ライフサイエンスコーパス: association constant

1 tion and dissociation rate constants and the association constant).

2 fourth transmembrane helix to predict their association constant.

3 r population and 510(5)-fold increase of the association constant.

4 y the number of sites but hardly changes the association constant.

5 crystal or liquid) and the other with a self-association constant.

6 icantly increase or decrease the equilibrium association constant.

7 se, our method finds the correct pathway and association constants.

8 isotherm and allow the determination of ion association constants.

9 his experimental measurement on the apparent association constants.

10 ts requires quantification of state-specific association constants.

11 gree well with the experimentally determined association constants.

12 constant was 9.1 +/- 1.3 mM(-1), and the Pi association constant 0.14 +/- 0.04 mM(-1).

13 ptionally weak affinity of MgATP for myosin (association constant, 0.2 mM(-1)), and a unique rate-lim

14 (1) in acetone solution with a high apparent association constant, 1.4 x 10(4) M(-)(1).

15 ond used in this work has a relatively large association constant (2.2 x 10(11)) but also undergoes f

16 antigen-antibody complex demonstrates a high association constant (5x10(12)L/mol) that results in hig

17 ologous alpha/beta complex displays a larger association constant [(6.6 +/- 0.4) x 10(6) M(-1)] than

18 The ionic strength dependence of the association constant allowed an estimation of the electr

19 where folded conformers are scarce, then the association constant and enantioselectivity clearly drop

20 olyte concentrations allowed us to obtain an association constant and free energy change for ion pair

21 Association constant and Gibbs free energy for the inter

22 Association constant and Gibbs free energy for the inter

23 When the product of the intermolecular association constant and the effective molarity KEM > 1,

24 The association constant and thus Gibbs energy of binding fo

25 Because of its exceedingly poor association constant and, in contrast with TIMP-2, TIMP-

26 The association constants and enantioselectivities for the c

27 The association constants and enthalpies for the binding of

28 s from this study suggest that the different association constants and formation of an intermediate c

29 cant errors in the evaluation of equilibrium association constants and the fractional coverage of mem

30 statistics is used to determine histone-DNA association constants and to test for differences in the

31 ists between translocase/phosphatidylcholine association constants and translocation half-lives.

32 The association constants and van't Hoff enthalpy changes de

33 e mutants showed significantly lower K0 (ADP association constant) and larger K4 (equilibrium constan

34 ine the receptor's stoichiometry of binding, association constants, and both the enthalpy and entropy

35 und to be stable, demonstrated fast receptor association constants, and showed high specificity for a

36 determination of complexation stoichiometry, association constants, and stereochemical features of th

37 of two classes of calcium-binding sites with association constants approximately 10(7.5) and approxim

38 t that those receptors that display the best association constants are able to sample folded conforma

39 The measured association constants are comparable to other pincer-pyr

40 Surprisingly, the PKA-RIalpha state-specific association constants are comparable to those of a struc

41 Experimentally determined association constants are examined by a combination of c

42 ely bound and cleaved, but in this case, the association constants are significantly lower ( approxim

43 rs also form duplexes, but the observed self-association constants are strongly affected by folding e

44 The data showed that the association constants are strongly dependent on the natu

45 However, observed association constants are typically population-averages,

46 to 5:1) and suggest two binding classes with association constants around 10(5) and 10(2) M(-1).

47 es 72-248) provides an estimate of the C1-C2 association constant as 7.7 x 10(6) M(-1).

48 ts, where the tracer assay predicts the same association constant as a traditional displacement compe

49 tion, expressing the experimentally observed association constant as the sum of products, each valid

50 fullerene-based guest molecules and present association constants as high as approximately 5 x 10(8)

51 Additionally, the association constant between the CRH and the immobilized

52 Host-guest interactions with different association constants between alpha-CD and azobenzene or

53 relate closely with literature values of the association constants between the respective ligands and

54 The apparent association constants between VAL and Li(+), Na(+), K(+)

55 on the alpha CD site, lowering the apparent association constant by a factor of 14.

56 s to the periphery of one dendron lowers the association constant by almost an order of magnitude.

57 This effect, which can reduce the apparent association constant by more than 60%, is found to be mo

58 as measured by a shift in the radical-dimer association constants by up to 100-fold toward the radic

59 n a near 1000-fold change in the equilibrium association constant, by varying the spatial distributio

60 f the same DNA strand in vitro, we found the association constants can be 13- to 163-fold higher in t

61 nding experiments showed the presence of two association constants corresponding to high-affinity (Ka

62 In the less polar CDCl(3), association constants could not be determined because ap

63 Low association constants create a more shallow moving bound

64 These findings reveal that high association constants create a steep moving boundary in

65 In general, for all the receptors, the association constants decrease with decrease of anion ba

66 The various association constants defined by the present study provi

67 more than 2 orders of magnitude greater than association constants derived for the other hosts.

68 n it was necessary to include the non-band 3 association constants determined from chymotrypsin-treat

69 Stepwise or microscopic association constants, determined from the fluorescence

70 (1/2-I)) was 0.77 h, increasing the antibody association constant enhanced AUC(C(IAR)) much more than

71 ative; that is, the ratios of the individual association constants exceeded the expected statistical

72 Association constants extracted from the NMR data are in

73 concentration dependence, but the ratios of association constants followed the expected statistical

74 ity and very tight binding, with an apparent association constant for C5O5(2-) of 5 x 10(10) M(-1).

75 imentation equilibrium results show that the association constant for dimerization of EI-C monomers i

76 Cryptand 12 exhibits the highest association constant for diquat ever reported (Ka = 1.9

77 pe H-chain ferritin whereas the enthalpy and association constant for Fe(2+) binding are similar for

78 UV-vis experiments reveal that the association constant for fluoride binding at the triaryl

79 urements reveal a systematic increase in the association constant for H.G1, H.G2, and H.G3 with a cha

80 near the middle of the domain decreases the association constant for human SIRPalpha to about one-th

81 The association constant for the dimer-to-tetramer transitio

82 Evaluation of the polynomial reveals an association constant for the formation of a complex betw

83 Binding stoichiometry (1:1), association constant for the respective [2]pseudorotaxan

84 The association constant for this low-affinity binding site

85 Association constants for 1:1 complexation (K(assoc)) ar

86 The association constants for a family of 96 closely related

87 method for the simultaneous determination of association constants for a guest binding to seven diffe

88 The protein/peptide data combined with the association constants for binding of each proline-rich p

89 The association constants for both the chaperone and target

90 Association constants for complexes of amino acids and r

91 Association constants for different aminoglycosides vari

92 ghts in the range 10-330 kDa and equilibrium association constants for dimer formation in the range 2

93 The association constants for formation a 1:1 complex betwee

94 e significantly steeper salt dependencies in association constants for noncognate loops, aiding discr

95 NO association constants for NP7 [KIII(eq)(NO)] reveal a dr

96 orted (Ka = 1.9 x 10(6) M(-1)) and very high association constants for paraquats (Ka > 10(5) M(-1)) i

97 etonitrile solution containing 2% water, the association constants for the 1:1 binding interaction be

98 Association constants for the binding of peptides corres

99 d ESI-MS assay, the proxy ligand method, the association constants for the CBM-B2NGL and CTB5-GM1 int

100 Measurement of association constants for the corresponding intermolecul

101 Association constants for the cyclophane itself, cycloph

102 The association constants found for the neutral guest with t

103 The association constant in CH2Cl2 corresponds to a binding

104 ctions (complex [5.6]), but only reduces the association constant in CH3CN by 2 orders of magnitude (

105 Each association constant in the binding scheme and the fract

106 ists in a monomer-trimer equilibrium with an association constant in the micromolar range.

107 e a general method to measure state-specific association constants in allosteric sensors based on thr

108 Association constants in excess of 10(10) M(-1) have bee

109 With quinone-type guests, association constants in excess of 10(8) m(-1) were obse

110 Association constants in solution have been determined b

111 nd HisG form inactive but stable dimers with association constants in the range of 2.5-3.3 x 10(5) M(

112 ituents on the bisurea binding pocket showed association constants in the range of 200-400 M(-1) in t

113 Association constants in water are approximately 1000 ti

114 2N(CH)nNH2, n = 6, 7, 8, 9, 10, 11, 12), the association constants increase as the length of the alka

115 i.e., statistical, and the average apparent association constant increased by nearly 5-fold; this ef

116 Based on the association constants inferred from fast exchange chemic

117 rom calculations based on a constant complex association constant is found and explained by a reduced

118 Upon deprotection of one dendron, the association constant is increased by more than an order

119 The highest association constant is K = 1.2 x 10(6) M(-1) for cyclou

120 of the cavity (cf. Rebek's 55% rule), so the association constant is sensitive to shape complementari

121 Toward physiological pH, association constant K(1:1) does not change (10(4) M(-1)

122 ds weakly within the oligomer cavity with an association constant K(a) = 2 M(-1), and the oligomer-me

123 in analogous complexes exhibited the highest association constant K(a) = 5.0 x 10(6) M(-1) in acetone

124 affinity for K5 was quantified, yielding an association constant K(a) approximately 2.08 x 10(4) mM(

125 The association constant K(a) for zinc cytochrome c(6) and c

126 adiometrically to give the cryptophane-radon association constant K(a)=49,000 +/- 12,000 M(-1) at 293

127 in concentration dependence of the apparent association constant K(a,exp), (= [complex]/[H][G(2+)2X(

128 that the potency achieved by increasing the association constant k(on) can be very different from th

129 In CD(3)CN and CD(3)COCD(3) the individual association constants K(1), K(2), and K(3) for 1:1, 1:2,

130 (3) for all three generations the individual association constants K(1), K(2), and K(3) for [2]-, [3]

131 e of the individual antibody fragments (with association constants K(A) and K(B)) by p(d(0))K(B) or p

132 measurements to determine the noncooperative association constants K(ds) to double-stranded DNA for g

133 of fullerene C(70) over C(60), with a large association constant ( K(a) = 8.066 x 10(5) M(-1) in tol

134 , NMR spectroscopy was used to determine the association constant ( K(a)) and the structure of the as

135 cognition in a 1:1 motif.(1) The equilibrium association constant (K(1)) for complexation of a specif

136 detachment step (K(2)), the phosphate (P(i)) association constant (K(5)) and the equilibrium constant

137 thermal titration calorimetry to measure the association constant (K(a)) and stoichiometry (n) values

138 termination of the site-specific equilibrium association constant (K(A)) for a DNA-binding protein.

139 mathematical framework for establishing the association constant (K(a)) for protein-ligand binding b

140 g the model to the experimental data gave an association constant (K(A)) of 4.95 x 10(12) over a PFOS

141 eptide was bound per hexamer of ClpA with an association constant (K(A)) of 5 x 10(6) m(-1).

142 tion between the GABP subunits determined an association constant (K(A)) of 6.0 x 10(8) M(-1) and tha

143 ive manner and with a consistent equilibrium association constant (K(a)) value of 2 x 10(6) M(-1) per

144 n is made possible by determining an average association constant (K(AVE)) for the binding of each re

145 specific binding of leptin to HSCs, with an association constant (K(d)) equal to 660 +/- 5.8 pmol/L.

146 of binding sites (N) and the number average association constant (K(n)()) were calculated for each p

147 onic composition on the apparent equilibrium association constant (K) for the formation of a 1:1 incl

148 The equilibrium association constant (K) of the Cob(+)@CB7 complex had b

149 SA with a rank order of apparent equilibrium association constants (K(a) values): desflurane > isoflu

150 peptidic guests in all solvent systems have association constants (K(A)'s) in the range of 1 x 10(4)

151 fraction bound to humic superstructures and association constants (K(a)) and Gibbs free energies of

152 that contain a variety of functional groups, association constants (K(A)) for N-Ac-Trp, indole, N-Ac-

153 The association constants (K(a)) of eight complexes have bee

154 technique for measuring the non-cooperative association constants (K(ds)) to double-stranded DNA to

155 The association constants (K(E)) in acetone-d(6) and tetrahy

156 The equilibrium association constants (K) for complexation by CB7 were m

157 ognate nsp3a with high affinity (equilibrium association constant [K(a)], [1.4 +/- 0.3] x 10(6) M(-1)

158 rse rate constant, k(r), and the equilibrium association constant, K(a), for binding of neutrophils t

159 The association constant, K(A), of the cyt and the rate of e

160 The equilibrium association constant, K(a), was determined to be approxi

161 The cryptophane-xenon association constant, K(a)=42,000 +/- 2,000 M(-1) at 293

162 K, a fraction of tetraradicals form a dimer (association constant, K(assoc) approximately 60 M(-1)),

163 The equilibrium association constant, K(eq) for binding between anti-GAB

164 interaction, it was possible to calculate an association constant, K(POLY), for the binding of the di

165 luster and divalent dialkylammonium ions, an association constant, K(POLY), was calculated from the v

166 with dielectric constants of 10 or less, ion association constants, K(A), are as much as 2 orders of

167 mately 2 orders of magnitude higher than the association constants, K(A), for the component interacti

168 ile, however, BlueCage6 PF6 exhibits a lower association constant Ka than its progenitor ExCage6 PF6.

169 teracted with two sets of binding sites with association constants Ka of 10(6) and 10(5)M(-1).

170 As a result, the association constant (Ka = (1.12 +/- 0.08) x 10(5) M(-1)

171 e calculated change in enthalpy (DeltaH) and association constant (Ka) became greater as the oligomer

172 The association constant (KA) for streptavidin/biotin and ST

173 interactions and can be used to estimate the association constant (Ka) of a complex.

174 The first determination of the association constant (Ka) of ortho-substituted boronic a

175 The association constant (Ka) of PVD with ciprofloxacin was

176 s with guests containing aromatic rings with association constants (Ka) ranging from 10(2) to 10(6) M

177 sis under acidic conditions, and the aqueous association constants (Ka) were estimated.

178 Equilibrium association constants (Ka) were measured for SERMs using

179 ) has been used to determine the equilibrium association constants (Ka), desorption rate constants (k

180 The association constant (Kassoc approximately 5 x 10(7) M(-

181 -linked protonation and pH dependence of the association constant (Kb) for the enzyme-aminoglycoside

182 hboring Pc1 molecules and gives rise to high association constants (KD approximately 10(11) M(-1)).

183 Association constant kon, dissociation constant koff, an

184 are believed to be the first evaluations of association constants leading to a [4]-pseudorotaxane.

185 s behavior is identical to that observed for association constants measured for the formation of 1:1

186 To our knowledge, this is the first reported association constant measurement between a protein and s

187 han Arixtra, which correlates with data from association constant measurements for CCL7-disulfated CC

188 the exo-tert-butyl ones, leading to apparent association constants more than one order of magnitude h

189 ction is significantly weaker, exhibiting an association constant of (3.0 +/- 0.6) x 10(6) M(-1).

190 An equilibrium association constant of (6 +/- 3) x 10(4) M(-1) was obta

191 lpha CD-EF (alpha/alpha) complex displays an association constant of (7.6 +/- 0.4) x 10(7) M(-1).

192 In pure water, the association constant of 1-F is estimated to be at least

193 in a monomer <--> dimer equilibrium with an association constant of 1.0 x 10(6) m(-1).

194 that Q7 binds to insulin with an equilibrium association constant of 1.5 x 10(6) M(-1) and with 50-10

195 binding, with the largest directly measured association constant of 1.7 x 10(9) M(-1) in 75:25 water

196 interacts with mGzmA, but not hGzmA, with an association constant of 1.9 +/- 0.8 x 10(5) M(-1) s(-1)

197 r-dimer self-association equilibrium with an association constant of 1.9x10(3)-2.2x10(3) M(-1).

198 An association constant of 1200 M(-1) was extracted from (1

199 a protein, vesicle complex with an apparent association constant of 2 x 10(6) M(-1) s(-1).

200 scherichia coli IscA binds iron with an iron association constant of 2.0 x 10(19) M(-1) in vitro.

201 o 30 S subunits with an observed equilibrium association constant of 2.0 x 10(6) m(-1), indicating th

202 m bis(hexafluorophosphate), PQ(PF6)2, has an association constant of 2.0(+/-0.3) x 10(4) M(-1).

203 ge of 2.40-48.26 nM and was found to have an association constant of 2.15 x 10(5) M(-1) s(-1).

204 ence titration reveals a 1:1 complex with an association constant of 2.63 +/- 0.05 x 10(5) M(-1).

205 termini to form a tetramer with an apparent association constant of 3 mum.

206 sulfur cluster assembly protein with an iron association constant of 3.0 x 10(19) m(-1), is able to o

207 to artificial light harvesting units with an association constant of 3.3 +/- 1.2 muM(-1).

208 fluorescence quenching assay to have a xenon association constant of 33,000 M(-1) at 293 K, which is

209 y specific interaction to protein (LDL) with association constant of 33.4 kM(-1) s(-1) indicating hig

210 d isopropylidene acetals on the other had an association constant of 520 M(-)(1).

211 r physiological conditions, with a weak self-association constant of 6.5 x 10(4) M(-)(1) for the mono

212 Stern-Volmer analysis gave an association constant of 9000 +/- 1,000 M(-1) at 298 K be

213 itration calorimetry (ITC) studies reveal an association constant of approximately 2 x 10(5) M(-)(1)

214 ical ultracentrifugation yielded an apparent association constant of approximately 3 x 10(6) M(-1) fo

215 According to the results, self-association constant of beta-carotene in the presence of

216 Competitive assays are used to measure the association constant of complementary strand DNA hybridi

217 ity stems primarily from changes in the O(2) association constant of deoxy (T-state)-Hb.

218 The receptor has an association constant of K(a) = 1.0 x 10(3) M(-1) with th

219 he 10-bp site match site with an equilibrium association constant of K(a) = 7.5 x 10(10) M(-1) and di

220 nearly 2 orders of magnitude, and (iii) the association constant of Keap1 for zinc is 1.02 (+/-0.19)

221 hylamino-substituted derivative has a proton association constant of log beta = 4.7, and the disubsti

222 The association constant of MgATP to cross-bridges (K(1)) af

223 en-bonding ability of the solvents while the association constant of the corresponding sites does not

224 ows us to quantify the stoichiometry and the association constant of the EGFR-Grb2 binding interactio

225 ng the acetic acid concentration affects the association constant of the enantiomers more than the nu

226 reases three to four orders of magnitude the association constant of the functional hexamer; ii), shi

227 0.2 to 0.9 M causes a large decrease in the association constant of the highest energy sites in CH(2

228 gle molecule method for measuring K(ss), the association constant of these proteins to single-strande

229 gle molecule method for measuring K(ss), the association constant of these proteins to ssDNA.

230 the density of high-energy sites than on the association constant of these sites.

231 icooperativity in CO binding with successive association constants of 0.24 and 0.02 microm(-1).

232 orms 1:1 complexes with C(60) and C(70) with association constants of 1.4 x 10(5) M(-1) (C(60)) and 1

233 The association constants of 1.55x10(4) and 1.45x10(4)M(-)(1

234 (2+) cooperatively with stepwise macroscopic association constants of 1.73 x 10 (6) and 8.06 x 10 (6)

235 he more preorganized cyclic ketones all have association constants of 10(4)-10(5) M(-1).

236 Scatchard analysis yielded association constants of 2.7 and 1.3 x 10(5) M(-1) for (

237 ding is sequential with apparent macroscopic association constants of 2.78 x 10 (4) and 170 M (-1).

238 200 molecules/microm(2) and two-dimensional association constants of 3.1 and 630 microm(2) for bival

239 Association constants of a bis-(acetylguanidinium)ferroc

240 Association constants of approximately 10(8) M(-)(1) wer

241 uadruplex DNAs is characterized by intrinsic association constants of approximately 2 x 10(5) M(-1) (

242 The derived intrinsic 1:1 association constants of Ba and Mg with PC are 1.0 and 0

243 PC are 1.0 and 0.4 M(-1); the intrinsic 1:1 association constants of Ba and Mg with PS are 1.9 and 1

244 provides the best fit and the intrinsic 1:1 association constants of Ba, Mg, and Ca with acidic grou

245 Herein, determinations of the association constants of benzotelluradiazoles with a var

246 rometry (nano-ESI TOF MS), we determined the association constants of C-C motif chemokine 7 (CCL7) wi

247 .7, and the disubstituted derivative has two association constants of log beta = 6.2 and 12.1 in etha

248 In the presence of ammonium cations, the association constants of nitrate binding reach an impres

249 ed greatly (4 x 10(4)-150 x 10(4)) while the association constants of several acyl-coenzyme A derivat

250 otropy titration experiments showed that the association constants of the bZIP at 20 degrees C with t

251 Equilibrium association constants of the drugs were obtained and cor

252 Association constants of the hosts bound to the sodium s

253 The association constants of the two receptors were evaluate

254 The basket binds small molecule guests with association constants of up to 10(4) M(-1) in mesitylene

255 all four anions are bound unselectively with association constants on the order of 10(5) M(-1).

256 oved to the erythrocyte stroma with apparent association constants on the order of 10(7) M(-1).

257 ; for larger C12 and C13 cyclic ketones, the association constant progressively decreases as the gues

258 Association constants quite regularly depend on the subs

259 The association constants range from approximately 10(3) M(-

260 Secondary association constants ranging from 10(2) to 10(4) M(-1)

261 tary unit, with no observable changes in the association constants regardless of the degree of functi

262 An increase in association constant relative to monomeric species was o

263 egardless of the structural state of betalg, association constants remained in the same order of magn

264 The overall association constants show the following order: HSO4(-)

265 Analysis of the salt dependence of the association constants showed that the electrostatic comp

266 The apparent association constants significantly increased in the ord

267 taining these mutations gave higher relative association constants, suggesting altered TM-TM interact

268 For over a 1000-fold change in association constant, the number of water molecules sequ

269 Using predetermined association constants, the binding responses to physiolo

270 aK(ATPase) complexes allowed the equilibrium association constants to be brought into an experimental

271 teins to ssDNA, as well as their equilibrium association constants to dsDNA.

272 h a wide range of hydrophobicities and whose association constants to HSA cover 3 orders of magnitude

273 (aze(2-)) have shown adipate preference with association constant value of K = 4900 M(-1) in a H2O/DM

274 e other methods for the determination of the association constant values (Ka) and the interaction ene

275 The association constant values calculated from the relative

276 Notable halide anion association constant values determined for the [2]catena

277 Association constant values greater than 10(4) M(-1) wer

278 The association constant values of the halogen-bonding compl

279 The association constant values of the halogen-bonding compl

280 The measured association constants vary by 3 orders of magnitude (10(

281 In control myocardium, the MgATP association constant was 9.1 +/- 1.3 mM(-1), and the Pi

282 The Xe-AFCA association constant was determined by fluorescence quen

283 calorimetry studies revealed that the PIP-H1 association constant was one order of magnitude higher t

284 in a monomer-dimer equilibrium, although the association constant was significantly less than that re

285 The binding free energy change (hence, the association constant) was nearly invariant over this tem

286 Association constants were also derived for the same gue

287 Large association constants were derived for the complexes in

288 Association constants were determined as 4600 M(-1) for

289 Association constants were determined by fitting mathema

290 Association constants were determined from (1)H NMR titr

291 Assuming 1:1 stoichiometry, formal association constants were determined to be 2.3 and 1.5

292 e equimolar solutions (<1 mM) of CxC and AyA association constants were estimated for the formation o

293 s peripheral groups were prepared, and their association constants were measured by (1)H NMR in CDCl(

294 eakens protein binding, unbiased protein-RNA association constants were obtained in competition exper

295 These association constants were used to construct 64 chemical

296 dissolution of 1a (reflective of the overall association constant which is too high to measure) incre

297 ion predominantly depends on its multivalent association constant, which itself exponentially increas

298 based on experimental determination of their association constants with a palladium ion.

299 termination of their low-temperature (212 K) association constants with C6F5I as 2.9 +/- 0.2, 2.5 +/-

300 phobic effects, and bicyclic substrates have association constants with the calix[4]resorcarene large

301 eriments showed that at this temperature the association constants with the PRDI binding site are 1.1