ライフサイエンスコーパス: associated

1 TR and its antiamyloid inhibitory effect are associated.

2 lbeit initially forming smaller, weakly self-associated, acutely synaptotoxic oligomers.

3 Thymus-associated B cell clones were detected in the circulatio

4 Many circulating thymus-associated B cell clones were inferred to have originate

5 Rationale: A subpopulation of B cells (age-associated B cells [ABCs]) is increased in mice and huma

6 n integral role for CaMKII in neuronal TRPV4-associated Ca(2+) responses, the importance of tightly r

7 relevance as a disease-causing serotype, the associated capsular polysaccharide remains poorly charac

8 The increase in yields and associated carbon input to the SOC pool counteracted the

9 of dicarbonyl electrophiles in inflammation-associated carcinogenesis.

10 ociated with pregnancy; 406 of the pregnancy-associated cases (87%) occurred in neonates.

11 ASD-associated cellular and behavioral deficits could be res

12 ting single-molecular tension events and the associated cellular force nanoscopy (CFN).

13 20 matched blood and aqueous samples; tumor-associated chromosomal changes were found in 0/20 blood

14 Prph2K/+ as well as amelioration of K153Del-associated defects in PRPH2/ROM1 oligomerization.

15 ling of familiarity to vivid recollection of associated details.

16 ssed macaques, there was a reduction in cell-associated DNA load, intact proviral DNA levels, and in

17 ty to elucidate molecular drivers of disease-associated dysbiosis across the microbiota.

18 on contained an intact ETT2 together with an associated eip locus which encodes putative secreted ETT

19 oM1000 appearing to be stable, tightly self-associated ensembles that coexist in dynamic equilibrium

20 e study visits were addressed as potentially associated factors for sPTB.

21 l cohorts revealed defects in cardiomyopathy-associated genes in patients with HLHS, which may porten

22 ed(4)) identified multiple new candidate PID-associated genes, including IVNS1ABP.

23 pes implicated by the expression patterns of associated genes.

24 ccurring at distal sites harboring virulence-associated genes.

25 a putative transcriptional regulator of ETT2 associated genes.

26 nd the first database recording 1218 disease-associated genetic mutations that may function through r

27 analysed the most recent Parkinson's disease-associated genetic risk score to detect genetic influenc

28 ability, but how cells respond to the R loop-associated genomic stress is still poorly understood.

29 trated activities and efficacy that parallel associated health benefits in humans, we propose C15:0 a

30 id use to manage uncontrolled asthma and its associated healthcare burden may account for important h

31 Patients' last histoplasmosis-associated healthcare visits occurred a median of 6 mont

32 de delivery significantly reduced triptolide-associated hepatic and cardiac toxicities.

33 Detectable Kaposi's sarcoma-associated herpesvirus (KSHV) DNA in blood and increased

34 ure accumulation.IMPORTANCE Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic gammaherpe

35 s also identify a significant amount of cell-associated Hg-S(3)/S(4) species, as studied by high ener

36 ted NFL concentrations in CSF and plasma are associated in AD-vulnerable regions in the presence of a

37 thod to rapidly and noninvasively detect the associated increase in flux from pyruvate to lactate cat

38 Here, we found an age-associated increase in stiffness in human lenses that wa

39 ELP1-associated medulloblastomas were restricted to the molec

40 larization and negatively regulates pathogen-associated molecular pattern-triggered immunity.

41 des (LPS), cytokines and damage- or pathogen-associated molecular patterns (DAMPs/PAMPs) from blood w

42 ponse to diverse stimuli, including pathogen-associated molecular patterns (PAMPs)(1).

43 To report the first case of belatacept-associated multidrug-resistant Cytomegalovirus retinitis

44 -threonine phosphatase-interacting protein 1-associated myeloid-related proteinemia inflammatory (PAM

45 ce, particularly among patients with alcohol-associated or NASH-related cirrhosis and those not follo

46 clude bone-targeted agents to inhibit tumour-associated osteolysis and prevent skeletal morbidity as

47 Age-related mitochondrial dysfunction and associated oxidative stress might induce senescence in j

48 We found 41 loci associated (P < 5 x 10(-8)) with left-handedness and 7 a

49 Here, participants associated pairs of faces in two conditions: a famous, h

50 in the nucleus and that Parkinson's disease-associated Parkin mutants, ParkinR42P and ParkinG430D, a

51 uding Ruminococcus gnavus, a Crohn's disease-associated pathobiont.

52 ted critically ill patients that mediate the associated pathogenesis, including vascular dysfunction,

53 y immunological leukocyte subsets as well as associated pathways in nACD, providing insights into pat

54 crop species, and their inbred germplasm and associated phenotypic and genotypic data serve as enduri

55 actor 4GI (eIF4GI) and of its homolog, death-associated protein 5 (DAP5), are elevated.

56 Tau is a microtubule-associated protein that plays a major role in Alzheimer'

57 l of the transcriptional regulators YAP (yes-associated protein) and TAZ.

58 e used to assess the expression levels of ER-associated proteins using immunohistochemistry (IHC).

59 tumor cells produced a diverse array of ECM-associated proteins, including secreted factors and modu

60 yeast and Adh2 in hyphae among the cell wall-associated proteins.

61 mall nuclear ribonucleoprotein particles and associated proteins.

62 n = 294) or from within canine mammary tumor associated regions (n = 471).

63 unt for a disproportionate burden of revisit-associated resource utilization in pediatric surgery.

64 d extracellular matrix as well as senescence-associated secretory proteins.

65 n 60 minutes daily on electronic devices was associated significantly with both myopia and high myopi

66 othalamus (LH)] mediates avoidance of stress-associated stimuli.

67 emains unclear whether activity in the tumor-associated stroma contributes to malignancy.

68 ation of CD11b function and reduction of PMN-associated tissue damage in chronic inflammatory disease

69 different orthopoxviruses bound to membrane-associated TNF and dampened inflammatory gene expression

70 these results show that consideration of BGC-associated transporter genes can inform predictions of s

71 The epigenetic traits of cancer cells and of associated tumor microenvironment components have been s

72 Here, in vivo characterization of tumor-associated USP22 upregulation and unbiased interrogation

73 Adeno-associated virus (AAV) is a promising vector for gene th

74 showed 1.3- to 1.7-fold-lower growth of cell-associated virus and 3- to 6.2-fold-lower growth of cell

75 a transgene or after infection with an adeno-associated virus that transferred an overlength HBV geno

76 xty intrabony defects in AgP and CP patients associated with >= 6 mm residual probing pocket depth (P

77 From 11 295 literature citations associated with 10 PICO questions, 20 relevant studies w

78 RSV was also associated with 25.0-37.5% of deaths from medical causes

79 Factors significantly associated with 90-day mortality were: P: age, gender an

80 Recent IS was independently associated with a 23% reduced risk of functional depende

81 nosuppressive mechanisms are not necessarily associated with a decreased antimicrobial activity.

82 The cost associated with a hybrid suite remains prohibitive for m

83 HSIL recurrence was associated with a LEEP biopsy result of HSIL and detecti

84 BNT162b2 was associated with a lower incidence and severity of system

85 line, compared to no yogurt consumption, was associated with a multivariable HR of 0.84 (95% CI, 0.70

86 Epstein-Barr virus (EBV) is associated with a number of T-cell diseases, including s

87 This is associated with a paradoxical mitochondrial hyper-functi

88 However, ADH1B*2, compared to ADH1B*1, was associated with a reduced risk of definite NASH (ADH1B*2

89 theter pulmonary valve replacement (TPVR) is associated with a risk of procedural serious adverse eve

90 therapy administration was not significantly associated with a severe or critical COVID-19 event (HR,

91 thological response rate (TRG1 = 8%) but was associated with a significant pathological regression (T

92 Furthermore, treatment was associated with a significant reduction in NT-proBNP and

93 eyes with history of retinoblastoma has been associated with a significant risk for recurrence, extra

94 In the ischemic FFR cohort, PCI was associated with a significantly lower rate and hazard of

95 itis and osteoporosis, whose pathogenesis is associated with a Th17/Treg imbalance.

96 nd steatosis of adipose tissue and liver are associated with a variety of serious health risks.

97 The activation of gene networks associated with adaptive immunity was linked to the supp

98 ectual disability gene set was significantly associated with ADHD risk in the discovery and replicati

99 The daily pattern of energy intake is associated with adiposity and robust circadian rhythms.

100 Ambrosia beetles collected on traps associated with all in-field treatments were identified

101 Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5x

102 (P < 5 x 10(-8)) with left-handedness and 7 associated with ambidexterity.

103 The enhanced program was associated with an 11.0% point (95% CI: -18.1, -3.8; P <

104 ence of residual shunt after PFO closure was associated with an increased incidence of recurrent stro

105 Compared with placebo, CBD was associated with an increased likelihood of withdrawal fo

106 ults suggest that the consumption of SSBs is associated with an increased risk of hyperuricemia in Me

107 g factors that are specific to women and are associated with an increased risk of incident atheroscle

108 Late transient rhinitis was associated with antenatal exposure to smoking, higher ma

109 5% CI, 1.54, 3.67, P = .001) were positively associated with ApoL1 test interest.

110 in barrier (BBB), 12 mo after murine TBI, is associated with arrested axonal neurodegeneration and co

111 artifacts on the RNFL scan was significantly associated with artifacts on the macular scan (P < .001)

112 We aimed to identify genetic variants associated with asthma hospitalizations.

113 es) have identified hundreds of genetic loci associated with atrial fibrillation (AF).

114 Mutations in Shank3 are strongly associated with autism spectrum disorders and neural cir

115 Replicating prior work, sustained effects associated with autobiographical recall periods (which a

116 Interdental cleaning is associated with better perceived oral health and less se

117 mfort at the implant site were significantly associated with both outcomes (increased probing depth a

118 Lean mass was positively associated with both the energy intake from the ad libit

119 n AD-typical regions were also significantly associated with Braak stage (|rho| > 0.45, P < 0.01) and

120 ses had ICU stays and 2% died; 3 deaths were associated with C. difficile and 1 with norovirus.

121 hift in iMo toward an inflammatory phenotype associated with CAD progression is unknown.

122 ls are elevated in obese adolescents and are associated with cardiovascular disease risk factors, HsC

123 Genetic risk scores were not associated with cardiovascular events in 357 882 unrelat

124 d DEGs in GO functional analysis were mainly associated with cell adhesion, inflammatory response, an

125 Fracture is associated with cessation of hunting, tree chopping, and

126 Whether premature menopause is associated with CHIP is unknown.

127 nd disease initiation and progression events associated with Chr1- and Chr10-directed AMD.

128 and Main Results: Six microRNA modules were associated with clinical features of asthma.

129 egree of CD8(+) T cell infiltration were not associated with clinical response, we discovered numerou

130 epair GAs are relatively frequent in GBC and associated with coexisting actionable mutations and a hi

131 Prior use of ACEI/ARBs was not significantly associated with COVID-19 diagnosis among patients with h

132 F and peak log contrast sensitivity were not associated with crash rate, whether defined as all crash

133 relationship between diabetes and variables associated with CRC risk and ADR.

134 s of community-acquired bacterial meningitis associated with CSF leakage from a prospective nationwid

135 e, we found that higher expression of CRY is associated with decreased activation of dopamine 1 recep

136 sts that patterns of morphological evolution associated with deep tetanuran divergences were more com

137 ource and sanitation facility alone were not associated with diarrhoea.

138 e correlated with histopathologic attributes associated with disease aggressiveness in GBM, particula

139 MDD was associated with disorders of lipid metabolism (OR 1.22,

140 ntified specific gene combinations that were associated with distinct MDS/MPN subtypes and that were

141 ological deficits in life and have also been associated with dysbiosis.

142 son to a single mouse bed, the cost and time associated with each scan were substantially reduced.

143 Implementation of an ERAS pathway was associated with effective post-operative analgesia, majo

144 In the adjusted model, factors associated with eGFR <90 mL/min/1.73 m2 included white r

145 ted cochlear adenosine in untreated mice was associated with enhanced Adora2b gene expression.

146 Vitamin E acetate was associated with EVALI in a convenience sample of 51 pati

147 Pneumococcal carriage was associated with exposure to young children (OR:2.71, 95%

148 ng those 759 CpG sites, methylation of 42 is associated with expression of 28 adjacent genes.

149 the CI+Txp group had tubular cell apoptosis associated with expression of caspase-8, TNFR1, and incr

150 Genetic risk variants strongly associated with expression of SNX19 transcript features

151 nd reduction of any potential infection risk associated with FcRn inhibition, in addition to highligh

152 ), and circulating micro RNAs in plasma, are associated with female fertility, measured by pregnancy

153 prefrontal-ventral striatal dysfunction was associated with fewer days of alcohol abstinence and als

154 ffected individuals presented optic atrophy, associated with foveopathy in half of the cases.

155 per microliter, and autoimmune disease were associated with frequent AECRS with statistically signif

156 MMP-8 concentration in GCF was associated with GDM (RR: 1.19; P = 0.045; CI 95% 1.00 to

157 nt classes and short tandem repeats that are associated with gene expression and human traits.

158 C1936, 22 of the proteins were significantly associated with general fluid cognitive ability (beta be

159 , some of them controlling transcript levels associated with glucagon action.

160 study, we observed an increased risk of CVDs associated with glucocorticoid dose intake even at lower

161 This was associated with greater dysbiosis but no change in liver

162 ICH was found to be positively associated with having a diagnosis of melanoma (odds rat

163 ow-fat) or yogurt consumption was positively associated with HDL cholesterol.

164 Frequently recombining genes include those associated with heptose biosynthesis, colonization, and

165 sequence type are dominant, endemic(6-8) and associated with high mortality(6,9,10).

166 Repeated bolus injections are associated with higher costs and poor compliance and can

167 Visual field (VF) loss severity is associated with higher driving simulator crash risk, tho

168 Symptomatic teeth were associated with higher levels of Porphyromonas (p < 0.05

169 dietary intake and blood concentrations are associated with higher mortality and a poorer physiologi

170 Lower Apgar scores were associated with higher relative risks of neonatal death

171 to PLHIV, viral load of >=1000 copies/mL was associated with higher TNF-alpha levels (P = .013).

172 Soft drink consumption was positively associated with HOMA-IR change.

173 own, particularly in cancers not classically associated with homologous recombination deficiency.

174 nt mechanisms, including those traditionally associated with HRS-1 and non-traditional factors, might

175 the discovery of loss-of-function mutations associated with human disease.

176 cessive mutations in podocalyxin (PODXL) are associated with human kidney disease.

177 tration rate and urinary potassium excretion associated with hyperkaliemia at day 3.

178 5% CI = 0.81-0.95; p = 0.002) were inversely associated with ICH risk, no significant associations we

179 ral area (OR = 1.38(1.01-1.89)) are strongly associated with immunogenicity.

180 antation may be a treatment option in sepsis associated with immunosuppression.

181 BACKGROUNDBeige adipose tissue is associated with improved glucose homeostasis in mice.

182 was of greater magnitude in females and was associated with improved glucose tolerance, increased me

183 017 ACC/AHA definition was not significantly associated with incident ASCVD (n = 1386 events; median

184 e SARS-CoV-2 infection of these organoids is associated with increased cell death and transcriptional

185 nd reversible action of TNF-alpha and is not associated with increased human-Abeta levels and AD path

186 Vitamin D deficiency has been associated with increased incidence of diabetes, both in

187 (n = 38 and n = 100; 67% collectively) were associated with increased inflammatory proteins and more

188 s (P-value > 0.05), but it was significantly associated with increased number of postoperative visits

189 is a chronic inflammatory condition that is associated with increased prevalence of high-risk corona

190 in ARR1 gain-of-function transgenic lines is associated with increased rates of protein synthesis, wh

191 e high-temperature requirement 1 (HTRA1) are associated with increased risk of age-related macular de

192 Type 2 diabetes (T2D) is associated with increased risk of cardiovascular disease

193 ncidence of major cardiovascular disease was associated with increased risk of ESKD, with the highest

194 There was enrichment of proteins associated with inflammation and extracellular matrix as

195 ed in craniofacial tissues, as well as genes associated with known autosomal dominant OFC syndromes.

196 P1 sheds many basal interactions and becomes associated with known lysosomal trafficking and proteoly

197 aphic analyses, H5N1 sequences that are only associated with large administrative areas of origin and

198 eptor (ar) and cytochrome P450 1A genes were associated with large shifts in allele frequencies betwe

199 urve for 30 and 60 seconds from DSC MRI were associated with local malignant lymph nodes (pN status).

200 n by selectively promoting specific memories associated with local sleep oscillations.

201 Neonatal morbidities are associated with long term neurological deficits in life

202 examine if early health status changes were associated with long-term clinical outcomes in the COAPT

203 d with higher vitamin B-12 was significantly associated with lower cognitive score (beta: -0.119; 95%

204 -ranked repositioned drugs are significantly associated with lower odds of AD diagnosis.

205 ition of HMG-CoA reductase was significantly associated with lower odds of epithelial ovarian cancer.

206 Furthermore, decline in WC was significantly associated with lower risk of HF with preserved EF but n

207 assessed whether patient travel distance was associated with lung transplant outcomes.

208 tation (seen in 58 of 103 patients, 56%) was associated with lymphadenopathy (relative risk [RR]: 1.7

209 transcription factor FOXC2 are predominately associated with lymphedema.

210 n between these two essential organelles are associated with metabolic disorders, neurodegenerative d

211 Compared with HDL-C, HDL-P was consistently associated with MI and ischemic stroke in the overall po

212 g eRNA initiation regions, both of which are associated with mRNA expression QTLs.

213 near regression to identify clinical factors associated with myocardial injury in COVID-19.

214 We have identified three loci associated with neck or shoulder pain in the UK Biobank

215 We found that all types of information are associated with neural patterns after a face is seen.

216 Disruption of autophagy is associated with neuronal dysfunction and neurodegenerati

217 e exposure was also used to identify changes associated with neutrophil counts in the airway.Measurem

218 54, 1.262; p < 0.001]) but not significantly associated with NO2 and PM10 (1.044 [0.998, 1.092; p = 0

219 Vitamin D was associated with nonsignificant increases in maternal lea

220 SUVmax (p <= 0.001) and TLG (p < 0.001) were associated with overall survival.

221 s (RSV) infection in mouse and human lung is associated with oxidative injury and pathogenic inflamma

222 Overweight in children is strongly associated with parental body mass index (BMI) and overw

223 to explain some of the more complex symptoms associated with parietal damage, such as constructional

224 a proxy for measuring subjective experiences associated with pathology.

225 tion (seen in 19 of 103 patients, 18.4%) was associated with peritoneal carcinomatosis (RR: 5.9; 95%

226 Protein levels of p27 were associated with plasticity/rigidity of the cell cycle an

227 detection, and comorbidities were negatively associated with Pn-IST carriage (odds ratios, <1.0).

228 mmunosuppression," and genetic polymorphisms associated with poor fungal immunity could lead to a per

229 uxtaposition of M2 TAM near tumor cells were associated with poor survival.

230 re and during chemotherapy was significantly associated with poorer disease-free survival (adjHR, 1.8

231 5% CI, 1.50-54.0; P = .02) was independently associated with post-HCT AIC.

232 D-MELD (donor age x recipients' MELD) was associated with postoperative mortality (HR: 8.027; 95%

233 This was associated with potentiated recall of fear extinction me

234 in the prevention of endothelial dysfunction associated with preeclampsia.

235 Uteroplacental hypoxia is associated with pregnancy disorders such as intrauterine

236 ses were identified, of which 465 (50%) were associated with pregnancy; 406 of the pregnancy-associat

237 ed epithelial cell expression of ST6Gal-I is associated with premalignant progression.

238 the entire hematopoietic system from changes associated with premature aging.

239 n in men (AOR = 0.44, 95%CI: 0.28-0.70), and associated with previous history of TB (AOR = 1.97, 95%C

240 t adopting defined core components of ESD is associated with providing a more responsive and intensiv

241 /or methylated genes, including RPS27L, were associated with pulmonary function deficits in obese chi

242 r reduced HCV replication after pregnancy is associated with recovery of CD4+ T cell immunity.

243 atient stability, the intervention was still associated with reduced omissions.

244 domethacin (P = 0.04), but not significantly associated with reductions in MCAv(mean) (Young: rho = -

245 y and safety while reducing treatment burden associated with regular IVT injections for patients with

246 Proteinuria is associated with renal function decline and cardiovascula

247 ylation signatures in proxy tissues that are associated with reproductive phenotypic variation, altho

248 discovered numerous chromosomal alterations associated with response or resistance to PD-1 blockade.

249 eline intrahepatic transcriptional signature associated with response to GS-9688 treatment provides i

250 ilization and patient benefits due to issues associated with reticuloendothelial system clearance, tu

251 , 5.67; P-trend <0.001) both were positively associated with risk of diabetes, whereas scores of glyc

252 yelins (even if having an SFA base) were not associated with risk of diabetes.

253 w that the known high-risk CNVs are not only associated with schizophrenia and other neurodevelopment

254 sychiatric risk variants, particularly those associated with schizophrenia.

255 veloped PGD (38.9%), and PGD development was associated with selective reduction of the ILC2 subset a

256 linkage disequilibrium with rs56151658 were associated with severe asthma exacerbations at a P value

257 (EIMFS) and several other forms of epilepsy associated with severe intellectual disability.

258 vist working 3 or fewer consecutive days was associated with shorter ICU length of stay (3 consecutiv

259 ve the inflammatory vaso-occlusive processes associated with sickle cell anemia (SCA).

260 criteria for GERD, while 107 (3.0%) had GERD associated with significant impairment of quality of lif

261 tio [HR], 0.92 [95% CI, 0.80-1.06]) but were associated with significant reductions in total myocardi

262 th good nutritional status, malnutrition was associated with significantly increased risk for all-cau

263 pregulation in human atherosclerotic plaques associated with smooth muscle cells (SMCs), inflammation

264 owever, neonatal mortality was significantly associated with SO2 (1.207 [1.154, 1.262; p < 0.001]) bu

265 ondary outcomes were the percentage of cases associated with specific genetic disorders and the propo

266 termine whether actin filaments are directly associated with specific membranes.

267 nd possible recall bias, which are typically associated with studies of patient pathways using patien

268 7 days of initial positive MSSA culture was associated with survival.

269 CVD was also marginally associated with symptomatic HAND.

270 esulted in a rapid thymocyte differentiation associated with the development of a thymic medulla.

271 60% and VE/VCO2 >=34 at 1 year after HTx are associated with the development of CAV.

272 gher concentrations of serum biomarkers were associated with the development of clinical AD; especial

273 t radical prostatectomy, combined biopsy was associated with the fewest upgrades to grade group 3 or

274 ps and showed a potent cell killing activity associated with the formation of micronuclei, a clear si

275 The parameters most associated with the increase of AFP >=10 ng/ml according

276 Thus, cell death is often closely associated with the induction of an immune response.

277 comes dominant among exhibition swine and is associated with the majority of zoonotic infections in 2

278 x 10-8) and one locus that was significantly associated with the metabolic subtype (KCNH7/FIGN, P = 1

279 Use of steroids was also not significantly associated with the number of courses of antibiotics (P-

280 This loss may be associated with the observed phenotype change but the me

281 We identified alleles in 4 loci that were associated with the reproductive subtype at genome-wide

282 Another limitation is the side effects associated with the treatment of chemotherapy or radioth

283 al strategies to overcome immune suppression associated with the tumor microenvironment.

284 drought is likely to be determined by traits associated with their hydraulic systems.

285 nd osteoclast differentiation and that it is associated with thinner cortical bone in adult male mice

286 To identify the underlying mechanisms associated with this phenomenon, we identified 18 novel

287 f stable PI4KII-containing endosomal tubules associated with this process.

288 EZH2-driven dedifferentiated invasive states associated with treatment resistance and defects in anti

289 It is well known that alcohol consumption is associated with type 2 diabetes mellitus.

290 r fatty levels, and by the ablation of genes associated with type 2 diabetes risk in genome-wide asso

291 readers, the breadth of chromatin functions associated with ubiquitin signaling is emerging.

292 idity, engaging in a healthier lifestyle was associated with up to 6.3 years longer life for men and

293 isolated hypogonadotropic hypogonadism (IHH) associated with variants of these genes in humans.

294 ATPases associated with various cellular activity are a set of p

295 pmental stage, anatomical region and whether associated with VGLUT1 or VGLUT2 terminals.

296 The only variable significantly associated with viral load was time since onset of sympt

297 o California, including epidemic WA1 strains associated with Washington state, with lack of a predomi

298 mental illness diagnosis, which was strongly associated with worse postoperative outcomes, as well as

299 n insulin sensitizer may alleviate ER stress associated with YIPF5 disruption by decreasing the deman

300 e molecular basis for malfunction of disease-associated XPA missense mutations, and contribute to und