ライフサイエンスコーパス: at least two

1 ere taking mTOR inhibitors and who underwent at least two abdominal CT or MRI examinations between 20

2 Here, we show that sNASP contains at least two additional histone interaction sites that,

3 Productive budding events required at least two additional Vps4 hexamers.

4 ated the presence of PLTX, hydroxy-PLTX and, at least, two additional compounds with PLTX-like profil

5 n 50% improvement of depression symptoms) to at least two adequate treatment courses during the curre

6 All patients treated with at least two adjacent NDIs or SDIs according to availabl

7 Each family consisted of at least two affected siblings diagnosed with schizophre

8 ic ligand-gated cation channels that include at least two alpha3 and two beta4 subunits.

9 c depression and a history of nonresponse to at least two antidepressants in the current episode, wit

10 At least two antigenic variants of H13 and at least one

11 Each protein has at least two apo and two holo structures for analysis.

12 ered dataset comprising 467 patients who had at least two assay measurements.

13 were present in 21/33 (63.6%) patients with at least two assessable lobes (including 10/21 [47.6%] w

14 scue therapy in the year before screening or at least two attacks requiring rescue therapy in the 2 y

15 At least two authors independently reviewed and abstract

16 two disparate Ser codon boxes, differing by at least two-base substitutions, in contrast to Leu and

17 support of recent theoretical calculations, at least two Bi-related traps were revealed and associat

18 ving missing parity data, and not having had at least two births (livebirth or stillbirth) in the 5 y

19 ing that a therapy becomes established when "at least two blinded randomized controlled clinical tria

20 c interactions were instead observed between at least two BODIPY chromophores along the edges of the

21 In participants who underwent at least two brain MRI examinations (subgroup), the firs

22 anticipate, researchers have identified that at least two broad sources of information are used: cont

23 nt pathway, widespread in bacteria, salvages at least two by-products of SAM-dependent enzymes for ca

24 326 asymptomatic Korean adults who underwent at least two CAC evaluations from December 2012 to Augus

25 onounced cancer suppressing activity towards at least two cancer cells, breast cancer MDA-MB-231 and

26 our results show that 24 genes are shared by at least two cancer types, including four genes for both

27 andidate functional variants at six loci and at least two candidate functional variants at each of th

28 sfer through the DNA being conducted through at least two channels, one involves the bases and is hig

29 th a drug hypersensitivity reaction (DHR) to at least two chemically unrelated drugs, confirmed by sk

30 males (56.3%), older adults (69.8%) and had at least two chronic conditions.

31 We show that at least two classes of enhancers are active during earl

32 The neuropil contains at least two classes of tangential elements, one connect

33 apy (HAART), combines two or more drugs from at least two classes.

34 Thus, CTCF loops fall into at least two classes: RBR(i)-independent and RBR(i)-depe

35 score of 7.5 or lower, and had a history of at least two clinical relapses during the previous 12 mo

36 ow-sakuranetin-accumulating cultivars formed at least two clusters, only one of which involves the pr

37 alkylperoxide that liberates acetophenone by at least two competitive processes, one of which involve

38 The prevalence of at least two complications increased across the clusters

39 Functional assessment confirmed at least two compounds as potent KOR antagonists, while

40 el in which the 5'UTR can transition between at least two conformational states.

41 nctions as an ensemble of molecules sampling at least two conformational states.

42 luding a lenalidomide-containing regimen for at least two consecutive cycles.

43 ients from THIN aged >=50 years who received at least two consecutive prescriptions for an antidepres

44 fferently methylated regions were defined as at least two consecutive probes that showed significant

45 ined evidence for 'trans SD-MMEJ,' involving at least two consecutive rounds of microhomology anneali

46 d that music evolved as a credible signal in at least two contexts: coalitional interactions and infa

47 of 140 sites with high-quality estimates for at least two continuous years shows that T/ET variabilit

48 l children younger than 18 years old who had at least two creatinine values measured during a hospita

49 inase-associated pancreatitis was defined by at least two criteria: abdominal pain, pancreatic enzyme

50 osophila Drosophila suzukii, is a complex of at least two cryptic species.

51 ell lung cancer, for which they had received at least two cycles of platinum-based chemoradiotherapy,

52 Further, the genes common to at least two data sets were analyzed using DisGeNET, whi

53 one of the five monkeys, and in ganglia from at least two dermatomes in three of five monkeys.

54 egulate sporophyte developmental programs in at least two different complex multicellular eukaryotic

55 complexes, the extended KASH-peptide adopts at least two different conformations.

56 dly had associations with frost tolerance in at least two different environments with two different s

57 that SM proteins can engage Qa-SNAREs using at least two different modes, one in which the SNARE is

58 nd that little phosphorylation occurs unless at least two different PDEs are concurrently inhibited i

59 n, L1Cy5-7OTD might be able to bind to GQ in at least two different primary orientations and occasion

60 on, conflict, and more - was domesticated in at least two different regions, but with the geographic

61 are consistent with flexoelectricity playing at least two different roles in bone remodelling: apopto

62 s a mechanism enabling bacteria to integrate at least two different sensory inputs, quorum sensing (v

63 that barcode multiplets can be derived from at least two different sources.

64 species within the Caryophyllales suggested at least two distinct [Na]shoot phenotypes within this o

65 show that DNA damage induces the assembly of at least two distinct activation platforms for caspase-2

66 These processes are mediated through at least two distinct cannabinoid receptors (CB), CB1 an

67 ytes during adipogenesis in vitro identifies at least two distinct classes of subcutaneous white adip

68 iochemical analyses reveal that Baf200 forms at least two distinct complexes.

69 otor memories driven by task errors comprise at least two distinct components: a time-consuming, flex

70 ed cross-linking studies, we have identified at least two distinct DOPA-based cross-linking pathways

71 sory neuron populations and mediated through at least two distinct dorsal horn circuit mechanisms.

72 protein via two antibodies that tightly bind at least two distinct epitopes of the same antigen and h

73 lineage, and that this latter genus includes at least two distinct evolutionary lines.

74 genetic clades were evident, while for H16, at least two distinct genetic clades were evident.

75 e is stimulated by 1,25(OH)(2) vitamin D(3.) At least two distinct mechanisms underlie phosphate abso

76 alters meiotic repair pathway decisions via at least two distinct mechanisms, impacting genome evolu

77 rk suggests that slowing may be comprised of at least two distinct neural mechanisms: slow oscillatio

78 Sleep in flies thus appears to involve at least two distinct stages: increased oscillatory acti

79 ormation occurs, and peptidoglycan regulates at least two distinct steps in the polarized division of

80 bserving the behavior of others, they deploy at least two distinct strategies.

81 de 100 published ones - enable us to discern at least two distinct temporal phases of dispersal, both

82 small-molecule inhibitor of CHK1 can elicit at least two distinct, context-dependent mechanisms of c

83 ferase-substrate recognition and distinguish at least two distinct, functionally critical contributio

84 at these membranes can harbor complexes with at least two distinctive classes of mobility.

85 None of the 49 infants living with at least two dogs developed food allergy, suggesting a d

86 ed cases, 1536 (92%) had previously received at least two doses of a vaccine containing the mumps vir

87 nto four categories as follows: (1) received at least two doses of MCV; (2) too young for first dose;

88 population (defined as patients who received at least two doses of melflufen and who had a response a

89 8181 children aged 2-11 months had received at least two doses of PCV10 and 23 298 (62.3%) of 37 416

90 Resistance to at least two drugs was common (196, 83%), and this was a

91 each Ebola virus outbreak suggests there are at least two Ebola virus strains in DR Congo, which have

92 isregulation of several lincRNAs showed that at least two ecotype-related lncRNAs regulate primary ro

93 3TC/LPV/r are more likely to have maintained at least two effective agents on their current HIV regim

94 rking model is that Lon engages DnaA through at least two elements, one of which anchors DnaA to Lon

95 -associated membranous nephropathy recognize at least two epitope regions in the N- and C-terminals o

96 s suggest that the M. annua Y chromosome has at least two evolutionary strata: a small old stratum sh

97 io, patients with bronchiectasis who had had at least two exacerbations in the previous year to recei

98 n, had elevated blood eosinophil counts, and at least two exacerbations or one severe exacerbation in

99 severe eosinophilic asthma and a history of at least two exacerbations requiring treatment in the pr

100 lished simulations to confirm that MTs have (at least) two experimentally relevant CCs and to clarify

101 flight is a unique environment that includes at least two factors which can negatively impact skeleta

102 These results are ascribed to at least two-fold increase in the concentrations of flav

103 the electron paramagnetic resonance spectra, at least two forms are observed with different g(z)-valu

104 nt variation across the genome and revealing at least two forms of pairing: tight pairing, spanning c

105 iven by learning to correct task errors take at least two forms: a time-consuming but flexible compon

106 Thus, there are (at least) two forms of object knowledge representations

107 tted to the data, indicating the presence of at least two fractions with different resistances.

108 m/z, retention time, and the confirmation of at least two fragment ions as criteria for matching.

109 correlation NMR experiments demonstrate that at least two framework Al(IV) sites with hydroxyl groups

110 Instead, BBA consists of at least two frequency bands.

111 incident cardiometabolic multimorbidity (ie, at least two from: type 2 diabetes, coronary heart disea

112 rdiometabolic multimorbidity (ie, developing at least two from: type 2 diabetes, coronary heart disea

113 , whereas defence priming was maintained for at least two generations.

114 s of 0 or 1, and who had previously received at least two HER2-targeted therapies for advanced diseas

115 distinct functional networks that constitute at least two homotopic maps of cerebral networks.

116 a pleiotropic endocrine organ that secretes at least two hormones, FGF23 and osteocalcin, which regu

117 ression of KSHV genes results in exposure to at least two host-mediated nuclear RNA decay pathways, t

118 HV transcripts are subject to degradation by at least two host-mediated nuclear RNA decay pathways, t

119 d blood pressure data, and contained data on at least two hypertension care cascade steps.

120 Many nonlymphoid cell types express at least two, if not all three, subunits of the IL-2R; a

121 ia meningitides, and previous treatment with at least two immunosuppressive therapies or one immunosu

122 es have shown that motor learning results in at least two important neurophysiological changes: modul

123 e to rapid progression in the visual fields (at least two in a short period of time).

124 ncers that were associated with melanoma, in at least two independent analyses, included breast, pros

125 howed that 35% of genes with a cis eQTL have at least two independent cis eQTLs; for several genes up

126 entry of ADPriboDB is annotated manually by at least two independent curators from the literature be

127 d in South Africa (D and G), confirming that at least two independent invasions occurred, one from Au

128 These findings suggest there are at least two independent processes in nucleation, one pr

129 We demonstrate at least two independent rewiring events for PUF3 orthol

130 RT017 strains have evolved in parallel from at least two independent sources and can readily transmi

131 ion, and the variably fragmentary remains of at least two individuals distributed across two bear nes

132 e employ a new framework to reveal that, for at least two infections, West Nile virus and Lyme diseas

133 for T1D is immensely attractive but entails at least two inherent and thus far unresolved hurdles: 1

134 chieved for all lipids that were detected by at least two instrument platforms.

135 We assessed the incidence of patients with at least two insurance claims of flushing, diarrhoea, or

136 At least two interdependent allosteric activation pathwa

137 At least two IPTp-SP doses were taken by 77.3% of the wo

138 ranscript levels of five aflatoxin genes and at least two key global regulators of secondary metaboli

139 rodeles deviate from anurans and amniotes in at least two key respects: their limbs exhibit preaxial

140 microglia are transiently activated and have at least two key roles in scar-free healing.

141 ermal titration calorimetry data, apparently at least two KN-93 molecules can bind to Ca(2+)/CaM.

142 al connectivity (FC) studies have identified at least two large-scale neural systems that constitute

143 These innovations evolved in at least two lineages of mammaliamorphs (Tritylodontidae

144 th relapsed or refractory DLBCL who received at least two lines of previous chemoimmunotherapy.

145 nts with a BRCA1/2 mutation who had received at least two lines of previous chemotherapy.

146 mance status 0 or 1, previously treated with at least two lines of therapy (excluding pomalidomide) a

147 reatment, with 260 (97%) patients having had at least two lines.

148 es that are characterized by the presence of at least two linkages within the same polymer.

149 ive bacterium Staphylococcus aureus secretes at least two lipases, Sal1 and glycerol ester hydrolase

150 ge admitted with ESLD, defined as those with at least two liver decompensation events, were included

151 solid solution and ordered phases involving at least two M n+1AX n end members.

152 Present day eukaryotes employ at least two main defence strategies that emerged as a r

153 we show that opening of the Strait involved at least two major episodes of erosion.

154 t dorsal root ganglion (DRG) neurons contain at least two major functional K(v)1.2 channel complexes:

155 The fossil record suggests that at least two major human dispersals occurred across the

156 thod, Stouffer's method, minP and maxP, have at least two major limitations: (i) they are sensitive t

157 uscle dynamics and heart rate-that there are at least two major sleep signatures in zebrafish.

158 ctors belong to a species complex comprising at least two major vectors, we investigated whether the

159 Finland's history includes at least two major waves of human migration, suggesting

160 eptides that induced CD8 T cell responses in at least two Mamu-A1*001-positive animals; two of these

161 ered k(SA) in type II system by ~10-fold via at least two mechanisms: by complexing Fe(2+) and thereb

162 tection of beta-glucan by host cells through at least two mechanisms: concealment of beta-glucans ben

163 Thus, GLD may be caused by at least two mechanisms: psychosine-induced demyelinatio

164 At least two members of the Toll-like receptor (TLR) fam

165 n addition to the inactive and active states-at least two metastable intermediate states.

166 Patients had at least two metastatic lesions: one that could be safel

167 uscle dysfunction, and arterial stiffness in at least two models of hypertension.

168 rial, we enrolled post-menopausal women with at least two moderate or one severe vertebral fracture a

169 utral state, with high stability lasting for at least two months and high junction formation probabil

170 ow essential genes and produced evidence for at least two Mycoplasma genitalium in silico minimal gen

171 ysiological evidence of axonal neuropathy in at least two nerves without any evidence of 'strict crit

172 ng genetic structuring, with the presence of at least two new lineages within the coastal upwelling z

173 5.9 to 10.7 years (n = 18,959 individuals on at least two occasions, n = 4444 on four occasions), fro

174 esting that HB was introduced into the BI on at least two occasions.

175 les, in conjunction with the development of (at least) two ocean levels.

176 All 12 studies included at least two of five data types that overlap with outsid

177 nse, defined as survival with improvement in at least two of four symptoms (cough, sputum production,

178 These clinical profiles were: fever and at least two of headache, retro-orbital pain, myalgia, a

179 ic manifestations, and leukopenia; fever and at least two of nausea or vomiting, rash, aches and pain

180 -2) infection, hyperinflammatory states, and at least two of the following signs: fever (body tempera

181 ation, while the pharmacological profiles of at least two of the generated ADCs compare well with the

182 d, incentive, penalty, or combination (i.e., at least two of the preceding policy approaches).

183 These effects of CsA involve at least two of the stress-activated protein kinases (GC

184 Group (ECOG) performance status of 0-2, and at least two of the three high-risk prognostic factors (

185 identifications (86%) showed consensus among at least two of the three models.

186 identified in the two pools concordantly by at least two of the tools.

187 blind, placebo-controlled food challenges to at least two of their offending foods.

188 12 TIM phosphorylation sites we identified, at least two of them are critical for circadian timekeep

189 The presence of at least two of these three features was an independent

190 In 10T1/2 cells expressing Jun, at least two of three alleles per cell were induced, a s

191 We randomly assigned adults who met at least two of three glycemic criteria for prediabetes

192 ted between intact and degraded cartilage in at least two -omics levels, 16 of which have not previou

193 umatic drugs, and had inadequate response to at least two or intolerance or contraindication to non-s

194 hotothermal effects, which generates a field at least two orders of magnitude larger than that found

195 oxygen, it requires that Archean magmas had at least two orders of magnitude lower fO2 than modern m

196 Human Nuclear Lipid Membranes were at least two orders of magnitude more elastic than the c

197 an increase the specificity of sequencing by at least two orders of magnitude over and above that ach

198 scattering constraints could be surpassed by at least two orders of magnitude.

199 Genetic alterations in at least two out of four genes were found in 95% of the

200 synthetic lethal interactions are present in at least two out of three cell lines and 14 of 24 (58%)

201 nly apparent when surveillance data included at least two outbreaks and the intervening inter-epidemi

202 Thus, there are at least two pathways by which L. pneumophila can disrup

203 A. mellifera colonised Europe through at least two pathways, across the Strait of Gibraltar an

204 Coverage with at least two PCV10 doses in children aged 2-11 months wa

205 monstrate that (1) food and drugs can engage at least two peripheral->central pathways to influence h

206 At least two pesticides contaminated the honey and beesw

207 croscopically similar or identical state via at least two phase transitions elicited by variation of

208 of FN to SAM-coated QCM crystals occurred in at least two phases: initial rapid coverage over the fir

209 ern Asia fat-tail and European sheep, reveal at least two phylogeographically distinct genepools of f

210 aging using a probe for F-actin reveals that at least two pools of F-actin are associated with mitoti

211 Peninsula and South Caucasus, resulting from at least two (post-LGM, Neolithic) waves of migration.

212 egression analyses, patients having received at least two prescriptions of grass pollen SLIT tablets

213 st samples from all patient categories, with at least two prevalent structures.

214 per kilogram of body weight after receiving at least two previous anticancer therapies for metastati

215 In individuals with at least two previous infections the risk of new infecti

216 refractory multiple myeloma who had received at least two previous lines of treatment, including lena

217 l, or fallopian tube carcinoma, had received at least two previous platinum-based chemotherapy regime

218 erformance status of 0 or 1 who had received at least two previous platinum-based chemotherapy regime

219 and disease progression on or intolerance to at least two previous systemic chemotherapy regimens wer

220 ere aged 18 years or older, and had received at least two previous systemic therapies.

221 onfirmed metastatic renal cell carcinoma and at least two previous systemic treatments (including at

222 thylating agents, and ten (59%) had received at least two previous therapies.

223 onvolts up to near-relativistic energies via at least two processes: 'impulsive' events, which are us

224 onary vessels of the mouse heart derive from at least two progenitor pools, the sinus venosus and end

225 Thus, at least two proteins enriched in young blood, THBS4 and

226 cleoprotein (RNP) complex by partnering with at least two proteins, OapA and OapB, that directly bind

227 non-cystic fibrosis bronchiectasis, had had at least two pulmonary exacerbations treated with antibi

228 However, many studies involve at least two random factors (e.g., participants and the

229 epitope can only be accessed by CR3022 when at least two RBDs on the trimeric S protein are in the "

230 curring in 692 (17%) children (175 [4%] with at least two re-admissions).

231 A cascade is defined as the combination of at least two reaction steps in a single reaction vessel

232 m functions are far from satisfactory due to at least two reasons: (i) unlike genes, isoform-level fu

233 R1 can be cleaved by caspase or calpain into at least two receptor fragments.

234 of children and adolescents (<18 years) with at least two recorded IBD diagnoses in specialist care.

235 ed by pre-treatment heterogeneity, such that at least two regions are necessary to detect treatment-i

236 uid in all three regions with >1 cm fluid in at least two regions).

237 s that for an efficient oxygen up-regulation at least two regulation mechanisms must be playing hand

238 prescription database, patients who received at least two relevant mite AIT prescriptions in two diff

239 dues driving amyloid formation upon deleting at least two repeats.

240 rium systems is a natural meeting point for (at least) two research areas: nonlinear optical spectros

241 ut GH5_4 and neighboring subfamilies reveals at least two residues (H149 and W203) that are linked to

242 m the conditions experienced by organisms in at least two respects.

243 This tsRNA binds at least two ribosomal protein mRNAs (RPS28 and RPS15) t

244 ighly expressed and naturally interacts with at least two RNA-binding proteins called OapA and OapB.

245 calls and 'B allele' frequencies (BAFs) from at least two samples derived from the same individual.

246 er their putaminal or caudate part; and (ii) at least two SEEG seizures were recorded.

247 An individual's knowledge is collective in at least two senses: it often comes from other people's

248 t increment of less than 5000-7500 following at least two sequential ABO-compatible fresh platelet tr

249 mutation carriers or non-carriers), and had at least two serum samples with a time interval of 6 mon

250 72/180) of dyads allocated to iCST completed at least two sessions per week, with 22% (39/180) comple

251 We show that the cornea must be described by at least two shear moduli, contrary to current single-mo

252 nce that such signaling noise can arise from at least two sources: (i) stochastic activities of adapt

253 We suggest the existence of at least two spatially distinct types of paracellular ch

254 71 derived rearrangements are shared between at least two species, and 24 of these are unambiguous sy

255 tinual evolution results from coevolution of at least two species.

256 genes that have been positively selected in at least two species.

257 quirement of COPI-coatomer subunits impacted at least two stages of the HAZV replication cycle: an ea

258 COPI components influenced at least two stages of the nairovirus replication cycle:

259 ss mechanism in which the transporter adopts at least two states, accessible from two different sides

260 and experiments indicate that MYC activates at least two steps in the transcription-cycle to explain

261 addition, our results suggest that there are at least two steps of incorporation of alpha-synuclein m

262 although 88% of proteins in our network has at least two structures in Protein Data Bank (PDB), only

263 e to college, and (b) have been evaluated in at least two studies.

264 collision was a multistage process involving at least two subduction systems.

265 om these OCs exhibits two kinetic phases and at least two subpopulations of ternary complexes.

266 evious hypotheses that cave lions existed as at least two subspecies during the Pleistocene, and that

267 We show that ROC is composed of at least two subunits of NAD(+)-dependent retinol dehydr

268 study procedures; and were able to complete at least two technically acceptable trials of multiple b

269 Individuals showing at least two teeth with proximal (clinical AL) progressi

270 Habituation is thought to occur via at least two temporally and molecularly distinct mechani

271 ialyzed with a catheter instead, may explain at least two thirds of the mortality benefit observed in

272 V ejection fraction is robustly preserved in at least two-thirds of older adults with prevalent HF (S

273 database for the United States, we show that at least two-thirds of the decline in organic aerosol ca

274 ationof the protein and its interaction with at least two THO subunits, THOC1 and THOC5.

275 anges in blood perfusion below the skin with at least two times better sensitivity, three times bette

276 of 35.9 Pg yr(-1) of soil eroded in 2012, is at least two times lower.

277 and ( S)-8g and -8h as well as ( R)-8j were at least two times more effective on a multidrug-resista

278 hat represented 13,840 transcripts each with at least two-times coverage.

279 training set data from clinical studies with at least two treatment arms.

280 received pembrolizumab for >/= 6 months and at least two treatments beyond confirmed CR could discon

281 different initiating CNS injuries can elicit at least two types of "reactive" astrocytes with strikin

282 , suggesting that mRNA decay components form at least two types of cytoplasmic granules.

283 mouse inner ear, cochlear hair cells display at least two types of mechanically gated ion channel: no

284 Here, we report that the primate BF contains at least two types of neurons that often process salient

285 At least two types of RNP granules populate the germ pla

286 heterogeneous capacity to respond to RA with at least two underlying causes.

287 uary 2009 and October 2017 who had undergone at least two unenhanced supine CT scans of the chest and

288 presence of one or more species that contain at least two units of the chiral entity.

289 It requires at least two unpaired nucleotides at the 5' end of its s

290 CL1 gene, revealing independent gene loss in at least two vertebrate lineages, after arising from gen

291 ancy viral load trajectory analyses (ie, had at least two viral loads in the year after end of pregna

292 endosomes, together with the recruitment of at least two Vps4 hexamers.

293 dization is thought to promote speciation in at least two ways - by fixation of heterozygosity from d

294 clude myosin IIA suppresses tumorigenesis in at least two ways that are modulated by the mechanics of

295 molecular diagnostic testing is negative and at least two weeks have passed since symptom onset; 2) a

296 peated after a complete abstinence period of at least two weeks.

297 peated after a complete abstinence period of at least two weeks.

298 ic withdrawal syndrome was defined as having at least two Withdrawal Assessment Tool-Version 1 scores

299 /larva) while 2(nd)-3(rd) larval instars had at least two wounds.

300 aft thickness (CGT) were measured in 30 eyes at least two years after penetrating keratoplasty for no