ライフサイエンスコーパス: atypia

1 gh-risk polyps (> or = 1 cm, villous, severe atypia).

2 sion initially to form regions of epithelial atypia.

3 prostatic epithelial hyperplasia and nuclear atypia.

4 in the same breast, especially in women with atypia.

5 f the 15 conjunctival PAMs, with and without atypia.

6 varian surface epithelium, lacks cytological atypia.

7 esions characterized by dysplasia and marked atypia.

8 were characterized by morphological nuclear atypia.

9 are follicular neoplasms and cells that show atypia.

10 hologically were found to have seminoma with atypia.

11 entiation pattern, and degree of cytological atypia.

12 6 ACF with dysplasia and in 2 of 48 ACF with atypia.

13 ER1(+) T cells lacking significant cytologic atypia.

14 inoma showing varying degrees of cytological atypia.

15 vi with architectural disorder and cytologic atypia.

16 ere negative for genetic alteration (GA) and atypia.

17 t PILs and in nearly all PILs having nuclear atypia.

18 ing squamous metaplasia and mild to moderate atypia.

19 ing patterns also correlated with increasing atypia.

20 patients had upper urinary tract multifocal atypia.

21 develop epithelial hyperplasia and cellular atypia.

22 tify their morphological characteristics and atypia.

23 d proliferation with prominent megakaryocyte atypia.

24 plasia (atypia), and 72 benign cases without atypia.

25 and lower levels of concordance for DCIS and atypia.

26 ivity increased significantly with worsening atypia.

27 rn made of large compact nests with variable atypia.

28 nsisted of small lymphoid cells with minimal atypia.

29 f the normal conjunctiva and did not display atypia.

30 ment, in a well-defined cohort of women with atypia.

31 ring a 65-month period revealed 147 cases of atypia.

32 ates the risk of breast cancer in women with atypia.

33 il model to counsel individual patients with atypia.

34 does not further increase risk in women with atypia.

35 ancers (19.9%) occurred among 331 women with atypia.

36 situ) carcinoma were as follow: CCL without atypia 1.5% (95% confidence interval [CI] 0.6%-4%), CCL

37 helium but was detected in 7% of SMs, 15% of atypias; 18% of LGDs, 47% of HGDs, and 42% of SCCs.

38 , or LGD (n = 12), but it was found in 9% of atypias (2 of 22), 33% of HGDs (7 of 21), and 54% of SCC

39 rinterpreted; and among benign cases without atypia (2070 interpretations), 87% (95% CI, 85%-89%) wer

40 9,376 women in the BBD cohort, 331 women had atypia (3.5%).

41 m; 7 endometrial hyperplasia with or without atypia; 32 endometrioid endometrial carcinoma (EEC), inc

42 iferative (181 women), or proliferative with atypia (33 women) between 1995 and 2000 and 1,070 unaffe

43 pia (6 of 32; 19%) relative to those without atypia (4 of 19; 21%).

44 errors resulting in the emergence of nuclear atypia(4-7), the underlying processes and rates of spont

45 n from normal/mild hyperplasia to those with atypia, 4) the degree of dysplasia, and 5) angiogenesis.

46 Verification is less probable for atypia (53.6% overinterpreted and 8.6% underinterpreted)

47 , and LGD, but it was overexpressed in 6% of atypias, 53% of HGDs, and 61% of SCCs.

48 N mutations in endometrial hyperplasias with atypia (6 of 32; 19%) relative to those without atypia (

49 confidence interval [CI] 0.6%-4%), CCL with atypia 9% (95% CI: 5%-14%), and atypical ductal hyperpla

50 yperplasias had focal or diffuse cytological atypia, a feature previously associated with risk for en

51 Tumors displayed cytological atypia, absence of biliary epithelia, loss of reticulin,

52 inomas (STICs) is characterized by cytologic atypia, accumulation of somatic mutations, and genomic i

53 gressive phenotype characterized by cellular atypia, adenoma and ultimately adenocarcinoma.

54 psy specimens with intraepithelial cytologic atypia, adipophilin results were negative.

55 here was a fourfold increase in detection of atypia after the introduction of digital mammography bet

56 Of 15 lesions showing atypia alone, 3 (20%) were malignant, all of which were

57 atypia, follicular neoplasms with atypia, or atypia alone.

58 a suggestion of a decreased risk of EH with atypia among current smokers.

59 ely matched with 20 patients with C-MIN with atypia and 20 with C-MIN without atypia regarding tumor

60 primary acquired melanosis (PAM; 11 without atypia and 4 with atypia) and five were conjunctival mel

61 Increased cell size, frequent nuclear atypia and a collapse of apoptosis were observed.

62 nic obstructive pulmonary disease and sputum atypia and a moderate-risk group randomly selected from

63 Patients with both atypia and aberrant p53 had the highest risk of high-gra

64 n of the SAC leads to rapid villous atrophy, atypia and apoptosis of the epithelia of the jejunum and

65 of patients with a CNB diagnosis of CCL with atypia and atypical ductal hyperplasia associated with C

66 NB diagnosis of CCL without atypia, CCL with atypia and atypical ductal hyperplasia associated with C

67 severe urocystitis with reactive urothelial atypia and carcinoma in situ (CIS) can be difficult, par

68 Reactive urothelial atypia and CIS were distinguishable on the basis of the

69 HPV-16 E6 is associated with marked nuclear atypia and concomitant accumulation of centrosomes.

70 ias, which vary in the extent of cytological atypia and degree of architectural complexity.

71 the development of urothelial preneoplasia (atypia and dysplasia), neoplasia, and metastasis and was

72 h the tumors were small, they showed nuclear atypia and exhibited features of human ccRCC.

73 a was detected in 15 women (50%) with ductal atypia and in seven women (47%) with discordant histopat

74 aepithelial neoplasia) with striking nuclear atypia and invasive, poorly differentiated carcinoma.

75 s, all mice developed PTC displaying nuclear atypia and marker expression characteristic of the human

76 picious atypia group: melanoma versus severe atypia and melanoma versus moderate atypia had P-values

77 elluarity, pleomorphic nucleoli, cytological atypia and necrosis, and positive staining for alpha-smo

78 6 to 2.12) for proliferative changes without atypia and of 1.27 (95 percent confidence interval, 1.15

79 ells to ovaries with stromal hyperplasia and atypia and on to tumors in adut mice.

80 for lesions exhibiting proliferation without atypia and OR = 1.5 (95% CI, 0.4 to 5.6) for the diagnos

81 ulation of enlarged liver cells with nuclear atypia and pleomorphism, frequent binuclearity, and mini

82 on and had reduced ciliation, increased cell atypia and proliferation, with multilayered epithelium,

83 ree survival rates (P = 0.041) in C-MIN with atypia and significantly lower recurrence-free (P = 0.00

84 early RNA+ lymphoid infiltrate with variable atypia and subcutaneous involvement.

85 tosis, and observed mitotic defects, nuclear atypia and substantial alterations in the mitotic phosph

86 with atypical hyperplasia, multiple foci of atypia and the presence of histologic calcifications may

87 local recurrence in patients with C-MIN with atypia and with an increased risk of local recurrence, l

88 ltrate of plasma cells in the dermis without atypia and with eosinophils.

89 ar versus high chromatin phenotypes, nuclear atypia) and (iii) overlapping nuclei.

90 melanosis (PAM; 11 without atypia and 4 with atypia) and five were conjunctival melanomas.

91 n situ (DCIS), 72 with atypical hyperplasia (atypia), and 72 benign cases without atypia.

92 15 papillary, 37 (55%) of 67 papillary with atypia, and 10 (71%) of 14 carcinoma in situ duct lesion

93 in one papilloma with florid hyperplasia and atypia, and 10 other PBD lesions were negative for genet

94 aluated were overexpression of p53, cellular atypia, and 17 clinical demographic variables.

95 y acquired melanosis with moderate to severe atypia, and conjunctival melanoma) that provided suffici

96 d by assessing urothelial thickness, nuclear atypia, and expression of luminal and basal markers at 6

97 f the lesions were follicular neoplasms with atypia, and four (44.4%) of these were malignant, includ

98 without atypia, in 10 of the 20 C-MINs with atypia, and in all 20 CMs.

99 timated risk of breast cancer for women with atypia, and individual risk estimates showed poor concor

100 astic nevi with structural and architectural atypia, and melanoma.

101 hundred ninety men with HGPIN, or HGPIN and atypia, and no PCa on prostate biopsy were randomly assi

102 ate-onset hyperplasia, umbrella cell nuclear atypia, and rare-occurring low-grade, superficial papill

103 ut atypia, follicular neoplasms with atypia, atypia, and suspicious for malignancy.

104 ylation markers (MYOD1 and RUNX3), glandular atypia, and TP53 mutation status.

105 ries, follicular neoplasms and cells showing atypia are included in a broad "suspicious" category, wi

106 onfirmed atypical hyperplasia of the breast (atypia) are at high risk for breast cancer.

107 women who had proliferative disease without atypia as compared with women who had nonproliferative d

108 selectively exhibited focal areas of nuclear atypia associated with less organized epithelia.

109 py, improving the ability to detect cellular atypia associated with neoplasia.

110 rchromasia are principal features of nuclear atypia associated with precancerous and cancerous change

111 to the lumen (hobnailing) and severe nuclear atypia at 6 months of age.

112 out and with malignancy or, for B3a lesions, atypia at DHE.

113 128 patients were subsequently found to have atypia at excision.

114 gnancy, and 19.9% (29 of 146) had associated atypia at initial biopsy.

115 Two eyes had minimal cellular atypia at the conjunctival epithelium.

116 tiginous) proliferation of cells with marked atypia at the DEJ, especially in interpapillary spaces;

117 ms without atypia, follicular neoplasms with atypia, atypia, and suspicious for malignancy.

118 exhibited erythrocytosis and megakaryocytic atypia but normal platelet number.

119 ion with erosions and ulcers, and epithelial atypia by 6 dpi in the descending colon.

120 5% CI, 12%-15%) were underinterpreted; among atypia cases (2070 interpretations), 48% (95% CI, 44%-52

121 patients with a CNB diagnosis of CCL without atypia, CCL with atypia and atypical ductal hyperplasia

122 Within nodules, there was cellular atypia consistent with nodular dysplasia.

123 is, including conjunctiva without epithelial atypia (controls); conjunctival intraepithelial neoplasi

124 Many atypia could represent risk factors rather than precurso

125 None of the melanocytomas with or without atypia demonstrated chromosomal imbalances or additional

126 Women with atypia detected more recently have lower rates of subseq

127 Women with atypia detected more recently have lower rates of subseq

128 of invasive breast cancer and benign without atypia diagnoses is highly probable; estimated predictiv

129 Annual mammography in the short term after atypia diagnosis might not be beneficial.

130 uring 19 088 person years of follow-up after atypia diagnosis, 141 women developed breast cancer.

131 to 55.1) at one, three, and six years after atypia diagnosis, respectively.

132 and appearance of papillary hyperplasia with atypia displayed a delayed pattern.

133 ho were diagnosed with complex EH or EH with atypia during the period 1985-2003 and whose diagnoses w

134 elevations in risk were seen with multifocal atypia (eg, three or more foci with calcifications [RR,

135 ced risk of epithelial proliferation without atypia (EP; HR, 0.62; 95% CI, 0.46-0.85) but increased r

136 ausal risks of epithelial proliferation with atypia (EPA; HR, 1.81; 95% CI, 1.07-3.07), fibrocystic c

137 Ductal hyperplasia with and without atypia exhibited higher PTEN protein levels than normal

138 categories are follicular neoplasms without atypia, follicular neoplasms with atypia, atypia, and su

139 categorized as follicular neoplasms without atypia, follicular neoplasms with atypia, or atypia alon

140 ions with benign pathologic findings without atypia found to be concordant with imaging at a consensu

141 by architectural complexity and cytological atypia greater than that seen in high-grade prostatic in

142 ween suspicious melanoma and each suspicious atypia group: melanoma versus severe atypia and melanoma

143 Conclusion RS without atypia had a low upgrade rate.

144 s severe atypia and melanoma versus moderate atypia had P-values of 0.0077 and 0.0009, respectively.

145 atypical alveolar hyperplasia, and isolated atypias) had a high proportion of cells strongly positiv

146 cells grouped as either benign or high-grade atypia (HGA) [>/=high-grade dysplasia].

147 eat biopsy was recommended because of ductal atypia in 30 patients, discordant imaging and histopatho

148 cent of women, proliferative lesions without atypia in 30 percent, and atypical hyperplasia in 4 perc

149 f adenomas and the size, type, and degree of atypia in 479 patients in a polyp prevention trial were

150 ihood of benign core biopsy findings without atypia in malignant calcifications versus masses (7% vs

151 a benign intraductal papilloma in each, with atypia in one.

152 Detection of squamous cell atypia in the digital samples by analysis with the DLS.

153 evoked a stratified architecture and nuclear atypia in the epithelial lining of all endometriotic cys

154 llary and cribriform structures with nuclear atypia in the lining of 42 and 50% of peritoneal and ova

155 an differentiate between reactive urothelial atypia in the setting of an acute or chronic cystitis an

156 olve before the development of morphological atypia in these epithelia.

157 were detected in none of the C-MINs without atypia, in 10 of the 20 C-MINs with atypia, and in all 2

158 sion (65%), performed more often as grade of atypia increased (P < .001).

159 Tumor nuclear grade (atypia) increased with tumor height and by tumor locatio

160 Tumor nuclear grade (atypia) increased with tumor height.

161 Its ability to discriminate women with atypia into those who did and did not develop breast can

162 Although cytologic atypia is minimal, studies for T-cell clonality confirm

163 epithelioid melanocytes with mild cytologic atypia, low mitotic activity, focal necrosis, and ulcera

164 cytology shows a follicular neoplasm without atypia, malignancy rates of 8% or less may allow nonsurg

165 tinguish between B3a lesions without or with atypia/malignancy at DHE after surgical excision and bet

166 ith HMB45 (96% specificity, 97% sensitivity; atypia marker).

167 iferation of the ductal epithelium, cellular atypia, metaplasia, and stromal alterations.

168 n demonstrated to detect underlying cervical atypia missed by conventional cytology, it is limited by

169 For CCL without atypia, more studies with a long-term follow-up are requ

170 a low prevalence of false-negative diagnoses atypia must be interpreted as potential malignancy.

171 mous metaplasia (SM; n = 28), and epithelial atypia (n = 34) were compared with that in low-grade dys

172 Clinicopathological features (eg, atypia, necrosis, and clinical outcome) did not appear t

173 There was absence of cytologic atypia of surface epithelium.

174 rgin of the deep plane and focal cytological atypia of the basaloid cells.

175 Atypia of the mammary ductal epithelium develops at abou

176 it causes, although the frequent cytological atypia of the stromal cells suggests that they may be ne

177 s) and a fine-needle aspiration diagnosis of atypia of undetermined significance or follicular lesion

178 a previous fine-needle aspiration report of "atypia of undetermined significance" or "follicular lesi

179 that are classified as indeterminate (i.e., atypia of undetermined significance/lesion of undetermin

180 al examination and lower frequency of marked atypia on melanocytes in the basal cell layer; it presen

181 opsy-proven concordant fibroadenomas without atypia only require excision if they were symptomatic, p

182 Of 74 follicular neoplasms without atypia, only 5 (6.8%) were malignant, and none of these

183 Primary acquired melanosis with atypia or a nevus are known as preexisting melanocytic l

184 2 years of follow-up without a diagnosis of atypia or breast malignancy and were therefore considere

185 Transection margins were involved with atypia or carcinoma in 32 patients (51%).

186 The presence of atypia or carcinoma in situ at the ductal resection marg

187 redicts a low likelihood that a diagnosis of atypia or DCIS would be verified by a reference consensu

188 sional biopsy after needle biopsy because of atypia or discordance, final surgical pathologic analysi

189 There was no evidence of atypia or dysplasia after 3 and 6 months.

190 ed as either negative (including negative or atypia or dysplasia) or positive (including carcinoma in

191 needle biopsy (CNB) that show or do not show atypia or malignancy at definitive histopathological exa

192 nce also between B3a lesions without or with atypia or malignancy at DHE, but only ADC(min) (not ADC(

193 % CI: 0.02, 4.7]); one RS without concurrent atypia or malignancy demonstrated invasive carcinoma at

194 A total of 66.7% (78 of 117) of RS without atypia or malignancy were surgically excised, 25.6% (30

195 17 of 146) of all RS did not have associated atypia or malignancy, and 19.9% (29 of 146) had associat

196 In 30 patients with 33 lesions without atypia or malignancy, sclerosing adenosis was the major

197 roups were identified: high risk, defined as atypia or p53 overexpression or both on Cytosponge; mode

198 ified 39 (17%) of 223 patients as high risk (atypia or p53 overexpression, or both) requiring endosco

199 agnosed as suspicious for malignancy or with atypia or unusual associated histologic findings should

200 The negative predictive values for "atypia (or follicular lesion) of undetermined clinical s

201 ms without atypia, follicular neoplasms with atypia, or atypia alone.

202 I, asymmetry, hyperchromatism, and cytologic atypia) outperformed standard histologic assessment in a

203 tive biopsy margin, increasing with grade of atypia (P < .001); 127 of 196 with positive biopsy margi

204 proliferating lymphatics than did C-MIN with atypia (P </= 0.001).

205 assification accuracy consisted of glandular atypia, P53 abnormality, and Aurora kinase A positivity,

206 Cytosponge atypia, p53 overexpression, and clinical risk factors (a

207 mographics, capsule sponge test result (TFF3/atypia/p53) and ongoing clinical management.

208 ferative (NP), proliferative disease without atypia (PDWA), or atypical hyperplasia (AH) are associat

209 n alterations were acquired in the normal-to-atypia (preneoplasia) transition, with only handful aber

210 , primary acquired melanosis with mild or no atypia, primary acquired melanosis with moderate to seve

211 d increased urothelial thickness and nuclear atypia, progressive disease was not observed at 12 month

212 C-MIN with atypia and 20 with C-MIN without atypia regarding tumor size, tumor location, tumor exten

213 , or high risk (p53 abnormality or glandular atypia regardless of clinical biomarkers, or both).

214 epithelial melanocytic proliferation without atypia represents increased numbers of normal-appearing

215 detected, including a lesion with high-grade atypia resembling lentiginous forms of malignant melanom

216 s with mucinous metaplasia and columnar cell atypia resembling low-grade PanIN in rats.

217 trial adenocarcinomas with prominent nuclear atypia, resembling human Type II cancers.

218 For detection of cervical cellular atypia, sensitivities were 95.7% (95% CI, 85.5%-99.5%) a

219 None of the five hyperplasias without atypia showed sigma-hypermethylation.

220 equivocal cases as well as between different atypia subgroups in the group of suspicious samples.

221 ohistochemical staining and in the degree of atypia, suggesting that multiple biopsies are necessary

222 y and biopsy techniques identifying forms of atypia that are more likely to represent overdiagnosis.

223 In the four women who did not have atypia, the procedure was diagnostic and appears to have

224 By 6 months, more extensive nuclear atypia, thickened "reactive" stroma, and basement membra

225 ce of histological progression from cellular atypia through various degrees of dysplasia, ultimately

226 asive carcinoma and, in some cases, cellular atypia (VIN).

227 tive incidence of cancer per 1000 women with atypia was 0.95 (95% confidence interval 0.28 to 2.69),

228 RR of breast cancer with atypia was 3.88 (95% CI, 3.00 to 4.94).

229 The relative risk associated with atypia was 4.24 (95 percent confidence interval, 3.26 to

230 omplete correlation between GAs and anatomic atypia was suggested.

231 ative, proliferative, and proliferative with atypia were 0.4 (95% confidence interval (CI): 0.2, 0.7)

232 No vascular invasion or cellular atypia were evident.

233 Actinic damage and squamous atypia were found in grafts of all groups receiving UV t

234 Among those, 331 women with atypia were identified by our study pathologists.

235 Women with atypia were identified from the Mayo Benign Breast Disea

236 Mitotic figures or atypia were not observed.

237 mice, colonic lesions, including epithelial atypia, were reversible, although a small percentage (5

238 ere identified in another PBD lesion without atypia, whereas another lesion from this second patient

239 with endometrial hyperplasia with or without atypia who would progress to cancer (p = 0.012).

240 th tumor height and by tumor location (least atypia with iris tumors).

241 0% of patients, and markers of risk (LCIS or atypia) with the potential to influence future decisions

242 affected lung revealed alveolar type II cell atypia, with numerous abnormal lamellar bodies.

243 lesion from this second patient had minimal atypia without GAs.