ライフサイエンスコーパス: attenuator

1 tulate that four-gene LRCs act as 'universal attenuators'.

2 allows formation of an intrinsic terminator (attenuator).

3 8, CTLA-4, PD-1, ICOS, or B and T lymphocyte attenuator.

4 substitutions in the T/U-tract of the pyrBI attenuator.

5 r hairpin and U-tract specified by the pyrBI attenuator.

6 fied inhibitory molecule, B and T lymphocyte attenuator.

7 cleavage to occur prior to synthesis of the attenuator.

8 leader peptide encoded by a transcriptional attenuator.

9 tenuator and up to 20.0 for the 20-cm radius attenuator.

10 ttenuator and up to 2.8 for the 20-cm radius attenuator.

11 tion via ligation of the B- and T-lymphocyte attenuator.

12 cludes an amplifier, a phase shifter, and an attenuator.

13 dditional role in causing termination at the attenuator.

14 binding riboswitches and other transcription attenuators.

15 ility is conditioned by intracellular signal attenuators.

16 eve it using the external phase shifters and attenuators.

17 de of phase shifters, frequency filters, and attenuators.

18 mple of the PyrR family of pyrimidine operon attenuators.

19 SV oncolysis can be overcome with interferon attenuators.

20 sion of upstream genes, and thus LRCs act as attenuators.

21 st-in-class modulators of B and T lymphocyte attenuator, 4-IBB, and CD27.

22 regulatory molecules, cytotoxic T-lymphocyte attenuator-4 (CTLA-4), lymphocyte activation gene-3 (LAG

23 We pinpoint an "attenuator": a minimal region relying on a nuclear recep

24 Ribo-attenuators allow riboswitches to be treated as truly mo

25 Mutagenesis of these functional attenuators allowed us to create a total of 11 new chime

26 that, as well as inhibiting the aptamer, the attenuator also acts as a structural guide, much like a

27 lymphocyte antigen-4 and B and T lymphocyte attenuator also interact with class 1A PI3K.

28 vators, including a small molecule-triggered attenuator and a group of five mutually orthogonal ribor

29 The 5' attenuator and DED1 dependence of RNA2 suggest that, des

30 he effects depended upon the identity of the attenuator and its orientation but only one of 16 sequen

31 transcriptional initiation site between the attenuator and the ilvG gene.

32 by factors of up to 1.8 for the 10-cm radius attenuator and up to 2.8 for the 20-cm radius attenuator

33 by factors of up to 4.5 for the 10-cm radius attenuator and up to 20.0 for the 20-cm radius attenuato

34 the construction of several transcriptional attenuators and activators, including a small molecule-t

35 of electronically controlled non-volatile RF attenuators and other reconfigurable devices.

36 membrane proteins, BTLA (B and T lymphocyte attenuator) and CD160.

37 t receptors such as BTLA (B and T lymphocyte attenuator) and PD-1 (programmed cell death protein 1) i

38 tor, checkpoint inhibitor B and T lymphocyte attenuator, and CD160.

39 g ligands for the CD160, B- and T-lymphocyte attenuator, and lymphocyte activation gene-3 inhibitory

40 shifters/filters, coaxial cables, splitters, attenuators, and a broadband amplifier.

41 cavities, unidirectional amplifiers, digital attenuators, and a digital phase shifter.

42 The attenuator anneals to conserved bases in the catalytic c

43 d ribozyme-attenuated probe), a 3' terminal "attenuator" anneals to conserved bases in the catalytic

44 Antisense RNA transcription attenuators are a key component of the synthetic biology

45 NF-kappaB), an amplifier (C/EBPdelta) and an attenuator (ATF3) forms a regulatory circuit that discri

46 receptors, of which both B and T lymphocyte attenuator (BTLA) and CD160 engage herpesvirus entry med

47 he Ig superfamily members B and T lymphocyte attenuator (BTLA) and CD160, both of which limit inflamm

48 e Ig superfamily members, B and T lymphocyte attenuator (BTLA) and CD160, limits the activation of T

49 the interaction between B- and T-lymphocyte attenuator (BTLA) and herpesvirus entry mediator (HVEM)

50 bed inhibitory receptors, B and T lymphocyte attenuator (BTLA) and programmed death-1 (PD-1), in the

51 heckpoint molecules PD-1, B and T lymphocyte attenuator (BTLA) and T cell immunoreceptor with Ig and

52 nown HVEM ligands such as B and T lymphocyte attenuator (BTLA) and the T lymphocyte receptor LIGHT.

53 The B and T lymphocyte attenuator (BTLA) appears to act as a negative regulator

54 red coinhibitory receptor B and T lymphocyte attenuator (BTLA) by herpesvirus entry mediator (HVEM) i

55 We present evidence that B and T lymphocyte attenuator (BTLA) coinhibitory signaling is required to

56 B and T lymphocyte attenuator (BTLA) functions as a negative regulator of T

57 Dardenne et al show that B- and T-lymphocyte attenuator (BTLA) functions as an inhibitory receptor on

58 Although B and T lymphocyte attenuator (BTLA) has been shown as a negative regulator

59 mmune checkpoint molecule B and T-lymphocyte attenuator (BTLA) has shown its potential to restrain in

60 mmune checkpoint molecule B and T-lymphocyte attenuator (BTLA) has shown potential for restraining in

61 mediator (HVEM) and the B- and T-lymphocyte attenuator (BTLA) inhibit B and T cell activation.

62 B and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor that inter

63 B and T lymphocyte attenuator (BTLA) is a negative regulator of T cell acti

64 B and T lymphocyte attenuator (BTLA) is a recently identified inhibitory Ig

65 The B and T lymphocyte attenuator (BTLA) is a recently identified member of the

66 entry mediator (HVEM) to B and T lymphocyte attenuator (BTLA) is known to activate an inhibitory sig

67 ammed death-1 (PD-1) and B- and T-lymphocyte attenuator (BTLA) is linked with dysregulation and exhau

68 point inhibitory receptor B and T lymphocyte attenuator (BTLA) limits immune responses of T and B lym

69 , we investigated whether B and T lymphocyte attenuator (BTLA) plays a similar role in functional imp

70 the coinhibitory receptor B and T lymphocyte attenuator (BTLA) predominantly on CD4(+) T cells but al

71 B and T lymphocyte attenuator (BTLA) provides an inhibitory signal to B and

72 ressed elevated levels of B and T lymphocyte attenuator (BTLA) relative to CD5(-) B cells, as opposed

73 B and T lymphocyte attenuator (BTLA) was initially identified as expressed

74 To determine the roles of B and T lymphocyte attenuator (BTLA), a CD28 family coinhibitory receptor,

75 find that activating the B and T lymphocyte attenuator (BTLA), a coinhibitory receptor for T cells,

76 Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing g

77 as a ligand that binds to B and T lymphocyte attenuator (BTLA), an immunoglobulin super family member

78 ently described receptor, B and T lymphocyte attenuator (BTLA), has been demonstrated to have an impo

79 entry mediator (HVEM) or B and T lymphocyte attenuator (BTLA).

80 the Ig superfamily member B and T lymphocyte attenuator (BTLA).

81 , programmed death-1, and B and T lymphocyte attenuator (BTLA).

82 lated recently and termed B and T lymphocyte attenuator (Btla).

83 ed protein 4 (CTLA-4), or B and T lymphocyte attenuator (BTLA).

84 the inhibitory receptor, B and T lymphocyte attenuator (BTLA).

85 hibitory Ig family member B and T lymphocyte attenuator (BTLA).

86 ath-ligand 1 (PD-L1), and B and T lymphocyte attenuator (BTLA); (iii) increasing CD8(+) T cells and P

87 ulin inhibitory receptor, B and T lymphocyte attenuator (BTLA); and the natural killer cell-activatin

88 The B and T lymphocyte attenuator (BTLA, CD272) is a novel coinhibitory molecul

89 B and T lymphocyte attenuator (BTLA; CD272) can deliver inhibitory signals

90 (i.e., LIGHT, CD160, and B and T lymphocyte attenuator [BTLA]) also decreased latency but not primar

91 gram death-1 [PD-1], and B- and T-lymphocyte attenuator [BTLA]) plays a critical role in controlling

92 The B and T lymphocyte attenuator, BTLA, is a recently discovered Ig superfamil

93 lar levels of CTP prevent termination at the attenuator by a mechanism that requires the nontemplate

94 ion of transcription termination at the pyrG attenuator by CTP were demonstrated.

95 e demonstrate our ability to create chimeric attenuators by fusing sequences from five different tran

96 2+ tunneling, we engineered a Ca2+ tunneling attenuator (CaTAr) that blocks tunneling without affecti

97 rpes virus entry mediator B and T lymphocyte attenuator/CD160 pathways.

98 a cis-complementary regulatory nucleic acid (attenuator) controls the ability of the aptamer to bind

99 ities of sense-antisense duplexes and of the attenuator-core duplexes correlate with observed rates o

100 f-cleavage of transcripts with a full-length attenuator could not be restored efficiently by renatura

101 Conversely, efficient low-frequency attenuators demand large volumes leading to unpractical

102 and provide design principles for RNA-based attenuator devices to be used in synthetic biology and R

103 ergy control (SC) motif embedded within the "attenuator domain" of CCAAT/enhancer-binding protein alp

104 that MIM tuning, aided by a digital tunable attenuator (DTA), can automatically adjust MIM operation

105 memory and possibly functions as a molecular attenuator during signal transduction.

106 show that a previously described frameshift attenuator element does not actually affect frameshiftin

107 ct genetic evidence for a role of BI-1 as an attenuator for cell death progression triggered by both

108 antisense sequence linking the ribozyme and attenuator frees the core to fold into an active conform

109 sions between the engineered transcriptional attenuator from plasmid pT181 and natural antisense RNA

110 igonucleotides that directly paired with the attenuator gave up to 1760-fold activation.

111 in HeLa cell extracts demonstrated that the attenuators give rise to premature termination of transc

112 We noted that the upstream attenuator hairpin activity is also functionally retaine

113 In this conformation, the attenuator hairpin and slippery site nucleotides are exp

114 The potential attenuator has been identified and point-mutated.

115 ammed death receptor-1 or B and T lymphocyte attenuator have persistent inflammation out to 15 days f

116 g and in situ hybridization show that the Hh attenuator Hhip is downregulated.

117 ated external defibrillator with a pediatric attenuator if available for cardiac arrest; and in infan

118 oduced a novel genetic element called a ribo-attenuator in Bacteria.

119 in the reporter genes tested, but acts as an attenuator in combination with upstream sequences.

120 dy identifies A20 as an antigen presentation attenuator in control of antitumor immune responses duri

121 elicolor is regulated by a ribosome-mediated attenuator in the 5' leader of its mRNA region.

122 mmed death receptor-1 and B and T lymphocyte attenuator in the regulation of allergic airway inflamma

123 There is a strong attenuator in the rpmG-fpg intergenic region and three t

124 sted met the criteria for a Tat-suppressible attenuator in vivo.

125 s process is governed by DNA elements called attenuators in concert with cellular transcription facto

126 arising from the presence of scatterers and attenuators in the domain of simulation, with the time-d

127 There also appear to be attenuators in the yggX-mltC and mltC-nupG intergenic re

128 on, but lend little support to their role as attenuators in vivo.

129 o protein family and function as cytoplasmic attenuators in Wnt and TGFbeta signaling.

130 ther a potential riboswitch or transcription attenuator involved in the regulation of cell division.

131 n enzyme-substrate pair that functions as an attenuator is a generalizable strategy that enables this

132 We show that the trp attenuator is a weak intrinsic terminator due to low GC

133 ly, because both the input and output of the attenuator is RNA, we show how these variants can be con

134 ion of the TRAP, between the aptamer and the attenuator, is complementary to a target nucleic acid, s

135 ompetitive IRE1alpha Kinase-Inhibiting RNase Attenuators-KIRAs-that allosterically inhibit IRE1alpha'

136 en-4, programmed death-1, B and T lymphocyte attenuator, LAG3, T-cell immunoglobulin and mucin domain

137 terminate at a putative Rho-factor-dependent attenuator located in the tyrS-pdxY intercistronic regio

138 specialized DNA elements, such as the Fab-7 attenuator, might play a general role in controlling the

139 ements with activating roles, and uncovered 'attenuator' motifs with repressive roles in active chrom

140 nsin DEFB103 acts as both a stimulant and an attenuator of chemokine and cytokine responses: a dichot

141 We identified miR-211 as a putative attenuator of cholinergic-mediated seizures by intersect

142 uggest that the inflammasome functions as an attenuator of colitis and CAC.

143 aspase-1 (IL-1beta-converting enzyme) and an attenuator of cytokine responsiveness to septic infectio

144 SCL3 seems to act as an attenuator of DELLA proteins.

145 f the mutation (named provisionally adr, for attenuator of drug resistance) into representatives of m

146 2 functions in cardiac valve formation as an attenuator of EMT by repressing GATA4 activity within th

147 The pyrBI attenuator of Escherichia coli is an intrinsic transcrip

148 Kalpha, a robust suppressor of mTORC1 and an attenuator of global protein synthesis.

149 s been considered as a potentially important attenuator of inflammation.

150 and uncover a function for FBXW7alpha as an attenuator of inflammatory signalling.

151 ings, this work identifies Alph as a general attenuator of MAPK signaling in Drosophila.

152 d-type cells with the cytokine BAFF, a known attenuator of p18(INK4c) function in B lymphocytes, was

153 MDM2, the cellular attenuator of p53, discriminates the FXXPhiPhi motif of

154 complexes regulate a common novel target and attenuator of RAS signalling, AJM-1 (Apical Junction Mol

155 We have discovered that Coronin1B is a novel attenuator of ROCK signaling.

156 iate level of backscatter and is the largest attenuator of signal at 850 nm.

157 support the hypothesis that myostatin is an attenuator of skeletal muscle growth in adult men and co

158 DAPK2 therefore comprises a new candidate attenuator of stress erythropoiesis.

159 t studies suggest alpha-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanism

160 The HD moiety of GalphatGDP is an attenuator of the activated catalytic core, whereas in t

161 PCD, increased BAX inhibitor-1, an effective attenuator of the death programs in eukaryotes, and rest

162 Thus, mkp3 encodes a feedback attenuator of the FGF pathway, the expression of which i

163 nal mechanism whereby AUF1 acts as a crucial attenuator of the inflammatory response, promoting the r

164 Integrator functions as a genome-wide attenuator of transcription that acts on elongation thro

165 sting that it does not act as a conventional attenuator of transcription.

166 we identified tmem88a, a recently described attenuator of Wnt signaling, as a discrete regulator of

167 location of the lesion in circularly-shaped attenuators of 10- and 20-cm radii, with and without att

168 iscs large proteins as tumor suppressors and attenuators of cell division, in T lymphocytes, DLGH1 fu

169 s short ORFs function as cysteine-responsive attenuators of operonic gene expression.

170 large-scale RNAi screen designed to identify attenuators of RAS signalling during vulval development.

171 Our work illuminates novel microRNA attenuators of RB, forging a promising new path for micr

172 , including coinhibitory molecules and other attenuators of TCR signaling, with a focus on their cont

173 vant beta2AR physiologic function, acting as attenuators of the acute response, and represent specifi

174 gulators of G-protein signaling (RGS) act as attenuators of the G-protein signal cascade by binding t

175 of Btn and Btnl molecules to act as specific attenuators of tissue-associated inflammatory responses.

176 sis indicate that Rho functions as a global "attenuator" of transcription, acting at the 5'UTR of hun

177 o acid (UAA) can be used as a small-molecule attenuator or activator of gene transcription, and the l

178 Fs and highlights the dual role of decoys as attenuators or amplifiers of gene expression noise depen

179 The fungal arginine attenuator peptide (AAP) is a regulatory peptide that co

180 The Arg attenuator peptide (AAP) is an evolutionarily conserved

181 The fungal arginine attenuator peptide (AAP) is encoded by a regulatory upst

182 ate translation of the uORF-encoded arginine attenuator peptide (AAP) is important for regulation.

183 m open reading frame (uORF) encoding the Arg attenuator peptide (AAP) that confers negative translati

184 The evolutionarily conserved fungal arginine attenuator peptide (AAP), as a nascent peptide, stalls t

185 -ORF by applying it to uORF-encoded arginine attenuator peptide (AAP)-mediated translational regulati

186 n reading frame (uORF) encoding the arginine attenuator peptide (AAP).

187 a arg-2 uORF encodes the 24-residue arginine attenuator peptide (AAP).

188 e and contains removable, variable thickness attenuator plates (copper or lead) to modulate the photo

189 RS operon exhibited a unique feature with an attenuator present between ygiW and firR that caused the

190 er 93 kDa (2)H,(15)N-labeled Trp RNA-binding attenuator protein tumbling with a correlation time tauc

191 etween the HVEM and BTLA (B and T lymphocyte attenuator) receptors.

192 p represses transcription through the leader-attenuator region of the ilvGMEDA operon.

193 rom its predicted binding site in the second attenuator region.

194 genes is limited to the leader sequences of attenuator-regulated operons.

195 immune checkpoint BTLA (B- and T-lymphocyte attenuator) represses T cell responses.

196 provide evidence that termination at the trp attenuator requires forward translocation of RNA polymer

197 The observation that the attenuator requires the presence of TRAP bound to the na

198 ingular example of a leader mRNA with tandem attenuators responding to different signals.

199 Previously, formation of the attenuator RNA structure was believed to be solely respo

200 orted by TMOs, is a Reflective-Type Variable Attenuator (RTVA), shown here.

201 fields as radio-frequency electronics, micro-attenuators, sensors and many others.

202 nfluenced, in part, by whether the available attenuator sequence could form structures with the riboz

203 tenuated probes (TRAP) design, antisense and attenuator sequences are appended onto the catalytic cor

204 ging task and to deviations from the assumed attenuator size and shape.

205 on of the antiterminator, and thus allow the attenuator structure to form constitutively, do not resu

206 ator and the thickness of the mercury in the attenuator system.

207 as fitted with a computer-controlled mercury attenuator that facilitated changes in dose rates as des

208 ozyme is a stretch of nucleotides termed the attenuator that functions to base-pair with and unfold t

209 The MFAO-2s outperform clioquinol, a metal attenuator that has been investigated for the treatment

210 amino acids that function as Cys-responsive attenuators that engage ribosome stalling at tracts of C

211 ry is creating larger families of orthogonal attenuators that function independently of each other.

212 ficient hearts are impervious to hypertrophy attenuators, that mitochondrial metabolism regulates car

213 This suggests that in the presence of the attenuator, the cleavage-active ribozyme fold is not the

214 d the process of low-dose image acquisition, attenuator thickness calculation, mask generation, mask

215 Changing this single motif converts the attenuator to an enhancer with the opposite regulatory b

216 sequences, suggesting that tight binding of attenuator to the core is assisted by a long antisense p

217 of inhibiting SOCS1, an antigen presentation attenuator, to break self tolerance and induce effective

218 atment, but not cotreatment, with interferon attenuators valproate, Jak1 inhibitor, or vaccinia virus

219 effect of the presence or absence of the his attenuator was assessed under these conditions as well.

220 ge of the ribozyme followed by a full-length attenuator was increased by decreasing the rate of trans

221 Termination of transcription at the attenuator was strongly promoted by the combination of P

222 t more fully and explore its role as an anti-attenuator, we examined the ability of several natural a

223 tions on termination efficiency at the pyrBI attenuator were also measured in vitro, which corroborat

224 Surprisingly, only 23 nt of attenuator were needed for strong inactivation of cleava

225 transcriptional fusions that lacked the leu attenuator were used, expression from the leu promoter v

226 The exception is BTLA (B and T lymphocyte attenuator), which instead interacts with the tumor necr

227 e studies suggest that Fab-7 functions as an attenuator, which weakens gene expression by reducing en

228 he 5' end of the transcript and the putative attenuator within the coding sequence were required for