ライフサイエンスコーパス: autism spectrum disorder

1 nction variants in TMPRSS9 are related to an autism spectrum disorder.

2 attention-deficit/hyperactivity disorder and autism spectrum disorder.

3 iatric disorders including schizophrenia and autism spectrum disorder.

4 nt, and also to some degree with findings in autism spectrum disorder.

5 ly implicated in intellectual disability and autism spectrum disorder.

6 attention deficit hyperactivity disorder and autism spectrum disorder.

7 Pten mutations are associated with autism spectrum disorder.

8 well as neurodevelopmental disorders such as autism spectrum disorder.

9 ed potential risk factors and biomarkers for autism spectrum disorder.

10 its and sociability in three mouse models of autism spectrum disorder.

11 ity, delayed speech and motor milestones and autism spectrum disorder.

12 e model for both intellectual disability and autism spectrum disorder.

13 of 2:1 in intellectual disability and 4:1 in autism spectrum disorder.

14 ures early behavioural signs associated with autism spectrum disorder.

15 environmental risk factors or biomarkers of autism spectrum disorder.

16 of oxytocin (48 IU/day) in adult males with autism spectrum disorder.

17 r infants showing early behavioural signs of autism spectrum disorder.

18 did not find a significant relationship with Autism Spectrum Disorder.

19 n group of participants, including some with autism spectrum disorder.

20 d candidate therapeutics in a mouse model of autism spectrum disorder.

21 57 subjects have a diagnosis of Autism Spectrum Disorder.

22 brain differences between men and women with autism spectrum disorder.

23 orders, particularly Tourette's disorder and autism spectrum disorder.

24 th social deficits typically associated with autism spectrum disorders.

25 communication is a common characteristic in autism spectrum disorders.

26 nce, spine dynamics, Parkinson's disease and autism spectrum disorders.

27 uR1 as potential target for the treatment of autism spectrum disorders.

28 unity or neurodevelopmental issues including autism spectrum disorders.

29 neurons is associated with both epilepsy and autism spectrum disorders.

30 sessions of videogame play in 39 youth with autism spectrum disorder and 23 age-matched youth with t

31 rts dimensional, nonbinary classification in autism spectrum disorder and ADHD.

32 unced for childhood-onset disorders, such as autism spectrum disorder and attention-deficit/hyperacti

33 Autism spectrum disorder and attention-deficit/hyperacti

34 from two related neuropsychiatric disorders-autism spectrum disorder and bipolar disorder-to show th

35 y gamma oscillations, was equivalent between autism spectrum disorder and control groups, but importa

36 nalysis of de novo variants in patients with autism spectrum disorder and intellectual disability or

37 re repeatedly identified as risk factors for autism spectrum disorder and intellectual disability, bu

38 enuated by missense variants associated with autism spectrum disorder and intellectual disability.

39 tent of brain tissue in Alzheimer's disease, autism spectrum disorder and multiple sclerosis is signi

40 mer's disease, familial Alzheimer's disease, autism spectrum disorder and multiple sclerosis.

41 r diverse developmental phenotypes including autism spectrum disorder and other neurodevelopmental di

42 he behavioural phenotypes, that characterize autism spectrum disorder and Phelan-McDermid syndrome.

43 and exhibits reduced cortical expression in autism spectrum disorder and Rett Syndrome.

44 s many neuropsychiatric illnesses, including autism spectrum disorder and schizophrenia.

45 severe neuropsychiatric disorders including autism spectrum disorder and schizophrenia.

46 1.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia.

47 their formal diagnostic criteria, including autism spectrum disorder and schizophrenia.

48 body movement is a distinguishing feature in autism spectrum disorder and that movement atypicalities

49 Participants aged 7.5-18 years with autism spectrum disorders and a total score of 6 or high

50 chizophrenia, obsessive-compulsive disorder, autism spectrum disorders and even personality disorders

51 tions in Shank3 are strongly associated with autism spectrum disorders and neural circuit changes in

52 other neurodevelopmental disorders, such as autism spectrum disorders and schizophrenia.

53 s that ADHD traits occur in individuals with autism spectrum disorder, and autism spectrum disorder t

54 evelopmental delay, intellectual disability, autism spectrum disorder, and behavioral abnormalities a

55 such as schizophrenia, Alzheimer's disease, autism spectrum disorder, and bipolar disorder.

56 s, including those associated with language, autism spectrum disorder, and drug addiction.

57 risk factor for global developmental delay, autism spectrum disorder, and epileptic encephalopathy.

58 risk factor for global developmental delay, autism spectrum disorder, and epileptic encephalopathy.

59 highly penetrant, monogenic risk factor for autism spectrum disorder, and is a cause of Phelan-McDer

60 intellectual disability/developmental delay, autism spectrum disorder, and multiple medical comorbidi

61 disorders such as Phelan-McDermid syndrome, autism spectrum disorder, and schizophrenia.

62 a, attention-deficit hyperactivity disorder, autism spectrum disorder, anxiety disorders, seizures an

63 A subset of children with autism spectrum disorder appear to show an improvement i

64 Autism spectrum disorders are associated with some degre

65 Autism spectrum disorders are often associated with atyp

66 he central nervous system or associated with autism spectrum disorder, as well as 773 genes under unu

67 development and behavior in 96 children with autism spectrum disorder (ASD) [45 with neurodevelopment

68 Autism spectrum disorder (ASD) affects 1 in 59 children,

69 Autism spectrum disorder (ASD) affects an estimated 1.85

70 stem disorder featuring cardiac arrhythmias, autism spectrum disorder (ASD) and adrenal gland dysfunc

71 lied to neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyp

72 s investigated neuroradiological findings in autism spectrum disorder (ASD) and attention-deficit hyp

73 isorders and neurogenetic syndromes, such as autism spectrum disorder (ASD) and Dravet, Fragile X, Pr

74 nal week 10-as a key point of convergence in autism spectrum disorder (ASD) and epilepsy.

75 nitial link between DIP2A gene variations in autism spectrum disorder (ASD) and highlight the contrib

76 We ascertained autism spectrum disorder (ASD) and intellectual disabili

77 AP1 have been identified in individuals with autism spectrum disorder (ASD) and intellectual disabili

78 eral neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disabili

79 been noted consistently in individuals with autism spectrum disorder (ASD) and their families, inclu

80 genomes from 1,902 individuals affected with autism spectrum disorder (ASD) and their unaffected sibl

81 riched for genes implicated in non-syndromic autism spectrum disorder (ASD) and were differentially e

82 quences of approximately 8,000 children with autism spectrum disorder (ASD) and/or attention deficit

83 The second spectrum manifested with autism spectrum disorder (ASD) and/or ID and epilepsy.

84 Sleep patterns in children with autism spectrum disorder (ASD) appear to diverge from ty

85 Several genes implicated in autism spectrum disorder (ASD) are chromatin regulators,

86 al motion (BM) and its putative anomalies in autism spectrum disorder (ASD) are not completely clarif

87 s of sociality in individuals diagnosed with autism spectrum disorder (ASD) are standardly explained

88 Social deficit is a core clinical feature of autism spectrum disorder (ASD) but the underlying neural

89 f the brain have been previously reported in autism spectrum disorder (ASD) but these alterations are

90 studying a missense variant in a well-known autism spectrum disorder (ASD) causing gene SHANK3.

91 n in neural suppression in young adults with autism spectrum disorder (ASD) compared to neurotypical

92 Individuals with an autism spectrum disorder (ASD) diagnosis are often descr

93 Autism spectrum disorder (ASD) does not have a distinct

94 Autism spectrum disorder (ASD) encompasses wide-ranging

95 ASD.SIGNIFICANCE STATEMENT Individuals with autism spectrum disorder (ASD) exhibit atypical attentio

96 mic studies have led to striking advances in autism spectrum disorder (ASD) genetics.

97 e hypothesized link between gut bacteria and autism spectrum disorder (ASD) has been explored through

98 Autism spectrum disorder (ASD) has been hypothesized to

99 Autism spectrum disorder (ASD) has been mostly associate

100 Autism spectrum disorder (ASD) has captured the attentio

101 Heterogeneity in autism spectrum disorder (ASD) has hindered the developm

102 range of dysregulation of gene expression in autism spectrum disorder (ASD) have been reported, the r

103 xposure to asthma medications with offspring autism spectrum disorder (ASD) have been reported.

104 r ex vivo histological postmortem studies of autism spectrum disorder (ASD) have shown gray matter mi

105 ting has been hypothesized to play a role in autism spectrum disorder (ASD) in an attempt to explain

106 olate were associated with increased risk of autism spectrum disorder (ASD) in children.

107 ombined previously distinct subcategories of autism spectrum disorder (ASD) into a single diagnostic

108 Autism spectrum disorder (ASD) is a brain disorder chara

109 Autism Spectrum Disorder (ASD) is a common neurodevelopm

110 Autism spectrum disorder (ASD) is a complex disorder wit

111 Autism spectrum disorder (ASD) is a complex neurodevelop

112 Autism spectrum disorder (ASD) is a constellation of neu

113 Autism spectrum disorder (ASD) is a continuum of neurode

114 Autism spectrum disorder (ASD) is a highly heritable and

115 Autism spectrum disorder (ASD) is a largely heritable, m

116 Autism spectrum disorder (ASD) is a multifactorial neuro

117 Autism spectrum disorder (ASD) is a neurodevelopmental c

118 Autism spectrum disorder (ASD) is a neurodevelopmental d

119 Autism spectrum disorder (ASD) is a neurodevelopmental d

120 and treatment of ASD.SIGNIFICANCE STATEMENT Autism spectrum disorder (ASD) is a neurodevelopmental p

121 Autism spectrum disorder (ASD) is a phenotypically and g

122 Autism Spectrum Disorder (ASD) is a set of heterogeneous

123 Autism spectrum disorder (ASD) is associated with noise

124 Autism spectrum disorder (ASD) is behaviorally and biolo

125 Autism spectrum disorder (ASD) is characterized by dysfu

126 Autism Spectrum Disorder (ASD) is characterized by early

127 Autism spectrum disorder (ASD) is characterized by impai

128 Autism spectrum disorder (ASD) is characterized by neuro

129 Autism spectrum disorder (ASD) is characterized partly b

130 Autism spectrum disorder (ASD) is consistently diagnosed

131 Autism spectrum disorder (ASD) is genetically heterogene

132 Autism spectrum disorder (ASD) is highly familial, with

133 The genetic architecture of autism spectrum disorder (ASD) is itself a diverse allel

134 Autism spectrum disorder (ASD) is more prevalent in male

135 Autism spectrum disorder (ASD) is often grouped with oth

136 Autism Spectrum Disorder (ASD) is one of the most common

137 g technology to evaluate the degree to which autism spectrum disorder (ASD) is related to reduced res

138 The complex etiology of autism spectrum disorder (ASD) is still unresolved.

139 Autism spectrum disorder (ASD) is strongly associated wi

140 Autism Spectrum Disorder (ASD) is the most prevalent neu

141 Autism spectrum disorder (ASD) manifests as alterations

142 It has been estimated that autism spectrum disorder (ASD) now affects 1 in 59 child

143 nditions with etiological heterogeneity like Autism Spectrum Disorder (ASD) often pose a challenge fo

144 Children with autism spectrum disorder (ASD) or attention deficit hype

145 seen in minimally-verbal (MV) children with Autism Spectrum Disorder (ASD) relates to deficits in co

146 Some children with autism spectrum disorder (ASD) show behavioral improveme

147 aracterize their diagnoses, individuals with autism spectrum disorder (ASD) show enhanced performance

148 Applying this framework to 1,790 autism spectrum disorder (ASD) simplex families reveals

149 The association between macrocephaly and autism spectrum disorder (ASD) suggests that the mechani

150 ection neurons (CPNs), has been linked to an autism spectrum disorder (ASD) syndrome.

151 are core features in schizophrenia (SZ) and autism spectrum disorder (ASD) that have been linked to

152 The syndromic autism spectrum disorder (ASD) Timothy syndrome (TS) is

153 resent the largest exome sequencing study of autism spectrum disorder (ASD) to date (n = 35,584 total

154 All patients had autistic features, and autism spectrum disorder (ASD) was diagnosed in 5 of 11

155 esents particular challenges for youths with autism spectrum disorder (ASD) who often struggle to beh

156 tations in PTEN account for ~10% of cases of autism spectrum disorder (ASD) with coincident macroceph

157 The identification of an early biomarker for autism spectrum disorder (ASD) would improve the determi

158 omes of families containing individuals with autism spectrum disorder (ASD)(2,3) and population contr

159 ability, is the leading monogenetic cause of autism spectrum disorder (ASD), a neurodevelopmental con

160 ion in neuropsychiatric conditions including autism spectrum disorder (ASD), a neurodevelopmental syn

161 m birth (PTB), term low birth weight (TLBW), autism spectrum disorder (ASD), and asthma.

162 b are associated with X-linked macrocephaly, autism spectrum disorder (ASD), and intellectual disabil

163 key phenotypes in individuals diagnosed with autism spectrum disorder (ASD), and may potentially cont

164 ntion deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive

165 s frequently disrupted in male subjects with autism spectrum disorder (ASD), but the functional conse

166 Hundreds of genes are implicated in autism spectrum disorder (ASD), but the mechanisms throu

167 urrently known about sleep in the context of autism spectrum disorder (ASD), including ASD-related co

168 ifferent neuropsychiatric diseases including Autism Spectrum Disorder (ASD), intellectual disabilitie

169 oduplications of 16p11.2 are associated with autism spectrum disorder (ASD), intellectual disability

170 Despite rising prevalence of autism spectrum disorder (ASD), its brain bases remain u

171 he effects of oxytocin on social deficits in autism spectrum disorder (ASD), no large-scale study has

172 Autism spectrum disorder (ASD), obsessive-compulsive dis

173 SIB) is among the most dangerous concerns in autism spectrum disorder (ASD), often requiring detailed

174 d neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like featu

175 Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and

176 aling, are prone to developing macrocephaly, autism spectrum disorder (ASD), seizures and intellectua

177 al environmental risk factor contributing to autism spectrum disorder (ASD), which compromises fetal

178 rived neurons are increasingly used to model Autism Spectrum Disorder (ASD), which is clinically and

179 Both CNVs are associated with autism spectrum disorder (ASD), while the deletion confe

180 Heredity has a major role in autism spectrum disorder (ASD), yet underlying causal ge

181 For a set of 13 autism spectrum disorder (ASD)-associated genes, we show

182 he most powerful windows into the biology of autism spectrum disorder (ASD).

183 rotransmission system has been implicated in autism spectrum disorder (ASD).

184 e Multisensory Integration (MSI) deficits in Autism Spectrum Disorder (ASD).

185 types have been observed in individuals with autism spectrum disorder (ASD).

186 fspring neurodevelopmental disorders such as autism spectrum disorder (ASD).

187 essions-is often altered in individuals with autism spectrum disorder (ASD).

188 ypothesized to contribute to the etiology of autism spectrum disorder (ASD).

189 in restricted, repetitive behaviors (RRB) in autism spectrum disorder (ASD).

190 on-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD).

191 ic disorders such as schizophrenia (SCZ) and autism spectrum disorder (ASD).

192 cy may be associated with increased risk for autism spectrum disorder (ASD).

193 s among the most frequently mutated genes in autism spectrum disorder (ASD).

194 ted and studied social behaviors affected by autism spectrum disorder (ASD).

195 ked to neurodevelopmental disorders, such as autism spectrum disorder (ASD).

196 c scaffold protein, play a causative role in autism spectrum disorder (ASD).

197 netic and environmental factors relevant for autism spectrum disorder (ASD).

198 activity disorder (ADHD) and, more recently, Autism Spectrum Disorder (ASD).

199 egulated oxytocin signaling is implicated in autism spectrum disorder (ASD).

200 l disorders including epilepsy, dementia and Autism Spectrum Disorder (ASD).

201 yroid, and other cancers and, in one subset, autism spectrum disorder (ASD).

202 th and neurodevelopmental disorders, such as autism spectrum disorder (ASD).

203 ated with several brain disorders, including autism spectrum disorder (ASD).

204 sfunction have been repeatedly implicated in autism spectrum disorder (ASD).

205 on deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD).

206 f the earliest observations in children with autism spectrum disorder (ASD).

207 heterogeneity underlies the neurobiology of autism spectrum disorder (ASD).

208 pathway has become a point of convergence in autism spectrum disorder (ASD).

209 on mutations revealed by exome sequencing in autism spectrum disorder (ASD).

210 ders, including schizophrenia, epilepsy, and autism spectrum disorder (ASD).

211 reported in children but not in adults with autism spectrum disorder (ASD).

212 ed, confer risk that is largely specific for autism spectrum disorder (ASD).

213 eages and associated with phenotypes such as autism spectrum disorder (ASD).

214 riants to identify 102 genes associated with autism spectrum disorder (ASD).

215 obustness of brain networks in children with autism spectrum disorder (ASD).

216 mechanism in many brain disorders including autism spectrum disorder (ASD).

217 Autism spectrum disorders (ASD) are a group of neurodeve

218 Autism spectrum disorders (ASD) are a group of related n

219 Autism spectrum disorders (ASD) are strongly associated

220 Genes that are mutated in Autism Spectrum Disorders (ASD) can be classified broadl

221 antibodies contributes to the development of autism spectrum disorders (ASD) has been entertained for

222 Diagnosing autism spectrum disorders (ASD) is a complicated, time-c

223 re found in intellectual disability (ID) and autism spectrum disorders (ASD) patients.

224 on to identify the functional variants among autism spectrum disorders (ASD) patients.

225 adsorption, is one of the possible causes of autism spectrum disorders (ASD) predominantly in patient

226 Autism spectrum disorders (ASD) refer to a range of neur

227 and debilitating symptom in individuals with autism spectrum disorders (ASD), but the neural basis un

228 tivate negative translation regulators cause autism spectrum disorders (ASD), which predominantly aff

229 ial symptoms following oxytocin treatment in autism spectrum disorders (ASD), while others point to e

230 ome) in the recent increase in prevalence of autism spectrum disorders (ASD).

231 l vitamin D concentrations influence risk of autism spectrum disorders (ASD).

232 , including intellectual disability (ID) and autism spectrum disorders (ASD).

233 uli were presented to adult individuals with autism spectrum disorders (ASD; n = 24, mean age 23 year

234 at PLR response was altered in children with autism spectrum disorders (ASDs) and other neurological

235 Autism spectrum disorders (ASDs) are developmental neuro

236 Taok2-dependent ASDs.SIGNIFICANCE STATEMENT Autism spectrum disorders (ASDs) are linked to abnormal

237 Autism spectrum disorders (ASDs) are pervasive neurodeve

238 cation of genetic biomarkers associated with autism spectrum disorders (ASDs) could improve recurrenc

239 Subjects with autism spectrum disorders (ASDs) have difficulty identif

240 Individuals with autism spectrum disorders (ASDs) imitate observed behavi

241 A major challenge facing the genetics of autism spectrum disorders (ASDs) is the large and growin

242 major hallmark of fragile X syndrome (FXS), autism spectrum disorders (ASDs), and other intellectual

243 elopmental defects.SIGNIFICANCE STATEMENT In autism spectrum disorders (ASDs), prenatal infection or

244 d to neurodevelopmental disorders, including autism spectrum disorders (ASDs).

245 ebellar dysfunction has been demonstrated in autism spectrum disorders (ASDs); however, the circuits

246 ng variants in MINT2 have been identified in autism spectrum disorders (ASDs); however, these rare va

247 ocial interaction (SI) are a core symptom of autism spectrum disorders (ASDs); however, treatments fo

248 smembrane transporter activity pathways, and autism spectrum disorder-associated gene sets.

249 neuropsychiatric disorders [e.g., increased autism spectrum disorder, attention deficit hyperactivit

250 ty, macrocephaly, and psychiatric disorders (autism spectrum disorders/attention deficit hyperactivit

251 2-week clinical phase 2 study in adults with autism spectrum disorder balovaptan demonstrated improve

252 ntion deficit hyperactivity disorder (ADHD), autism spectrum disorder, bipolar disorder, major depres

253 athology of psychiatric disorders, including autism spectrum disorder, bipolar disorder, major depres

254 pothesis that aberrant sensory processing in autism spectrum disorder could be linked to atypical int

255 Such altered sensory perception in autism spectrum disorders could arise from disruptions i

256 Affective and autism spectrum disorders exhibited a SNP heritability o

257 ng the inherited intellectual disability and autism spectrum disorder, fragile X syndrome (FXS).

258 dy movement may distinguish individuals with autism spectrum disorder from individuals with typical d

259 changes during treatment, and the higher the autism spectrum disorder genetic load, the less the depr

260 nteraction effect (B = 0.09, p < 0.001): the autism spectrum disorder genetic risk score correlated w

261 cillations, was significantly reduced in the autism spectrum disorder group.

262 phase amplitude coupling) was reduced in the autism spectrum disorder group.

263 Autism spectrum disorder has been characterized by atypi

264 and repeated administration of oxytocin for autism spectrum disorder have led researchers to hypothe

265 Neurodevelopmental disorders, including autism spectrum disorder, have complex polygenic etiolog

266 surrogates of social behavior in adults with autism spectrum disorder in an exploratory proof-of-mech

267 ncy and increased risks of schizophrenia and autism spectrum disorder in the offspring.

268 lted in a behavioral phenotype suggestive of autism spectrum disorder in the xCT(-/-) mice; in tests

269 ndary microcephaly in two other children and autism spectrum disorder in three previously healthy chi

270 xiety and mood disorders, schizophrenia, and autism spectrum disorder, in which they have been identi

271 e of neurodevelopmental disorders, including autism spectrum disorder, intellectual disability, and e

272 s of neurodevelopmental disorders, including autism spectrum disorders, intellectual disabilities, an

273 morbidity maps of a cohort of children with autism spectrum disorder/intellectual disability versus

274 r, attention-deficit/hyperactivity disorder, autism spectrum disorder, intelligence, and educational

275 Autism spectrum disorder involves persistent difficultie

276 Autism spectrum disorder is a construct used to describe

277 Autism Spectrum Disorder is a neuropsychiatric condition

278 The etiology of autism spectrum disorder is poorly understood.

279 The recurrence risk for autism spectrum disorders is substantial, leading many f

280 ental challenge in developing treatments for autism spectrum disorders is the heterogeneity of the co

281 In sum, social communication difficulties in autism spectrum disorder may involve deficits in cross-m

282 e features of fragile X syndrome and related autism spectrum disorder models.

283 renia (N = 696), bipolar disorder (N = 211), autism spectrum disorder (N = 126), or major depressive

284 ivo Perturb-Seq, to functionally evaluate 35 autism spectrum disorder/neurodevelopmental delay (ASD/N

285 A pre-emptive intervention for the autism spectrum disorder prodrome had no immediate treat

286 or depressive disorder, depressive symptoms, autism spectrum disorder, psychosis, and alcohol use dis

287 d that mosaicism quantification can stratify autism spectrum disorders recurrence risk due to de novo

288 ive in the Mecp2 knockout mouse model of the autism spectrum disorder Rett syndrome, which has defici

289 , objective, and quantitative measurement of autism spectrum disorder's core symptoms are lacking, ma

290 ric, and neurodegenerative disorders such as autism spectrum disorder, schizophrenia, and Huntington'

291 erived from RNA-sequencing studies including autism spectrum disorder, schizophrenia, and Zika virus

292 in our cohort were intellectual disability, autism spectrum disorder, seizures, variable brain malfo

293 nd that schizophrenia, bipolar disorder, and autism spectrum disorder share similar white matter micr

294 Individuals with autism spectrum disorder struggle with motor difficultie

295 e had no immediate treatment effect on early autism spectrum disorder symptoms, the quality of parent

296 any anxiety disorder (OR 2.9, 1.2-6.7), and autism spectrum disorder traits (OR 44.1, 15.3-127.5) wa

297 dividuals with autism spectrum disorder, and autism spectrum disorder traits in individuals with ADHD

298 a model of synaptic dysfunction relevant to autism spectrum disorders, were highly replicable across

299 Behavioral problems, including autism spectrum disorders, were reported in 47% of indiv

300 pplication to heterogenous disorders such as autism spectrum disorder will require individual-subject