ライフサイエンスコーパス: atopic eczema

1 eczema case collection (0-16 year olds with atopic eczema).

2 h atopic eczema and 2,569,030 people without atopic eczema.

3 gests increased fracture risk in people with atopic eczema.

4 month of life was associated with subsequent atopic eczema.

5 ts in adult patients with moderate to severe atopic eczema.

6 suggest that this phototherapy might improve atopic eczema.

7 atecholamine concentrations of patients with atopic eczema.

8 that there is no deficit of linoleic acid in atopic eczema.

9 ere matched to 2,567,872 individuals without atopic eczema.

10 with the most severe or predominantly active atopic eczema.

11 eczema, atopy alone, non-atopic eczema, and atopic eczema.

12 ronger in carriers of fewer risk alleles for atopic eczema.

13 ic asthma, chronic spontaneous urticaria and atopic eczema.

14 is phenotype differs from genetically driven atopic eczema.

15 y and any fracture in those with and without atopic eczema.

16 s and low mood have been linked to offspring atopic eczema.

17 and corticosteroids as treatment options for atopic eczema.

18 treatment of some skin conditions including atopic eczema.

19 ) and related to the odds ratio of infantile atopic eczema.

20 standardization of outcome measurements for atopic eczema.

21 crobiota diversity have been associated with atopic eczema.

22 they have a role in alleviating symptoms of atopic eczema.

23 n CYP27A1 was found to be protective against atopic eczema.

24 t less than 4.5 months increased the risk of atopic eczema.

25 onjunctivitis (54.1%), food allergy (53.8%), atopic eczema (42.6%) and anaphylaxis (28.8%).

26 Similarly, the incidence of atopic eczema (6[5%] of 118 vs 3[2%] of 137), food aller

27 d domestic water has been reported to worsen atopic eczema (AE) and may contribute to its development

28 Atopic eczema (AE) is a challenge for modern medicine, b

29 Atopic eczema (AE) is a chronic inflammatory skin diseas

30 Atopic eczema (AE) is an inflammatory skin disease with

31 Atopic eczema (AE) is characterized by skin barrier and

32 A characteristic of atopic eczema (AE) is colonization by S. aureus, with ex

33 Undertaking atopic eczema (AE) research using such data is challengi

34 of BMI and GWG on risk of asthma, wheezing, atopic eczema (AE), and hay fever in children during the

35 SE, and LILACS (1945-2016) for the terms AD, atopic eczema (AE), and multiple other eczematous disord

36 riants are well-established risk factors for atopic eczema (AE).

37 c factors play a role in the pathogenesis of atopic eczema (AE).

38 t it is unclear whether SIT is effective for atopic eczema (AE).

39 eviews (SRs) on nonallergic comorbidities of atopic eczema (AE).

40 ociated with common skin disorders including atopic eczema (AE)/dermatitis.

41 Atopic eczema affects 1-2% of adults, and can cause cons

42 Atopic eczema affects up to 10% of adults and is becomin

43 nst atopic manifestations such as hay fever, atopic eczema, allergic sensitization, or asthma.

44 tiple genetic and environmental factors, but atopic eczema also shows great complexity in its heterog

45 We identified 526,808 people with atopic eczema and 2,569,030 people without atopic eczema

46 ic sensitisation, asthma, allergic rhinitis, atopic eczema and adverse events based on RCT evidence.

47 n = 696) who were later assessed for asthma, atopic eczema and atopy.

48 Allergic rhinitis, atopic eczema and food hypersensitivity were covered in

49 sent with short stature, immune dysfunction, atopic eczema and gastrointestinal pathology associated

50 ); polygenic risk score for a combination of atopic eczema and general atopic disease had the stronge

51 velopmental contribution to the aetiology of atopic eczema and pointing to potentially modifiable inf

52 oducts was related to a reduced incidence of atopic eczema and rhinoconjunctivitis, but no associatio

53 based studies assessing associations between atopic eczema and specific cardiovascular outcomes.

54 Many research studies have been published on atopic eczema and these are often summarised in systemat

55 on, uterine leiomyoma, vitamin D deficiency, atopic eczema) and phenotypes defined in the PheWAS Cata

56 Asthma, wheeze, atopic eczema, and allergic rhinitis were measured by us

57 groups: no atopy or eczema, atopy alone, non-atopic eczema, and atopic eczema.

58 systemic monotherapy for moderate-to-severe atopic eczema, and the therapeutic importance of the thi

59 adjunctive treatment for moderate to severe atopic eczema, and the treatment is well tolerated by mo

60 a significant reduction in the incidence of "atopic eczema," "any positive SPT [skin-prick test]," "s

61 diated diseases, such as allergic asthma and atopic eczema, as well as purpose-developed biologics, h

62 es 6 (n = 2956) and 12 (n = 2872) months and atopic eczema ascertained (based on UK Working Party Cri

63 sonal hay fever, through the food allergies, atopic eczema, asthma, to anaphylaxis.

64 rd methylation of CpG loci within IL-4R with atopic eczema at 12 months (median ratio 1.02, P = .028)

65 ith a slightly reduced relative risk (RR) of atopic eczema at 6 months (adjusted RR, 0.94; 95% CI, 0.

66 sociated with an increased risk of offspring atopic eczema at age 12 months but not at 6 months, robu

67 sociated with an increased risk of infantile atopic eczema at age 12 months, but no significant assoc

68 ntrations were not associated with offspring atopic eczema at age 6 months.

69 n the UK Southampton Women Survey, infantile atopic eczema at ages 6 and 12 months was ascertained (m

70 based on repeated measures of self-reported atopic eczema at each survey wave.

71 Inflammatory skin diseases such as atopic eczema (atopic dermatitis [AD]) affect children a

72 Atopic eczema (atopic dermatitis, AD) is characterized b

73 This study aimed to identify subtypes of atopic eczema based on patterns of disease activity thro

74 eyond childhood may reveal clear subtypes of atopic eczema based on patterns of disease activity.

75 ubstantial improvements in the management of atopic eczema, but many patients still suffer a burden o

76 plays an important part in the aetiology of atopic eczema, but specific causes are unknown.

77 Atopic eczema decreased between 2008 and 2015.

78 lidate evidence on dietary interventions for atopic eczema/dermatitis (AD) skin symptoms in children

79 The corresponding figures for atopic eczema/dermatits (AD) were 0.82 (95% CI, 0.68-1.0

80 during the first year of life in relation to atopic eczema development.

81 ce by age, and among adults reporting active atopic eczema during a given year, only 38% had symptom

82 Asthma, allergic rhinitis, and atopic eczema end points were assessed by using the Inte

83 Allergic disease (eczema, atopic eczema, food allergy, wheeze, atopic sensitizatio

84 to generate polygenic risk scores (PRSs) for atopic eczema, general atopic disease, or a combination,

85 atopic eczema subtypes and the infrequent/no atopic eczema group, but only female sex differentiated

86 For example, patients with severe atopic eczema had a 62% increased hazard (hazard ratio =

87 remain high after childhood, and adult-onset atopic eczema has different risk factor associations tha

88 of azathioprine as systemic monotherapy for atopic eczema has major advantages, which should allow c

89 People with atopic eczema have increased fracture risk, particularly

90 hazard for all-cause mortality in those with atopic eczema (hazard ratio = 1.04; 99% CI = 1.03-1.06),

91 gh many risk factors have been described for atopic eczema in children, little is known about the ecz

92 ial of water softeners for the prevention of atopic eczema in high-risk infants is feasible and accep

93 ations were identified with hypertension and atopic eczema in models accounting for age, sex, and eth

94 ne the relation of maternal stress/mood with atopic eczema in the offspring, focusing particularly on

95 amide and related metabolites to the risk of atopic eczema in the offspring.

96 Commonly studied risk factors for atopic eczema included dietary and microbial factors, wh

97 genetic mutations previously associated with atopic eczema, including filaggrin-null mutations, and a

98 Few studies have assessed whether atopic eczema increases the risk of death.

99 Atopic eczema is a common inflammatory skin disease.

100 Atopic eczema is an itchy inflammatory skin disease.

101 We sought to examine whether atopic eczema is associated with fracture and whether fr

102 Atopic eczema is characterized by a heterogenous waxing

103 Any link could have substantial effect; atopic eczema is common, and fractures have associated m

104 Atopic dermatitis (atopic eczema) is a chronic inflammatory skin disease th

105 Atopic dermatitis (AD, also known as atopic eczema) is driven by a complex relationship betwe

106 of eczema (also called atopic dermatitis or atopic eczema) is poorly understood.

107 on-and also a strong genetic risk factor for atopic eczema, marked a significant breakthrough in the

108 ics), including adults (>=18 years old) with atopic eczema matched (by age, sex, general practice, an

109 Atopic eczema may be a minor inherited abnormality of EF

110 Atopic eczema may be associated with multiple health con

111 sly described environmental associations for atopic eczema may be due to reverse causation.

112 Atopic eczema may be related to multiple subsequent adve

113 sex, and ethnicity, and the association with atopic eczema (odds ratio [OR], 1.68; 95% CI, 1.36-2.07;

114 Atopic eczema onset is described primarily in early chil

115 sition may play a role in the development of atopic eczema or atopic sensitization in breastfed infan

116 (OR = 1.15 [95% CI 0.98-1.36]) and prevalent atopic eczema (OR = 1.26 [1.00-1.59]).

117 7-44.54] and 13.97 [95% CI, 7.33-26.4]), and atopic eczema (OR, 9.39 [95% CI, 4.9-19.3] and 9.5 [95%

118 czema trials, to define quality criteria for atopic eczema outcome measures and to prioritize topics

119 utcome measures and to prioritize topics for atopic eczema outcomes research.

120 HOME is open to anyone with an interest in atopic eczema outcomes research.

121 ational multiprofessional group dedicated to atopic eczema outcomes research.

122 02) or respiratory allergies coexistent with atopic eczema (P < .001).

123 Evidence that atopic eczema partly originates in utero is increasing,

124 czema were identified based on self-reported atopic eczema period prevalence at multiple occasions.

125 The annual period prevalence of atopic eczema ranged from 5% to 15% in 2 cohorts of more

126 cores were used to investigate the effect of atopic eczema-related risk alleles on this association.

127 Rates of self-reported atopic eczema remain high after childhood, and adult-ons

128 The effects of atopic eczema reported in cross-sectional studies were h

129 This mapping of atopic eczema reviews is a valuable resource.

130 ancy and infancy with questionnaire-reported atopic eczema, rhinoconjunctivitis, and asthma in 40,614

131 of probiotic milk products protects against atopic eczema, rhinoconjunctivitis, and asthma in early

132 idual- and school-level results for multiple atopic eczema risk factors.

133 linking maternal stress at preconception to atopic eczema risk, supporting a developmental contribut

134 t patients with a mean (SD) patient Recap of Atopic Eczema score of 11.7 (7.2), mean (SD) patient age

135 ses and to assess whether the risk varied by atopic eczema severity and activity.

136 o estimate the slope of effect of increasing atopic eczema severity on cardiovascular outcomes.

137 Increasing atopic eczema severity was associated with increased ris

138 erstood that primary skin disorders, such as atopic eczema, skin dryness, psoriasis, and urticaria, c

139 feeding, predicted differences between the 3 atopic eczema subtypes and the infrequent/no atopic ecze

140 outcome was the age period of self-reported atopic eczema symptom onset based on repeated measures o

141 ren in schools (the sampling unit) regarding atopic eczema symptoms and potential risk factors.

142 ermine the proportion of subjects who report atopic eczema symptoms between birth and midadulthood an

143 assessed the effect of these risk factors on atopic eczema symptoms using mixed-effect logistic regre

144 y relevant improvement in moderate-to-severe atopic eczema that remains active despite optimum therap

145 2) In one trial outcome, atopic eczema, the intervention had a positive effect on

146 ss and MCID of four outcome measures used in atopic eczema: the Severity Scoring of Atopic Dermatitis

147 ture of trials of calcineurin inhibitors for atopic eczema to document the extent to which comparison

148 response to skin stress in diseases such as atopic eczema, to various agents such as retinoic acid,

149 otal of 174 randomized controlled trials for atopic eczema treatments were identified in which pimecr

150 d inadequately validated outcome measures in atopic eczema trials is a major obstacle to practising e

151 ustry) to determine core outcome domains for atopic eczema trials, to define quality criteria for ato

152 ife into the core set of outcome domains for atopic eczema trials.

153 primary or secondary endpoints in all future atopic eczema trials.

154 ial (children 1-5 years with moderate-severe atopic eczema); UK BEEP trial (2 year olds at high risk

155 rial (2 year olds at high risk of developing atopic eczema); UK-Irish eczema case collection (0-16 ye

156 In cohort studies atopic eczema was associated with increased risk of myoc

157 Atopic eczema was associated with rs4674343 of CYP27A1 (

158 cant association between post-natal mood and atopic eczema was seen after taking account of preconcep

159 3.71; P = .05), whereas the association with atopic eczema was significant in White participants (OR,

160 We aimed to determine whether adults with atopic eczema were at increased risk of death overall an

161 Subtypes of atopic eczema were identified based on self-reported ato

162 A total of 526,736 patients with atopic eczema were matched to 2,567,872 individuals with

163 d, milk, and adipose tissue of patients with atopic eczema, whereas concentrations of linoleic acid m

164 2% to 3%) probability of reporting prevalent atopic eczema with age.

165 tent class analysis identified 4 subtypes of atopic eczema with distinct patterns of disease activity