138 placing conserved serines 1712 and 1836 with aspartic acids individually or together.

139 Food restriction also enhanced aspartic acid-induced burst firing of dopamine neurons i

140 We show that aspartic acid inhibits aragonite precipitation from seaw

141 mutation of a single leucine residue (L6) to aspartic acid inhibits proteolysis.

142 Substitution of the surface-exposed Y1544 to aspartic acid is able to stabilize the domain in the abs

143 The negative charge of aspartic acid is believed to be able to mimic the phosph

144 The protonation state of aspartic acid is coupled to protein folding; the apparen

145 c reaction mechanism when the catalytic base aspartic acid is missing, as is the case in some LTs (mu

146 FFD-NH2) and a second novel one in which the aspartic acid is substituted by an asparagine (Ac-LPFFN-

147 mologue of Garner's aldehyde, derived from l-aspartic acid, is reported.

148 Aspartic acid isomerization rates can be predicted from

149 ifications such as asparagine deamidation or aspartic acid isomerization.

150 Several carbon sources (L-Asparagine, L-Aspartic Acid, L- Glutamic Acid, m- Erythritol, D-Melezi

151 amino acids, such as L-serine, L-leucine, L-aspartic acid, L-glutamic acid, histamine, glycine.

152 ict the effect of mutating each glutamic and aspartic acid located in MTBD domain to alanine.

153 use of asparaginase to convert asparagine to aspartic acid may provide a means to reduce acrylamide f

154 f cMyBP-C were replaced by either alanine or aspartic acid, mimicking the fully nonphosphorylated and

155 vivo MRI studies in mice; however, only the aspartic acid modified chelates produced an amide proton

156 n o-boronato-phosphonium amino ester with an aspartic acid moiety.

157 A phosphomimetic Ser-500 to aspartic acid mutation (eEF-2K S500D) enhances the rate

158 The aspartic acid mutation of beta4 T1736 impaired hemidesmo

159 previous reports; brain volume and N-acetyl aspartic acid (NAA) decreased steadily, but no published

160 ppocampal neurons, treatment with N-methyl-D-aspartic acid (NMDA) (10 muM) for 48 hours reduced the s

161 -tert-nitrone (alphaPBN), and the N-methyl-D-aspartic acid (NMDA) antagonist MK801-in mouse and rat m

162 e sensitive conductances, such as N-methyl-D-aspartic acid (NMDA) channels can be more easily activat

163 ynaptic vesicles was dependent on N-methyl-D-aspartic acid (NMDA) receptor activation during LTP.

164 hetic ketamine, a non-competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist, is widely util

165 subunits required for assembly of N-methyl-d-aspartic acid (NMDA) receptors (NMDA-Rs), alpha-amino-3-

166 Blockade of N-methyl-D-aspartic acid (NMDA) receptors by intra-CA3 infusion of

167 is accompanied by the increase of N-Methyl-D-aspartic acid (NMDA) receptors in the hippocampus follow

168 st common targets and mechanisms: N-methyl-d-aspartic acid (NMDA) receptors, voltage gated calcium ch

169 ic the tripeptide sequence (arginine-glycine-aspartic acid) of the natural ligands; however, the RGD-

170 mHTT gene within a BAC to express either an aspartic acid or an alanine at position 421, mimicking t

171 For example, isomerization of aspartic acid or epimerization of any chiral residue wit

172 , we examined the impact of isomerization of aspartic acid or epimerization of serine at four sites m

173 < 0.05) and 200 mug/mL of glutamic acid and aspartic acid (p < 0.001) without affecting cell integri

174 report the efficacy of RGD (arginine-glycine-aspartic acid) peptide-modified polylactic acid-co-glyco

175 esults imply that the racemization ratios of aspartic acid, phenylalanine, and tyrosine can be used a

176 gher threonine, serine, proline, asparagine, aspartic acid, phenylalanine, tyrosine, and histidine le

177 ffinity amino acid sequence arginine-glycine-aspartic acid-phenylalanine-cysteine (RGDFC) attached.

178 Furthermore, we showed that a serine 120 to aspartic acid phospho-mimetic mutant of Rpt6 (S120D) inc

179 ected mutagenesis of predicted histidine and aspartic acid phosphoacceptor residues.

180 idases exhibit a monoglutamase activity when aspartic acid precedes a single glutamate, which, togeth

181 mical design relies on the modification of l-aspartic acid precursor to controllably combine, through

182 egy was developed utilizing homoserine as an aspartic acid precursor.

183 Mutation of tyrosine 89 to aspartic acid (PrimPolY89D) has been identified in a num

184 form stabilized by interaction with a second aspartic acid, probably via a H-bond to the phenolic oxy

185 ening that binds to a specific pocket of the aspartic acid protease, beta-secretase (BACE-1).

186 In addition, the aspartic acid racemization ratio of this specimen was al

187 to LRP1, we demonstrate that the N-methyl-D-aspartic acid receptor (NMDA-R) is expressed by macropha

188 K-801, a specific pore blocker of N-Methyl-D-aspartic acid receptor (NMDAR) channels, and this occurr

189 Because N-methyl-D-aspartic acid receptor (NMDAR) dysregulation has been st

190 By measuring N-methyl-d-aspartic acid receptor (NMDAR)-driven calcium responses

191 (CSF) levels of the glia-derived N-methyl-D-aspartic acid receptor antagonist kynurenic acid (KYNA)

192 beta2* activation did not enhance N-methyl-D-aspartic acid receptor function.

193 The N-methyl-d-aspartic acid receptor hypofunction model of schizophren

194 chizophrenia, as predicted by the N-methyl-d-aspartic acid receptor hypofunction model.

195 ent, we found abnormally enhanced N-methyl-d-aspartic acid receptor-dependent long-term depression in

196 ed to glucocorticoids, exhibit an N-methyl-d-aspartic acid receptor-independent form of long-term pot

197 panoic acid receptor-mediated and N-methyl-D-aspartic acid receptor-mediated synaptic currents in lam

198 cine agonist-binding sites of the N-methyl-d-aspartic acid receptor.

199 n of CA2 synapses relies on NMDA (N-methyl-D-aspartic acid) receptor activation, calcium and calcium/

200 es by interacting and trafficking N-methyl-D-aspartic acid receptors (NMDAR) and alpha-amino-3-hydrox

201 asing glutamatergic excitation at N-methyl-D-aspartic acid receptors, alters both the amplitude and f

202 titution of the N-terminal position S27 with aspartic acid rescued this loss of upregulation.

203 ity was shown to be dependent on a conserved aspartic acid residue (Asp(666)), identified as the cata

204 Previous studies have suggested that the aspartic acid residue (D) at the third position is criti

205 p) CX(5)R and the loop containing a critical aspartic acid residue (D-loop), required for the catalyt

206 ymes share a consensus sequence harboring an aspartic acid residue as a catalytic nucleophile.

207 polymorphism, causing the replacement of the aspartic acid residue at position 398 with an asparagine

208 cid at position 838 (equivalent to the human aspartic acid residue at position 835) with a tyrosine (

209 al metalloenzyme in which a glutamic acid or aspartic acid residue engineered into streptavidin acts

210 analysis of isomaltase predicts that another aspartic acid residue functions as a proton donor in hyd

211 reported previously for other proteins, the aspartic acid residue in Kremen1 is not critical.

212 In a previous report, a conserved aspartic acid residue in the NqrB subunit at position 39

213 with a non-histidine zinc ligand, having an aspartic acid residue instead.

214 tamic acid residues, or changing the l- to d-aspartic acid residue on MitoFlag abolishes the traffick

215 Whereas mutation of a key active-site aspartic acid residue prevents OAS2 activity, a C-termin

216 A nearby aspartic acid residue side-chain transiently stores prot

217 e carboxyl function at the side chain of the aspartic acid residue, which was selected on the basis o

218 absolute specificity of hydrolysis after an aspartic acid residue.

219 the L-selectin tail as well as a doublet of aspartic acid residues ((369)DD(370)) in the membrane-di

220 length LRPIV variants with glycine replacing aspartic acid residues 3394, 3556, and 3674 in the calci

221 nduced two-proton transfer between catalytic aspartic acid residues and the hydroxy group of the boun

222 alogues show that, like GH31 hydrolases, the aspartic acid residues Asp(553) and Asp(665) are the cat

223 pecificity for cleavage after asparagine and aspartic acid residues during in-solution digestions of

224 neutral, despite harboring the two conserved aspartic acid residues found in NapA and other bacterial

225 egration activity of PGBD5 requires distinct aspartic acid residues in its transposase domain, and sp

226 ked homodimers that contain a pair of acidic aspartic acid residues in their transmembrane (TM) domai

227 Focusing on the two key aspartic acid residues of NhaA, D163 and D164, shows tha

228 By mutating two aspartic acid residues predicted to be responsible for t

229 Mutation of the aspartic acid residues to alanine in the C-terminal doma

230 This peptide contains a blocking motif (aspartic acid residues) flanked on either side by cleava

231 Essential aspartic acid residues, in the predicted S1 binding pock

232 bonds formed via catalytic glutamic acid or aspartic acid residues.

233 inner Odelta1 oxygen atoms of the catalytic aspartic acid residues.

234 c acid residues are replaced by arginine and aspartic acid, respectively as refractive increment incr

235 atives which are prepared from L-serine or L-aspartic acid, respectively.

236 y, substitution with the sulfinic acid mimic aspartic acid resulted in constitutive Hsf1 activation.

237 2-glutaric acid] and RGD is arginine-glycine-aspartic acid.) RESULTS: alphavbeta3 integrin is express

238 esive through exhibition of arginine-glycine-aspartic acid (RGD) adhesion peptides under stretching.

239 ty and accessibility of the arginine-glycine-aspartic acid (RGD) binding site in FN, which, in turn,

240 Cyclic arginine-glycine-aspartic acid (RGD) containing peptides are known to mim

241 with acetylenic bombesin or arginine-glycine-aspartic acid (RGD) derivatives, either in solution or o

242 x protein, has a functional arginine-glycine-aspartic acid (RGD) domain for binding to integrin.

243 lphavbeta6, via a conserved arginine-glycine-aspartic acid (RGD) motif in the exposed, antigenic, GH

244 ing a ketone-functionalized arginine-glycine-aspartic acid (RGD) peptide to modify the O-hydroxylamin

245 ecorated with two different arginine-glycine-aspartic acid (RGD) peptides: one is cyclic (RGDFC) and

246 eta5/beta3 integrins and an arginine-glycine-aspartic acid (RGD) sequence in the first extracellular

247 old electrode surface using arginine-glycine-aspartic acid (RGD) tripeptide was electrochemically con

248 Arginyl-glycyl-aspartic acid (RGD), a cell adhesion tripeptide motif, i

249 Arginine-glycine-aspartic acid (RGD)-based imaging tracers allow specific

250 ith hydrogels modified with arginine-glycine-aspartic acid (RGD)-containing peptides.

251 Arginine-glycine-aspartic acid (RGD)-mimetic platelet inhibitors act by o

252 ds in alginate and alginate-arginine-glycine-aspartic acid (-RGD) microgel was demonstrated, with enh

253 nteracting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) a

254 ng transactivators with E [glutamic acid]/D [aspartic acid]-rich-carboxylterminal domain4) is induced

255 o either alanine (S225A; phosphoablatant) or aspartic acid (S225D; phosphomimetic) in the context of

256 replacing serine with phosphoserine-mimetic aspartic acid (S386D) in ANDV N robustly inhibited inter

257 whereas replacing S47 with phospho-mimicking aspartic acid (S47D) abolished the antisenescent, growth

258 emonstrated with the accurate analysis of 10 aspartic acid samples covering a wide concentration rang

259 t peptides and small proteins containing the aspartic acid semialdehyde (Asa) side chain can be easil

260 ks containing cell adhesive Arginine-Glycine-Aspartic acid-Serene (RGDS) peptide and/or nanocrystalli

261 lcium ion that is coordinated by a conserved aspartic acid side chain and is essential for catalytic

262 heets and beta-turns, and negatively charged aspartic acid side chain of FiP35 were measured independ

263 velopment of an algorithm combining glycine, aspartic acid, SM(42:3), and SM(43:2) permitted to accur

264 d type (WT) or with alanine or glutamic acid/aspartic acid substitutions at the phosphorylation sites

265 wild type (WT) sequences or with alanine or aspartic acid substitutions at the phosphorylation sites

266 Among all the substitutions screened, aspartic acid substitutions were generally well-tolerate

267 Mg(2+), which neutralizes the Ca(2+)-binding aspartic acids that likely contribute to the C2B interfa

268 oxidised lipid was absent, cysteine, serine, aspartic acid, threonine, asparagine, tryptophan, tyrosi

269 ect dog cells, a single mutation changing an aspartic acid to a glycine at capsid (VP2) position 300

270 Although an amino acid substitution from aspartic acid to alanine at position 168 (D168A) reduced

271 changing coat protein N-arm residue 14 from aspartic acid to alanine causes a lethal phenotype.

272 amino acid in the nAChR alpha5 subunit from aspartic acid to asparagine (D398N), with greater risk f

273 (glutamic acid to lysine at position 627 and aspartic acid to asparagine at position 701) of A(H7N9)

274 ), which changes a conserved amino acid from aspartic acid to asparagine.

275 urthermore, we found that a single change of aspartic acid to glutamic acid in CW3 NS1/2 was sufficie

276 c.298G-->T) in LEP, leading to a change from aspartic acid to tyrosine at amino acid position 100 (p.

277 frequent kinase domain mutation, converting aspartic acid to tyrosine.

278 variability, which enables the two catalytic aspartic acids to be brought closer to each other.

279 ith cTn having cTnI serines 23/24 mutated to aspartic acids to mimic phosphorylation always shifted a

280 A/H1N1/pdm09 in the lung tissue harbored an aspartic acid-to-glycine substitution at position 222 (D

281 characteristic, with cyclic arginine-glycine-aspartic acid tripeptide (cRGD), a targeting ligand to i

282 ment to the high density of arginine-glycine-aspartic acid tripeptide present in DAPF.

283 utation by substituting the S936-TRP site to aspartic acid (trp(S936D) ) set the frequency response o

284 ctures of the WoA variants in complex with L-aspartic acid versus L-glutamic acid provide insights in

285 technique based on the racemization rate of aspartic acid was applied to dating human bone, as well

286 li (E. coli) HCB33 to the chemoattractant dl-aspartic acid was quantified in terms of change in total

287 acterization of mutant enzymes in which this aspartic acid was substituted by other residues that cha

288 N-[3',4'-dihydroxy-(E)-cinnamoyl]-l-aspartic acid was the most abundant metabolite, followed

289 lices, and the residues in the beta-turn, by aspartic acid was used examine the importance of the con

290 ncluding 2-hydroxyglutaric acid and N-acetyl-aspartic acid, was also observed in the DESI mass spectr

291 -1-F-box protein (SCF)-[F-box and tryptophan-aspartic acid (WD) repeat domain containing 7 (FBXW7)] u

292 rylcarnitine/malonylcarnitine and asparagine/aspartic acid were associated with worse clinical rank s

293 lanine, glutamine, glutamic acid, aspargine, aspartic acid were detected.

294 made of cyanophycin [multi-L-arginyl-poly (L-aspartic acid)], which is synthesized by cyanophycin syn

295 lpha mutant, where serine 41 was replaced by aspartic acid, which mimics phosphorylation.

296 tamylases, with CCP3 being able to hydrolyze aspartic acids with similar efficiency.

297 inine residue at a similar register to these aspartic acids, with the activating immunoreceptors.

298 multiple phyla reveals a uniquely conserved aspartic acid within an FFXRX6RX12PXD motif, two uniquel

299 A point mutation neutralizing a conserved aspartic acid within the intracellular loop close to the

300 lytic zinc ion ligated by the histidines and aspartic acid within the motif (HEXXHXXGXXD).