ライフサイエンスコーパス: asymmetric hydrogenation

1 e recent breakthroughs and opportunities for asymmetric hydrogenation.

2 available on iridium- and rhodium-catalyzed asymmetric hydrogenation.

3 action has to be classified as heterogeneous asymmetric hydrogenation.

4 ,3]-sigmatropic rearrangement with catalytic asymmetric hydrogenation.

5 ial utility of more earth-abundant metals in asymmetric hydrogenation.

6 for the electronic effects often observed in asymmetric hydrogenation.

7 tion reaction followed by a PtO(2)-catalyzed asymmetric hydrogenation.

8 r the development of such compelling and new asymmetric hydrogenations.

9 Catalytic asymmetric hydrogenation, a reaction of broad academic a

10 Asymmetric hydrogenation, a seminal strategy for the syn

11 iral amines, many of them based on catalytic asymmetric hydrogenation (AH).

12 calculated, the technique was applied to an asymmetric hydrogenation, and various interferents expec

13 Asymmetric hydrogenations are increasingly being used to

14 d remote homoallylic hydroxyl group-directed asymmetric hydrogenation at ambient temperature and pres

15 CFLP@MOF as a new platform for heterogeneous asymmetric hydrogenation, but also opens a new avenue fo

16 etric hydroboration is diverted to catalytic asymmetric hydrogenation (CAH) upon the addition of a pr

17 an insightful understanding of the superior asymmetric hydrogenation catalysis performances of CFLPF

18 stimulated the development of heterogeneous asymmetric hydrogenation catalysis.

19 ly chiral ligands were found to be effective asymmetric hydrogenation catalysts for the reduction of

20 innamates and subsequent ruthenium-catalyzed asymmetric hydrogenation conditions affording the desire

21 lement in many important reactions including asymmetric hydrogenation, epoxidation and lithiation.

22 Asymmetric hydrogenation has evolved as one of the most

23 Inspired by asymmetric hydrogenation, here we report stereoPHIP, whi

24 metal catalyzed transformations, including (asymmetric) hydrogenation, hydroformylation, C-H activat

25 st CFLP@MOF that can efficiently promote the asymmetric hydrogenation in a heterogeneous manner, whic

26 s undertaken to demonstrate the potential of asymmetric hydrogenations mediated by the chiral, carben

27 ton first culminate in the development of an asymmetric hydrogenation method for a diverse set of bis

28 This is demonstrated for the Rh-catalyzed asymmetric hydrogenation of (E)-beta-aryl-N-acetyl enami

29 ate-of-the-art in transition-metal catalysed asymmetric hydrogenation of (hetero)arenes, to highlight

30 catalysts have been screened for the double-asymmetric hydrogenation of 2,6-di-(1-phenylethenyl)-4-m

31 Iridium-catalyzed asymmetric hydrogenation of 20 with the complex of [Ir(C

32 highly enantioselective manner using Noyori asymmetric hydrogenation of a B-keto ester and Sharpless

33 ex forms a highly effective catalyst for the asymmetric hydrogenation of a range of dehydroamino acid

34 A simple asymmetric hydrogenation of a styrenic olefin, enabled b

35 A general asymmetric hydrogenation of a wide range of 2-alkyl- and

36 played excellent enantioselectivities in the asymmetric hydrogenation of a wide range of acyclic imin

37 f 50,000 catalyst turnovers per hour for the asymmetric hydrogenation of a wide variety of dehydro-al

38 inchona-modified Pt and Pd catalysts for the asymmetric hydrogenation of activated C horizontal lineO

39 Asymmetric hydrogenation of activated olefins using tran

40 vers (TON up to 10 000) were achieved in the asymmetric hydrogenation of aliphatic carbocyclic and he

41 opensity to impact the enantioselectivity of asymmetric hydrogenation of alkenes and imines.

42 Asymmetric hydrogenation of alkenes is one of the most w

43 Asymmetric hydrogenation of allylic dimethylcarbinamide

44 Rh-DuPhos-catalyzed asymmetric hydrogenation of alpha,beta-diamidoacrylates

45 The asymmetric hydrogenation of alpha,beta-unsaturated carbo

46 oselective phosphine-nickel catalyst for the asymmetric hydrogenation of alpha,beta-unsaturated ester

47 chirally modified platinum catalysts for the asymmetric hydrogenation of alpha-activated ketones as a

48 of beta-amino acid derivatives (1a-c) using asymmetric hydrogenation of alpha-aminomethylacrylates (

49 d Pt catalysts are used in the heterogeneous asymmetric hydrogenation of alpha-ketoesters.

50 d on either chiral rhodium catalyst-mediated asymmetric hydrogenation of an enamide or transamination

51 ld of an amine produced by iridium catalyzed asymmetric hydrogenation of an iminium salt.

52 se Ru catalysts thus gave the highest ee for asymmetric hydrogenation of aromatic ketones among all o

53 These Ru complexes were used for asymmetric hydrogenation of aromatic ketones in a highly

54 was previously shown to be effective for the asymmetric hydrogenation of aryl ketones is also a very

55 found to be new efficient catalysts for the asymmetric hydrogenation of arylated alpha,beta-unsatura

56 The ligands were applied in the Rh-catalyzed asymmetric hydrogenation of benchmark substrates furnish

57 xes with 5-7 are efficient catalysts for the asymmetric hydrogenation of beta-substituted enamides an

58 The asymmetric hydrogenation of biomass-derived molecules fo

59 Asymmetric hydrogenation of CI-1008 (pregabalin) precurs

60 The asymmetric hydrogenation of cyclic alkenes lacking coord

61 displayed excellent enantioselectivities in asymmetric hydrogenation of cyclic imines, affording bio

62 The asymmetric hydrogenation of dehydroamino acid derivative

63 complexes, which serve as catalysts for the asymmetric hydrogenation of di-, tri-, and tetrasubstitu

64 ination with [Rh(cod)2]BArF (1 mol %) in the asymmetric hydrogenation of dimethyl itaconate.

65 ins, were evaluated in the rhodium-catalyzed asymmetric hydrogenation of dimethyl itaconate.

66 ring the last few decades, rhodium-catalysed asymmetric hydrogenation of diverse alkene classes has e

67 We present a highly efficient convergent asymmetric hydrogenation of E/Z mixtures of enamides cat

68 rk's [Rh(COD)(2R,5R)-Et-DuPhos]BF4-catalyzed asymmetric hydrogenation of enamides with a variety of r

69 hown outstanding enantioselectivities in the asymmetric hydrogenation of enamides.

70 The catalyst shows exceptional reactivity in asymmetric hydrogenation of enamines and unhindered imin

71 These complexes were tested in asymmetric hydrogenation of functionalized olefins.

72 plexes act as versatile precatalysts for the asymmetric hydrogenation of isocoumarines, benzothiophen

73 In the (S)-proline-mediated asymmetric hydrogenation of isophorone (IP) on supported

74 , as an effective ligand in the Cu-catalyzed asymmetric hydrogenation of ketones and aminoboration of

75 ave proven to be excellent catalysts for the asymmetric hydrogenation of ketones, giving reduction pr

76 count the early breakthroughs concerning the asymmetric hydrogenation of largely unfunctionalized ole

77 venues for its potential applications in the asymmetric hydrogenation of more challenging aromatic co

78 Iridium-catalyzed asymmetric hydrogenation of N-alkyl-2-alkylpyridinium sa

79 The transition-metal-catalyzed asymmetric hydrogenation of olefins is one of the key tr

80 lysts that has been successfully used in the asymmetric hydrogenation of olefins with poorly coordina

81 method to predict the enantioselectivity of asymmetric hydrogenation of olefins.

82 onsted acidity of catalytic intermediates in asymmetric hydrogenation of olefins.

83 phine-phosphite ligands for the Rh-catalyzed asymmetric hydrogenation of olefins.

84 ondary phosphines from the rhodium-catalyzed asymmetric hydrogenation of phosphaalkenes.

85 es is also a very effective catalyst for the asymmetric hydrogenation of prochiral aryl imines activa

86 st decade on noble metal-based heterogeneous asymmetric hydrogenation of prochiral C horizontal lineO

87 The mechanism of the asymmetric hydrogenation of prochiral enamides by well-d

88 Asymmetric hydrogenation of prochiral substrates such as

89 The asymmetric hydrogenation of substituted benzenes with ox

90 ntioenriched molybdenum precatalysts for the asymmetric hydrogenation of substituted quinolines and n

91 The asymmetric hydrogenation of tetrasubstituted olefins pro

92 yl-alpha-amino acids and esters, through the asymmetric hydrogenation of tetrasubstituted olefins, so

93 In the second step, asymmetric hydrogenation of the ketone functionality in

94 ed pyridinium C-H arylation and Ir-catalyzed asymmetric hydrogenation of the resulting fused tricycli

95 The catalytic asymmetric hydrogenation of trisubstituted enol esters u

96 When they were used in the iridium-catalyzed asymmetric hydrogenation of unfunctionalized 1-aryl-3,4-

97 ere successfully applied in the Ir-catalyzed asymmetric hydrogenation of unfunctionalized alkenes wit

98 However, the asymmetric hydrogenation of unfunctionalized tetrasubsti

99 Homogeneous asymmetric hydrogenation of unprotected benzophenone N-H

100 Homogeneous asymmetric hydrogenation of unprotected N-H ketoimines 3

101 Asymmetric hydrogenation of unprotected NH imines cataly

102 re highly enantioselective catalysts for the asymmetric hydrogenation of various kinds of functionali

103 e complexes 1a-c were prepared and tested in asymmetric hydrogenations of a series of largely unfunct

104 ine analogue of Crabtree's catalyst "cat" in asymmetric hydrogenations of allylic amine derivatives o

105 -heterocyclic carbene oxazoline ligands 1 in asymmetric hydrogenations of arylalkenes.

106 rial review lessons learned from research on asymmetric hydrogenation on chirally modified noble meta

107 diamine-diphosphine catalysts, well-known in asymmetric hydrogenation, racemic secondary alcohols are

108 olefins were prepared and evaluated for the asymmetric hydrogenation reaction using novel N,P-ligate

109 ds were prepared using the iridium catalyzed asymmetric hydrogenation reaction.

110 were prepared by kinetic resolution through asymmetric hydrogenation, resulting in an ee of up to 98

111 Asymmetric hydrogenation routes to homologues of The Roc

112 phosphonation-olefination-rhodium-catalyzed asymmetric hydrogenation sequence for the urea.

113 These sites served as novel asymmetric hydrogenation sites for the C=O group and hyd

114 scovery programs and endeavored to devise an asymmetric hydrogenation strategy to improve access to t

115 -alkylprolinols and prolines via a divergent asymmetric hydrogenation strategy.

116 tions used for catalyst preactivation in the asymmetric hydrogenation studies), the products are iden

117 the Heck reaction and subsequent successful asymmetric hydrogenation to afford alpha-hydroxyl esters

118 e lactone carbonyl group of 2 and subsequent asymmetric hydrogenation to generate the corresponding a

119 Asymmetric hydrogenation using catalyst precursor 36 on

120 nowledge, this is the first demonstration of asymmetric hydrogenation via iron-catalyzed mHAT.

121 An asymmetric hydrogenation was employed to set the C6 ster

122 pplications in highly efficient Ru-catalyzed asymmetric hydrogenations were explored.

123 e-derived phosphonate, followed by catalytic asymmetric hydrogenation, which proceeds with excellent

124 nols have been prepared in up to 97.8% ee by asymmetric hydrogenation with cationic rhodium Me-BPE or

125 the synthetic sequence involve (a) catalytic asymmetric hydrogenation with chiral DM-SEGPHOS-Ru(II) c

126 The obtained isocoumarins, upon asymmetric hydrogenation with the Ru-BINAP catalyst, pro

127 ids 7 and 13 derived from 5 or 11, underwent asymmetric hydrogenations with Burk's DuPHOS Rh(I)-based