ライフサイエンスコーパス: astrocytic

1 poE4 impairs microglial function and impedes astrocytic Abeta clearance in brain, but the direct neur

2 of neuronal uPA to astrocytic uPAR promotes astrocytic activation and that astrocytes activated by u

3 g of neuronal uPA to astrocytic uPAR induces astrocytic activation by a mechanism that does not requi

4 Furthermore, astrocytic activation decreased the firing rate of CeM n

5 rtite synapses, and we provide evidence that astrocytic activation enhances PSD95 expression.

6 but with putative evidence of microglial and astrocytic activation in the high immune subgroup.

7 inding is necessary and sufficient to induce astrocytic activation in the ischemic brain and that ast

8 In summary, we show that uPA/uPAR-induced astrocytic activation mediates a cross talk between astr

9 ) model, with an additional layer simulating astrocytic activation.

10 However, it remains unclear how the astrocytic activities in the DMS differentially affect t

11 lial fibrillary acidic protein, a marker for astrocytic activity, was elevated in the IC of MeHg-expo

12 To investigate the astrocytic activity-driven neuronal synaptic events and

13 Importantly, mice lacking an astrocytic adenosine transporter, ENT1 (equilibrative nu

14 ircuit whereby noradrenergic transmission at astrocytic alpha1ARs activates wake-promoting vPAG(DA) n

15 gs define a metabolic mechanism regulated by astrocytic alpha2-Na/K ATPase that triggers episodic mot

16 Interestingly, astrocytic alphaBc overexpression was neuroprotective ag

17 pe and revealing how it can be influenced by astrocytic alterations, but also reveal potential target

18 1-AS/BACE1 axis in Tat-mediated induction of astrocytic amyloidosis, which could be targeted as adjun

19 njury (SCI) is characterized by formation of astrocytic and fibrotic scars, both of which are necessa

20 sion, lymphocyte infiltration, and neuronal, astrocytic and microglial markers.

21 neural circuit function, it seems as though astrocytic and neuronal biology continue to advance in p

22 y, overexpression of astrocyte Ezrin rescued astrocytic and neuronal dysfunctions and fully corrected

23 the gene expression profiles associated with astrocytic and neuronal EAAT2 deletion are substantially

24 Here, we show that conditional deletion of astrocytic and neuronal EAAT2 results in age-related cog

25 hemistry revealed GFP expression in cells of astrocytic and neuronal morphology.

26 ations in the mRNA and protein expression of astrocytic and neuronal proteins necessary for optimal e

27 for the clinical care of adult patients with astrocytic and oligodendroglial gliomas, including gliob

28 nalysis reveals altered constituents of both astrocytic and RGC lineages, suggesting a requirement fo

29 to undergo in-depth autoimmune screening for astrocytic antibodies.

30 models, we show that increased expression of astrocytic apoE4, but not apoE3, during the seeding stag

31 athophysiological outcomes of IgG binding to astrocytic AQP4 are poorly understood.

32 gnificantly attenuated astrocyte activation, astrocytic aromatization, and decreased hippocampal E2 l

33 Lastly, astrocytic association of excitatory synapses decreases.

34 or Lrp4, in response to agrin, in modulating astrocytic ATP release and synaptic transmission.

35 Importance: A novel astrocytic autoantibody has been identified as a biomark

36 t the possible existence of yet undiscovered astrocytic autoimmune targets.

37 to human diseases that have a known primary astrocytic basis.

38 Nonetheless, whether mHtt affects astrocytic BDNF in the HD brain remains unknown.

39 , there was a positive feedback loop whereby astrocytic BDNF induced cancer cell BDNF translation.

40 The first attempts to develop astrocytic biomarkers and targeted therapies are emergin

41 the necrotic core, which is surrounded by an astrocytic border.

42 Glioblastoma (GBM) is an astrocytic brain tumor with median survival times of <15

43 urotrophic factor in the IC, suggesting that astrocytic brain-derived neurotrophic factor is a potent

44 Astrocytic, but not neuronal EAAT2, deletion leads to ea

45 ss, elevation of anaphylatoxin C5a receptor, astrocytic-C3, and microglial-TLR4 expression in the bra

46 ing neurovascular coupling (NVC) via several astrocytic Ca(2+) -dependent signalling pathways such as

47 ological meaning of these dynamic changes in astrocytic Ca(2+) activity has remained a major challeng

48 Here we simultaneously monitored astrocytic Ca(2+) and cAMP and demonstrate that astrocyt

49 ndent manner, promoting further increases in astrocytic Ca(2+) and resulting in a positive-feedback l

50 events in NAcSh astrocytes, while decreasing astrocytic Ca(2+) blocks cocaine-induced generation of s

51 l alpha1-adrenergic receptors triggers rapid astrocytic Ca(2+) elevation and facilitates synaptic pla

52 in noradrenaline release and large cytosolic astrocytic Ca(2+) elevations, cAMP changes were not dete

53 nceptual challenges in the interpretation of astrocytic Ca(2+) events and their spatio-temporal patte

54 s Oct-TyrR and Wtrw as key components of the astrocytic Ca(2+) signalling machinery, provides direct

55 We find that astrocytic calcium activity precedes spontaneous circuit

56 nous MrgA1Rs expressed in astrocytes tripled astrocytic calcium oscillation frequency in both the pre

57 ic neuron, orchestrated by endocannabinoids, astrocytic calcium signaling, and presynaptic N-methyl-D

58 This astrocytic Cav1.2 knock-out mouse was tested in the cupr

59 l (blood-brain barrier), ATPase activity and astrocytic cell functions contribute to MDD and suicide,

60 Here, using murine neuronal and astrocytic cell lines, we find that ANG triggers the act

61 l 3-kinase (PI3K) pathways were evaluated in astrocytic cell models in the presence and absence of LR

62 s expressed at the surface of cultured human astrocytic cells and rat cortical astrocytes.

63 rol in excitatory and inhibitory neurons and astrocytic cells to these behaviors remains unknown.

64 SVG astrocytic cells were pretreated with TIMBD or resveratr

65 rn, males and females show increased GFAP(+) astrocytic cells; however, only males demonstrate an inc

66 These astrocytic changes do not cause loss of motor neurons in

67 roups that can be correlated to neuronal and astrocytic classifications and lipid classes.

68 These results show that astrocytic clearance of extracellular glutamate is slowe

69 Astrocytic clocks achieve this by reinstating clock gene

70 Blockade of the astrocytic CN/NFAT pathway in rats using adeno-associate

71 The blockade of astrocytic CN/NFAT signaling in a common mouse model of

72 However, the impact of astrocytic CN/NFAT signaling on neural function/recovery

73 The results reveal astrocytic CN/NFAT4 as a key pathologic mechanism for dr

74 termediary molecule between the neuronal and astrocytic compartment in the regulation of GABAergic in

75 al epilepsy and found the involvement of the astrocytic compartment.

76 Here we report that astrocytic complement activation also regulates Abeta dy

77 ted activity-dependent upregulation of major astrocytic components of the astrocyte-neuron lactate sh

78 This indicates that Cx43, a typically astrocytic connexin, is the main connexin forming functi

79 t microbial taxa are related to neuronal and astrocytic consequences of cirrhosis-associated brain dy

80 strocyte reactivity, what is known about the astrocytic contribution to remyelination, and highlight

81 Astrocytic contributions to Alzheimer's disease (AD) pro

82 ocytes are unknown despite the fact that the astrocytic CREB is also activity-driven and neuroprotect

83 The astrocytic cystine/glutamate antiporter system x(c)(-) r

84 in mice results in a switch from neuronal to astrocytic d-serine release.

85 sion demonstrates that neuronal, rather than astrocytic d-serine, modulates synaptic plasticity.

86 Astrocyte-specific elimination of the astrocytic d-serine-synthesizing enzyme serine racemase

87 Impairing astrocytic delivery of energy substrates by reducing ast

88 nism, suggesting upstream impairment, likely astrocytic-dependent.

89 The SCZ glial chimeras also showed delayed astrocytic differentiation and abnormal astrocytic morph

90 The mHTT hGPCs also manifested impaired astrocytic differentiation and developed abnormal fiber

91 and dysconnectivity, whereas the failure of astrocytic differentiation results in abnormal glial cov

92 By contrast, retinal astrocytic differentiation was accelerated by the exposu

93 While astrocytic differentiation was not impaired in FTD NPCs

94 gen from the retinal circulation may promote astrocytic differentiation, in part by triggering oxygen

95 nal vascular development but also suppressed astrocytic differentiation, reducing the abundance of di

96 YAP in NSCs was required for neocortical astrocytic differentiation, with no apparent role in sel

97 ors, and undergo less proliferation and less astrocytic differentiation.

98 MP2 induction and stabilization of SMAD1 and astrocytic differentiation.

99 Astrocytic EAAT2 buffers basal glutamate activation of A

100 Astrocytic EAAT2 deficiency also shows transcriptomic ov

101 dysregulation of the kynurenine pathway, and astrocytic EAAT2 deficiency results in dysfunction of in

102 se data shed new light on the important role astrocytic EAAT2 plays on buffering nTS excitation and o

103 ws that in addition to the widely recognized astrocytic EAAT2, neuronal EAAT2 plays a role in hippoca

104 (CSF) both at the choroid plexus and at the astrocytic end feet and defects in the synthesis of cere

105 n the choroid plexus but is expressed in the astrocytic end feet and ependymal cells.

106 w that AQP4 polarization in the perivascular astrocytic end feet was impaired after TBI, which was mo

107 ater-permeable channel aquaporin-4 (AQP4) to astrocytic endfeet is dependent on interactions between

108 ane that seperates the endothelial cells and astrocytic endfeet that comprise the blood-brain barrier

109 We conclude that NO can modulate astrocytic energy metabolism in the short term, reversib

110 creating a barrier for neuronal access to an astrocytic energy reservoir in the hippocampus and neoco

111 We provide new evidence that astrocytic ephrin-B1 differentially regulates developmen

112 iature IPSC amplitude were reduced following astrocytic ephrin-B1 loss.

113 The ability of astrocytic ephrin-B1 to influence both excitatory and in

114 The ability of astrocytic ephrin-B1 to influence both excitatory and in

115 utamate concentration occurs in part through astrocytic excitatory amino acid transporters (EAATs).

116 Astrocytic exosomes carry heat shock proteins that can r

117 Furthermore, addition of astrocytic exosomes in neuronal cultures resulted in a s

118 Conversely, injection of astrocytic exosomes into the striatum of HD140Q KI mice

119 We found that mHtt is not present in astrocytic exosomes, but can decrease exosome secretion

120 ng oligodendrocytes (OLs) while promoting an astrocytic fate in vitro.

121 with intact axons and instead divert into an astrocytic fate.

122 ization requires AQP4-bound IgG to engage an astrocytic Fcgamma receptor (FcgammaR).

123 The influence that neurons exert on astrocytic function is poorly understood.

124 t chemical pathways that preserve beneficial astrocytic functions in response to AD pathology.

125 ocytes and demonstrate that they perform key astrocytic functions in vitro, including trophic support

126 t dopaminergic neurons by blocking excessive astrocytic GABA could be an effective therapeutic strate

127 Blocking the astrocytic GABA synthesis recapitulates the therapeutic

128 n is enhanced by the loss-of-function of the astrocytic GABA transporter GAT-1 that does not necessar

129 eport a previously unrecognized role for the astrocytic GABA transporter, GAT-3.

130 inhibition, which is attributed to excessive astrocytic GABA.

131 These proneurotoxic effects of astrocytic GAP43 knockdown were accompanied by attenuate

132 In sum, the present study suggests that astrocytic GAP43 mediates glial plasticity during astrog

133 Genomic analysis has connected altered astrocytic gene expression with synaptic deficits in a n

134 uncovers a wide programme of neuron-induced astrocytic gene expression, involving Notch signalling,

135 Separately, hundreds of astrocytic genes are acutely regulated by synaptic activ

136 Moreover, the groups of astrocytic genes induced by neurons or neuronal activity

137 iously found that Mertk and its ligand Gas6, astrocytic genes involved in phagocytosis, are upregulat

138 Interestingly, BMP4 increased astrocytic GFAP expression, and BMP4-treated astrocytes

139 icity in vivo, at least in part, by reducing astrocytic GLAST/GLT-1.

140 lood-brain barrier (BBB) and then across the astrocytic glia limitans (GL).

141 yma may acquire protection from the reactive astrocytic Glia Limitans not only during neuroinflammati

142 Astrocytic glial cells interact with synapses throughout

143 Immunohistochemistry using astrocytic (glial fibrillary acidic protein) and microgl

144 ecting neurodegeneration, demyelination, and astrocytic gliosis in the injured cervical cord.

145 suggest the pharmacological relevance of NTS astrocytic GLP-1R activation for food intake and body we

146 ollectively, data demonstrate a role for NTS astrocytic GLP-1R signaling in energy balance control.

147 Thus, astrocytic Glu transport remains a promising target for

148 Treatment of WT preparations with the astrocytic Glu uptake blocker TFB-TBOA (100 nm) mimicked

149 ention.SIGNIFICANCE STATEMENT Alterations in astrocytic Glu uptake can play a role in synaptic plasti

150 tle, leading to a CREB-dependent increase in astrocytic glucose metabolism and elevated lactate expor

151 However, the mechanisms of astrocytic glutamate release have been debated.

152 abolic enzyme levels in the VMH, 4) examined astrocytic glutamate reuptake mechanisms, and 5) used (1

153 d glutamate was also associated with reduced astrocytic glutamate transport in the VMH.

154 utamate levels are tightly controlled by the astrocytic glutamate transporter EAAT2, influencing syna

155 Glioblastoma brain tumor stem cells with low astrocytic glutamate transporter expression are dependen

156 xFAD mice led to increased expression of the astrocytic glutamate transporter GLT-1 and to attenuated

157 ized glutamate signaling dynamics, increased astrocytic glutamate transporter levels and alleviated m

158 phic factors, BDNF and IGF-1, as well as the astrocytic glutamate transporter, GLT-1.

159 negatively correlated with expression of the astrocytic glutamate transporters EAAT1 and EAAT2.

160 Mn dysregulates astrocytic glutamate transporters, GLT-1 and GLAST, and

161 developmental disorders, while alteration in astrocytic glutamate uptake is a core feature of multipl

162 As astrocytic glutamate uptake is a fundamental and essenti

163 Insufficiency of astrocytic glutamate uptake is a major element in the pa

164 ered EAAT expression, our findings show that astrocytic glutamate uptake is dynamic on a fast time-sc

165 el experimentally by showing that inhibiting astrocytic glutamate uptake using TFB-TBOA nearly quadru

166 weeks of life, coincident with increases in astrocytic glutamate uptake.

167 y stimulation before and after inhibition of astrocytic glutathione and PgE2 synthesis.

168 expression using chemogenetic activation of astrocytic Gq signaling or in vivo morpholinos and deter

169 However, stimulation of retinal astrocytic growth by intravitreal delivery of PDGF-A was

170 r telangiectasia type 2 and solitary retinal astrocytic hamartoma in one patient.

171 , macular telangiectasia type 2 and solitary astrocytic hamartoma was detected as a unique and rare o

172 Retinal astrocytic hamartomas (RAH) is a benign vascularized gli

173 h significantly inhibited the expression of astrocytic HIF-1alpha, and the downstream genes GLUT-1,

174 Moreover, astrocytic IL-1beta plays a role in the enhanced synapti

175 unknown, and it is unclear whether impairing astrocytic infiltration of the neuropil alters synaptic

176 corresponding mechanisms of seizure-induced astrocytic injury have not been documented.

177 Our data indicate astrocytic injury occurs in some patients with double-Ab

178 by biomarker evidence of ongoing neuronal or astrocytic injury/activation or induction of dementia-re

179 astrocytes, in line with a primary role for astrocytic inputs in their activation.

180 To determine whether astrocytic insulin sensing plays a role in the regulatio

181 Here we explore the relationship between astrocytic intracellular pH dynamics and the synchronous

182 ect the circuit deficits by synapse type and astrocytic involvement will be crucial for understanding

183 directly CNS glucose levels in mice lacking astrocytic IRs indicates a role in glucose transport acr

184 Astrocytic l-serine was proposed to regulate NMDAR activ

185 gs suggest that NO modulates the size of the astrocytic lactate reservoir involved in neuronal fuelin

186 Local astrocytic lactate shuttling was not required.

187 We found that the astrocytic layer of the olfactory bulb is a distinct bar

188 preferentially in PSDs, and in perisynaptic astrocytic leaflets, provides morphologic evidence that

189 ed in hyperactive neurons are transferred to astrocytic lipid droplets by ApoE-positive lipid particl

190 addition to the traditional presynaptic and astrocytic locations.

191 Intriguingly, astrocytic LPL deficiency also triggered increased ceram

192 Likewise, astrocytic LPL deletion reduced the accumulation of lipi

193 Together, our study demonstrates that astrocytic LRP4 plays an important role in Abeta patholo

194 (CF) to PC synapses, while both neuronal and astrocytic MAGL significantly contributes to the termina

195 ation into neurons, proper expression of the astrocytic marker GFAP and corticogenesis.

196 g of neurons and increased expression of the astrocytic marker GFAP in the cortex of 7-day old pups.

197 rease in the transcription of microglial and astrocytic markers in schizophrenia cases and MIA offspr

198 Notch signalling, which drives and maintains astrocytic maturity and neurotransmitter uptake function

199 ll death of patient-derived motor neuron and astrocytic-mediated neurotoxicity in co-culture assays.

200 Transcriptomic profiles from mouse astrocytic membralin KO motor cortex indicated significa

201 vating FcgammaR's gamma subunit and involves astrocytic membrane loss of an inhibitory FcgammaR, CD32

202 gammaR engagement for internalization of two astrocytic membrane proteins critical to CNS homeostasis

203 s gating of synaptic plasticity in stress by astrocytic metabolic networks indicates a broader role o

204 , (b) brain glucose uptake and neuronal- and astrocytic metabolism, and (c) synaptic plasticity.

205 Lastly, inhibition of astrocytic miR-223 abrogated the exosomal-mediated reduc

206 cerebral ischaemia in mice induced entry of astrocytic mitochondria into adjacent neurons, and this

207 ayed astrocytic differentiation and abnormal astrocytic morphologies.

208 This study suggests that astrocytic Mt-derived HN could act as a beneficial secre

209 properties of pial ILA and confirming their astrocytic nature.

210 E3 knockout reduces functional expression of astrocytic NBCe1.

211 y gene expressions, low permeability, and 3D astrocytic network with reduced reactive gliosis and pol

212 1, potentially by engagement of the enmeshed astrocytic network.

213 ring glucose and lactate trafficking through astrocytic networks.

214 and time within single astrocytes and across astrocytic networks.

215 ignalling events in single astrocytes and in astrocytic networks.

216 from interdependent and mutually supportive astrocytic-neuronal signaling.

217 Notably, ossification of vessels and astrocytic neurotoxic response is associated with specif

218 nal dependencies for astrocytes and identify astrocytic NFIA as a key transcriptional regulator of hi

219 Furthermore, in the absence of astrocytic NL2, the formation and function of cortical e

220 Astrocytic Norrin appears to regulate dendrites and spin

221 Furthermore, we show that astrocytic NRCAM interacts transcellularly with neuronal

222 Moreover, loss of astrocytic NRCAM markedly decreases inhibitory synaptic

223 Depletion of astrocytic NRCAM reduces numbers of inhibitory synapses

224 ased reader will follow our argumentation on astrocytic or microglial P2X7Rs being the primary target

225 (CSF), or both that yielded a characteristic astrocytic pattern of mouse tissue immunostaining; (2) c

226 pression of the water channel aquaporin-4 at astrocytic perivascular endfeet of the BBB.

227 Rapid astrocytic pH changes are highly temporally correlated w

228 AM phagocytic receptors, which were the main astrocytic phagocytic receptors for cell debris in the a

229 r short and long sleep loss, suggesting that astrocytic phagocytosis may represent the brain's respon

230 r damage.SIGNIFICANCE STATEMENT We find that astrocytic phagocytosis of synaptic elements, mostly of

231 This astrocytic phagocytosis was also observed in Irf8-defici

232 Astrocytic phagocytosis, mainly of presynaptic component

233 In neonatal mice, astrocytic PHD2 deficiency led to elevated HIF-2alpha pr

234 o identify a nuclear marker pathognomonic of astrocytic phenotype, we assessed differential RNA expre

235 We now report that inhibition of astrocytic Phgdh suppressed the de novo synthesis of l-a

236 The effects of AE3 knockout on astrocytic pHi homeostasis in MAc-related assays require

237 Recent work examining astrocytic physiology centers on fluorescence imaging, d

238 By histology, astrocytic plaques are diagnostic of CBD(7,8); by SDS-PA

239 The early prominence of the astrocytic plaques in relation to sparse neuronal lesion

240 els enable the high conductance state of the astrocytic plasma membrane, which ensures the driving fo

241 nsity and distribution of cholesterol in the astrocytic plasmalemma, consequently modulating a host o

242 2-dependent HIF-2alpha degradation in nearby astrocytic precursors, thus limiting their further growt

243 g oxygen dependent HIF-2alpha degradation in astrocytic precursors.

244 apses were always located within 1 mum of an astrocytic process, but none were ensheathed by those pr

245 elicited a reduction in the total length of astrocytic processes and an increase in the expression o

246 t caused a delayed loss of mitochondria from astrocytic processes and increased colocalization of mit

247 Perisynaptic astrocytic processes are an integral part of central ner

248 Fine astrocytic processes are in tight contact with neurons a

249 ume measurements of synapses and surrounding astrocytic processes in mouse frontal cortex after 6-8 h

250 ere coordinated with changes in perisynaptic astrocytic processes in the border region between head a

251 Total astrocytic processes length, number of endpoints, the ex

252 s of neurons in area CA1 and mitochondria in astrocytic processes were blocked by ionotropic glutamat

253 ecently, mitochondria have been localized to astrocytic processes where they shape Ca(2+) signaling;

254 otransmission: the extracellular space, fine astrocytic processes, and neuronal terminals.

255 equired to restrict neuropil infiltration by astrocytic processes.

256 ead of differentiated astrocytes, but behind astrocytic progenitor cells (APCs) and immature astrocyt

257 However, YAP in astrocytes was necessary for astrocytic proliferation.

258 We tested the hypothesis that astrocytic prostaglandin E2 (PgE2) plays a key role for

259 inal hydrolase (UCH-L1) and glial fibrillary astrocytic protein (GFAP) in acute stroke patients and h

260 brain, increased plasma levels of S100B, an astrocytic protein, and down-regulation of tight junctio

261 Our study suggests that astrocytic Rab3a is a potential therapeutic target for H

262 Here we show that astrocytic rather than neuronal beta2ARs in the hippocam

263 Here, we show the importance of astrocytic reactivity on the pathogenesis of AD using Gi

264 ss, direct evidence of the role of LRRC8A in astrocytic regulatory volume decrease remains to be prov

265 p-me signal that activates a neuroprotective astrocytic response, which fails in ALS, and therefore r

266 Preventing astrocytic scar formation significantly reduced this sti

267 scar-forming astrocytes, or ablating chronic astrocytic scars all failed to result in spontaneous reg

268 rocytic Ca(2+) and cAMP and demonstrate that astrocytic second messengers are regulated in a temporal

269 activity state in astrocytes that alters the astrocytic secretome, leading to loss of synaptogenic fu

270 these data suggest that mGlu3 can influence astrocytic signaling and modulate betaAR-mediated effect

271 Our findings suggest distinct astrocytic signaling pathways can integrate noradrenergi

272 a unidimensional process involving neuronal-astrocytic signaling to local blood vessels to a multidi

273 l networks at presynaptic, postsynaptic, and astrocytic sites to the time window of t-LTD induction.

274 ochondrial epilepsy by the application of an astrocytic-specific aconitase inhibitor, fluorocitrate,

275 dent transient astrocytic volume changes and astrocytic structural elaboration.

276 of Schwann cells on inhibitory aggrecan and astrocytic substrates.

277 ring pathological cell swelling, deletion of astrocytic Swell1 attenuated glutamate-dependent neurona

278 hway in vivo corrected several HD-associated astrocytic, synaptic, and behavioral phenotypes, with ac

279 in in the absence of neuronal tau pathology, astrocytic tau pathology did not.

280 y also identifies BMP2 as an effector of the astrocytic terminal differentiation mediated by SNRPN.

281 e hypoxic injury via a mechanism mediated by astrocytic thrombospondin-1 (TSP1) and synaptic low-dens

282 d by ERK1/2-regulated STAT3 phosphorylation, astrocytic thrombospondin-1 (TSP1) and synaptic low-dens

283 Astrocytic TIMP-1 was demonstrated to play a pivotal rol

284 , neurons and neuronal activity regulate the astrocytic transcriptome with the potential to shape ast

285 ing of extracellular glutamate, we find that astrocytic transients in glutamate co-occur with shifts

286 lize glutamate uptake but also restore other astrocytic transporter activities afflicted with HD.

287 caine administration and examine the role of astrocytic TSP-alpha2delta-1 signaling in cocaine-induce

288 f other cellular clocks, the cell-autonomous astrocytic TTFL alone can drive molecular oscillations i

289 activation in the form of a reactive retinal astrocytic tumor.

290 c injury and that binding of neuronal uPA to astrocytic uPAR induces astrocytic activation by a mecha

291 We found that binding of neuronal uPA to astrocytic uPAR promotes astrocytic activation and that

292 Although astrocytic VEGF-A was also increased, anti-VEGF failed t

293 uring demyelination; and that attenuation of astrocytic voltage-gated Ca(2+) influx may be an effecti

294 nisms that included AQP4-dependent transient astrocytic volume changes and astrocytic structural elab

295 swelling and receptor stimulation activated astrocytic VRAC, which requires its only obligatory subu

296 lox/flox) mice to generate a region-specific astrocytic YY1 conditional knockout (cKO) mouse model.

297 Astrocytic YY1 deletion also attenuated the Mn-induced d

298 tors into the SN resulted in region-specific astrocytic YY1 deletion and attenuation of Mn-induced im

299 Here, we investigated if in vivo astrocytic YY1 deletion mitigates Mn-induced dopaminergi

300 These results indicate that astrocytic YY1 plays a critical role in Mn-induced neuro